المؤلفون: Paolo Colangelo, Ian Marc Bonapace, Laura Gramolini, Emanuela Solano, Elisa Desiato, Paolo Franchini, Leonardo Gentile, Roberto Guadagnini, Oddmund Kleven, Jonas Kindberg, Alexander Kopatz, Paolo Ciucci

المصدر: Frontiers in Ecology and Evolution, Vol 12 (2025)

مصطلحات موضوعية: RRBS, methylome, non-model, gene ontology, conservation, population, Evolution, QH359-425, Ecology, QH540-549.5

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fevo.2024.1504225/full; https://doaj.org/toc/2296-701X

URL الوصول: https://doaj.org/article/5978ca6c64224580a90370aa212fe955

المؤلفون: Nicoletta Lotrecchiano, Luigi Montano, Ian Marc Bonapace, Tenore Giancarlo, Paolo Trucillo, Daniele Sofia

المساهمون: Lotrecchiano, Nicoletta, Montano, Luigi, Bonapace, IAN MARC, Giancarlo, Tenore, Trucillo, Paolo, Sofia, Daniele

مصطلحات موضوعية: PM10, chronicle daily intake, pollution absorption, pollution damage, heavy metal, ecofoodfertility, land of fires

Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:000833111100001; volume:10; issue:7; firstpage:1409; journal:PROCESSES; http://hdl.handle.net/11588/890910; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85134898361; https://www.mdpi.com/2227-9717/10/7/1409

الاتاحة: http://hdl.handle.net/11588/890910
https://doi.org/10.3390/pr10071409
https://www.mdpi.com/2227-9717/10/7/1409

المؤلفون: Luigi Montano, Francesco Donato, Pietro Massimiliano Bianco, Gennaro Lettieri, Antonino Guglielmino, Oriana Motta, Ian Marc Bonapace, Marina Piscopo

المصدر: International Journal of Environmental Research and Public Health; Volume 18; Issue 13; Pages: 6846

مصطلحات موضوعية: COVID-19, SARS-CoV-2, male fertility, semen quality, air pollution, ACE2

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Public Health Statistics and Risk Assessment; https://dx.doi.org/10.3390/ijerph18136846

الاتاحة: https://doi.org/10.3390/ijerph18136846

المؤلفون: Luigi Montano, Ian Marc Bonapace, Francesco Donato, Pietro Massimiliano Bianco, Antonino Guglielmino, Marina Piscopo

مصطلحات موضوعية: air pollution, COVID-19, semen quality, environmental marker, health marker, oxidative stress, SARS-CoV-2

Relation: https://doi.org/10.20944/preprints202006.0314.v2; oai:zenodo.org:4453739

الاتاحة: https://doi.org/10.20944/preprints202006.0314.v2

المؤلفون: Pietro Massimiliano Bianco, Oriana Motta, Marina Piscopo, Luigi Montano, Gennaro Lettieri, Francesco Donato, Ian Marc Bonapace, Antonino Guglielmino

المساهمون: Montano, Luigi, Donato, Francesco, Bianco, Pietro Massimiliano, Lettieri, Gennaro, Guglielmino, Antonino, Motta, Oriana, Bonapace, Ian Marc, Piscopo, Marina

المصدر: Environmental Science and Pollution Research International

مصطلحات موضوعية: Male, Health, Toxicology and Mutagenesis, Population, Environmental pollution, Review Article, Population health, 010501 environmental sciences, Air pollution, COVID-19, Environmental marker, Health marker, Oxidative stress, SARS-CoV-2, Semen quality, Disease Outbreaks, Humans, Semen Analysis, Air Pollution, 01 natural sciences, 03 medical and health sciences, Environmental health, Environmental Chemistry, Medicine, education, 030304 developmental biology, 0105 earth and related environmental sciences, Pollutant, 0303 health sciences, education.field_of_study, business.industry, Mortality rate, Outbreak, General Medicine, Pollution, Review article, Oxidative stre, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d04006a0d00be3fa36346e23b8216f6
https://doi.org/10.1007/s11356-021-14579-x

المؤلفون: Monica Mancini, Elena Magnani, Filippo Macchi, Ian Marc Bonapace

المصدر: Nucleic Acids Research

مصطلحات موضوعية: Genome instability, DNA Repair, DNA repair, DNA damage, AcademicSubjects/SCI00010, Ubiquitin-Protein Ligases, Animals, CCAAT-Enhancer-Binding Proteins, DNA Damage, Epigenesis, Genetic, Genomic Instability, Histone Code, Humans, Epigenome, 03 medical and health sciences, 0302 clinical medicine, Genetic, Genetics, Histone code, Epigenetics, Survey and Summary, 030304 developmental biology, 0303 health sciences, biology, Cell biology, Histone, 030220 oncology & carcinogenesis, DNA methylation, biology.protein, Epigenesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30359ce89b234d0258b4291bd35f8fef
http://europepmc.org/articles/PMC8216287

المؤلفون: Gian Carlo Tenore, Nicoletta Lotrecchiano, Daniele Sofia, Paolo Trucillo, Luigi Montano, IAN MARC BONAPACE

المساهمون: Lotrecchiano, Nicoletta, Montano, Luigi, Bonapace, IAN MARC, Giancarlo, Tenore, Trucillo, Paolo, Sofia, Daniele

المصدر: Processes; Volume 10; Issue 7; Pages: 1409

مصطلحات موضوعية: PM10, Process Chemistry and Technology, chronicle daily intake, Chemical Engineering (miscellaneous), pollution damage, Bioengineering, heavy metal, heavy metals, pollution absorption, ecofoodfertility, land of fires

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901a85fa3484bd5dafb6f1ae439153c4
https://hdl.handle.net/11383/2149771

المؤلفون: Monica Mancini, Margherita Grasso, Livio Muccillo, Federica Babbio, Francesca Precazzini, Ilaria Castiglioni, Valentina Zanetti, Francesca Rizzo, Christian Pistore, Maria Giovanna De Marino, Michele Zocchi, Valerio Del Vescovo, Valerio Licursi, Giorgio Giurato, Alessandro Weisz, Paola Chiarugi, Lina Sabatino, Michela Alessandra Denti, Ian Marc Bonapace

المساهمون: Mancini, Monica, Grasso, Margherita, Muccillo, Livio, Babbio, Federica, Precazzini, Francesca, Castiglioni, Ilaria, Zanetti, Valentina, Rizzo, Francesca, Pistore, Christian, DE MARINO, MARIA GIOVANNA, Zocchi, Michele, Del Vescovo, Valerio, Licursi, Valerio, Giurato, Giorgio, Weisz, Alessandro, Chiarugi, Paola, Sabatino, Lina, Alessandra Denti, Michela, Bonapace, IAN MARC

مصطلحات موضوعية: MICRORNA, PROSTATE CANCER, DNA METHYLATION

وصف الملف: STAMPA

Relation: info:eu-repo/semantics/altIdentifier/pmid/34687205; info:eu-repo/semantics/altIdentifier/wos/WOS:000743133500005; volume:42; issue:12; firstpage:1449; lastpage:1460; numberofpages:12; journal:CARCINOGENESIS; https://hdl.handle.net/11383/2137511; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85125007739; https://academic.oup.com/carcin/article/42/12/1449/6409027?searchresult=1

الاتاحة: https://hdl.handle.net/11383/2137511
https://doi.org/10.1093/carcin/bgab101
https://academic.oup.com/carcin/article/42/12/1449/6409027?searchresult=1

المؤلفون: Ilaria Castiglioni, Federica Babbio, Lina Sabatino, Francesca Precazzini, Monica Mancini, Margherita Grasso, Michela A. Denti, Michele Zocchi, Valentina Zanetti, Ian Marc Bonapace, Alessandro Weisz, Valerio Licursi, Valerio Del Vescovo, Francesca Rizzo, Maria Giovanna De Marino, Livio Muccillo, Christian Pistore, Paola Chiarugi, Giorgio Giurato

المصدر: Carcinogenesis. 42(12)

مصطلحات موضوعية: Gene isoform, Male, Cancer Research, Chromatin Immunoprecipitation, Epithelial-Mesenchymal Transition, Binding Sites, Computational Biology, DNA Methylation, DNA Methyltransferase 3A, Disease Susceptibility, Humans, MicroRNAs, Promoter Regions, Genetic, Prostatic Neoplasms, Protein Binding, RNA Interference, Tumor Microenvironment, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Biology, PROSTATE CANCER, Promoter Regions, Prostate cancer, Genetic, microRNA, medicine, Epithelial–mesenchymal transition, Epigenetics, Neoplastic, epigenetics, Transition (genetics), MICRORNA, MICRORNA, PROSTATE CANCER, DNA METHYLATION, Promoter, General Medicine, medicine.disease, Gene Expression Regulation, Prostate cancer, microRNA, epigenetics, embryonic structures, Cancer research, H3K4me3, Epigenesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bd0c4c7ace3b02d4f317ec74092118
https://pubmed.ncbi.nlm.nih.gov/34687205

المؤلفون: Luigi Montano, Ian Marc Bonapace, Francesco Donato, Pietro Massimiliano Bianco, Antonino Guglielmino, Marina Piscopo

مصطلحات موضوعية: air pollution, COVID-19, semen quality, environmental marker, health marker, oxidative stress, SARS-CoV-2, urology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fda27ef35509eb6972e32e31c25aae61

المؤلفون: Monica Mancini, Filippo Macchi, Christian Pistore, Sara Cogliati, Ian Marc Bonapace, Anne-Catherine Dock-Bregeon, Elena Magnani, Martina Mandruzzato, Vanessa Veronica Lomazzi

المصدر: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1861:258-270

مصطلحات موضوعية: Male, 0301 basic medicine, RNA, Untranslated, Ubiquitin-Protein Ligases, Biophysics, Biology, Models, Biological, Biochemistry, Epigenesis, Genetic, 03 medical and health sciences, Antigens, CD, Structural Biology, Cell Line, Tumor, Genetics, Epigenetic Profile, Humans, Gene silencing, Gene Silencing, RNA, Messenger, Epigenetics, Promoter-associated non-coding RNAs, UHRF1, Promoter Regions, Genetic, Molecular Biology, Gene, Psychological repression, CDH1, Bidirectional promoters, Prostatic Neoplasms, Promoter, Cadherins, Non-coding RNA, Chromatin, Cell biology, Gene Expression Regulation, Neoplastic, 030104 developmental biology, CCAAT-Enhancer-Binding Proteins, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75e041b1aa4076a1382300f47a07c06
https://doi.org/10.1016/j.bbagrm.2018.02.006

المؤلفون: Andrea Rottach, Carina Frauer, Garwin Pichler, Ian Marc Bonapace, Fabio Spada, Heinrich Leonhardt

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://nar.oxfordjournals.org/content/38/6/1796.full-text-lowres.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.332.7382; http://nar.oxfordjournals.org/content/38/6/1796.full-text-lowres.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.332.7382
http://nar.oxfordjournals.org/content/38/6/1796.full-text-lowres.pdf

المؤلفون: Roberto Papait, Christian Pistore, Ursula Grazini, Federica Babbio, Sara Cogliati, Daniela Pecoraro, Laurent Brino, Anne-laure Mor, Anne-marie Dechampesme, Fabio Spada, Heinrich Leonhardt, Fraser Mcblane, Pierre Oudet, Ian Marc Bonapace, Yixian Zheng

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://edoc.mdc-berlin.de/9561/1/9561oa.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.571.8524; http://edoc.mdc-berlin.de/9561/1/9561oa.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.571.8524
http://edoc.mdc-berlin.de/9561/1/9561oa.pdf

المؤلفون: Elisabetta Citterio, Roberto Papait, Francesco Nicassio, Manuela Vecchi, Paola Gomiero, Roberto Mantovani, Paolo Di Fiore, Ian Marc Bonapace, Pier Paolo Di Fiore

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://mcb.asm.org/content/24/6/2526.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.334.2036; http://mcb.asm.org/content/24/6/2526.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.334.2036
http://mcb.asm.org/content/24/6/2526.full.pdf

المؤلفون: Mauro Pitaro, Suzanne Sommer, Federica Castani, Alex Ferrandi, Paola Barbieri, Monica Mancini, Sara Tagliaferri, Rosa Alduina, Claire Bouthier de la Tour, Ian Marc Bonapace, Mauro Fasano

المساهمون: Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Radiorésistance des bactéries et des archées (RBA), Département Biologie des Génomes (DBG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Biologia Strutturale e Funzionale, Universitá degli Studi dell’Insubria = University of Insubria [Varese] (Uninsubria), Department of Structural and Functional Biology, Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Universitá degli Studi dell’Insubria, Ferrandi A, Castani F, Pitaro M, Tagliaferri S, de la Tour CB, Alduina R, Sommer S, Fasano M, Barbieri P, Mancini M, Bonapace IM.

المصدر: Biochimica et Biophysica Acta (BBA)-General Subjects
Biochimica et Biophysica Acta (BBA)-General Subjects, 2019, 1863 (1), pp.118--129. ⟨10.1016/j.bbagen.2018.09.020⟩
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2019, 1863 (1), pp.118--129. ⟨10.1016/j.bbagen.2018.09.020⟩

مصطلحات موضوعية: DNA Repair, DNA cytosine-methylation, DNA damage, DR1533 locus, Genotoxic agents, Mn2+, SRA domain, Biophysics, Biochemistry, Molecular Biology, [SDV]Life Sciences [q-bio], perspective, Settore BIO/19 - Microbiologia Generale, chemistry.chemical_compound, 0302 clinical medicine, Kanamycin, Cloning, Molecular, cytosine, 0303 health sciences, biology, Chemistry, Genotoxic agent, uhrf1, Mn(2+), Deinococcus, recognition, manganese(ii), DNA, Bacterial, DNA repair, oxidation, Ubiquitin-Protein Ligases, Settore BIO/11 - Biologia Molecolare, resistance, 03 medical and health sciences, Bacterial Proteins, Protein Domains, DR1533 locu, Drug Resistance, Bacterial, Escherichia coli, Humans, features, Amino Acid Sequence, Gene, 030304 developmental biology, Oligonucleotide, Computational Biology, Deinococcus radiodurans, DNA Methylation, biology.organism_classification, Molecular biology, genomic DNA, repair, Mutation, CCAAT-Enhancer-Binding Proteins, Homologous recombination, 030217 neurology & neurosurgery, DNA, Genome, Bacterial, Mutagens

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0e77f1046a0f5866038ec8987b9627
http://hdl.handle.net/11383/2074651

المؤلفون: Axel Imhof, Nan Liu, David Hörl, Hartmann Harz, Stephanie Link, Fabio Spada, Ignasi Forné, Garwin Pichler, Patricia Wolf, Weihua Qin, Ian Marc Bonapace, Karin Fellinger, Federica La Mastra, Heinrich Leonhardt, Martha Smets

المصدر: Cell Research

مصطلحات موضوعية: DNA (Cytosine-5-)-Methyltransferase 1, Ubiquitin-Protein Ligases, DNA methylation, DNMT1, histone ubiquitination, UHRF1, Cell Biology, Molecular Biology, Cell Line, Histones, Mice, Proliferating Cell Nuclear Antigen, Histone methylation, Nucleosome, Histone code, Animals, Humans, DNA (Cytosine-5-)-Methyltransferases, Epigenomics, Genetics, Histone ubiquitination, biology, Ubiquitination, Cell biology, Histone, Histone methyltransferase, biology.protein, CCAAT-Enhancer-Binding Proteins, Original Article, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23548150c165a72d68c65dab332be854
http://europepmc.org/articles/PMC4528052

المؤلفون: Monica Mancini, Vittorio Colantuoni, S Rizzo, Elisa Giannoni, Nora Sahnane, Elena Magnani, Tommaso Colangelo, Martina Mandruzzato, Paola Chiarugi, Ian Marc Bonapace, Francesca Rizzo, Miriam Riccardi, Mattia Pelizzola, Michela A. Denti, V Del Vescovo, Livio Muccillo, Christian Pistore, Giorgio Giurato, Alessandro Weisz, Filippo Macchi, Daniela Furlan, Kamal Kishore

مصطلحات موضوعية: 0301 basic medicine, Male, Transcriptional Activation, Cancer Research, prostate cancer, epithelial to mesenchymal transition, epigenetics, DNA methylation, Biology, Mesoderm, 03 medical and health sciences, Cytosine, Cancer-Associated Fibroblasts, Cancer stem cell, Cell Line, Tumor, DNA methylation, epithelial-to-mesenchymal transition, prostate cancer, Genetics, Humans, Epithelial–mesenchymal transition, Epigenetics, DNA (Cytosine-5-)-Methyltransferases, Molecular Biology, Regulation of gene expression, Epithelial to mesenchymal transition, Prostate cancer, Cancer stem cells, Stem Cells, Prostate cancer, Epithelial to mesenchymal transition, DNA methylation, Cancer stem cells, Prostatic Neoplasms, Epithelial Cells, Methylation, DNA, Neoplasm, Cell cycle, Molecular biology, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Cell Transformation, Neoplastic, CpG site, Culture Media, Conditioned, embryonic structures, Cancer research, epithelial-to-mesenchymal transition

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f1a5e01386f4ae996ba7fdab9b1d97
http://hdl.handle.net/11383/2061806

المؤلفون: Carlo V. Catapano, Paolo Kunderfranco, Giovanna Chiorino, Manuela Sarti, E Roggero, Ian Marc Bonapace, Ilaria Castiglioni, Pierre Oudet, Federica Babbio, Giuseppina M. Carbone, Laura Curti, Sandra Pinton, Maurizia Mello-Grand, Christian Pistore, Roland Seiler, Laurent Brino, G N Thalman

المصدر: Oncogene. 31:4878-4887

مصطلحات موضوعية: Male, Cancer Research, Ubiquitin-Protein Ligases, Cell Growth Processes, Biology, Epigenesis, Genetic, Histones, Prostate cancer, Cell Line, Tumor, Genetics, medicine, Humans, Immunoprecipitation, Enhancer of Zeste Homolog 2 Protein, Genes, Tumor Suppressor, Gene Silencing, EZH2, Cancer epigenetics, Epigenetics, Promoter Regions, Genetic, UHRF1, Molecular Biology, Polycomb Repressive Complex 2, Prostate, Prostatic Neoplasms, Cancer, Acetylation, Histone-Lysine N-Methyltransferase, Chromoplexy, DNA Methylation, medicine.disease, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, HEK293 Cells, Histone methyltransferase, DNA methylation, CCAAT-Enhancer-Binding Proteins, Disease Progression, Histone Methyltransferases, Cancer research

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de7429d8d8febd2d6b4997207537e18
https://doi.org/10.1038/onc.2011.641

المؤلفون: Wolfgang E. F. Klinkert, Heinrich Leonhardt, Karin Fellinger, Ian Marc Bonapace, Ulrich Rothbauer, Fabio Spada, Daniela Meilinger, Sebastian Bultmann

المصدر: EMBO Reports

مصطلحات موضوعية: Ubiquitin-Protein Ligases, Scientific Report, Cytomegalovirus, Biology, Uhrf1, Biochemistry, DNA methyltransferase, DNA Methyltransferase 3A, Epigenesis, Genetic, Mice, Cricetulus, Epigenetics of physical exercise, Cricetinae, Histone methylation, Genetics, Animals, Humans, DNMT3a, histone modification, DNA (Cytosine-5-)-Methyltransferases, Gene Silencing, Cancer epigenetics, Promoter Regions, Genetic, Molecular Biology, RNA-Directed DNA Methylation, Embryonic Stem Cells, Epigenomics, DNA methylation, epigenetics, Np95, DNMT1, Nuclear Proteins, Methyltransferases, Molecular biology, Protein Structure, Tertiary, Histone methyltransferase, silencing, embryonic structures, CCAAT-Enhancer-Binding Proteins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ac38b032a8f003df7fb9a41009d34c
https://doi.org/10.1038/embor.2009.201

المؤلفون: Alessia Guarda, Ian Marc Bonapace, Fabrizio Bolognese, Gianfranco Badaracco

المصدر: Experimental Cell Research. 315:1895-1903

مصطلحات موضوعية: Vesicle-associated membrane protein 8, Methyl-CpG-Binding Protein 2, Nuclear Envelope, Recombinant Fusion Proteins, Receptors, Cytoplasmic and Nuclear, Lamin B receptor, Biology, Transfection, Epigenesis, Genetic, Bacterial Proteins, MeCP2, LBR, nuclear membrane, Heterochromatin, Humans, Inner membrane, Protein Interaction Domains and Motifs, Nuclear receptor co-repressor 1, DNA Primers, Sequence Deletion, Nuclear receptor co-repressor 2, Epigenomics, Microscopy, Confocal, Base Sequence, Genetic Complementation Test, Cell Biology, Molecular biology, Chromatin, Cell biology, Luminescent Proteins, Multiprotein Complexes, Nuclear lamina, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e0976c7386edd8b944c5b3a21dc9b6
https://doi.org/10.1016/j.yexcr.2009.01.019