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المصدر: Genes and Diseases, Vol 7, Iss 3, Pp 380-391 (2020)
Genes & Diseasesمصطلحات موضوعية: 0301 basic medicine, Hepatocellular carcinoma, Gene mutation, medicine.disease_cause, Biochemistry, Somatic evolution in cancer, 0302 clinical medicine, Gene ontology (GO), Exome, Genetics (clinical), Exome sequencing, Mutation, lcsh:R5-920, CDS, coding for amino acids in protein, Clonal evolution, Genome-wide association, Encyclopedia of genes and genomes (KEGG), NTR, N-terminal region, SNP, single nucleotide polymorphism, 030220 oncology & carcinogenesis, lcsh:Medicine (General), WES, whole exome sequencing, CTR, C-terminal region, lcsh:QH426-470, Somatic gene mutation, CUL3, Cullin3, IVR, intervening region, Single-nucleotide polymorphism, Biology, KEGG, Kyoto Encyclopedia of Genes and Genomes, Article, Frameshift mutation, BTB, Broad-complex, Tramtrack, and Bric-a-brac, OS, overall survival, 03 medical and health sciences, GO, Gene Ontology, medicine, DGR, DC domain harboring six Kelch-repeat domain, Molecular Biology, Gene, CNC, cap’n’collar, FA, fatty acid, Whole exome sequencing, Cell Biology, lcsh:Genetics, 030104 developmental biology, Metastatic potentiality, Cancer research, bZIP, basic-region leucine zipper, HCC, hepatocellular carcinoma
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المؤلفون: Anna-Liisa Levonen, Carlos Cruz Cortés, Tommi Patinen, Jouni Härkönen, Ashik Jawahar Deen, Simone Adinolfi
المصدر: Redox Biology, Vol 23, Iss, Pp-(2019)
Redox Biologyمصطلحات موضوعية: RES, Reactive electrophilic species, ARE, Antioxidant response element, Biochemistry, Lipid peroxidation, 0302 clinical medicine, Heat Shock Transcription Factors, HSR, Heat shock response, lcsh:QH301-705.5, Protein lipoxidation, SILAC, Stable isotope labeling with amino acids in cell culture, chemistry.chemical_classification, CUL3, (Cullin-3)-ubiquitin E3 ligase complex, Kelch-Like ECH-Associated Protein 1, PGA2, Prostaglandin A2, NTR, N-terminal region, CTD, C-terminal domain, RD, Regulatory domain, Cell biology, NO2-CLA, nitro-conjugated linoleic acid, KEAP1, Kelch-like ECH-associated protein 1, OA-NO2, Nitro-oleic acid, lcsh:Medicine (General), NF-E2-Related Factor 2, 4-HNE, 4-hydroxy-2-nonenal, NRF2, LNO2, 9-, 10-, 12-, or 13-nitro-octadeca-9, 12-dienoic acid, 03 medical and health sciences, Humans, NTD, N-terminal domain, PARP13, Poly(ADP-ribose) Polymerase 13, Heat shock, LDE, Lipid-derived electrophiles, MS, Mass spectrometry, GCLC, Glutamate cysteine ligase catalytic, POLK, DNA polymerase kappa, Heat shock proteins, SH, sulfhydryl group, T-REX, Targetable reactive electrophiles and oxidants, DMSO, Dimethyl sulfoxide, 15d-PGJ2, 15-deoxy-Δ-12,14-prostaglandin J2, SQSTM1, Autophagosome cargo protein Sequestosome 1, KEAP1, 030104 developmental biology, HSP90, 90-kDa heat shock proteins from HSP90 family, chemistry, Redox regulation, Lipid Peroxidation, Biomarkers, 030217 neurology & neurosurgery, PEIPC, 1-palmitoyl-2-(5, 6)-epoxy isoprostane E2)-sn-glycero-3-phosphocholine, ROS, Reactive oxygen species, LC-MS, Liquid chromatography-mass spectrometry, 0301 basic medicine, Cysteine modification, Clinical Biochemistry, H2O2, Hydrogen peroxide, IA, Iodoacetamide alkyne, PARP1, Poly(ADP-ribose) polymerase 1, chemistry.chemical_compound, HSPD1/E1, Heat shock protein family D/E (Hsp60/Hsp10) member 1, LOX12/15, 12/15-Lipoxygenase, HSF1, HSPA8, Heat shock protein family A (Hsp70) member 8, Ub, ubiquitin, lcsh:R5-920, IER5, Immediate early response 5, HSP, Heat shock protein, NQO1, NAD(P)H:quione oxidoreductase 1, HSP40, 40-kDa heat shock proteins from HSP40 family, LZ4, Leucine zipper 4 domain, sMAF, small musculoaponeurotic fibrosarcoma oncogene homolog protein family, TEV, Tobacco etch virus, HSE, Heat shock element, GST, Gluthathione S-transferase, Second messenger system, Signal transduction, Oxidation-Reduction, Signal Transduction, CTAD, C-terminal transactivation domain, MD, Middle domain, ZAK, Animal-specific MAP kinase found in stress responses, Stress, Physiological, Implications of lipoxidation in cellular defense and stress pathway, Heat shock protein, GCLM, Glutamate-Cysteine Ligase Modifier Subunit, Animals, aLA, Alkyne-labeled linoleic acid, oxPAPC, Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine, Cysteine, ABPP, Affinity based protein profiling, IVR, Intervening region, Stress response, PRDX1, Peroxiredoxin 1, Organic Chemistry, Neh, Nrf2-ECH homology, HSF1, Heat shock factor 1, NRF2, NF-E2-related factor 2, Oxidative Stress, BTB, Broad complex, Tram-track, and Bric-a-Brac, Enzyme, lcsh:Biology (General), DBD, DNA binding domain, TXNR1D1, Thioredoxin reductase 1, LZ1–3, Leucine zipper 1–3 domains, HSP70, 70-kDa heat shock proteins from HSP70 family, G-REX, Genome-wide variant of T-REX, MRP, Multidrug-resistance-associated protein
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المؤلفون: Huijuan Jin, Dhulfiqar Ali Abed, Haifa Albanyan, Melanie Goldstein, Longqin Hu
المصدر: Acta Pharmaceutica Sinica B, Vol 5, Iss 4, Pp 285-299 (2015)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: vitamin E, tocopherols, AD, Alzheimer׳s disease, Direct inhibitors of protein–protein interaction, Review, medicine.disease_cause, HTS, high-throughput screening, GST, glutathione S-transferase, General Pharmacology, Toxicology and Pharmaceutics, GCL, glutamate-cysteine ligase, PD, Parkinson׳s disease, chemistry.chemical_classification, GPx, glutathione peroxidase, Chemistry, Nrf2, nuclear factor erythroid 2–related factor 2, NTR, N-terminal region, respiratory system, Small molecule, MD, molecular dynamics, Keap1, Kelch-like ECH-associated protein 1, TRX, thioredoxin, Biochemistry, CBP, cAMP response element binding (CREB) protein, H2O2, hydrogen peroxide, CDDO-Me, bardoxolone methyl, HO-1, heme-oxygenase-1, FP, fluorescence polarization, THIQ, tetrahydroisoquinoline, 1O2, singlet oxygen, CTR, C-terminal region, Keap1, PPI, protein–protein interaction, Protein domain, IVR, intervening region, ARE, antioxidant response element, SPR, surface plasmon resonance, CVD, cardiovascular disease, DGR, double glycine repeats, O2−, superoxide, OH·, hydroxyl radical, STZ, streptozotocin, Nrf2, Protein–protein interaction, RNS, reactive nitrogen species, Structure–activity relationships, ROS, reactive oxygen species, Downregulation and upregulation, ONO2−, peroxynitrate, SOD, superoxide dismutase, medicine, FITC, flurescein isothiocyanate, X-ray crystallography, NO, nitric oxide, NMR,, lcsh:RM1-950, Bach1, BTB and CNC homology 1, vitamin C, ascorbate, KEAP1, NQO1, NAD(P)H quinone oxidoreductase I, Enzyme, lcsh:Therapeutics. Pharmacology, COPD, chronic obstructive pulmonary disease, Oxidative stress, High throughput screening assays, BTB, broad complex, tramtrack and bric-a-brac, IBS, inflammatory bowel disease, Cysteine