المؤلفون: Mohamed, Mohamed-Eslam, Qian, Yuli, DCunha, Ronilda, Sligh, Teresa, Ferris, Laura, Eldred, Ann, Levy, Gweneth, Hao, Shuai, Gannu, Shashikanth, Rizzo, David, Liu, Wei, Jazayeri, Sasha, Sofen, Howard, Carcereri De Prati, Roberto

المصدر: Clinical and Translational Science. 17(1)

مصطلحات موضوعية: Humans, Double-Blind Method, Drug Inverse Agonism, Healthy Volunteers, Itraconazole, Psoriasis, Treatment Outcome

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6qb4k3kz
https://escholarship.org/content/qt6qb4k3kz/qt6qb4k3kz.pdf

المؤلفون: Cao, Can, Kang, Hye Jin, Singh, Isha, Chen, He, Zhang, Chengwei, Ye, Wenlei, Hayes, Byron W, Liu, Jing, Gumpper, Ryan H, Bender, Brian J, Slocum, Samuel T, Krumm, Brian E, Lansu, Katherine, McCorvy, John D, Kroeze, Wesley K, English, Justin G, DiBerto, Jeffrey F, Olsen, Reid HJ, Huang, Xi-Ping, Zhang, Shicheng, Liu, Yongfeng, Kim, Kuglae, Karpiak, Joel, Jan, Lily Y, Abraham, Soman N, Jin, Jian, Shoichet, Brian K, Fay, Jonathan F, Roth, Bryan L

المصدر: Nature. 600(7887)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Chemical Sciences, Chronic Pain, Pain Research, 2.1 Biological and endogenous factors, Generic health relevance, Cryoelectron Microscopy, Drug Inverse Agonism, GTP-Binding Protein alpha Subunits, Gi-Go, GTP-Binding Protein alpha Subunits, Gq-G11, Humans, Models, Molecular, Nerve Tissue Proteins, Pruritus, Receptors, G-Protein-Coupled, Receptors, Neuropeptide, General Science & Technology

URL الوصول: https://escholarship.org/uc/item/78f5d3k9

المؤلفون: Jacqueline C. Calderón, Passainte Ibrahim, Dorothea Gobbo, Francesco Luigi Gervasio, Timothy Clark

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Pharmacology, Immunology, Cancer, Hematology, Chemical Sciences not elsewhere classified, inverse agonists carazolol, inverse agonist ligands, agonist activity, inverse agonism, tempered multiple, seem also, receptor activity, neutral antagonists, neutral antagonist, neutral antagonism, metadynamics simulations, known microswitches, energy profiles, conformational states

Relation: https://figshare.com/articles/journal_contribution/Determinants_of_Neutral_Antagonism_and_Inverse_Agonism_in_the_sub_2_sub_Adrenergic_Receptor/25356196

الاتاحة: https://doi.org/10.1021/acs.jcim.3c01763.s001
https://figshare.com/articles/journal_contribution/Determinants_of_Neutral_Antagonism_and_Inverse_Agonism_in_the_sub_2_sub_Adrenergic_Receptor/25356196

المؤلفون: Drop, Marcin, Koczurkiewicz-Adamczyk, Paulina, Bento, Ophélie, Pietruś, Wojciech, Satała, Grzegorz, Blicharz-Futera, Klaudia, Canale, Vittorio, Grychowska, Katarzyna, Bantreil, Xavier, Pękala, Elżbieta, Kurczab, Rafał, Bojarski, Andrzej, J, Chaumont-Dubel, Séverine, Marin, Philippe, Lamaty, Frédéric, Zajdel, Paweł

المساهمون: Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Institut des Biomolécules Max Mousseron Pôle Chimie Balard (IBMM), Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Université de Montpellier (UM), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Polska Akademia Nauk = Polish Academy of Sciences = Académie polonaise des sciences (PAN), Institut universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)

المصدر: ISSN: 0223-5234.

مصطلحات موضوعية: 5-HT6 receptor, Constitutive activity, Neutral antagonism, Inverse agonism, 2-phenylpyrrole, Cytoprotection, Human astrocytes, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology

Relation: info:eu-repo/semantics/altIdentifier/pmid/38936149; PUBMED: 38936149

الاتاحة: https://hal.science/hal-04626976
https://hal.science/hal-04626976v1/document
https://hal.science/hal-04626976v1/file/Drop%20et%20al%202024.pdf
https://doi.org/10.1016/j.ejmech.2024.116615

المؤلفون: Khalil, Jawad, Dimofte, Tudor, Roberts, Timothy, Keith, Michael, Amaradasa, Kumuthu, Hindle, Matthew S, Bancroft, Sukhinder, Hutchinson, James L, Naseem, Khalid, Johnson, Thomas, Mundell, Stuart J

المصدر: Khalil , J , Dimofte , T , Roberts , T , Keith , M , Amaradasa , K , Hindle , M S , Bancroft , S , Hutchinson , J L , Naseem , K , Johnson , T & Mundell , S J 2024 , ' Ticagrelor inverse agonist activity at the P2Y12 receptor is non-reversible versus its endogenous agonist adenosine 5´-diphosphate ' , British Journal of Pharmacology , vol. 181 , no. 1 , pp. 21-35 . https://doi.org/10.1111/bph.16204

مصطلحات موضوعية: Humans, Ticagrelor/pharmacology, Diphosphates/metabolism, Adenosine/pharmacology, Drug Inverse Agonism, Purinergic P2Y Receptor Antagonists/pharmacology, Platelet Aggregation Inhibitors/pharmacology, Adenosine Diphosphate/pharmacology, Blood Platelets, Acute Coronary Syndrome/drug therapy, Receptors, Purinergic P2Y12/metabolism

Relation: https://research-information.bris.ac.uk/en/publications/806a7433-427e-46a4-9ec4-1db6e4eb2895

الاتاحة: https://hdl.handle.net/1983/806a7433-427e-46a4-9ec4-1db6e4eb2895
https://research-information.bris.ac.uk/en/publications/806a7433-427e-46a4-9ec4-1db6e4eb2895
https://doi.org/10.1111/bph.16204

المؤلفون: Stein, Reed M, Kang, Hye Jin, McCorvy, John D, Glatfelter, Grant C, Jones, Anthony J, Che, Tao, Slocum, Samuel, Huang, Xi-Ping, Savych, Olena, Moroz, Yurii S, Stauch, Benjamin, Johansson, Linda C, Cherezov, Vadim, Kenakin, Terry, Irwin, John J, Shoichet, Brian K, Roth, Bryan L, Dubocovich, Margarita L

المصدر: Nature. 579(7800)

مصطلحات موضوعية: Sleep Research, Neurosciences, Underpinning research, 1.1 Normal biological development and functioning, Animals, Circadian Rhythm, Darkness, Drug Evaluation, Preclinical, Drug Inverse Agonism, Female, Humans, Ligands, Light, Male, Mice, Mice, Knockout, Molecular Docking Simulation, Receptor, Melatonin, MT1, Receptor, Melatonin, MT2, Receptors, Melatonin, Small Molecule Libraries, Substrate Specificity, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3sp0d3rw

المؤلفون: Agnès Ribes, Cédric Garcia, Marie-Pierre Gratacap, Evi Kostenis, Laurent O. Martinez, Bernard Payrastre, Jean-Michel Sénard, Céline Galés, Véronique Pons

المصدر: BMC Biology, Vol 21, Iss 1, Pp 1-16 (2023)

مصطلحات موضوعية: GPCR, Constitutive signaling, Inverse agonism, MRS2179, P2Y receptor, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1741-7007

URL الوصول: https://doaj.org/article/6ae6386caf484ccca6c2de46387787d6

المؤلفون: Mokhtar, Nazarine, Drop, Marcin, Jacquot, Florian, Lamoine, Sylvain, Chapuy, Eric, Prival, Laetitia, Aissouni, Youssef, Canale, Vittorio, Lamaty, Frédéric, Zajdel, Paweł, Marin, Philippe, Doly, Stéphane, Courteix, Christine

المساهمون: Neuro-Dol (Neuro-Dol), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), Institut des Biomolécules Max Mousseron Pôle Chimie Balard (IBMM), Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Université de Montpellier (UM), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), ANR-16-IDEX-0001,CAP 20-25,CAP 20-25(2016), ANR-19-CE18-0018,SERO6Pain,Les voies de signalisation du récepteur 5-HT6: de nouvelles cibles pour le traitement de la douleur neuropathique?(2019)

المصدر: ISSN: 2218-273X ; Biomolecules ; https://uca.hal.science/hal-04094286 ; Biomolecules, 2023, Recent Advances on 5-HT6 Receptors, 13 (2), pp.364. ⟨10.3390/biom13020364⟩.

مصطلحات موضوعية: Neuropathic pain, diabetes, 5-HT6 receptor, constitutive activity, inverse agonism, mTOR, Streptozocin, MESH: Animals, MESH: Diabetes Mellitus, Experimental / complications, MESH: TOR Serine-Threonine Kinases, MESH: Neuralgia, MESH: serotonin 6 receptor, MESH: Diabetic Neuropathies, MESH: Drug Inverse Agonism, MESH: Hyperalgesia, MESH: Ligands, MESH: Rats, MESH: Serotonin / pharmacology, [SDV]Life Sciences [q-bio]

Relation: info:eu-repo/semantics/altIdentifier/pmid/36830733; PUBMED: 36830733; PUBMEDCENTRAL: PMC9953062

الاتاحة: https://uca.hal.science/hal-04094286
https://uca.hal.science/hal-04094286v1/document
https://uca.hal.science/hal-04094286v1/file/Mokhtar%20et%20al.,%202023.pdf
https://doi.org/10.3390/biom13020364

المؤلفون: Morgan Scott-Dennis, Fikri A. Rafani, Yicheng Yi, Themiya Perera, Clare R. Harwood, Wolfgang Guba, Arne C. Rufer, Uwe Grether, Dmitry B. Veprintsev, David A. Sykes

المصدر: Frontiers in Pharmacology, Vol 14 (2023)

مصطلحات موضوعية: G-protein signaling, Gαi signaling pathway, cannabinoid receptors (CBRs), inverse agonism, BRET—bioluminescence resonance energy transfer, GPCR signalling assay, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1158091/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/bd3b602001cb48838825a2f74ab966f7

المؤلفون: Laetitia Jacquot, Océane Pointeau, Célia Roger-Villeboeuf, Patricia Passilly-Degrace, Rim Belkaid, Isaline Regazzoni, Julia Leemput, Chloé Buch, Laurent Demizieux, Bruno Vergès, Pascal Degrace, Glenn Crater, Tony Jourdan

المصدر: Frontiers in Nephrology, Vol 3 (2023)

مصطلحات موضوعية: nephropathy, diabetes, CB1 receptors, inverse agonism, peripherally-restricted, fibrosis, Diseases of the genitourinary system. Urology, RC870-923

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneph.2023.1138416/full; https://doaj.org/toc/2813-0626

URL الوصول: https://doaj.org/article/97f8a94235a049d3a30516336677a728

المؤلفون: Wágner, Gábor, Mocking, Tamara A.M., Ma, Xiaoyuan, Slynko, Inna, Da Costa Pereira, Daniel, Breeuwer, Robin, Rood, Niek J.N., van der Horst, Cas, Vischer, Henry F., de Graaf, Chris, de Esch, Iwan J.P., Wijtmans, Maikel, Leurs, Rob

المصدر: Wágner , G , Mocking , T A M , Ma , X , Slynko , I , Da Costa Pereira , D , Breeuwer , R , Rood , N J N , van der Horst , C , Vischer , H F , de Graaf , C , de Esch , I J P , Wijtmans , M & Leurs , R 2023 , ' SAR exploration of the non-imidazole histamine H 3 receptor ligand ZEL-H16 reveals potent inverse agonism ' , Archiv der Pharmazie , vol. 356 , no. 1 , 2200451 . https://doi.org/10.1002/ardp.202200451

مصطلحات موضوعية: agonism, G protein-coupled receptor (GPCR), histamine H3 receptor, inverse agonism, non-imidazole

الاتاحة: https://research.vu.nl/en/publications/56a103e1-37a8-4ea1-9649-4b9ecc8ca260
https://doi.org/10.1002/ardp.202200451
https://hdl.handle.net/1871.1/56a103e1-37a8-4ea1-9649-4b9ecc8ca260
http://www.scopus.com/inward/record.url?scp=85141214528&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85141214528&partnerID=8YFLogxK

المؤلفون: Canale, Vittorio, Trybała, Wojciech, Chaumont-Dubel, Séverine, Koczurkiewicz-Adamczyk, Paulina, Satała, Grzegorz, Bento, Ophélie, Blicharz-Futera, Klaudia, Bantreil, Xavier, Pękala, Elżbieta, Bojarski, Andrzej, J, Lamaty, Frédéric, Marin, Philippe, Zajdel, Paweł

المساهمون: Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Polska Akademia Nauk = Polish Academy of Sciences = Académie polonaise des sciences (PAN), Institut des Biomolécules Max Mousseron Pôle Chimie Balard (IBMM), Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Université de Montpellier (UM), Institut universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), ANR-16-IDEX-0006,MUSE,MUSE(2016)

المصدر: ISSN: 2218-273X ; Biomolecules ; https://hal.science/hal-03933561 ; Biomolecules, 2023, 13 (1), pp.12. ⟨10.3390/biom13010012⟩.

مصطلحات موضوعية: mechanochemical synthesis, 5-HT6 receptor inverse agonism/neutral antagonism, Gs and Cdk5 signaling pathways, glioprotective properties, rotenone toxicity, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology

الاتاحة: https://hal.science/hal-03933561
https://hal.science/hal-03933561v1/document
https://hal.science/hal-03933561v1/file/165-2023-Biomol.pdf
https://doi.org/10.3390/biom13010012

المؤلفون: Pottie, Eline, Suresh, R. Rama, Jacobson, Kenneth A., Stove, Christophe

المصدر: ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE ; ISSN: 2575-9108

مصطلحات موضوعية: Medicine and Health Sciences, SYNTHETIC CANNABINOIDS, DERIVATIVES, LIGANDS, EFFICACY, DISEASES, POTENT, adenosine receptor, GPCR, nucleosides, second messengers, inverse agonism, antagonism

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

Relation: https://biblio.ugent.be/publication/01HKSP4M4CA9VNCXASH96HCRE7; http://doi.org/10.1021/acsptsci.3c00071; https://biblio.ugent.be/publication/01HKSP4M4CA9VNCXASH96HCRE7/file/01HKSPM5BRBAP50HQTG20CFR12

الاتاحة: https://biblio.ugent.be/publication/01HKSP4M4CA9VNCXASH96HCRE7
http://hdl.handle.net/1854/LU-01HKSP4M4CA9VNCXASH96HCRE7
https://doi.org/10.1021/acsptsci.3c00071
https://biblio.ugent.be/publication/01HKSP4M4CA9VNCXASH96HCRE7/file/01HKSPM5BRBAP50HQTG20CFR12

المؤلفون: Laura Kate Gadanec, Jordan Swiderski, Vasso Apostolopoulos, Kostantinos Kelaidonis, Veroniki P. Vidali, Aleksander Canko, Graham J. Moore, John M. Matsoukas, Anthony Zulli

المصدر: International Journal of Molecular Sciences, Vol 24, Iss 24, p 17559 (2023)

مصطلحات موضوعية: angiotensin II, angiotensin II receptor blockers, bisartans, inverse agonism, sartans, Biology (General), QH301-705.5, Chemistry, QD1-999

Relation: https://www.mdpi.com/1422-0067/24/24/17559; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/a14c1bf20a4c480ab561d4f30eebe81a

الاتاحة: https://doi.org/10.3390/ijms242417559
https://doaj.org/article/a14c1bf20a4c480ab561d4f30eebe81a

المؤلفون: Donthamsetti, Prashant C, Winter, Nils, Schönberger, Matthias, Levitz, Joshua, Stanley, Cherise, Javitch, Jonathan A, Isacoff, Ehud Y, Trauner, Dirk

المصدر: Journal of the American Chemical Society. 139(51)

مصطلحات موضوعية: Mental Health, Neurosciences, Brain Disorders, Good Health and Well Being, Binding Sites, Cysteine, Dopamine, Dopamine D2 Receptor Antagonists, Drug Inverse Agonism, Humans, Ligands, Receptors, Dopamine D1, Receptors, Dopamine D2, Chemical Sciences, General Chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8cj0d5dz

المؤلفون: Ehlert, Frederick J, Griffin, Michael T

المصدر: Journal of Pharmacological and Toxicological Methods. 69(3)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Allosteric Regulation, Computer Simulation, Drug Inverse Agonism, Humans, Ligands, Receptors, G-Protein-Coupled, Signal Transduction, Allosterism, Agonist-bias, Ligand-bias, Probe-dependence, Efficacy modulation, Affinity modulation, Constitutive activity, Receptor states, Muscarinic receptor, Monod-Wyman-Changeux, Pharmacology & Pharmacy, Pharmacology and pharmaceutical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/2nt48005

المؤلفون: Drop, Marcin, Canale, Vittorio, Chaumont-Dubel, Séverine, Kurczab, Rafał, Satała, Grzegorz, Bantreil, Xavier, Walczak, Maria, Koczurkiewicz-Adamczyk, Paulina, Latacz, Gniewomir, Gwizdak, Anna, Krawczyk, Martyna, Gołębiowska, Joanna, Grychowska, Katarzyna, Bojarski, Andrzej, Nikiforuk, Agnieszka, Subra, Gilles, Martínez, Jean, Pawłowski, Maciej, Popik, Piotr, Marin, Philippe, Lamaty, Frédéric, Zajdel, Paweł

المساهمون: Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Polska Akademia Nauk = Polish Academy of Sciences = Académie polonaise des sciences (PAN), Institut des Biomolécules Max Mousseron Pôle Chimie Balard (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), ANR-17-CE16-0010,Sero6Dev,Réseau de signalisation associé au récepteur 5-HT6 et développement neuronal(2017), ANR-17-CE16-0013,StopSero6TOR,La signalisation mTOR induite par le récepteur 5-HT6 comme cible thérapeutique pour prévenir l'apparition des déficits cognitifs dans la schizophrénie(2017)

المصدر: ISSN: 1948-7193 ; ACS Chemical Neuroscience ; https://hal.science/hal-03192567 ; ACS Chemical Neuroscience, 2021, 12 (7), pp.1228-1240. ⟨10.1021/acschemneuro.1c00061⟩.

مصطلحات موضوعية: 2-phenyl-1H-pyrrole-3-carboxamide, 5-HT6 receptor, Cdk5 signaling, Cognition, Attentional set shifting task, Constitutive activity, Inverse agonism, Novel object recognition test, Metrics & More Article Recommendations Cognition, 5-HT 6 receptor, MESH: Animals, MESH: Cognition, MESH: Pyrroles, MESH: Rats, MESH: Receptors, Serotonin, MESH: Structure-Activity Relationship, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [CHIM]Chemical Sciences, [SCCO.NEUR]Cognitive science/Neuroscience

Relation: info:eu-repo/semantics/altIdentifier/pmid/33705101; hal-03192567; https://hal.science/hal-03192567; https://hal.science/hal-03192567/document; https://hal.science/hal-03192567/file/acschemneuro.1c00061.pdf; PUBMED: 33705101; PUBMEDCENTRAL: PMC8041276; WOS: 000639017700016

الاتاحة: https://hal.science/hal-03192567
https://hal.science/hal-03192567/document
https://hal.science/hal-03192567/file/acschemneuro.1c00061.pdf
https://doi.org/10.1021/acschemneuro.1c00061

المؤلفون: Drop, Marcin, Jacquot, Florian, Canale, Vittorio, Chaumont-Dubel, Séverine, Walczak, Maria, Satała, Grzegorz, Nosalska, Klaudia, Mahoro, Gilbert Umuhire, Słoczyńska, Karolina, Piska, Kamil, Lamoine, Sylvain, Pękala, Elżbieta, Masurier, Nicolas, Bojarski, Andrzej, Pawłowski, Maciej, Martinez, Jean, Subra, Gilles, Bantreil, Xavier, Lamaty, Frédéric, Eschalier, Alain, Marin, Philippe, Courteix, Christine, Zajdel, Paweł

المساهمون: Institut des Biomolécules Max Mousseron Pôle Chimie Balard (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Neuro-Dol (Neuro-Dol), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Jagiellonian University - Medical College, ANR-17-CE16-0010,Sero6Dev,Réseau de signalisation associé au récepteur 5-HT6 et développement neuronal(2017), ANR-17-CE16-0013,StopSero6TOR,La signalisation mTOR induite par le récepteur 5-HT6 comme cible thérapeutique pour prévenir l'apparition des déficits cognitifs dans la schizophrénie(2017), ANR-19-CE18-0018,SERO6Pain,Les voies de signalisation du récepteur 5-HT6: de nouvelles cibles pour le traitement de la douleur neuropathique?(2019), ANR-18-CE18-0018,SMARt-TB,Molécules de réversion de la résistance aux prodrogues chez M. tberculosis(2018)

المصدر: ISSN: 0045-2068.

مصطلحات موضوعية: 5-HT(6) receptor inverse agonism, Cdk5 signaling, Flow chemistry, Neuropathic pain, Spinal nerve ligation, mTOR kinase, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology

Relation: info:eu-repo/semantics/altIdentifier/pmid/34365058; hal-03324439; https://hal.science/hal-03324439; https://hal.science/hal-03324439/document; https://hal.science/hal-03324439/file/154-2021-BC.pdf; PUBMED: 34365058

الاتاحة: https://hal.science/hal-03324439
https://hal.science/hal-03324439/document
https://hal.science/hal-03324439/file/154-2021-BC.pdf
https://doi.org/10.1016/j.bioorg.2021.105218

المؤلفون: Matthias Apweiler, Soraya Wilke Saliba, Jana Streyczek, Thomas Hurrle, Simone Gräßle, Stefan Bräse, Bernd L. Fiebich

المصدر: International Journal of Molecular Sciences; Volume 22; Issue 21; Pages: 11665

مصطلحات موضوعية: oxidative stress, GPR55, coumarin-based compounds, ROS, inverse agonism, 8-Iso-PGF 2α

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Endocrinology and Metabolism; https://dx.doi.org/10.3390/ijms222111665

الاتاحة: https://doi.org/10.3390/ijms222111665

المؤلفون: Shigenori Inagaki, Ryo Iwata, Masakazu Iwamoto, Takeshi Imai

المصدر: Cell Reports, Vol 31, Iss 13, Pp 107814- (2020)

مصطلحات موضوعية: odorant receptor, olfactory sensory neuron, inhibition, inverse agonism, antagonism, synergy, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124720307956; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/d2eb2e63e8fe4e72ba13318caa25589e