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المؤلفون: Hofer, Sebastian, J, Daskalaki, Ioanna, Abdellatif, Mahmoud, Stelzl, Ulrich, Sedej, Simon, Tavernarakis, Nektarios, Kroemer, Guido, Madeo, Frank
المساهمون: Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria, BioTechMed-Graz, Graz University of Technology Graz (TU Graz)-Karl-Franzens-Universität Graz-Medical University of Graz = Medizinische Universität Graz, University of Graz, Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, Heraklion, Greece, Department of Biology, School of Sciences and Engineering, University of Crete, Heraklion, Institute of Physiology, Faculty of Medicine, University of Maribor, Maribor, Division of Basic Sciences, School of Medicine, University of Crete, Heraklion, Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Institut Gustave Roussy (IGR), Cancer Research and Personalized Medicine - CARPEM Paris (SIRIC CARPEM), Hôpital Européen Georges Pompidou APHP (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpital Cochin AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut national du cancer (INCa)-Université Paris Cité (UPCité), This research was funded in whole, or in part, by the AustrianScience Fund (FWF) 10.55776/P37278, 10.55776/P37016, 10.55776/P31727, 10.55776/W1226 . For the purpose of open access, theauthor has applied a CC BY public copyright licence to anyAuthor Accepted Manuscript version arising from this submission.SJH is grateful for support from the Styrian Government for thegrant “AutoKomm.” SS and MA acknowledge funding received fromthe Medical University of Graz (Flagship Project VASC-HEALTH).MA and GK acknowledge funding received from the FWF (DOI:10.55776/I6931) and ANR under the umbrella of the PartnershipFostering a European Research Area for Health (ERA4Health) (GAN° 101095426 of the EU Horizon Europe Research and InnovationProgramme). MA acknowledges additional support from the FWF(DOI:10.55776/P34926), and BioTechMed-Graz (Young ResearcherGroup). SS acknowledges the support from FWF through grantsP27637-B28 and I3301, BioTechMed-Graz (Flagship projectINTERACD+), and Medical University of Graz (Flagship projectVASC-HEALTH). NT acknowledges support from the EuropeanResearch Council (grant ERC-GA695190-MANNA), the EuropeanCommission (FETOPEN project Dynamic-GA-863203, andResearch Excellence Hub CHAngeing-GA-101087071), the GreekNational Research Infrastructure project BIOIMAGING-GR-MIS5002755, the Hellenic Foundation for Research and Innovationand the General Secretariat for Research and Innovation.GK is sup-ported by the Ligue contre le Cancer (équipe labellisée), AgenceNational de la Recherche (ANR-22-CE14-0066 VIVORUSH, ANR-23-CE44-0030 COPPERMAC, ANR-23-R4HC-0006 Ener-LIGHT), Association pour la recherche sur le cancer (ARC), CancéropôleIle-de-France, Fondation pour la Recherche Médicale (FRM), adonation by Elior, European Joint Programme on Rare Diseases(EJPRD) Wilsonmed, European Research Council AdvancedInvestigator Award (ERC-2021-ADG, Grant No. 101052444, projectacronym: ICD-Cancer, project title: Immunogenic cell death (ICD)in the cancer-immune dialogue), The ERA4 Health Cardinoff GrantEner-LIGHT, European Union Horizon 2020 research and innova-tion programmes Oncobiome (grant agreement number: 825410,Project Acronym: ONCOBIOME, Project title: GutOncoMicrobiome Signatures GOMS associated with cancer inci-dence, prognosis and prediction of treatment response, Prevalung(grant agreement number 101095604, Project Acronym:PREVALUNG EU, project title: Biomarkers affecting the transitionfrom cardiovascular disease to lung cancer: towards stratified inter-ception), Neutrocure (grant agreement number 861878 : ProjectAcronym: Neutrocure, project title: Development of “smart” ampli-fiers of reactive oxygen species specific to aberrant polymorphonuc-lear neutrophils for treatment of inflammatory and autoimmunediseases, cancer and myeloablation), National support managed bythe Agence Nationale de la Recherche under the France 2030 pro-gramme (reference number 21-ESRE-0028, ESR/Equipex+ Onco-Pheno-Screen), Hevolution Network on Senescence in Aging (refer-ence HF-E Einstein Network), Institut National du Cancer (INCa), Institut Universitaire de France, LabEx Immuno-Oncology ANR-18-IDEX-0001, a Cancer Research ASPIRE Award from the MarkFoundation, PAIR-Obésité INCa_1873, the RHUs Immunolife andLUCA-pi (ANR-21-RHUS-0017 and ANR-23-RHUS-0010, both dedi-cated to France Relance 2030), Seerave Foundation, SIRIC CancerResearch and Personalized Medicine (CARPEM, SIRIC CARPEMINCa-DGOS-Inserm-ITMO Cancer_18006 supported by InstitutNational du Cancer, Ministère des Solidarités et de la Santé andINSERM). This study contributes to the IdEx Université de ParisCité ANR-18-IDEX-0001. FM is grateful for support from theUniversity of Graz for the grant “Fast4Health,” the AustrianScience Fund (FWF) for the grants P 37278-B, P 37016-B, P31727-B21, W 1226, as well as BioTechMed-Graz (Flagship projectEPIAge) and the University of Graz Field of Excellence BioHealth., ANR-22-CE14-0066,VIVORUSH,Le système RUSH : un système chemo-génétique pour la manipulation in vivo de circuits de communication.(2022), ANR-23-CE44-0030,COPPERMAC,Ciblage du cuivre mitochondrial pour moduler l'inflammation(2023), ANR-18-IDEX-0001,Université de Paris,Université de Paris(2018), ANR-21-RHUS-0017,IMMUNOLIFE,Microbiota-centered interventions to solve antibiotics-induced primary resistance to immune checkpoint inhibitors(2021), ANR-23-RHUS-0010,LUCA-pi,Lung cancer prevention and interception(2023), ANR-23-R4HC-0006,Ener-LIGHT,Energizing the failing heart(2023), ANR-21-ESRE-0028,ONCO-PHENO-SCREEN,Next-generation phenotypic screening for oncological applications(2021)
المصدر: ISSN: 1554-8627.
مصطلحات موضوعية: EIF5A: eukaryotic translation initiation factor 5A IGF1: insulin like growth factor 1 MTOR: mechanistic target of rapamycin kinase ODC1: ornithine decarboxylase 1 TFEB: transcription factor EB Aging autophagy lifespan rapamycin spermidine MTOR, EIF5A: eukaryotic translation initiation factor 5A, IGF1: insulin like growth factor 1, MTOR: mechanistic target of rapamycin kinase, ODC1: ornithine decarboxylase 1, TFEB: transcription factor EB Aging, autophagy, lifespan, rapamycin, spermidine, MTOR, [SDV]Life Sciences [q-bio]
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المؤلفون: Banrida Wahlang, Monika Thapa, Michael L. Merchant, Jian Jin, Sudhir Srivastava, Josiah E. Hardesty, Russell A. Prough, Shesh N. Rai, Matthew C. Cave, Kimberly Z. Head
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3806-3819 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: WT, wild type, TAT, tyrosine aminotransferase, PCB126, AHR, IGF1, insulin-like growth factor 1, PCB, polychlorinated biphenyl, Blood lipids, FGF21, fibroblast growth factor 21, miR, microRNA, Pheromones, AHR, aryl hydrocarbon receptor, AUC, area under the curve, Liver disease, HFD, high fat diet, AST, aspartate transaminase, LDL, low-density lipoprotein, VLDL, very low-density lipoprotein, Environmental liver disease, General Pharmacology, Toxicology and Pharmaceutics, Receptor, MUP, major urinary protein, ANOVA, analysis of variance, NFKBIA, nuclear factor kappa-inhibitor alpha, PNPLA3, patatin-like phospholipase domain-containing protein 3, biology, ZFP125, zinc finger protein 125, PXR, pregnane-xenobiotic receptor, MCP-1, monocyte chemoattractant protein-1, respiratory system, EPF, enrichment by protein function, IL-6, interleukin 6, nHDLc, non-HDL cholesterol, IPF, interaction by protein function, PAI-1, plasminogen activator inhibitor-1, PLIN2, perilipin-2, Proteome, CYP, cytochrome P450, Original Article, CAR, constitutive androstane receptor, SGK1, serum/glucocorticoid regulated kinase, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, FDR, false discovery rate, ALT, alanine transaminase, Endocrine disruption, HDL, high-density lipoprotein, H&E, hematoxylin-eosin, RM1-950, CD36, cluster of differentiation 36, Perilipin-2, Internal medicine, medicine, Nonalcoholic fatty liver disease, Pheromone binding, GO, gene ontology, TASH, toxicant-associated steatohepatitis, PPARα, peroxisome proliferator-activated receptor alpha, TAFLD, toxicant-associated fatty liver disease, TMT, tandem mass tag, medicine.disease, Aryl hydrocarbon receptor, Insulin receptor, Endocrinology, biology.protein, GCR, glucocorticoid receptor, Therapeutics. Pharmacology, Steatosis
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المؤلفون: Sri Lilidjanti Widjaja, Soetrisno, Indah Yulianto, Harsono Salimo
المصدر: Saudi Journal of Biological Sciences, Vol 28, Iss 8, Pp 4399-4407 (2021)
Saudi Journal of Biological Sciencesمصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, Angiogenesis, Cell, TGF-β, Transforming Growth Factor-Beta, 01 natural sciences, HIF-1α, Hypoxia Inducible Factor-1α, ATP, Adenosine Triphosphate, Biology (General), Hypoxia, Secretome, PBS, Phosphate-buffered Saline, biology, medicine.diagnostic_test, VEGF, Vascular Endothelial Growth Factor, IGF1, Insulin-like Growth Factor 1, LF, Lactoferrin, SMAD, Signals Mothers Against the Decapentaplegic, LC-MS, Liquid Chromatography-Mass Spectrometry, MSC, Mesenchymal Stem Cell, Cell biology, hBSC, medicine.anatomical_structure, Original Article, Stem cell, General Agricultural and Biological Sciences, MPS, Multi Proliferative Supplement, Mesenchymal stem-like cell, BMPR-II, Bone morphogenetic protein type II, FACS, Fluorescence-Activated Cell Sorting, EHD3, EH Domain-containing Protein 3, QH301-705.5, SMA, Smooth Muscle Actin, cDNA, complementary Deoxyribonucleic Acid, hBSC, Human Breastmilk Stem Cell, Flow cytometry, AFP, Alpha-Fetoprotein, 03 medical and health sciences, mRNA, messenger Ribonucleic Acid, medicine, CD90, BD, Becton Dickinson, CD44, Mesenchymal stem cell, MAPK, Mitogen-Activated Protein Kinase, LALBA, α-Lactalbumin, LC-MS, 030104 developmental biology, Cell culture, biology.protein, MPZL1, Myelin Protein Zero-like Protein 1, BSA, Bovine Serum Albumin, SDS, Sodium Dodecyl Sulfate, 010606 plant biology & botany, FBS, Fetal Bovine Serum
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المؤلفون: Bernard L. Schneider, Rashmi Kothary, Maica Llavero-Hurtado, Thomas H. Gillingwater, Abdelmadjid Atrih, Alexandra Tierney, Jean Michaud, Ariane Beauvais, Thomas M. Wishart, Lucia Chehade, Marc-Olivier Deguise, Douglas J. Lamont, Simon H. Parson, Yves De Repentigny, Mary-Ellen Harper, Chantal A. Pileggi
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 354-377.e3 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Deguise, M-O, Pileggi, C, De Repentigny, Y, Beauvais, A, Tierney, A, Chehade, L, Michaud, J, Llavero hurtado, M, Lamont, D, Atrih, A, Wishart, T, Gillingwater, T, Schneider, B L, Harper, M-E, Parson, S & Kothary, R 2021, ' SMN depleted mice offer a robust and rapid onset model of non-alcoholic fatty liver disease ', Cellular and Molecular Gastroenterology and Hepatology . https://doi.org/10.1016/j.jcmgh.2021.01.019مصطلحات موضوعية: 0301 basic medicine, LC-MS, liquid chromatography-mass spectrometry, DAVID, Database for Annotation, Visualization and Integrated Discovery, IGF1, insulin-like growth factor 1, AST, aspartate aminotransferase, RC799-869, muscular-atrophy phenotype, CS, citric synthase, animal-models, Mice, 0302 clinical medicine, iron, Fibrosis, Non-alcoholic Fatty Liver Disease, LDL, low-density lipoprotein, Nonalcoholic fatty liver disease, MCD, methionine and choline deficient diet, steatosis, Medicine, TNFR1, tumor necrosis factor receptor superfamily member 1A, defects, ANOVA, analysis of variance, Original Research, Mice, Knockout, P, postnatal day, FasR, Fas receptor, NEFA, non-esterified fatty acid, p53, tumor protein p53, TEAB, triethyl ammonium bicarbonate, Fatty liver, Gastroenterology, NASH, CPT1, carnitine palmitoyl transferase 1, p21, cyclin dependent kinase inhibitor 1A, Diseases of the digestive system. Gastroenterology, 3. Good health, ECM, extracellular matrix, SMN, TMT, tandem mass tagging, mouse-model, qPCR, quantitative polymerase chain reaction, 030211 gastroenterology & hepatology, NASH, nonalcoholic steatohepatitis, medicine.medical_specialty, insulin, HDL, high-density lipoprotein, PBS, phosphate-buffered saline, steatohepatitis, Hypoglycemia, SMN1, survival motor neuron 1, 03 medical and health sciences, Insulin resistance, ROS, reactive oxygen species, VLDL, very low density lipoprotein, Internal medicine, ALT, alanine aminotransferase, NAFLD, mitochondrial dysfunction, Animals, MCL, Markov Clustering Algorithm, Hepatology, ALP, alkaline phosphatase, business.industry, T2DM, type 2 diabetes mellitus, IPA, ingenuity pathway analysis, medicine.disease, WT, wild-type, Survival of Motor Neuron 1 Protein, igfals, insulin-like growth factor binding protein acid labile subunit, digestive system diseases, Fatty Liver, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Endocrinology, Metabolism, AAV9, adeno-associated virus 9, SMA, spinal muscular atrophy, network, Akt, protein kinase B, Hepatic stellate cell, NAFLD, nonalcoholic fatty liver disease, Steatosis, Steatohepatitis, business, Bax, BCL2 associated X protein, HFN4a, hepatic nuclear factor 4 alpha
وصف الملف: application/pdf
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المؤلفون: Zhi-Ren Liu, Jenny J. Yang, Malvika Sharma, Shiyuan Wang, Falguni Mishra, Sun Li, Ravi Chakra Turaga, Alyssa M. Krasinskas, Yi Yuan, Chunfeng Liu
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 161-179 (2021)مصطلحات موضوعية: 0301 basic medicine, endocrine system diseases, Angiogenesis, Dck, deoxycytidine kinase, medicine.medical_treatment, PDAC, pancreatic ductal adenocarcinoma, OrKPC, KPC 961 cell line, IGF1, insulin-like growth factor 1, Apoptosis, Metastasis, GEM, genetically engineered mouse, Mice, 0302 clinical medicine, CAPaSC, cancer-associated pancreatic stellate cells, Original Research, Pancreatic Stellate Cells, Gastroenterology, Shh, Sonic hedgehog, Pancreatic Cancer Treatment, mRNA, messenger RNA, Integrin αvβ3, 030211 gastroenterology & hepatology, Collagen, IGF1R, Insulin-like growth factor 1 receptor, Carcinoma, Pancreatic Ductal, Primary Cell Culture, Antineoplastic Agents, Mice, Transgenic, 03 medical and health sciences, Cda, cytidine deaminase, Stroma, Pancreatic cancer, Cell Line, Tumor, medicine, Tdk, Thymidine kinase, Animals, Humans, lcsh:RC799-869, CAF, cancer-associated fibroblast, KPC, LSL-KrasG12D/+, LSL-Trp53R172H/+, Pdx-1-Cre, Hepatology, business.industry, Growth factor, Cancer, dFDC, 2′,2′-difluorodeoxcytidine, dFdU, 2′,2′-difluorodeoxyuridine, medicine.disease, Integrin alphaVbeta3, Gemcitabine, Xenograft Model Antitumor Assays, Pancreatic Neoplasms, dFdCTP, gemcitabine triphosphate, Disease Models, Animal, 030104 developmental biology, Cancer cell, LSL, Lox-Stop-Lox, Hepatic stellate cell, Cancer research, Gem, gemcitabine, lcsh:Diseases of the digestive system. Gastroenterology, α-SMA, α smooth muscle actin, business
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المؤلفون: Martin Bidlingmaier, Birgit Rathkolb, Martin Hrabĕ de Angelis, Arne Hinrichs, Werner F. Blum, Sebastian Bultmann, Heinrich Leonhardt, Maik Dahlhoff, Simone Renner, Andreas Blutke, Eckhard Wolf, Barbara Kessler, Andreas Hoeflich, Hiroshi Nagashima, Maren Bernau, Mayuko Kurome, Rüdiger Wanke, Elisabeth Kemter, Armin M. Scholz
المصدر: Molecular Metabolism, Vol 11, Iss, Pp 113-128 (2018)
Molecular Metabolism
Mol. Metab. 11, 113-128 (2018)
Molecular metabolism, 11: 113-128مصطلحات موضوعية: 0301 basic medicine, Insulin-like growth factor 1, Swine, INSR, insulin receptor, medicine.medical_treatment, 4EBP1, eukaryotic initiation factor 4E binding protein 1, IGFBP3, Dwarfism, IGF1, insulin-like growth factor 1, Growth hormone receptor, PCR, polymerase chain reaction, LDL, low-density lipoprotein, Laron syndrome, STAT5 Transcription Factor, Insulin-Like Growth Factor I, LSM, least squares mean, CRISPR/Cas, clustered regularly interspaced short palindromic repeats/CRISPR-associated, JAK2, Janus kinase 2, Adiposity, mTOR, mechanistic target of rapamycin, HOMA, homeostatic model assessment, DXA, dual-energy X-ray absorptiometry, ELISA, enzyme-linked immunosorbent assay, Pig model, eIF4E, eukaryotic translation initiation factor 4E, AKT, serine-threonine protein kinase, PPARG, peroxisome proliferator-activated receptor gamma, STAT, signal transducer and activator of transcription, GHR, growth hormone receptor, LPL, lipoprotein lipase, Liver, mTORC, mTOR complex, S6K, protein S6 kinase 1, Original Article, IRS1, insulin receptor substrate 1, Growth Hormone Receptor, Laron Syndrome, Pig Model, Hypoglycemia, Insulin-like Growth Factor 1, Signaling, HSL, hormone-sensitive lipase, PI3K, phosphoinositide 3 kinase, hormones, hormone substitutes, and hormone antagonists, Signal Transduction, medicine.medical_specialty, lcsh:Internal medicine, aa, amino acid, HDL, high-density lipoprotein, IgG, immunoglobulin G, Mechanistic Target of Rapamycin Complex 2, Biology, 03 medical and health sciences, GSK3B, glycogen synthase 3 beta, Internal medicine, medicine, Animals, LS, Laron syndrome, lcsh:RC31-1245, Molecular Biology, Leptin receptor, DAB, 3,3′-diaminobenzidine, SE, standard error, Growth factor, Body Weight, sgRNA, single guide RNA, Cell Biology, Receptors, Somatotropin, Janus Kinase 2, medicine.disease, IRS1, GH, growth hormone, TBS, Tris-buffered saline, Insulin receptor, Insulin-Like Growth Factor Binding Protein 2, AMPK, AMP-activated protein kinase, 030104 developmental biology, Endocrinology, Insulin-Like Growth Factor Binding Protein 3, IGFBP, IGF-binding protein, LEPR, leptin receptor, Growth Hormone, biology.protein, RIA, radioimmunoassay, MRI, magnetic resonance imaging, MAPK, mitogen-activated protein kinase
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المؤلفون: Xin Tong, Lei Yin, Ram K. Menon, Colin L. Stewart, Min-Jung Park, Makayla J. Brunt, M. Bishr Omary, Raymond Kwan, Maria Brzozowski, Graham F. Brady, Sujith V.W. Weerasinghe, Hope Martin
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 4, Iss 3, Pp 365-383 (2017)مصطلحات موضوعية: WT, wild type, 0301 basic medicine, Premature aging, HFD, high-fat diet, Stat, signal transducer and activator of transcription, Nonalcoholic Fatty Liver Disease, Lipodystrophy, Laminopathy, Growth Hormone Signaling, % liver weight, liver percentage of body mass, PBS, phosphate-buffered saline, Igf1, insulin-like growth factor 1, Biology, FPLD2, Dunnigan familial partial lipodystrophy, Het, heterozygous, Erk, extracellular signal–regulated kinase, LMNA, 03 medical and health sciences, Hepatocyte homeostasis, Jak2, Janus kinase 2, medicine, lcsh:RC799-869, STAT5, Original Research, KO, knockout, Hepatology, ND, normal diet, Gastroenterology, medicine.disease, Fibrosis, GH, growth hormone, 3. Good health, Cell biology, 030104 developmental biology, Cancer research, biology.protein, qPCR, quantitative polymerase chain reaction, Nuclear lamina, lcsh:Diseases of the digestive system. Gastroenterology, NAFLD, nonalcoholic fatty liver disease, Steatohepatitis, Lamin
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المؤلفون: Elio Riboli, Jochen Hampe, Ruth C. Travis, Andrea N. Burnett-Hartman, Anna H. Wu, Steven Gallinger, Stephen B. Gruber, Christopher I. Li, Bethany Van Guelpen, Kala Visvanathan, Loic Le Marchand, Veronika Vymetalkova, Demetrius Albanes, Jeroen R. Huyghe, Lori C. Sakoda, Jennifer Ose, Daniel D. Buchanan, Kenneth Offit, D. Timothy Bishop, John D. Potter, Sonja I. Berndt, Neil Murphy, Vittorio Perduca, Roger L. Milne, Niki Dimou, Marc J. Gunter, Ulrike Peters, Wen Yi Huang, Sergi Castellví-Bel, Graham Casey, Robert E. Schoen, Martha L. Slattery, Kathryn E. Bradbury, Albert de la Chapelle, Temitope O. Keku, Andrea Gsur, Wei Zheng, Gad Rennert, Hermann Brenner, Tabitha A. Harrison, Claudia Agnoli, Fränzel J.B. Van Duijnhoven, Sabina Rinaldi, Catherine M. Tangen, Jane C. Figueiredo, Ludmila Vodickova, Andrew T. Chan, Tilman Kühn, Hansong Wang, Mingyang Song, Sun-Seog Kweon, Annika Lindblom, Amanda I. Phipps, Cornelia M. Ulrich, Victor Moreno, Mark A. Jenkins, Li Hsu, Emily White, Conghui Qu, Peter T. Campbell, Stéphane Bézieau, Nikos Papadimitriou, Michael O. Woods, Jelena Bešević, Polly A. Newcomb, Pavel Vodicka, Heather Hampel, Barbara L. Banbury, Amanda J. Cross, Robert Carreras-Torres, Alicja Wolk, Graham G. Giles, Michael Hoffmeister, Elizabeth A. Platz, N. Charlotte Onland-Moret, Dallas R. English, Li Li, Jenny Chang-Claude, Vicente Martín, Richard M. Martin, María Dolores Chirlaque, Konstantinos K. Tsilidis, Clemens Schafmayer, Shuji Ogino
المساهمون: Nutrition and Metabolism Section, International Agency for Research on Cancer, Centre international de Recherche sur le Cancer (CIRC), School of Public Health - Department of Epidemiology and Biostatistics, Imperial College London, Nuffield Department of Population Health - Cancer Epidemiology Unit, University of Oxford [Oxford], International Agency for Cancer Research (IACR), School of Public Health [London, UK] (Faculty of Medicine), Candiolo Cancer Institute (IRCCS), National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Division of Cancer Epidemiology and Genetics [Bethesda, MD, États-Unis], National Institutes of Health [Bethesda] (NIH)-National Institutes of Health [Bethesda] (NIH), Interactions récepteurs ligands en immunocancérologie et immunopathologie, IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de génétique médicale - Unité de génétique clinique [Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), St. James's University Hospital, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), University Medical Center [Utrecht], The Cancer, Ageing and Somatic Mutation Programme [Cambridgeshire, UK], The Wellcome Trust Sanger Institute [Cambridge], Department of Preventive Medicine, University of Southern California (USC), Division of Cancer Epidemiology, Consorcio de Investigación Biomédica en Red especializado en Epidemiología y Salud Pública (CIBERESP), Los Centros de Investigación Biomédica en Red (CIBER), Ohio State University [Columbus] (OSU), Cancer Epidemiology Centre, Cancer Council Victoria, Samuel Lunenfeld Research Institute, Mount Sinai Hospital [Toronto, Canada] (MSH), University of Melbourne, Department of Internal Medicine, Epidemiology, Human Genetics, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Medical Department 1 [Dresden, Germany], Technische Universität Dresden = Dresden University of Technology (TU Dresden), FESTO, Universität Stuttgart [Stuttgart], Division of Cancer Epidemiology and Genetics, Department of Medical Genetics, HMNC Brain Health, University of Hawai‘i [Mānoa] (UHM), Chinese Center for Disease Control and Prevention, Department of Clinical Genetics, Karolinska University Hospital [Stockholm], Dell-EMC, Biomedical Research Centre Network for Rare Diseases, CIBER de Enfermedades Raras (CIBERER), Memorial Sloane Kettering Cancer Center [New York], Department of Pathology, Brigham and Women's Hospital [Boston], Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Gustave Roussy (IGR), Mathématiques Appliquées Paris 5 (MAP5 - UMR 8145), Institut National des Sciences Mathématiques et de leurs Interactions (INSMI)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), Department of Community Medicine and Epidemiology, CHS National Cancer Control Center, Department of Visceral and Thoracic Surgery [Kiel, Germany], University Hospital Schleswig-Holstein [Kiel, Germany], Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Helmholtz Centre for Ocean Research [Kiel] (GEOMAR), Department of Medical Biosciences and Pathology, Umeå University, Institute of Experimental Medicine, Czech Academy of Sciences [Prague] (CAS), Karolinska Institutet [Stockholm], Center for Astrophysical Sciences [Baltimore]
المصدر: Dipòsit Digital de la UB
Universidad de Barcelona
Gastroenterology 158 (2020) 5
1312.e20
Gastroenterology, 158(5), 1300-1312.e20
Gastroenterology
Gastroenterology, WB Saunders, 2020, 158 (5), pp.1300-1312.e20. ⟨10.1053/j.gastro.2019.12.020⟩
Gastroenterology, 158(5), 1300. W.B. Saunders Ltdمصطلحات موضوعية: Oncology, Male, Nutrition and Disease, Colorectal cancer, BMI, body mass index, PLASMA-INSULIN, IGFBP3, IGF1, insulin-like growth factor 1, Genome-wide association study, GWAS, genome-wide association studies, MR-PRESSO, Mendelian Randomization Pleiotropy RESidual Sum and Outlier, FACTOR (IGF)-I, 0302 clinical medicine, Risk Factors, Voeding en Ziekte, Insulina, Medicine, Insulin, GWAS, Registries, Insulin-Like Growth Factor I, ComputingMilieux_MISCELLANEOUS, 0303 health sciences, ICC, intraclass correlation coefficient, Incidence, Hazard ratio, MR, Mendelian randomization, Gastroenterology, MEN, SNP, single nucleotide polymorphism, Middle Aged, SERUM-LEVELS, 3. Good health, IGF-I, CRC, 030220 oncology & carcinogenesis, CRP, C-reactive protein, Female, Colorectal Neoplasms, Life Sciences & Biomedicine, Medical Genetics, REGRESSION DILUTION, Signal Transduction, medicine.medical_specialty, HbA1c, glycolated hemoglobin, FACTOR-I, Polymorphism, Single Nucleotide, Risk Assessment, Article, C-PEPTIDE, 03 medical and health sciences, Sex Factors, Insulin-Like Growth Factor II, Càncer colorectal, Internal medicine, COLON, Mendelian randomization, Biomarkers, Tumor, Journal Article, Humans, IGFBP3, insulin-like growth factor binding protein 3, 030304 developmental biology, Aged, VLAG, Medicinsk genetik, Cancer och onkologi, Science & Technology, Gastroenterology & Hepatology, Hepatology, business.industry, Case-control study, Cancer, IGFBP-3, 1103 Clinical Sciences, Odds ratio, Mendelian Randomization Analysis, medicine.disease, HR, hazard ratio, United Kingdom, CI, confidence interval, OR, odds ratio, Insulin-Like Growth Factor Binding Protein 3, Case-Control Studies, Cancer and Oncology, SHBG, sex hormone binding globulin, 1114 Paediatrics and Reproductive Medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, SD, standard deviation, 1109 Neurosciences, Follow-Up Studies
وصف الملف: application/pdf; text/plain; image/pdf
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المؤلفون: Jaw-Yuan Wang, Wei-Chih Su, Hsiang-Lin Tsai, Hsiu-Chung Cheng, Tsung-Kun Chang
المصدر: Translational Oncology, Vol 14, Iss 7, Pp 101089-(2021)
Translational Oncologyمصطلحات موضوعية: Oncology, endocrine system diseases, TCF4, Transcription factor 4, Colorectal cancer, RR, relative risk, Review, I2, I-square, HbA1c, Hemoglobin A1c, ADM, antidiabetic medications, AGEs, advanced glycation end-products, SMAD3, Mothers against decapentaplegic homolog 3, US, United States, Impaired glucose tolerance, ADA, American Diabetes Association, Diabetes mellitus, 0302 clinical medicine, GREM1, Gremlin 1, SEPT9, septin 9, RC254-282, APC, Adenomatous polyposis coli, pCR, pathologic complete response, RFS, recurrence-free survival, Metformin, 030220 oncology & carcinogenesis, CRC, colorectal cancer, TCF7L2, Transcription Factor 7 Like 2, medicine.medical_specialty, CSCs, cancer stem cells, WNT, Wingless-related integration site, mTOR, mammalian target of rapamycin, BMI, Body mass index, GLUT1, glucose transporter 1, STZ, streptozotocin, EHMT2, Euchromatic Histone Lysine Methyltransferase 2, VEGFR2, vascular endothelial growth factor 2, mCRC, metastatic colorectal cancer, 03 medical and health sciences, NIDDM, non-insulin-dependent diabetes mellitus, PFS, Progression-free survival, ERFC, Emerging Risk Factors Collaboration, PKC, protein kinase C, KRAS, Kirsten rat sarcoma viral oncogene homolog, AKT, RAC-alpha serine/threonine-protein kinase, WFS1, Wolframin ER Transmembrane Glycoprotein, IGF, Insulin-Like Growth Factor, nutritional and metabolic diseases, medicine.disease, PPARG, Peroxisome Proliferator Activated Receptor Gamma, 030104 developmental biology, Hyperglycemia, TCF7L2, Oncological outcome, 0301 basic medicine, Cancer Research, TP53, tumor protein p53, FOLFOX, Folinic acid, Fluorouracil, Oxaliplatin, RPG, random plasma glucose, Cancer risk, DNA, deoxyribonucleic acid, DM, diabetes mellitus, HNF1B, Hepatocyte nuclear factor-1-beta, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, HR, hazard ratios, CENTRAL, Cochrane Central Register of Controlled Trials, GWAS, Genome-wide association studies, IGF1, Insulin-Like Growth Factor 1, HBP, hexosamine biosynthetic pathway, medicine.drug, PI3K, Phosphoinositide 3-kinases, KCNQ1, Potassium Voltage-Gated Channel Subfamily Q Member 1, EMT, epithelial mesenchymal transition, CAMK1D, Calcium/Calmodulin Dependent Protein Kinase ID, TTR, the time to recurrence, 2-h PG, 2-h plasma glucose, OS, overall survival, ROS, reactive oxygen species, IGFBPs, insulin-like growth factor-binding protein, Internal medicine, RAS, Rat sarcoma, medicine, FPG, fasting plasma glucose, PI3K/AKT/mTOR pathway, VTI1A, Vesicle Transport Through Interaction With T-SNAREs 1A, U.S.FDA, United States Food and Drug administration, OGTT, Oral Glucose Tolerance Test, business.industry, IGF2BP2, Insulin Like Growth Factor 2 MRNA Binding Protein 2, ACF, aberrant crypt foci, AMPK, Cancer, BMJ, British Medical Journal, CI, confidence interval, OR, odds ratio, AMPK, AMP-activated protein kinase, DKD, diabetic kidney disease, TP53INP1, Tumor Protein P53 Inducible Nuclear Protein 1, 5-FU, 5-fluorouracil, NEJM, The New England Journal of Medicine, business
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10
المؤلفون: Valéry Payen, Pierre Sonveaux, Jhudit Pérez-Escuredo, Luc Pellerin, Jorge Falces, Vincent F. Van Hée, Martina Sboarina
المصدر: Biochimica et Biophysica Acta
مصطلحات موضوعية: 0301 basic medicine, Angiogenesis, OXPHOS, oxidative phosphorylation, IGF1, insulin-like growth factor 1, Ketone Bodies, DBDS, 4,4′-dibenzamidostilbene-2,2′-disulphonate, TM, transmembrane (domain), Oxidative Phosphorylation, Mice, bFGF, basic fibroblast growth factor, CTL, cytolytic T lymphocyte, DC, dendritic cell, Cognition, Neoplasms, Pyruvic Acid, Glycolysis, PHD, prolylhydroxylase, Lymphocytes, NF-kB, nuclear factor-kB, pCMBS, p-chloromercuribenzene sulphonate, Neurons, Brain Diseases, LDH, lactate dehydrogenase, Neurodegeneration, MCP, monocarboxylate porter, glpT, glycerol phosphate transporter, Brain, Hydrogen-Ion Concentration, VEGF, vascular endothelial growth factor, 3. Good health, Cell biology, Neoplasm Proteins, Biochemistry, NFAT, nuclear factor of activated T cells, Tumor microenvironment, Organ Specificity, NK, natural killer (cell), BDNF, brain-derived neurotrophic factor, Lactates, EAAT1, excitatory amino acid transporter 1, Monocarboxylic Acid Transporters, Stromal cell, AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Biological Transport, Active, Metabolic cooperation, Oxidative phosphorylation, Biology, Tumor cells, Article, CN, calcineurin, IkBα, inhibitor of NF-kB α, 03 medical and health sciences, ROS, reactive oxygen species, MDSC, myeloid-derived suppressor cell, NSCLC, non-small cell lung cancer, medicine, Animals, Humans, MCT, monocarboxylate transporter, Lactate shuttle, Molecular Biology, CHC, α-cyano-4-hydroxycinnamate, Iκκβ, inhibitor of NF-κB kinase β, CAF, cancer-associated fibroblast, NMDA, N-methyl-D-aspartate, MFS, major facilitator superfamily, Cell Biology, medicine.disease, Rats, AMPK, AMP-activated protein kinase, 030104 developmental biology, Gene Expression Regulation, Basigin, Astrocytes, Cancer cell, CA, carbonic anhydrase, DIDS, 4,4′-diisothiocyano-2,2′-stilbenedisulfonic acid
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11
المؤلفون: Xiaofang Hu, Jian Jing, Cheng Xun, Lijuan Sun, Yong Chen, Jichao Liang
المصدر: Acta Pharmaceutica Sinica B, Vol 5, Iss 5, Pp 454-460 (2015)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: medicine.medical_specialty, ST2 cells, AR, Astragalus membranaceus, DKK-1, dickkopf-1, IGF1, insulin-like growth factor 1, BMP signaling pathway, ECL, enhanced chemiluminescence, Fibroblast growth factor, PVDF, polyvinylidine fluoride, Bone morphogenetic protein 2, CG, calycosin-7-O-β-d-glucopyranoside, Osteoclast, Internal medicine, medicine, OBM, osteogenic differentiation medium, General Pharmacology, Toxicology and Pharmaceutics, Calycosin-7-O-β-d-glucopyranoside, Bone regeneration, MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide, OVX, ovariectomized, WNT, wingless-type MMTV integration site family, TGF-β, transforming growth factor β, ALP, alkaline phosphatase, Chemistry, lcsh:RM1-950, Wnt signaling pathway, Ocal, osteocalcin, Osteoblast, BMP, bone morphogenetic protein, WNT/β-catenin signaling pathway, HAase, hyaluronidase, Cell biology, FGF, fibroblast growth factor, RUNX2, medicine.anatomical_structure, Endocrinology, lcsh:Therapeutics. Pharmacology, OPN, osteopontin, Original Article, Osteoblastic differentiation, MAPK, mitogen-activated protein kinase
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12
المؤلفون: Wilson, K.S., Baily, J., Tucker, C.S., Matrone, G., Vass, S., Moran, C., Chapman, K.E., Mullins, J.J., Kenyon, C., Hadoke, P.W.F., Denvir, M.A.
المصدر: Molecular and Cellular Endocrinology
مصطلحات موضوعية: animal structures, IOD, inflow: outflow distance, mef2c, myosin enhancer factor 2c, Mo, morpholino, Development, UPL, universal probes library, Biochemistry, Article, Dexamethasone, fgf, fibroblast growth factor, gata4, gata binding factor 4, Dex, Dexamethasone, Embryo Culture Techniques, Ventricular Myosins, pdgf, platelet derived growth factor, ryr, ryanodine receptor, Receptors, Glucocorticoid, Endocrinology, PBS, phosphate buffered saline, Somatomedins, Animals, Myocytes, Cardiac, Glucocorticoids, nkx2.5, homeobox protein Nkx-2.5, Molecular Biology, Zebrafish, GFP, green fluorescent protein, GR, glucocorticoid receptor (various, see gene nomenclature below), serca, sarco/endoplasmic reticulum Ca2+-ATPase, vmhc, ventricular myosin heavy chain, HPA, hypothalamic-pituitary-adrenal, (GR −/−), glucocorticoid receptor knockdown, gapdh, glyceraldehyde 3-phosphate dehydrogenase, qRT-PCR, quantitative real-time polymerase chain reaction, Gene Expression Regulation, Developmental, Heart, Zebrafish Proteins, GC, Glucocorticoid, igf1, insulin-like growth factor 1, Echocardiography, hpf, hours post fertilisation, Tg (CMLC2:GFP), transgenic cardiomyosin light chain 2: green fluorescent protein, Heart Function Tests, H&E, hematoxylin and eosin, plb, phospholamban, HPI, hypothalamic-pituitary-interrenal, PFA, paraformaldehyde, ef1α, elongation factor 1 alpha, GCs, Glucocorticoids
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13
المؤلفون: Bradford K. Poulos, Ross C. Gruber, Bridget Shafit-Zagardo, Hillary Guzik, Kathleen O’Guin, Cedric S. Raine
المصدر: ASN Neuro, Vol 6 (2014)
ASN NEUROمصطلحات موضوعية: Cell, IGF1, insulin-like growth factor 1, MAG, myelin-associated glycoprotein, Fluorescent Antibody Technique, TAM, Tyro3, Axl, and Mer, MBP+, myelin basic protein-positive, Myelin, Ganglia, Spinal, pAb, polyclonal antibody, Axon, Myelin Sheath, Microscopy, Confocal, General Neuroscience, myelination, Gas6, growth-arrest-specific protein 6, OL, oligodendrocyte, Cell biology, Oligodendroglia, medicine.anatomical_structure, BDNF, brain-derived neurotrophic factor, Intercellular Signaling Peptides and Proteins, PI3K, phosphoinositide 3-kinase, Research Article, human OPC/DRG co-culture, Confocal, NGF, nerve growth factor, Enzyme-Linked Immunosorbent Assay, Biology, CNS, central nervous system, ERK, extracellular-signal-regulated kinase, S5, lcsh:RC321-571, CSF, cerebral spinal fluid, medicine, T4, thyroxine, In Situ Nick-End Labeling, Humans, mAb, monoclonal antibody, NF, neurofilament, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, GAS6, OPC, oligodendrocyte progenitor cell, Myelin Basic Protein, Oligodendrocyte, Axons, Coculture Techniques, Myelin basic protein, DRG, dorsal root ganglia, Chemically defined medium, NB, neurobasal, nervous system, biology.protein, Neurology (clinical), Neuroscience, oligodendrocyte, MAPK, mitogen-activated protein kinase, growth arrest-specific protein 6, T3, tri-iodothyronine
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14Academic Journal
المؤلفون: Neuhausen, Susan L.
المساهمون: CALIFORNIA UNIV IRVINE
المصدر: DTIC
مصطلحات موضوعية: Medicine and Medical Research, GENETICS, EPIDEMIOLOGY, PROSTATE GLAND, PROSTATE CANCER, HORMONES, INTERACTIONS, GLYCOPROTEINS, VARIATIONS, CELLS(BIOLOGY), SHBG(SEX HORMONE BINDING GLOBULIN), IGF1(INSULIN-LIKE GROWTH FACTOR 1)
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