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1Academic Journal
المؤلفون: Godefridus J. Peters, Ietje Kathmann, Elisa Giovannetti, Kees Smid, Yehuda G. Assaraf, Gerrit Jansen
المصدر: Frontiers in Pharmacology, Vol 15 (2024)
مصطلحات موضوعية: leucovorin stereo-isomers, l-leucovorin, thymidylate synthase, 5-fluorouracil, antifolates, pemetrexed, Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
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2Academic Journal
المؤلفون: Godefridus J. Peters, Frank P. A. van Gemert, Ietje Kathmann, Guru Reddy, Saskia A. G. M. Cillessen, Gerrit Jansen
المصدر: Frontiers in Cell and Developmental Biology, Vol 8 (2020)
مصطلحات موضوعية: antifolates, pralatrexate, histone deacetylase inhibitors, belinostat, peripheral T-cell lymphoma, diffuse B-cell lymphoma, Biology (General), QH301-705.5
وصف الملف: electronic resource
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3Academic Journal
المؤلفون: Richard Honeywell, Sarina Hitzerd, Ietje Kathmann, Godefridus Peters
المصدر: ADMET and DMPK, Vol 6, Iss 3, Pp 258-266 (2018)
مصطلحات موضوعية: tyrosine kiase inhibitors, lysosomal accumulation, subcellular distribution, sunitinib, erlotinib, dasatinib, Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
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4Academic Journal
المصدر: ADMET and DMPK, Vol 4, Iss 1, Pp 23-34 (2016)
مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
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5Conference
المؤلفون: Godefridus J. Peters, Frank P. A. van Gemert, Ietje Kathmann, Guru Reddy, Saskia A. G. M. Cillessen, Gerrit Jansen
مصطلحات موضوعية: Cell Biology, Marine Biology, Cell Development, Proliferation and Death, Cell Metabolism, Cell Neurochemistry, Cellular Interactions (incl. Adhesion, Matrix, Cell Wall), antifolates, pralatrexate, histone deacetylase inhibitors, belinostat, peripheral T-cell lymphoma, diffuse B-cell lymphoma
الاتاحة: https://doi.org/10.3389/fcell.2020.577215.s001
https://figshare.com/articles/presentation/Presentation_1_Schedule-Dependent_Synergy_Between_the_Histone_Deacetylase_Inhibitor_Belinostat_and_the_Dihydrofolate_Reductase_Inhibitor_Pralatrexate_in_T-and_B-cell_Lymphoma_Cells_in_vitro_pdf/13071704 -
6Academic Journal
المؤلفون: Richard J. Honeywell, Ietje Kathmann, Elisa Giovannetti, Carmelo Tibaldi, Egbert F. Smit, Maria N. Rovithi, Henk M.W. Verheul, Godefridus J. Peters
المصدر: Cancers; Volume 12; Issue 11; Pages: 3322
مصطلحات موضوعية: tyrosine kinase inhibitors, CaCo2 model system, gut-epithelial transfer, efflux ratio, red blood cell accumulation
وصف الملف: application/pdf
Relation: Molecular Cancer Biology; https://dx.doi.org/10.3390/cancers12113322
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7Academic Journal
المؤلفون: Dzjemma Sarkisjan, Joris R. Julsing, Btissame El Hassouni, Richard J. Honeywell, Ietje Kathmann, Larry H. Matherly, Young B. Lee, Deog J. Kim, Godefridus J. Peters
المصدر: International Journal of Molecular Sciences; Volume 21; Issue 8; Pages: 2717
مصطلحات موضوعية: RX-3117, 5-aza-2′-deoxycytidine, hypomethylation, proton-coupled folate receptor, methotrexate
جغرافية الموضوع: agris
وصف الملف: application/pdf
Relation: Molecular Oncology; https://dx.doi.org/10.3390/ijms21082717
الاتاحة: https://doi.org/10.3390/ijms21082717
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8Academic JournalABCG2 Harboring the Gly482 Mutation Confers High-Level Resistance to Various Hydrophilic Antifolates
المؤلفون: Assaf Shafran, Ilan Ifergan, Eran Bram, Contact The Aacr, Gerrit Jansen, Ietje Kathmann, Godefridus J. Peters, Robert W. Robey, Susan E. Bates, Yehuda G. Assaraf, Rheumatology
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.322.7874; http://cancerres.aacrjournals.org/content/65/18/8414.full.pdf
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9
المؤلفون: Daniel S. K. Liu, Patrick Pauwels, René J. P. Musters, Nele Van Der Steen, Adam E Frampton, Elisa Giovannetti, Godefridus J. Peters, Kaylee Keller, Rob Ruijtenbeek, Ietje Kathmann, Richard Honeywell, Johan Van Meerloo, Christian Rolfo, Henk Dekker, Letizia Porcelli
المساهمون: Medical oncology laboratory, Physiology, CCA - Cancer biology and immunology, AGEM - Re-generation and cancer of the digestive system
المصدر: Journal of cellular physiology
Van Der Steen, N, Keller, K, Dekker, H, Porcelli, L, Honeywell, R J, Van Meerloo, J, Musters, R J P, Kathmann, I, Frampton, A E, Liu, D S K, Ruijtenbeek, R, Rolfo, C, Pauwels, P, Giovannetti, E & Peters, G J 2020, ' Crizotinib sensitizes the erlotinib resistant HCC827GR5 cell line by influencing lysosomal function ', Journal of Cellular Physiology, vol. 235, no. 11, pp. 8085-8097 . https://doi.org/10.1002/jcp.29463
Journal of Cellular Physiology
Journal of Cellular Physiology, 235(11), 8085-8097. Wiley-Liss Inc.مصطلحات موضوعية: 0301 basic medicine, OSIMERTINIB, erlotinib, Cell cycle checkpoint, Physiology, Clinical Biochemistry, SEQUESTRATION, 0601 Biochemistry and Cell Biology, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Original Research Articles, Antineoplastic Combined Chemotherapy Protocols, tyrosine kinase inhibitors, Original Research Article, Epidermal growth factor receptor, biology, Chemistry, Gefitinib, Proto-Oncogene Proteins c-met, ErbB Receptors, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, MET, AUTOPHAGY, Erlotinib, Life Sciences & Biomedicine, Intracellular, medicine.drug, Biochemistry & Molecular Biology, cMET, EGFR, Erlotinib Hydrochloride, 03 medical and health sciences, lysosomes, LUNG-CANCER, Cell Line, Tumor, medicine, Humans, Kinase activity, Protein Kinase Inhibitors, Biology, Cell Proliferation, crizotinib, Science & Technology, Crizotinib, KINASE INHIBITORS, AMPLIFICATION, Cell Biology, 030104 developmental biology, Drug Resistance, Neoplasm, Cell culture, PHYSICOCHEMICAL PROPERTIES, 1116 Medical Physiology, Mutation, Cancer research, biology.protein, Human medicine, GROWTH-FACTOR RECEPTOR
وصف الملف: pdf
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10
المؤلفون: Deog Joong Kim, Ietje Kathmann, Young Bok Lee, Chang-Ho Ahn, Godefridus J. Peters, Aric Orbach, Leonardo Vecchi, Nienke Losekoot, Kees Smid, Richard J. Honeywell, Eran Blaugrund, Osnat Ohne, Lak Shin Jeong, Dzjemma Sarkisjan
المساهمون: Medical oncology laboratory, CCA - Innovative therapy
المصدر: Peters, G J, Smid, K, Vecchi, L, Kathmann, I, Sarkisjan, D, Honeywell, R J, Losekoot, N, Ohne, O, Orbach, A, Blaugrund, E, Jeong, L S, Lee, Y B, Ahn, C H & Kim, D J 2013, ' Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360) ', Investigational New Drugs, vol. 31, no. 6, pp. 1444-1457 . https://doi.org/10.1007/s10637-013-0025-x
Investigational New Drugs, 31(6), 1444-1457. Kluwer Academic Publishersمصطلحات موضوعية: Pharmacology, DNA synthesis, RNA, Cytidine, Antineoplastic Agents, Cytidine deaminase, DNA, Biology, Molecular biology, Uridine, Uridine kinase, chemistry.chemical_compound, Oncology, chemistry, Biochemistry, Cell Line, Tumor, Cytidine Deaminase, Humans, Pharmacology (medical), Uridine Kinase, Nucleotide salvage, DNA Modification Methylases
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11
المؤلفون: Nienke Losekoot, Gerrit Jansen, Godefridus J. Peters, Jan Hendrik Hooijberg, Clara Lemos, Ietje Kathmann
المساهمون: Medical oncology laboratory, Medical oncology, Rheumatology, CCA - Innovative therapy
المصدر: Pteridines, Vol 24, Iss 1, Pp 81-86 (2013)
Pteridines, 24(1), 81-86. International Society of Pteridinology
Peters, G J, Kathmann, I, Lemos, C, Hooijberg, J H, Losekoot, N & Jansen, G 2013, ' Folate homeostasis of cancer cells affects sensitivity to not only antifolates but also other non-folate drugs: effect of MRP expression ', Pteridines, vol. 24, no. 1, pp. 81-86 . https://doi.org/10.1515/pterid-2013-0019مصطلحات موضوعية: anthracyclines, Crystallography, business.industry, Clinical Biochemistry, mrp1, Pharmacology, folate, Biochemistry, methotrexate, abcc1, multidrug resistance, QD901-999, Cancer cell, Molecular Medicine, Medicine, leucovorin, Sensitivity (control systems), business, Homeostasis
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12
المؤلفون: Godefridus J. Peters, Michael H. Kristensen, Richard J. Honeywell, Dzjemma Sarkisjan, Ietje Kathmann
المساهمون: Medical oncology laboratory, CCA - Target Discovery & Preclinial Therapy Development, Medical oncology
المصدر: Honeywell, R J, Sarkisjan, D, Kathmann, I, Kristensen, M H & Peters, G J 2016, ' Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA ', Nucleosides, Nucleotides and Nucleic Acids, vol. 35, no. 10-12, pp. 652-662 . https://doi.org/10.1080/15257770.2016.1216566
Nucleosides, Nucleotides and Nucleic Acids, 35(10-12), 652-662. Taylor and Francis Ltd.مصطلحات موضوعية: 0301 basic medicine, Metabolite, Cytidine, Biochemistry, Deoxycytidine, Mass Spectrometry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Liquid chromatography–mass spectrometry, Limit of Detection, Cell Line, Tumor, Genetics, medicine, Humans, Chemistry, General Medicine, Methylation, DNA, DNA Methylation, Molecular biology, Gemcitabine, Deoxyuridine, 030104 developmental biology, Cell culture, 030220 oncology & carcinogenesis, DNA methylation, Molecular Medicine, RNA, Floxuridine, medicine.drug, Chromatography, Liquid
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13
المؤلفون: Y.C. Mayur, V.V.S. Rajendra Prasad, Ietje Kathmann, G.J. Peters, Clara Lemos
المساهمون: Medical oncology laboratory, Medical oncology, CCA - Innovative therapy
المصدر: Prasad, V V S R, Peters, G J, Lemos, C, Kathmann, I & Mayur, Y C 2011, ' Cytotoxicity studies of some novel fluoro acridone derivatives against sensitive and resistant cancer cell lines and their mechanistic studies ', European Journal of Pharmaceutical Sciences, vol. 43, no. 4, pp. 217-224 . https://doi.org/10.1016/j.ejps.2011.04.010
European Journal of Pharmaceutical Sciences, 43(4), 217-224. Elsevierمصطلحات موضوعية: Male, Tertiary amine, Pharmaceutical Science, HL-60 Cells, Structure-Activity Relationship, chemistry.chemical_compound, Calmodulin, Cell Line, Tumor, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Cytotoxicity, P-glycoprotein, biology, Aminoacridines, HEK 293 cells, DNA, Drug Resistance, Multiple, In vitro, Acridone, HEK293 Cells, chemistry, Biochemistry, 3',5'-Cyclic-AMP Phosphodiesterases, Doxorubicin, Drug Resistance, Neoplasm, Cell culture, biology.protein, Calcium, Female, Drug Screening Assays, Antitumor, Acridones
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14
المؤلفون: Velivela V. S. Rajendra Prasad, Godefridus J. Peters, Y.C. Mayur, Zaheeruddin, Ietje Kathmann, Clara Lemos
المساهمون: Medical oncology laboratory, Medical oncology, CCA - Disease profiling
المصدر: Archiv der Pharmazie, 342(11), 640-650. Wiley-VCH Verlag
Mayur, Y C, Zaheeruddin, N N, Peters, G J, Lemos, C, Kathmann, I & Prasad, V V S R 2009, ' Synthesis of 2-Fluoro N-10-Substituted Acridones and Their Cytotoxicity Studies in Sensitive and Resistant Cancer Cell Lines and Their DNA Intercalation Studies ', Archiv der Pharmazie, vol. 342, no. 11, pp. 640-650 . https://doi.org/10.1002/ardp.200900046مصطلحات موضوعية: biology, Tertiary amine, Chemistry, Stereochemistry, Intercalation (chemistry), Pharmaceutical Science, Cancer, medicine.disease, Binding constant, Intercalating Agents, Acridone, Structure-Activity Relationship, chemistry.chemical_compound, Drug Resistance, Neoplasm, Cell Line, Tumor, Drug Discovery, biology.protein, medicine, Side chain, Humans, Drug Screening Assays, Antitumor, Cytotoxicity, Acridones, P-glycoprotein
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15
المؤلفون: Godefridus J. Peters, E. M. Comijn, Herbert M. Pinedo, Gerrit Jansen, P. Noordhuis, Habte Teshale, Robert Mauritz, Ietje Kathmann
المساهمون: Medical oncology, Internal medicine, Medical oncology laboratory, Hematology laboratory, Rheumatology, CCA - Oncogenesis
المصدر: Mauritz, R, Peters, G J, Kathmann, I, Teshale, H, Noordhuis, P, Comijn, E M, Pinedo, H M & Jansen, G 2008, ' Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo ', Cancer Chemotherapy and Pharmacology, vol. 62, no. 6, pp. 937-948 . https://doi.org/10.1007/s00280-008-0683-0
Cancer Chemotherapy and Pharmacology, 62(6), 937-948. Springer Verlagمصطلحات موضوعية: Cancer Research, Maximum Tolerated Dose, medicine.drug_class, Receptors, Cell Surface, Folic Acid Deficiency, In Vitro Techniques, Pharmacology, Toxicology, Aminopterin, Thymidylate synthase, Antimetabolite, Mice, Reduced Folate Carrier Protein, chemistry.chemical_compound, Cell Line, Tumor, Dihydrofolate reductase, medicine, Animals, Ascitic Fluid, Pharmacology (medical), Leukemia L1210, biology, Folate Receptors, GPI-Anchored, Membrane Transport Proteins, Biological Transport, Thymidylate Synthase, Neoplasm Proteins, Tetrahydrofolate Dehydrogenase, Polyglutamic Acid, Oncology, Biochemistry, chemistry, Mice, Inbred DBA, Folate receptor, Antifolate, biology.protein, Folic Acid Antagonists, Female, Methotrexate, Carrier Proteins, Raltitrexed, medicine.drug
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16
المؤلفون: Godefridus J. Peters, Michal Stark, Ietje Kathmann, Jacek Gregorczyk, Gerrit Jansen, Lilah Rothem, Freidoun Albertioni, Kambiz Fotoohi, Yehuda G. Assaraf
المساهمون: Rheumatology, Medical oncology
المصدر: Fotoohi, K, Jansen, G, Assaraf, Y G, Rothem, L, Stark, M, Kathmann, I, Gregorczyk, J, Peters, G J & Albertioni, F 2004, ' Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells : implications for efficacy of methotrexate therapy ', Blood, vol. 104, no. 13, pp. 4194-201 . https://doi.org/10.1182/blood-2004-04-1493
Blood, 104(13), 4194-201. American Society of Hematologyمصطلحات موضوعية: musculoskeletal diseases, Drug, Antimetabolites, Antineoplastic, medicine.drug_class, Glutamine, Metabolite, media_common.quotation_subject, Immunology, Pharmacology, Biology, Biochemistry, Antimetabolite, chemistry.chemical_compound, immune system diseases, Cell Line, Tumor, medicine, Humans, Gene silencing, heterocyclic compounds, skin and connective tissue diseases, media_common, Leukemia, Biological Transport, Cell Biology, Hematology, medicine.disease, Methotrexate, chemistry, Drug Resistance, Neoplasm, Cell culture, Antifolate, medicine.drug
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17
المؤلفون: Yehuda G. Assaraf, Jan Hendrik Hooijberg, Godefridus J. Peters, Ben A. C. Dijkmans, Ilan Ifergan, Gerrit Jansen, Lilah Rothem, Ietje Kathmann, Michal Stark
المساهمون: Laboratory Medicine, Medical oncology, Pediatric surgery, Rheumatology, Medical oncology laboratory, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, CCA - Cancer Treatment and quality of life, AII - Inflammatory diseases
المصدر: Assaraf, Y G, Rothem, L, Hooijberg, J H, Stark, M, Ifergan, I, Kathmann, I, Dijkmans, B A C, Peters, G J & Jansen, G 2003, ' Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells ', Journal of Biological Chemistry, vol. 278, no. 9, pp. 6680-6 . https://doi.org/10.1074/jbc.M209186200
Journal of Biological Chemistry, 278(9), 6680-6. American Society for Biochemistry and Molecular Biology Inc.مصطلحات موضوعية: Time Factors, Abcg2, Blotting, Western, Leucovorin, Pharmacology, Biochemistry, Cell Line, chemistry.chemical_compound, Folic Acid, Multidrug Resistance Protein 1, Tumor Cells, Cultured, medicine, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Molecular Biology, biology, Multidrug resistance-associated protein 2, Cell Membrane, Biological Transport, Cell Biology, Flow Cytometry, Fluoresceins, medicine.disease, Calcein, Probenecid, Leukemia, Methotrexate, Microscopy, Fluorescence, chemistry, Cell culture, Mutation, biology.protein, Efflux, Cell Division, medicine.drug
وصف الملف: application/pdf
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18
المؤلفون: Ietje Kathmann, Stavit Drori, David G. Priest, Godefridus J. Peters, Yehuda G. Assaraf, Herbert M. Pinedo, Marlene A. Bunni, Jan H. Schornagel, R. Mauritz, Paul Noordhuis, Hannah Sprecher, Gerrit Jansen
المصدر: Journal of Biological Chemistry. 273:30189-30198
مصطلحات موضوعية: Lysine, Biology, Biochemistry, Reduced Folate Carrier Protein, Structure-Activity Relationship, chemistry.chemical_compound, Folic Acid, Glutamates, immune system diseases, Tumor Cells, Cultured, medicine, Humans, Nucleotide, Molecular Biology, Polyglutamylation, Tetrahydrofolates, chemistry.chemical_classification, Leukemia, Membrane transport protein, Wild type, Membrane Proteins, Membrane Transport Proteins, Affinity Labels, Biological Transport, Cell Biology, Blotting, Northern, Kinetics, Methotrexate, Pyrimethamine, Pyrimidines, Trimetrexate, chemistry, Drug Resistance, Neoplasm, Cell culture, Antifolate, biology.protein, Folic Acid Antagonists, Carrier Proteins, medicine.drug
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19
المؤلفون: Jan Hendrik Hooijberg, Godefridus J. Peters, Ietje Kathmann, Gertjan J.L. Kaspers, Gerrit Jansen, Rob Pieters, A.C. Laan, Ina van Zantwijk
المساهمون: Rheumatology, Pediatric surgery, Medical oncology laboratory, CCA - Innovative therapy, Pediatrics
المصدر: Cancer Chemotherapy and Pharmacology, 73(5), 911-917. Springer Verlag
Cancer Chemotherapy & Pharmacology, 73(5), 911-917. Springer-Verlag
Hooijberg, J H, Jansen, G, Kathmann, I, Pieters, R, Laan, A C, van Zantwijk, I, Kaspers, G J L & Peters, G J 2014, ' Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1) ', Cancer Chemotherapy and Pharmacology, vol. 73, no. 5, pp. 911-917 . https://doi.org/10.1007/s00280-014-2421-0مصطلحات موضوعية: Cancer Research, Daunorubicin, Drug Resistance, Drug resistance, Pharmacology, Biology, Toxicology, chemistry.chemical_compound, Folic Acid, Multidrug Resistance Protein 1, Cell Line, Tumor, medicine, Humans, Pharmacology (medical), Biological Transport, Calcein, Multiple drug resistance, Methotrexate, Oncology, chemistry, ABCC1, biology.protein, Efflux, Multidrug Resistance-Associated Proteins, medicine.drug
وصف الملف: application/pdf
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20
المؤلفون: Ietje Kathmann, Deog Joong Kim, Godefridus J. Peters, Young Ho Lee, Kees Smid, Joris J. Julsing, Ahmed Hassan, Dzjemma Sarkisjan
المصدر: Cancer Research. 76:4725-4725
مصطلحات موضوعية: A549 cell, Cancer Research, Methyltransferase, Oncology, Downregulation and upregulation, DNA repair, DNMT1, Methylation, Cell cycle, Biology, Molecular biology, DNA methyltransferase