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المؤلفون: Rugo, Hope S., Lacouture, Mario E., Goncalves, Marcus D., Masharani, Umesh, Aapro, Matti S., O'Shaughnessy, Joyce A.
المصدر: Breast, Vol 61, Iss, Pp 156-167 (2022)
The Breast : Official Journal of the European Society of Mastologyمصطلحات موضوعية: OGTT, oral glucose tolerance test, Clinical Trials and Supportive Activities, Clinical Sciences, HbA1c, glycosylated hemoglobin, Breast Neoplasms, Review, mTOR, mammalian target of rapamycin, PI3K, phosphatidylinositol-3-kinase, SGLT2i, sodium-glucose co-transporter 2 inhibitor, Alpelisib, Phosphatidylinositol 3-Kinases, AE, adverse events, Breast cancer, PI3Ki, phosphatidylinositol-3-kinase inhibitor, Clinical Research, Antineoplastic Combined Chemotherapy Protocols, IM, intramuscular, Humans, HER2, human epidermal growth factor receptor 2, BID, twice a day, FPG, fasting plasma glucose, FSBG, fingerstick blood glucose, Oncology & Carcinogenesis, RC254-282, Cancer, Prevention, eGFR, estimated glomerular filtration rate, AE management, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, PG, plasma glucose, PIK3CA, General Medicine, GI, gastrointestinal, HR, hazard ratio, TID, thrice daily, SC, subcutaneous, Thiazoles, Public Health and Health Services, PI3Kα, phosphatidylinositol-3-kinase regulatory subunit alpha, Female, Surgery, HR+, hormone receptor-positive, Digestive Diseases, IV, intravenous
وصف الملف: application/pdf
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المؤلفون: Eric Destexhe, Sarah Paris-Robidas, Charlotte Dubé, Nathalie Landry, Sonia Trépanier, Iryna Primakova, Brian J. Ward
المصدر: Reproductive Toxicology (Elmsford, N.y.)
مصطلحات موضوعية: TM, transmembrane domainVLP virus-like particle, PND, postnatal day, alpha-Tocopherol, Physiology, GMT, geometric mean titer, Polysorbates, Toxicology, Antibodies, Viral, AS03, PPN, pre and postnatal, Fetal Development, Rats, Sprague-Dawley, Pregnancy, Lactation, HCD, historical control data, Maternal-Fetal Exchange, media_common, COVID-19, coronavirus disease 2019, EFD, embryofetal development, OECD, organisation for economic co-operation and development, ELISA, enzyme-linked immunosorbent assay, Virus-like particles, Immunogenicity, Recombinant Proteins, GLP, good laboratory practice, Vaccination, Drug Combinations, medicine.anatomical_structure, Spike Glycoprotein, Coronavirus, Gestation, Female, GD, gestation day, Squalene, S, spike, COVID-19 Vaccines, Offspring, media_common.quotation_subject, Embryonic Development, Fertility, CoVLP, coronavirus-like particle, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, Article, Developmental and reproductive toxicity study, RBD, receptor binding domain, PBS, phosphate buffered saline, Tobacco, medicine, Weaning, IM, intramuscular, Animals, Vaccines, Virus-Like Particle, HRP, horse-radish peroxidase, CT, cytoplasmic tail DART developmental and reproductive toxicity, business.industry, SARS-CoV-2, AS, adjuvant system, COVID-19, medicine.disease, CI, confidence interval, MRD, minimum required dilution, SOP, standard operating procedure, Animals, Newborn, SD, study day, Immunoglobulin G, business, QA, quality assurance, COVID-19 vaccine
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المؤلفون: Keita Sasaki, Akifumi Kyuno, Shunji Haruta, Yuji Sasaki, Akihide Tanimoto, Yusuke Torikai
المصدر: Journal of Pharmaceutical Sciences
مصطلحات موضوعية: Nasal cavity, MRI, Magnetic resonance imaging, Mn, Manganese, Pharmaceutical Science, Controlled delivery, 02 engineering and technology, Pharmaceutics, Drug Delivery and Pharmaceutical Technology, 030226 pharmacology & pharmacy, Mice, IgA, Immunoglobulin A, 0302 clinical medicine, MAD, Mucosal atomization device, Controlled release, IM, Intramuscular, SEM, Scanning electron microscopy, Respiratory system, MALT, Mucosa-associated lymphoid tissue, Mice, Inbred BALB C, IgG, Immunoglobulin G, OVA, Ovalbumin, 3D, Three dimensions, biology, Immunogenicity, Antibody titer, respiratory system, 021001 nanoscience & nanotechnology, Mucosal vaccination, PBS, Phosphate-buffered saline, medicine.anatomical_structure, CT, Computed tomography, Powder technology, Powders, Nasal drug delivery, TMB, 3, 3′, 5, 5′- tetramethylbenzidine, 0210 nano-technology, Ovalbumin, Drug delivery system, NALT, Nasopharyngeal-associated lymphoid tissue, 03 medical and health sciences, BSA, Bovine serum albumin, Immune system, Adjuvants, Immunologic, Antigen, otorhinolaryngologic diseases, medicine, Animals, Distribution (pharmacology), MEMRI, Manganese-enhanced magnetic resonance imaging, Immunity, Mucosal, Administration, Intranasal, HE, Hematoxylin and eosin, business.industry, Macaca fascicularis, Formulation, Immunology, SIgA, Secretory immunoglobulin A, biology.protein, Mucoadhesive, business, Vaccine
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المؤلفون: Yulia Eygeris, Gaurav Sahay, Mohit Gupta, Jeonghwan Kim
المصدر: Advanced Drug Delivery Reviews
مصطلحات موضوعية: HPLC, High-performance liquid chromatography, TH1, Type 1 T helper cell, DMG-PEG-2000, 1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000, IV, Intravenous, Genetic enhancement, APC, Antigen-presenting cell, Pharmaceutical Science, PET-CT, Positron emission tomography- computed tomography, 02 engineering and technology, LNP, Lipid nanoparticle, UTR, Untranslated region, IL, Ionizable lipid, PEG, Poly(ethylene glycol), SARS-CoV-2, Severe acute respiratory syndrome coronavirus-2, ID, Intradermal,
ARCA, “Anti-reverse" cap analog, Nanotechnology, IM, Intramuscular, Gene delivery, GMP, Good manufacturing practice, IVT, In vitro transcription, Vaccines, Synthetic, 0303 health sciences, SAXS, Small-angle X-ray scattering, Gene Transfer Techniques, Self-assembly, PBAE, Poly(beta-amino esters), 021001 nanoscience & nanotechnology, DC, Dendritic cell, mRNA, Messenger RNA, Vaccination, DSPC, 1,2-Distearoyl-sn-glycero-3-phosphocholine, HIV, Human immunodeficiency virus, COVID-19, Coronavirus Disease 2019, siRNA, Small interfering RNA, DOTAP, 1,2-Dioleoyl-3-trimethylammonium-propane, RSV, Respiratory syncytial virus, ApoE, Apolipoprotein E, 0210 nano-technology, EUA, Emergency Use Authorization, DOTMA, 1,2-Di-O-octadecenyl-3-trimethylammonium propane, TLR, Toll-like receptor, Immune activation, DODMA, 1,2-Dioleyloxy-3-dimethylaminopropane, COVID-19 Vaccines, Coronavirus disease 2019 (COVID-19), GC, Germinal center, Computational biology, BCR, B-cell receptor, Biology, DLin-MC3-DMA, MC3, (6Z,9Z,28Z,31Z)-Heptatriacont-6,9,28,31-tetraene-19-yl 4-(dimethylamino)butanoate, Article, Self assembled, saRNA, Self-amplifying RNA, 03 medical and health sciences, PEI, Poly(ethylene imine), DOPE, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, SAR, Structure-activity relationship, mRNA delivery, ACE2, Angiotensin-converting enzyme 2, DGTS, 1,2-Dipalmitoyl-sn-glycero-3-O-4'-(N,N,N-trimethyl)-homoserine, Animals, Humans, RNA, Messenger, IgA, IgG, Immunoglobulin A, G, 030304 developmental biology, MHC, Major histocompatibility complex, Messenger RNA, PLGA, Poly(lactic-co-glycolic acid), SC, Subcutaneous, COVID-19, LN, Lymph node, RBD, Receptor Binding Domain, Immunization, Drug Design, DOGS, N1,N1'-(8-(dioctadecylamino)-5,8-dioxooctane-1,4-diyl)bis(propane-1,3-diaminium), Lipid nanoparticles, Nanoparticles, pDNA, Plasmid DNA, Cryo-(T)EM, Cryogenic (transmission) electron microscopy -
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المؤلفون: Xueyuan Yang, Soo K. Shin, Jin Xie, Kylee J. Duberstein, Madison M. Fagan, Simon R. Platt, Kelly M. Scheulin, Erin E. Kaiser, Holly A. Kinder, Elizabeth S. Waters, Julie Jeon, Franklin D. West, Anil Kumar, Hea Jin Park
المصدر: IBRO Neuroscience Reports
IBRO Neuroscience Reports, Vol 10, Iss, Pp 18-30 (2021)مصطلحات موضوعية: Baic, Baicalin, Tan IIA-NPs, Tan IIA-loaded nanoparticles, ICH, intracerebral hemorrhage, ddH2O, double-distilled water, NP, nanoparticle, NSCs, neural stem cells, MLS, midline shift, T2W, T2Weighted, FA, fractional anisotropy, Lead (electronics), Stroke, TNF-α, tumor necrosis factor α, ANOVA, analysis of variance, Tan IIA-NPs, Tan IIA PLGA NPs, PLGA-b-PEG-OH, poly (lactide-co-glycolide)-b-poly (ethylene glycol)-maleimide, DLS, dynamic light scattering, Ischemic stroke, General Neuroscience, T2FLAIR, T2 Fluid Attenuated Inversion Recovery, Neural stem cell, TD, transdermal, Tan IIA, Tanshinone IIA, DAMPS, damaged-associated molecular patterns, BBB, blood brain barrier, UGA, University of Georgia, IL-6, interleukin 6, medicine.anatomical_structure, Nanomedicine, Cardiology, PLGA, Poly (lactic-co-glycolic acid), AU, arbitrary units, LPS, lipopolysaccharide, Edar, Edaravone, RC321-571, Research Paper, Resv, Resveratrol, medicine.medical_specialty, STAIR, Stroke Therapy Academic and Industry Roundtable, DTI, Diffusion Tensor Imaging, Neurosciences. Biological psychiatry. Neuropsychiatry, Tanshinone IIA, CNS, central nervous system, White matter, Piog, Pioglitazone, CSF, cerebral spinal fluid, ROS, reactive oxygen species, Midline shift, PBS, phosphate buffered saline, Internal medicine, SOD, superoxide dismutase, medicine, IM, intramuscular, DWI, Diffusion-Weighted Imaging, WM, white matter, TEM, transmission electron microscopy, MCAO, middle cerebral artery occlusion, Pathological, business.industry, Pig stroke model, Therapeutic effect, T2*, T2Star, PLGA nanoparticle, medicine.disease, PEG–PLGA, polyethyleneglycol–polylactic-co-glycolic acid, FDA, Food and Drug Administration, tPA, Tissue plasminogen activator, Bioavailability, Puer, Puerarin, GM, gray matter, IC, inhibitory concentration, MCA, middle cerebral artery, business, ADC, Apparent Diffusion Coefficient, GABA, γ-aminobutyric acid
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المؤلفون: Fatemeh Namazi, Seifollah Dehghani Nazhvani, Iman Haghani, Abbas Ghaderi, Fatemeh Dehghani Nazhvani
المصدر: Annals of Medicine and Surgery
مصطلحات موضوعية: α-MEM, Minimum essential medium α, Pathology, medicine.medical_specialty, Cirrhosis, Experimental Research, Liver fibrosis, VEGF, Vascular endothelial growth factor, PBS, Phosphate buffered saline, CCL4, CCL4, Carbon tetracholoride, 03 medical and health sciences, 0302 clinical medicine, Parenchyma, Adipose-derived mesenchymal stem cells, medicine, Animal model, IM, Intramuscular, ALT, Alanine transaminase, business.industry, CNS, Central nervous system, Regeneration (biology), Mesenchymal stem cell, General Medicine, EDTA, Ethylenediaminetetraacetic acid, MSCs, Mesenchymal stem cells, HGF, Hepatocyte growth factor, medicine.disease, AST, Aspartate transaminase, Transplantation, ADSCs, Multipotent adipose-derived stem cells, IP, Intraperitoneal, medicine.anatomical_structure, Hepatic cirrhosis, 030220 oncology & carcinogenesis, FBS, Fetal bovine serum, Abdomen, 030211 gastroenterology & hepatology, Surgery, Stem cell, business
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المؤلفون: Raymond Fung, Mary Kathleen Greenaway, Giancarlo McEvenue
المصدر: AACE Clinical Case Reports
AACE Clinical Case Reports, Vol 7, Iss 6, Pp 350-352 (2021)مصطلحات موضوعية: Agonist, Pediatrics, medicine.medical_specialty, gynecomastia, medicine.drug_class, transgender hormone therapy, Case Report, Gonadotropin-releasing hormone, Diseases of the endocrine glands. Clinical endocrinology, Transgender, medicine, GnRH, gonadotropin-releasing hormone, IM, intramuscular, testosterone therapy, Chest surgery, skin and connective tissue diseases, Breast development, business.industry, Testosterone (patch), General Medicine, medicine.disease, RC648-665, Gynecomastia, puberty suppression, gender-affirming hormone therapy, business, Hormone
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المصدر: JAAD Case Reports, Vol 6, Iss 9, Pp 838-840 (2020)
JAAD Case Reportsمصطلحات موضوعية: biology, ACE, angiotensin-converting enzyme, business.industry, Interleukin, Angiotensin-converting enzyme, Dermatology, JAK, janus kinase, lcsh:RL1-803, Programmed Cell Death 1 Receptor, IL, interleukin, PD-1, programmed cell death-1 receptor, Cytotoxic T-Lymphocyte-Associated Antigen 4, CTLA-4, ACE - Angiotensin-converting enzyme, Images in Dermatology, Cancer research, biology.protein, lcsh:Dermatology, IM, intramuscular, Medicine, CTLA-4, cytotoxic T-lymphocyte-associated antigen-4, Janus kinase, business
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المؤلفون: Anna J. Nichols, Robert S. Kirsner, George W. Burke, Tim Ioannides, Valeria De Bedout, Rachel Fayne
المصدر: JAAD Case Reports
JAAD Case Reports, Vol 6, Iss 4, Pp 289-291 (2020)مصطلحات موضوعية: Hpv human papillomavirus, business.industry, Case Report, HPV, human papillomavirus, SOTR, solid organ transplant recipient, human papillomavirus vaccine, Dermatology, lcsh:RL1-803, Human papillomavirus vaccine, SCCIS, squamous cell carcinoma in situ, squamous cell carcinoma in situ, Renal transplant, lcsh:Dermatology, Cancer research, IM, intramuscular, Medicine, Basal cell, Human papillomavirus, business, solid organ transplant recipient
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المؤلفون: Jasminka Bozic, Anh Tran, Catalina Soare, Barthelemy Ontsouka, Anne-Catherine Fluckiger, Tanvir Ahmed, Mingmin Liao, Diane Duque, Francisco Diaz-Mitoma, David E. Anderson, Michael J McCluskie, Abebaw Diress, Tamara Berthoud
المصدر: Vaccine
مصطلحات موضوعية: SARS, Severe acute respiratory syndrome, viruses, immunogenicity, Ab, antibody, Antibodies, Viral, Neutralization, Mice, Alum, aluminum, VIDO, Vaccine and Infectious Disease Organization, Cricetinae, vaccine, IM, Intramuscular, PRNT, plaque reduction neutralization test, COVID-19, Coronavirus disease 2019, Chemistry, Immunogenicity, EPT, end-point titer, Titer, IP, Intraperitoneal, Infectious Diseases, Spike Glycoprotein, Coronavirus, Molecular Medicine, virus-like-particles, TM-CTD, transmembrane cytoplasmic terminal domain, ELISPOT, Enzyme Linked ImmunoSpot Test, SARS-CoV-2, Severe acute respiratory syndrome- coronavirus-2, COVID-19 Vaccines, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), SARS-COV-2, eVLP, enveloped virus-like particules, Article, RBD, receptor binding domain, nAb, neutralizing antibody, Viral envelope, Immunity, Animals, Humans, neutralizing antibodies, Vaccines, Virus-Like Particle, ELISA, enzyme-linked-immuno-sorbent-assay, MLV, murine leukemia virus, General Veterinary, General Immunology and Microbiology, MERS, Middle East respiratory syndrome, Public Health, Environmental and Occupational Health, Spike Protein, COVID-19, Virology, Antibodies, Neutralizing, Immunization, NRC, National Research Council Canada
وصف الملف: application/pdf
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المؤلفون: Nandini MK, Poonam Vishwakarma, and Ansar Kamran C
مصطلحات موضوعية: B. Gibsoni, Canine, Clindamycin, Metronidazole, Doxycycline, Combination therapy, Haematology, Biochemistry Hb: Haemoglobin, TLC: Total Leucocyte Count: SGOT: Serum Glutamic Oxaloacetic Transaminase, SGPT: Serum Glutamic-Pyruvic Transaminase, ALP: Alkaline Phosphatase, @: at sign, SC: Subcutaneous, IM: Intramuscular
وصف الملف: application/pdf
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المؤلفون: Xiangyu Wang, An Lu, Qiang Zhang, Zakia Belhadj, Yujie Shi, Jiancheng Wang
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2396-2415 (2021)مصطلحات موضوعية: Nanocrystal suspensions, HP, hypoparathyroidism, PEG - Polyethylene glycol, Design elements and principles, NDS, nanochannel delivery system, Review, FcRn, Fc receptor, PVA, polyvinyl alcohol, Drug pharmacokinetics, Biomimetic strategies, ENA, ethylene-bridged nucleic acid, ART, antiretroviral therapy, 0302 clinical medicine, DDS, drug delivery systems, hGH, human growth hormone, Fc/HSA fusion, Medicine, mPEG, methoxypolyethylene glycol, General Pharmacology, Toxicology and Pharmaceutics, PTH, parathyroid hormone, ISFI, in situ forming implants, HA, hyaluronic acid, 0303 health sciences, STC, standard template chemistry, Hydrogels, HES, hydroxy-ethyl-starch, ECM, extracellular matrix, GLP-1, glucagon like peptide-1, RNAi, RNA interference, Risk analysis (engineering), SCID, severe combined immunodeficiency, 030220 oncology & carcinogenesis, Drug release, Implantable systems, OA, osteoarthritis, MNs, microneedles, SAR, structure‒activity relationship, Microneedles, PMPC, poly(2-methyacryloyloxyethyl phosphorylcholine), GS, glycine–serine, IgG, immunoglobulin G, Clinical settings, ASO, antisense oligonucleotide, RM1-950, 2′-O-MOE, 2′-O-(2-methoxyethyl), ESC, enhanced stabilization chemistry, LAFs, long-acting formulations, LNA, locked nucleic acid, 03 medical and health sciences, 2′-F, 2′-fluoro, 2′-OMe, 2′-O-methyl, sc, subcutaneous, NPs, nanoparticles, 030304 developmental biology, PEG, polyethylene glycol, PS, phase separation, iv, intravenous, PCPP-SA, poly(1,3-bis(carboxyphenoxy)propane-co-sebacic-acid), im, intramuscular, PVA - Polyvinyl alcohol, PNAs, peptide nucleic acids, SE, solvent extraction, business.industry, Long-acting, 3D, three-dimensional, LAPFs, long-acting parenteral formulations, PSA, polysialic acid, TNFR2, tumor necrosis factor receptor 2, Oa osteoarthritis, EVA, ethylene vinyl acetate, PM, platelet membrane, Long acting, RBCs, red blood cells, Therapeutics. Pharmacology, business, RES, reticuloendothelial system, HSA, human serum albumin, Chemical modification
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المؤلفون: John Davison, Simon Doe
المصدر: Respiratory Medicine Case Reports, Vol 34, Iss, Pp 101557-(2021)
Respiratory Medicine Case Reportsمصطلحات موضوعية: Pulmonary and Respiratory Medicine, Quality of life, Pediatrics, medicine.medical_specialty, Eosinophilic asthma, Case Report, Omalizumab, OCS, oral corticosteroid(s), Biologics, ACQ, Asthma Control Questionnaire, chemistry.chemical_compound, Diseases of the respiratory system, Refractory, QD, once daily, BID, twice daily, Eosinophilia, IM, intramuscular, Medicine, Medical prescription, SC, subcutaneously, SAC, severe asthma center, Bronchial thermoplasty, RC705-779, business.industry, Severe eosinophilic asthma, ICS, inhaled corticosteroid(s), FEV1, forced expiratory volume in 1 second, Benralizumab, Ig, immunoglobulin, Q4W, every 4 weeks, IL, interleukin, LABA, long-acting β2-agonist, chemistry, FeNO, fractional exhaled nitric oxide, Q8W, every 8 weeks, FVC, forced vital capacity, business, Mepolizumab, medicine.drug
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المؤلفون: R. Pinkham, D. Eckery, R. Mauldin, M. Gomm, F. Hill, F. Vial, G. Massei
المصدر: Vaccine: X, Vol 10, Iss, Pp 100138-(2022)
Vaccine: Xمصطلحات موضوعية: NT, No detectable titre, Fertility control, General Veterinary, General Immunology and Microbiology, Immunocontraception, Human-wildlife conflicts, Public Health, Environmental and Occupational Health, RC581-607, MAF, Mycobacterium avium fragments, GnRH, Gonadotropin-releasing hormone, Rats, Anti-GnRH vaccine, Litter size, Infectious Diseases, Regular paper, Wildlife management, Molecular Medicine, IM, Intramuscular, Immunologic diseases. Allergy
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المؤلفون: H.H. Stoecklein, Michael A. Johnson, Joseph E. Tonna, Guillaume L. Hoareau, Andrew Pugh, Scott T. Youngquist
المصدر: Resuscitation Plus
Resuscitation Plus, Vol 7, Iss, Pp 100142-(2021)مصطلحات موضوعية: IRB, Institutional Review Board, OHCA, Out of hospital cardiac arrest, Specialties of internal medicine, Out-of-hospital cardiac arrest (OHCA), IV - Intravenous, Return of spontaneous circulation, Time saving, Out of hospital cardiac arrest, Animal data, Hospital discharge, IM, intramuscular, Medicine, PSAP, Public Safety Access Point, CPR - Cardiopulmonary resuscitation, CPR, cardiopulmonary resuscitation, ROSC, return of spontaneous circulation, TXA, tranexamic acid, Earth-Surface Processes, AHA, American Heart Association, EMS, Emergency Medical Services, business.industry, Small sample, CQI, Care Quality Improvement, IO, intraosseus, RC581-951, Anesthesia, Clinical Paper, SLCFD, Salt Lake City Fire Department, business, IV, intravenous, Intramuscular adrenaline
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المؤلفون: Mariana Rodrigues de Magalhães, Liane Esteves Daudt, Maria Lucia de Martino Lee, Isabel Cristina Ribas Werlang, Mariana Bohns Michalowski, Daiane Keller Cecconello
المصدر: Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Hematology, Transfusion and Cell Therapy, Vol 42, Iss 3, Pp 275-282 (2020)
Hematology, Transfusion and Cell Therapy, Volume: 42, Issue: 3, Pages: 275-282, Published: 18 SEP 2020
Hematology, Transfusion and Cell Therapyمصطلحات موضوعية: Drug, Silent inactivation, Asparaginase, Allergy, media_common.quotation_subject, Lymphoblastic Leukemia, Leucemia-linfoma linfoblástico de células precursoras, Review Article, 030204 cardiovascular system & hematology, Acute lymphoblastic leukemia, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Inativação metabólica, Hypersensitivity, IM, intramuscular, Immunology and Allergy, Medicine, Effective treatment, TDM, Therapeutic drug monitoring, In patient, media_common, Hipersensibilidade, PEG-ASNase, pegylated asparaginase, biology, business.industry, lcsh:RC633-647.5, ASN, asparagine, Hematology, lcsh:Diseases of the blood and blood-forming organs, ASP, aspartate, ALL, acute lymphoblastic leukemia, medicine.disease, chemistry, Erwinia chrysanthemi, Immunology, biology.protein, ASNase, asparaginase, Antibody, business, IV, intravenous, 030215 immunology
وصف الملف: application/pdf; text/html
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المؤلفون: Menglu Han, Wenbin Liao, Weian Zhao, Yongjun Liu, Henry P. Farhoodi, Guangyang Liu, Linan Liu, Chi Wut Wong
المصدر: EBioMedicine
مصطلحات موضوعية: 0301 basic medicine, Oncology, Research paper, IDO, indoleamine 2, 3-Dioxygenase, AM, amniotic membrane, AD, adipose tissues, RA, rheumatoid arthritis, CarrIA, carrageenan-induced arthritis, IA, intra-articular injection, IM, intramuscular injection, Umbilical cord, Arthritis, Rheumatoid, 0302 clinical medicine, Clinical trials, CAIA, collagen antibody-induced arthritis, CIA, collagen-induced arthritis, IL-6, interleukin-6, REML, restricted maximum-likelihood estimator, STA, K/BxN serum-transfer arthritis, TNF, tumor necrosis factor, UC, umbilical cord, AIA, adjuvant-induced arthritis, General Medicine, MD, mean difference, NSAIDs, non-steroidal anti-inflammatory drugs, 3. Good health, hPG, proteoglycan-induced arthritis, IV, intravenous injection, Mesenchymal stromal (or stem) cells, medicine.anatomical_structure, Treatment Outcome, IBM, intra-bone marrow injection, SM, synovial membrane, 030220 oncology & carcinogenesis, Meta-analysis, Rheumatoid arthritis, MSC, mesenchymal stromal cells, Regression Analysis, OE, olfactory ecto, TGF, transforming growth factors, Intramuscular injection, IS, intrasplenic injection, Pre-clinical study, medicine.medical_specialty, SYRCLE, SYstematic Review Centre for Laboratory Animal Experimentation, RoB, risk of bias, ESC, embryonic stem cells, DMARDs, non-biologic disease-modifying anti-rheumatic drugs, GI, gingival tissue, Mesenchymal Stem Cell Transplantation, General Biochemistry, Genetics and Molecular Biology, MSC, 03 medical and health sciences, PBS, phosphate buffered saline, SC, subcutaneous injection, Internal medicine, medicine, Animals, Humans, ED, exfoliated deciduous teeth, MOA, mechanism of action, IL, intralymphatic injection, AA, adjuvant-induced arthritis, business.industry, Mesenchymal stem cell, OIA, ovalbumin-induced arthritis, Mesenchymal Stem Cells, hUC-MSC, MSC derived from human umbilical cords, medicine.disease, Confidence interval, IP, intraperitoneal injection, SF, synovial fluid, Treg, regulatory T cells, Clinical trial, CI, confidence interval, UCB, umbilical cord blood, Disease Models, Animal, 030104 developmental biology, SMD, Standardised mean difference, BM, bone marrow, Bone marrow, business, Publication Bias, LRT, likelihood ratio test
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المؤلفون: Benno Ingelse, René Holm, Peter Langguth, Erik Mannaert, Sandy Van Hemelryck, Jonatan Dewulf, Marjolein van Heerden, Harm Niekus
المصدر: International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X, Vol 1, Iss, Pp-(2019)مصطلحات موضوعية: In situ, PO, Propylene oxide, IV, Intravenous, P338, Poloxamer 338, lcsh:RS1-441, Pharmaceutical Science, chemistry.chemical_compound, n, Sample size, SD, Standard deviation, IM, Intramuscular, chemistry.chemical_classification, C0, Analyte plasma concentration at time zero, DoE, Design of experiments, UV, Ultraviolet, Pharmacology. Therapy, K2.EDTA, Potassium ethylenediaminetetraacetic acid, LC–MS/MS, Liquid chromatography-tandem mass spectrometry, H&E, Hematoxylin and eosin, tmax, Sampling time to reach the maximum observed analyte plasma concentration, In situ forming gels, CMC, Critical micellar concentration, Cmax, Maximum observed analyte plasma concentration, Intramuscular injection, DN, Dose normalized, GPT, Gel point temperature, PLGA, Poly-(DL-lactic-co-glycolic acid), TFA, Trifluoroacetic acid, CAN, Acetonitrile, ATP, Adenosine 5′ triphosphate, Salt (chemistry), Polyethylene glycol, Poloxamer, Article, lcsh:Pharmacy and materia medica, Pharmacokinetics, In vivo, UHPLC, Ultra-high performance liquid chromatography, AUClast, Area under the analyte concentration versus time curve from time zero to the time of the last measurable (non-below quantification level) concentration, EO, Ethylene oxide, NMP, N-methyl-2-pyrrolidone, ComputingMethodologies_COMPUTERGRAPHICS, AUC∞, Area under the analyte concentration vs time curve from time zero to infinite time, P407, Poloxamer 407, In vitro release, CMT, Critical micellar temperature, Gel erosion, In vitro, t1/2, Apparent terminal elimination half-life, chemistry, MDR-TB, Multi-drug resistant tuberculosis, AUC80h, Area under the analyte concentration versus time curve from time zero to 80 h, tlast, Sampling time until the last measurable (non-below quantification level) analyte plasma concentration, MRM, Multiple reaction monitoring, Nuclear chemistry, Sustained release
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المؤلفون: Robert W. Kaminski, James Blanchard, Robert L. Wilson, Pamela A. Kozlowski, Anna Aldovini, Edwin V. Oaks, Morgan Singletary, Jeremy V. Camp
المصدر: Vaccine: X, Vol 8, Iss, Pp 100105-(2021)
Vaccine: Xمصطلحات موضوعية: Mucosal adjuvant, viruses, medicine.medical_treatment, T cell, Respiratory tract, medicine.disease_cause, NS, nasal secretions, DNA vaccination, Reproductive, medicine, CVS, cervicovaginal secretions, IM, intramuscular, NHP, nonhuman primates, Cytotoxic T cell, Shigella vaccine, Th, T helper, General Veterinary, General Immunology and Microbiology, biology, business.industry, Ad, adenovirus, Public Health, Environmental and Occupational Health, virus diseases, RC581-607, Simian immunodeficiency virus, Virology, RS, rectal secretions, S-IgA, secretory IgA, Infectious Diseases, medicine.anatomical_structure, Regular paper, Env, envelope, biology.protein, HIV/AIDS, Molecular Medicine, Nasal administration, Immunologic diseases. Allergy, Antibody, IN, intranasal, business, Adjuvant, IgA, ICS, intracellular cytokine staining
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المؤلفون: Mercedes Lopez-Santalla, Juan A. Bueren, Marina I. Garin
المصدر: EBioMedicine, Vol 69, Iss, Pp 103427-(2021)
EBioMedicineمصطلحات موضوعية: Oncology, ID, intradermal, RANTES, regulated upon activation normal T cells expressed and presumably secreted, AS, arthritis score, RA, rheumatoid arthritis, PPAR, peroxisome proliferator-activated receptor, Etanercept, TNF-α, tumour necrosis factor α, Bzb, bortezomib, iLNs, inguinal lymph nodes, CXCR3, chemokine receptor 3-alternative, BMZ, betamethasone, Medicine, CIA, collagen-induced arthritis, PP, peyer's patch, GIP, gastric inhibitory polypeptide, D, days, EVs, extracellular vesicles, Mtx, methotrexate, mAIA, antigen-induced arthritis in mouse, MTC, Masson´s trichrome, 030220 oncology & carcinogenesis, Rheumatoid arthritis, CTLA4, cytotoxic T lymphocyte antigen, iNOS, inducible nitric oxide synthase, KC, keratinocyte chemo-attractant, OCPs, osteoclast precursors, MCP-1, monocyte chemotactic protein 1, PTPN22, protein tyrosine-phosphatase 22, medicine.medical_specialty, rAIA, adjuvant-induced arthritis in rats, MensMSCs, MSCs from menstrual fluid, BM-MSCs, MSCs from bone marrow, MIP-2, macrophage inflammatory protein 2, 03 medical and health sciences, R5-920, IP10, IFN-γ-induced protein 10, IM, intramuscular, NRP-1, neuropilin-1, S, syngeneic, ESR, erythrocyte sedimentation rate, MPs, microparticles, PBMCs, peripheral blood mononuclear cells, AD, adipose tissue, MVs, microvesicles, P, placenta, sCIA, collagen-induced arthritis in sheep, Bregs, regulatory B cells, X, xenogeneic, Improvements in MSC-based therapy, AD-MSCs, MSCs from adipose tissue, 030104 developmental biology, TF, tissue factor, Protocols, Gilz, glucocorticoid-induced leucine zipper, DM, dexamethasone, STAT3, signal transducer and activator of transcription 3, ANA, Anti-nuclear antibodies, SAA, serum amyloid-A, ERDF, European Regional Development Fund, µCT, micro computed tomography imaging, Arthritis, Rheumatoid, T-AOC, total antioxidant capacity, rCIA, collagen-induced arthritis in rats, ISCT, international society for cellular therapy, NF-κB, nuclear factor-kappa B, RORγT, retinoic acid-related orphan receptor, TCR, T cell receptor, OVAIA, ovalbumin-induced arthritis, UC, umbilical cord, CAIA, collagen-antibody induced arthritis, Flk, tyrosine kinase receptor for vascular endothelial growth factor, IDO, indoleamine 2,3-dioxygenase, MMP, matrix metalloproteinase, Tr1, IL-10-expressing T cells, SM, synovial membrane, medicine.anatomical_structure, IAA, indoleacetic acid, MPCs, mesenchymal precursor cells, SNP, sodium nitroprusside, medicine.drug, NA, not available, IL-1RA, IL-1 receptor antagonist, CD, cluster of differentiation, DMARDs, antirheumatic drugs, TBO, toluidine blue O, =, similar to or equal, SM-MSCs, MSCs from synovial membrane, Mesenchymal Stem Cell Transplantation, PB, peripheral blood, G, gingiva tissue, IFA, incomplete Freund´s adjuvant, OVA, ovalbumin, MSCs, mesenchymal stem/ stromal cells, SO, safranin, TRAF, tumour necrosis factor receptor-associated factor, Animals, SP, spleen, ILA, indole-3-lactic acid, mBSA, methylated bovine serum albumin, business.industry, F, female, SF, synovial fluid, Th, T helper cells, TLR, toll-like receptors, BM, bone marrow, Bone marrow, Synovial membrane, MRI, magnetic resonance imaging, WT, wild type, Medicine (General), IHC, immunohistochemical analysis, Review, miR, microRNA, TRACP, tartrate-resistant acid phosphatase, AAV, adeno-associated virus, 0302 clinical medicine, GSH, glutathione, SVF, stromal vascular fraction, H/E, haematoxylin/eosin staining, GITR, glucocorticoid-induced tumour necrosis factor receptor, pLNs, popliteal lymph nodes, FOXP3, General Medicine, IFI, indirect immunofluorescence, Tregs, regulatory T cells, M, male, RF, rheumatoid factor, RNA, ribonucleic acid, TNFR, tumour necrosis factor receptor, <, worse than, IP, intraperitoneal, NuMa, nuclear mitotic apparatus, COMP, cartilage oligomeric matrix protein, GSH-Px, glutathione peroxidase, >, better than, LP, lamina propria, LPS, lipopolysaccharide, IN, intranodal, AT, antithrombin, General Biochemistry, Genetics and Molecular Biology, CM, conditioned medium, Consec., consecutive, RAGE, receptor for advanced glycation products, ETN, etanercept, Humans, dLNs, draining lymph nodes, MDA, malondialdehyde, IFN-γ, interferon gamma, ALP, alkaline phosphatase, HSCs, hematopoietic stem cells, Mesenchymal stem cell, Mesenchymal Stem Cells, medicine.disease, EMA, European medicine agency, IL, interleukin, CFA, Freund's complete adjuvant, DAB, 3,3´-diaminobenzidine, OPG, osteoprotegerin, HMGB-1, high-mobility group box-1, CRP, C reactive protein, Tol-DCs, tolerogenic dendritic cells, 0301 basic medicine, CII, collagen II, SF-MSCs, MSCs from synovial fluid, MPO, myeloperoxidease, A, allogeneic, LDL, low density lipoprotein, APCP, α, β methylene selective A2A adenosine receptor competitive antagonist (CD73 inhibitor), Translational Research, Biomedical, SSEA, severe spontaneous erosive arthritis, mLNs, mesenteric lymph nodes, PGIA, proteoglycan-induced arthritis, Exos, small vesicles/Exosomes, FOXP3, forkhead box P3, RANKL, receptor activator of nuclear factor κB ligand, TGF-β, transforming growth factor β, Stromal vascular fraction, NSAIDs, non-steroidal anti-inflammatory drugs, VEGF, vascular endothelial growth factor, Animal models, AhR, aryl hydrocarbon receptor, DCs, dendritic cells, IV, intravenous, Stromal cell, IA, intra-articular, SIRT1, sirtuin 1, O-MSCs, MSCs from nasal tissue, PA, peri-articular, Tfh, follicular T helper cells, AxLNs, axillar lymph nodes, NK, natural killer cells, T-MSCs, MSCs from tonsil tissue, SOD, superoxide dismutase, Internal medicine, MHC, major histocompatibility complex, GLP-1, glucagon-like peptide 1, G-MSCs, MSCs from gingiva tissue, Mesenchymal stem/stromal cells, PG, proteoglycan, HLA-II, human leukocyte antigen-II, PLGA, poly-lactic-co-glycolic acid, HDL, high density lipoprotein, Ig, immunoglobulin, SC, subcutaneous, P-MSCs, MSCs from placenta tissue, POM-1, sodium polyoxotungstate (CD39 inhibitor), UC-MSCs, MSCs from umbilical cord, business, sIL6R, soluble IL-6 receptor