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1
المؤلفون: David R. Witty, Jonathan Brand, Ho Y. Li, Paul Goldsmith, Michael Stott, Robert W. Ward, Jennifer Farge, Fiona Nimmo, Nicola Shuker, Sanjeet Singh Sehmi, Mathilde D’Angeli, Ian R. Kilford, Rio Hutchings, Jennifer Sweeting, Andrew K. Takle, John Skidmore, Hasmi Tajuddin, Michael A. Briggs, Giancarlo Trani, David Matthew Wilson, Francis Dominic Sanderson, Paula L. Nichols, David MacPherson, Stephen L. Garland, Ian D. Wall
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:1368-1372
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Migraine Disorders, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Oxadiazole, Pharmacology, Calcitonin gene-related peptide, Biochemistry, chemistry.chemical_compound, Calcitonin Gene-Related Peptide Receptor Antagonists, Drug Discovery, medicine, Animals, Potency, Molecular Biology, CGRP receptor, Oxadiazoles, Molecular Structure, Chemistry, Organic Chemistry, medicine.disease, Rats, Migraine, Drug Design, Molecular Medicine, Pharmacophore
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2
المؤلفون: Ian R. Kilford, Andy Billinton, Barry Passingham, Anita Chowdhury, Alan Naylor, Adrian Hall, Gerard Martin Paul Giblin, Thomas George Christopher Hayhow, Leanne Cutler, Paul Goldsmith, Susan H. Brown, Alan K. Bristow, D. Anthony Rawlings
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:4027-4032
مصطلحات موضوعية: Central Nervous System, medicine.drug_class, Stereochemistry, Chemistry, Pharmaceutical, Carboxylic acid, Clinical Biochemistry, Carboxylic Acids, Pharmaceutical Science, Carboxamide, Pyrazole, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Amide, Drug Discovery, medicine, Humans, Receptors, Prostaglandin E, Solubility, Molecular Biology, chemistry.chemical_classification, Molecular Structure, Organic Chemistry, Brain, Isoquinolines, Amides, Receptors, Prostaglandin E, EP1 Subtype, Models, Chemical, chemistry, Drug Design, Pyrazoles, Molecular Medicine, Pharmacophore, Penetrant (biochemical)
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3
المؤلفون: Barry Passingham, Adrian Hall, Nicholas Maughan Clayton, Thomas George Christopher Hayhow, Gerard Martin Paul Giblin, Ian R. Kilford, Alan Naylor, Andy Billinton, Susan H. Brown, Paul Goldsmith, Lisa Winyard, David N. Hurst, Anita Chowdhury
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:3392-3399
مصطلحات موضوعية: Central Nervous System, Stereochemistry, Carboxylic acid, Clinical Biochemistry, Analgesic, Pharmaceutical Science, Pharmacology, Pyrazole, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Amide, Drug Discovery, Animals, Combinatorial Chemistry Techniques, Receptors, Prostaglandin E, Receptor, Molecular Biology, Pain Measurement, chemistry.chemical_classification, Analgesics, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Antagonist, Brain, Receptors, Prostaglandin E, EP1 Subtype, Rats, Disease Models, Animal, chemistry, Pyrazoles, Molecular Medicine
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4
المؤلفون: Adrian Hall, Gerard Martin Paul Giblin, David N. Hurst, Xiao Qing Lewell, Ian R. Kilford, Anita Chowdhury, Susan H. Brown, Alan Naylor, Rino A. Bit, Tiziana Scoccitti
المصدر: Bioorganicmedicinal chemistry letters. 18(5)
مصطلحات موضوعية: Models, Molecular, Molecular model, Isostere, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Pyrazole, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Structure-Activity Relationship, Heterocyclic Compounds, Drug Discovery, Pyridine, Receptors, Prostaglandin E, Methylene, skin and connective tissue diseases, Thiazole, Molecular Biology, Molecular Structure, fungi, Organic Chemistry, Receptors, Prostaglandin E, EP1 Subtype, body regions, chemistry, Molecular Medicine, Linker, Protein Binding
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5
المؤلفون: David J. Spalding, Adrian Hall, Shiyam Mohamed, Helene M. Chaignot, Ian R. Kilford, Gerard Martin Paul Giblin, Lee Skinner, Iain P. Chessell, Tanya Coleman, Richard J. Wilson, Anton D. Michel, Rino A. Bit, Susan H. Brown, Sac P. Tang, Alan Naylor, Riccardo Novelli, Xiao Qing Lewell, David N. Hurst
المصدر: Bioorganicmedicinal chemistry letters. 16(10)
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Isostere, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, In Vitro Techniques, Biochemistry, Receptors, Prostaglandin E, EP1 Subtype, In vitro, Pyrrole derivatives, Rats, chemistry.chemical_compound, chemistry, Heterocyclic compound, In vivo, Heterocyclic Compounds, Drug Discovery, Thiophene, Triazole derivatives, Molecular Medicine, Animals, Receptors, Prostaglandin E, Receptor, Molecular Biology
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6
المؤلفون: David R. Vesey, Christopher H. Hill, Rino A. Bit, Christopher J. Hobbs, Eric A. Kitas, Brad S. Sherborne, David Pole, Fiona Wilson, Antonin Kroehn, Glyn Williams, Bill Harris, Ian R. Kilford, David Banner, Neera Borkakoti, D.Lee Walmsley, David Whittaker, Paul Rugman, Andrew Cansfield, Ian Edward David Smith, Allan Surgenor, Katherine L. Hilyard, Peter Lovell
المصدر: Bioorganicmedicinal chemistry letters. 12(10)
مصطلحات موضوعية: Models, Molecular, Peptidomimetic, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Glutamic Acid, SH2 domain, Crystallography, X-Ray, Ligands, Biochemistry, src Homology Domains, Residue (chemistry), Structure-Activity Relationship, Cricetinae, Drug Discovery, Structure–activity relationship, Animals, Enzyme Inhibitors, Molecular Biology, Tetrapeptide, Ligand, Chemistry, Organic Chemistry, Glutamic acid, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Drug Design, Molecular Medicine, Isoleucine, Oligopeptides