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المؤلفون: Siying Zhu, Matthew S. Tremblay, Sean B. Joseph, Seung Hyuk Choi, Mitch Hull, Weijun Shen, Valeria Marrocco, Sijia Li, Marta Diez Cunado, Ana M. Gamo, Tuan Tran, Jason Roland, Arnab K. Chatterjee, Qiangwei Fu, Van Nguyen-Tran, Nikki Rogers
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3983-3993 (2021)مصطلحات موضوعية: TG, thapsigargin, Cell signaling, ATF4, activating transcription factor 4, IKKβ, inhibitor of nuclear factor kappa-B kinase subunit beta, PERK, PKR-like ER kinase, XBP1, X-box-binding protein 1, OGTT, oral glucose tolerance test, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, Unfolded protein response, 0302 clinical medicine, UPR, unfolded protein response, GLuc, Gaussia luciferase, Chaperones, Protein biosynthesis, IL1β, interleukin 1β, General Pharmacology, Toxicology and Pharmaceutics, uHTS, ultra-high throughput screening, IRE1, inositol requiring enzyme 1α/β, 0303 health sciences, ASGR, asialoglycoprotein receptor 1, biology, Chemistry, Small molecules, Diabetes, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, ATF6, activating transcription factor 6α/β, β cells, i.p., intraperitoneal, Cell biology, Liver, 030220 oncology & carcinogenesis, T1/2D, type1/2 diabetes, Tm, tunicamycin, Protein folding, Original Article, ER stress, NASH, nonalcoholic steatohepatitis, INFγ, interferon gamma, TNFα, tumor necrosis factor alpha, RM1-950, GRPRP94, glucose-regulated protein 94, ER, endoplasmic reticulum, 03 medical and health sciences, SP1/2, serine protease1/2, GRP78, 78-kDa glucose-regulated protein, BID, twice a day, Pancreas, 030304 developmental biology, Reporter gene, Nod, non-obese diabetic, Activator (genetics), Endoplasmic reticulum, Metabolic diseases, Chaperone (protein), EGFP-VSVG, enhanced green fluorescence protein-vesicular stomatitis virus ts045 G protein, GSIS, glucose stimulated insulin secretion, biology.protein, Asialoglycoprotein receptor, Therapeutics. Pharmacology, CLuc, Cypridina luciferase, ERP72, endoplasmic reticulum proteins 72
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المؤلفون: Geoffrey D.E. Cuvelier, Marlis L. Schroeder, Tamar S. Rubin, Roona Sinha, Donna A. Wall, Alan M. Rosenberg, Anne K. Junker
المصدر: Clinical Immunology (Orlando, Fla.)
مصطلحات موضوعية: 0301 basic medicine, Male, Combined Immune Deficiency, RSV, Respiratory Syncytial Virus, medicine.disease_cause, TRECs, T-cell receptor excision circles, Hematopoietic Stem Cell Transplant, Hypogammaglobulinemia, 0302 clinical medicine, Agammaglobulinemia, SCID, Severe combined immune deficiency, Immunology and Allergy, IKBKB, IKKβ (IKK2), Mutation, PHA, Phytohemagglutinin, Hematopoietic Stem Cell Transplantation, Hematopoietic stem cell, Bacterial Infections, Mycobacterium bovis, I-kappa B Kinase, NEMO, Nuclear factor Kappa-B essential modifier, medicine.anatomical_structure, Treatment Outcome, Virus Diseases, Female, CID, Combined Immune Deficiency, Primary Immunodeficiency Diseases, Immunology, Secondary Graft Failure, Article, 03 medical and health sciences, Immune system, BCG, Bacillus Calmette-Guerin, medicine, Humans, Tuberculosis, Lymphocyte Count, CMV, Cytomegalovirus, Newborn screening, Innate immune system, business.industry, Infant, Newborn, Infant, IKKβ, Inhibitor of nuclear factor kappa B kinase subunit beta, medicine.disease, IKK/NF-κB, 030104 developmental biology, Mycoses, TCR, T-cell receptor, Primary immunodeficiency, business, HSCT, Hematopoietic stem cell transplant, HLH, Hemophagocytic Lymphohistiocytosis, 030215 immunology
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المؤلفون: Barry Shaw, Sarah L. Rea, Robert Layfield, Mark S. Searle, Alice Goode, Melanie Sultana
المصدر: Molecular and Cellular Neurosciences
مصطلحات موضوعية: 0301 basic medicine, SQSTM1/p62, LIR, LC3-interacting region, ARE, Antioxidant response element, mTORC1, ALS, Amyotrophic lateral sclerosis, PDB, Paget's disease of bone, SALS, Sporadic ALS, Sequestosome-1 Protein, Genetics, Kelch-Like ECH-Associated Protein 1, Nrf2, Nuclear erythroid 2-related factor 2, FTLD, Frontotemporal lobar degeneration, IKKβ, Inhibitor of nuclear factor kappa-B kinase subunit beta, 3. Good health, Keap1, Kelch-like ECH-associated protein 1, Signal transduction, Protein Binding, Signal Transduction, ALS-FTLD, RBM45, RNA binding motif protein 45, NF-E2-Related Factor 2, NQO1, NAD(P)H dehydrogenase, Quinone 1, Mutation, Missense, Repressor, NFE2L2, Nuclear factor erythroid 2-like 2, UBA, Ubiquitin-associated (domain), Biology, Response Elements, Article, SOD1, Superoxide dismutase 1, 03 medical and health sciences, Cellular and Molecular Neuroscience, Humans, KIR, Keap1-interacting region, Gene, Transcription factor, Molecular Biology, Binding Sites, Amyotrophic Lateral Sclerosis, HEK 293 cells, Cell Biology, mTORC1, Mammalian target of rapamycin complex 1, KEAP1, HEK293 Cells, 030104 developmental biology, Oxidative stress, SQSTM1/p62, Sequestosome 1/p62 protein, Keap1-Nrf2, TDP-43, TAR DNA-binding protein 43, Frontotemporal Lobar Degeneration
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