المؤلفون: S. L. Pearce, D. F. Clarke, P. D. East, S. Elfekih, K. H. J. Gordon, L. S. Jermiin, A. McGaughran, J. G. Oakeshott, A. Papanikolaou, O. P. Perera, R. V. Rane, S. Richards, W. T. Tay, T. K. Walsh, A. Anderson, C. J. Anderson, S. Asgari, P. G. Board, A. Bretschneider, P. M. Campbell, T. Chertemps, J. T. Christeller, C. W. Coppin, S. J. Downes, G. Duan, C. A. Farnsworth, R. T. Good, L. B. Han, Y. C. Han, K. Hatje, I. Horne, Y. P Huang, D. S. T. Hughes, E. Jacquin-Joly, W. James, S. Jhangiani, M. Kollmar, S. S. Kuwar, S. Li, N-Y. Liu, M. T. Maibeche, J. R. Miller, N. Montagne, T. Perry, J. Qu, S. V. Song, G. G. Sutton, H. Vogel, B. P. Walenz, W. Xu, H-J. Zhang, Z. Zou, P. Batterham, O. R. Edwards, R. Feyereisen, R. A. Gibbs, D. G. Heckel, A. McGrath, C. Robin, S. E. Scherer, K. C. Worley, Y. D. Wu

المصدر: BMC Biology, Vol 15, Iss 1, Pp 1-30 (2017)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s12915-017-0402-6; https://doaj.org/toc/1741-7007

URL الوصول: https://doaj.org/article/fa3879e27c4f4d9abbe1ca1ebf7101a3

المؤلفون: Muntasir Kamal, Jessica Knox, Robert I. Horne, Om Shanker Tiwari, Andrew R. Burns, Duhyun Han, Davide Levy, Dana Laor Bar-Yosef, Ehud Gazit, Michele Vendruscolo, Peter J. Roy

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/32f38f45c042472bbab5c90925875d7e

المؤلفون: S. L. Pearce, D. F. Clarke, P. D. East, S. Elfekih, K. H. J. Gordon, L. S. Jermiin, A. McGaughran, J. G. Oakeshott, A. Papanicolaou, O. P. Perera, R. V. Rane, S. Richards, W. T. Tay, T. K. Walsh, A. Anderson, C. J. Anderson, S. Asgari, P. G. Board, A. Bretschneider, P. M. Campbell, T. Chertemps, J. T. Christeller, C. W. Coppin, S. J. Downes, G. Duan, C. A. Farnsworth, R. T. Good, L. B. Han, Y. C. Han, K. Hatje, I. Horne, Y. P. Huang, D. S. T. Hughes, E. Jacquin-Joly, W. James, S. Jhangiani, M. Kollmar, S. S. Kuwar, S. Li, N-Y. Liu, M. T. Maibeche, J. R. Miller, N. Montagne, T. Perry, J. Qu, S. V. Song, G. G. Sutton, H. Vogel, B. P. Walenz, W. Xu, H-J. Zhang, Z. Zou, P. Batterham, O. R. Edwards, R. Feyereisen, R. A. Gibbs, D. G. Heckel, A. McGrath, C. Robin, S. E. Scherer, K. C. Worley, Y. D. Wu

المصدر: BMC Biology, Vol 15, Iss 1, Pp 1-1 (2017)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s12915-017-0413-3; https://doaj.org/toc/1741-7007

URL الوصول: https://doaj.org/article/b3c7b99472254a81a1fbf31e0fe7fcc4

المؤلفون: Robert I. Horne, Jared Wilson-Godber, Alicia González Díaz, Z. Faidon Brotzakis, Srijit Seal, Rebecca C. Gregory, Andrea Possenti, Sean Chia, Michele Vendruscolo

مصطلحات موضوعية: Biochemistry, Genetics, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, negative developability features, large chemical libraries, initial inactive compound, desirable developability properties, poor drug metabolism, drug discovery process, using generative modeling, good dmpk properties, generative modeling, drug development, process associated, good bioavailability, dmpk ), typically screened, synuclein aggregation, results illustrate, parkinson ’, opportunities offered, machine learning, low toxicity, inhibitory activity, identify compounds

Relation: https://figshare.com/articles/journal_contribution/Using_Generative_Modeling_to_Endow_with_Potency_Initially_Inert_Compounds_with_Good_Bioavailability_and_Low_Toxicity/25050309

الاتاحة: https://doi.org/10.1021/acs.jcim.3c01777.s001
https://figshare.com/articles/journal_contribution/Using_Generative_Modeling_to_Endow_with_Potency_Initially_Inert_Compounds_with_Good_Bioavailability_and_Low_Toxicity/25050309

المؤلفون: Sarah E. Sandler, Robert I. Horne, Sara Rocchetti, Robert Novak, Nai-Shu Hsu, Marta Castellana Cruz, Z. Faidon Brotzakis, Rebecca C. Gregory, Sean Chia, Gonçalo J. L. Bernardes, Ulrich F. Keyser, Michele Vendruscolo

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Genetics, Molecular Biology, Neuroscience, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, quantify oligomer populations, multiplexed dna barcoding, multiplexed digital characterization, throughput methods, therapeutic methods, synuclein oligomers, synuclein aggregation, still needed, state nanopores, several small, potential applicability, parkinson ’, oligomeric species, multiple samples, molecule inhibitors, characterize oligomers, central importance, alzheimer ’, accurate high

Relation: https://figshare.com/articles/journal_contribution/Multiplexed_Digital_Characterization_of_Misfolded_Protein_Oligomers_via_Solid-State_Nanopores/24578668

الاتاحة: https://doi.org/10.1021/jacs.3c09335.s001
https://figshare.com/articles/journal_contribution/Multiplexed_Digital_Characterization_of_Misfolded_Protein_Oligomers_via_Solid-State_Nanopores/24578668

المؤلفون: Roxine Staats, Z. Faidon Brotzakis, Sean Chia, Robert I. Horne, Michele Vendruscolo

المصدر: Frontiers in Molecular Biosciences, Vol 10 (2023)

مصطلحات موضوعية: Parkinson’s disease, drug discovery, secondary nucleation, kinetic theory, docking, Biology (General), QH301-705.5

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2023.1155753/full; https://doaj.org/toc/2296-889X; https://doaj.org/article/b790c6f95fb74fe99a38cf76ceda6bf8

الاتاحة: https://doi.org/10.3389/fmolb.2023.1155753
https://doaj.org/article/b790c6f95fb74fe99a38cf76ceda6bf8

المؤلفون: Francesco Simone Ruggeri, Johnny Habchi, Sean Chia, Robert I. Horne, Michele Vendruscolo, Tuomas P. J. Knowles

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

مصطلحات موضوعية: Science

Relation: https://doi.org/10.1038/s41467-020-20782-0; https://doaj.org/toc/2041-1723; https://doaj.org/article/7f8ac1eb0b6149b48b24e7005907776f

الاتاحة: https://doi.org/10.1038/s41467-020-20782-0
https://doaj.org/article/7f8ac1eb0b6149b48b24e7005907776f

المؤلفون: Roxine Staats, Thomas C. T. Michaels, Patrick Flagmeier, Sean Chia, Robert I. Horne, Johnny Habchi, Sara Linse, Tuomas P. J. Knowles, Christopher M. Dobson, Michele Vendruscolo

المصدر: Communications Chemistry, Vol 3, Iss 1, Pp 1-9 (2020)

مصطلحات موضوعية: Chemistry, QD1-999

Relation: https://doi.org/10.1038/s42004-020-00412-y; https://doaj.org/toc/2399-3669; https://doaj.org/article/25cc20ef6fa54796a866e8e34065ca87

الاتاحة: https://doi.org/10.1038/s42004-020-00412-y
https://doaj.org/article/25cc20ef6fa54796a866e8e34065ca87

المؤلفون: Robert I. Horne, Mhd Hussein Murtada, Donghui Huo, Z. Faidon Brotzakis, Rebecca C. Gregory, Andrea Possenti, Sean Chia, Michele Vendruscolo

المصدر: Journal of Chemical Theory and Computation.

مصطلحات موضوعية: Physical and Theoretical Chemistry, Computer Science Applications

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8c7ad2a92ef4436437266ebcfc42f0c5
https://doi.org/10.1021/acs.jctc.2c01303

المؤلفون: Sean Chia, Z. Faidon Brotzakis, Robert I. Horne, Andrea Possenti, Benedetta Mannini, Rodrigo Cataldi, Magdalena Nowinska, Roxine Staats, Sara Linse, Tuomas P. J. Knowles, Johnny Habchi, Michele Vendruscolo

المساهمون: Mannini, Benedetta [0000-0001-6812-7348], Linse, Sara [0000-0001-9629-7109], Knowles, Tuomas PJ [0000-0002-7879-0140], Vendruscolo, Michele [0000-0002-3616-1610], Apollo - University of Cambridge Repository

مصطلحات موضوعية: Amyloid, Pharmaceutical Science, structure-based small-molecule discovery, Parkinson Disease, kinetic-based small-molecule discovery, computational docking, Article, protein aggregation, Kinetics, Protein Aggregates, Drug Discovery, alpha-Synuclein, Humans, Molecular Medicine, Parkinson’s disease, α-synuclein, Cell Proliferation

وصف الملف: application/pdf; application/zip; text/xml

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbd8e1463d5fe67caafd768422b1f10

المؤلفون: Roxine Staats, Z. Faidon Brotzakis, Sean Chia, Robert I. Horne, Michele Vendruscolo

مصطلحات موضوعية: Biochemistry, Molecular Biology, Structural Biology, Enzymes, Protein Trafficking, Proteomics and Intermolecular Interactions (excl. Medical Proteomics), Receptors and Membrane Biology, Signal Transduction, Structural Biology (incl. Macromolecular Modelling), Synthetic Biology, Parkinson’s disease, drug discovery, secondary nucleation, kinetic theory, docking

Relation: https://figshare.com/articles/dataset/DataSheet1_Optimization_of_a_small_molecule_inhibitor_of_secondary_nucleation_in_-synuclein_aggregation_PDF/24041169

الاتاحة: https://doi.org/10.3389/fmolb.2023.1155753.s001
https://figshare.com/articles/dataset/DataSheet1_Optimization_of_a_small_molecule_inhibitor_of_secondary_nucleation_in_-synuclein_aggregation_PDF/24041169

المؤلفون: Sean Chia, Z. Faidon Brotzakis, Robert I. Horne, Andrea Possenti, Benedetta Mannini, Rodrigo Cataldi, Magdalena Nowinska, Roxine Staats, Sara Linse, Tuomas P. J. Knowles, Johnny Habchi, Michele Vendruscolo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1901b63d50de592df73d68c39000fa2c
https://doi.org/10.1101/2021.12.05.471256

المؤلفون: Faidon Brotzakis, Andrea Possenti, Michele Vendruscolo, Roxine Staats, Sean Chia, Johnny Habchi, Robert I. Horne

مصطلحات موضوعية: Synucleinopathies, Computer science, business.industry, Drug discovery, Nucleation, Machine learning, computer.software_genre, Small molecule, Chemical space, Drug development, Docking (molecular), Hit rate, Artificial intelligence, business, computer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0bef78b836df2b33dab5bcdb6037f0e4
https://doi.org/10.1101/2021.11.10.468009

المؤلفون: Tuomas P. J. Knowles, Michele Vendruscolo, Johnny Habchi, Robert I. Horne, Sean Chia, Francesco Simone Ruggeri

المساهمون: Ruggeri, Francesco Simone [0000-0002-1232-1907], Horne, Robert I. [0000-0003-1534-2639], Vendruscolo, Michele [0000-0002-3616-1610], Knowles, Tuomas P. J. [0000-0002-7879-0140], Apollo - University of Cambridge Repository, Horne, Robert I [0000-0003-1534-2639], Knowles, Tuomas PJ [0000-0002-7879-0140]

المصدر: Nature Communications, 12(1)
Nature Communications
Nature Communications 12 (2021) 1
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

مصطلحات موضوعية: 631/45/470/2284, 147/136, Spectrophotometry, Infrared, 123, General Physics and Astronomy, 02 engineering and technology, Protein aggregation, Microscopy, Atomic Force, Atomic force microscopy, Platelet inhibitor, 631/57/2272/2273, Bexarotene, 0303 health sciences, Multidisciplinary, Drug discovery, Chemistry, article, Molecular conformation, 021001 nanoscience & nanotechnology, Organische Chemie, Small molecule, Recombinant Proteins, Single Molecule Imaging, 9, 631/57/2265, 0210 nano-technology, medicine.drug, 147/3, Science, Protein Aggregation, Pathological, Vibration, General Biochemistry, Genetics and Molecular Biology, Protein Aggregates, Structure-Activity Relationship, 03 medical and health sciences, Single-molecule biophysics, Alzheimer Disease, medicine, Life Science, Humans, Molecule, 140/125, 030304 developmental biology, Amyloid beta-Peptides, Organic Chemistry, Neurotoxicity, 631/154, Hydrogen Bonding, General Chemistry, medicine.disease, Peptide Fragments, In vitro, Kinetics, Biophysics, Feasibility Studies, 631/535/1262

وصف الملف: application/pdf; application/zip; text/xml; application/vnd.openxmlformats-officedocument.wordprocessingml.document

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3a177d8784656f10bdffe59197f316
https://www.repository.cam.ac.uk/handle/1810/316861

المؤلفون: Michele Vendruscolo, Sean Chia, Thomas C. T. Michaels, Sara Linse, Roxine Staats, Tuomas P. J. Knowles, Johnny Habchi, Christopher M. Dobson, Patrick Flagmeier, Robert I. Horne

المساهمون: Staats, Roxine [0000-0001-6457-0959], Horne, Robert I [0000-0003-1534-2639], Vendruscolo, Michele [0000-0002-3616-1610], Apollo - University of Cambridge Repository, Horne, Robert I. [0000-0003-1534-2639]

المصدر: Communications Chemistry, Vol 3, Iss 1, Pp 1-9 (2020)

مصطلحات موضوعية: 0301 basic medicine, Context (language use), Computational biology, Neurodegenerative, Biochemistry, Oligomer, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, 631/92/56, 631/154/309/507, Materials Chemistry, Acquired Cognitive Impairment, Environmental Chemistry, 3404 Medicinal and Biomolecular Chemistry, 5 Development of treatments and therapeutic interventions, QD1-999, Selection (genetic algorithm), Synucleinopathies, Parkinson's Disease, 34 Chemical Sciences, Drug discovery, Chemistry, FOS: Clinical medicine, article, Neurosciences, General Chemistry, Small molecule, Brain Disorders, 030104 developmental biology, 5.1 Pharmaceuticals, 9, α synuclein, Dementia, Flux (metabolism), 030217 neurology & neurosurgery

وصف الملف: application/pdf; text/xml

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40ec416fec1981e7ccad4421aa80de4
https://www.repository.cam.ac.uk/handle/1810/311894

المؤلفون: William I. Horne

المصدر: The Journal of African American History. 103:496-525

مصطلحات موضوعية: Reconstruction Era, media_common.quotation_subject, Art history, Art, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e2a726a688792afca4b7a23d6da908a0
https://doi.org/10.1086/699950

المؤلفون: Dennis S. Weiner, Walter I. Horne, Melanie A. Morscher, William J. Landis, Dylan R. Childs, Richard Steiner, Jason C. Tank, Robin Jacquet, Todd F. Ritzman

المصدر: Journal of Orthopaedic Research. 31:1986-1991

مصطلحات موضوعية: endocrine system, medicine.medical_specialty, Triiodothyronine, endocrine system diseases, business.industry, Miniature swine, Histology, Hindlimb, Endocrinology, Thyroid-stimulating hormone, Internal medicine, Gene expression, Extracellular, medicine, Orthopedics and Sports Medicine, business, hormones, hormone substitutes, and hormone antagonists, Aggrecan

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4c37c7fef8435790bd482979e2af7c4a
https://doi.org/10.1002/jor.22467

المؤلفون: Judit E. Puskas, Goy Teck Lim, Stephanie A. Valente, Cherie R. Hart-Spicer, Walter I. Horne, Mary M. Evancho-Chapman, Steven P. Schmidt

المصدر: Journal of the Mechanical Behavior of Biomedical Materials. 21:47-56

مصطلحات موضوعية: Materials science, Biocompatibility, Breast Implants, Biomedical Engineering, Biocompatible Materials, Prosthesis Design, Silicone rubber, complex mixtures, Styrenes, Biomaterials, chemistry.chemical_compound, Mammary Glands, Animal, Silicone, Breast cancer, Tensile Strength, Materials Testing, medicine, Animals, technology, industry, and agriculture, Biomaterial, Capsular contracture, medicine.disease, Equipment Failure Analysis, Molecular Weight, chemistry, Mechanics of Materials, Silicone Elastomers, Female, Rabbits, Implant, Breast reconstruction, Biomedical engineering

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9aa63962505f59a34e21526f7c07f0
https://doi.org/10.1016/j.jmbbm.2013.01.025

المؤلفون: Patricia Sloan, Jill Zink, Walter I. Horne, Robert Netzley, William Lanzinger, Kimberly Sloan Stakleff, Andrew J. Schoenfeld, Joseph Caldwell, Dennis Wright

المصدر: Journal of Vascular Surgery: Venous and Lymphatic Disorders. 1:68-74

مصطلحات موضوعية: medicine.medical_specialty, Lung, business.industry, Long bone, Hemodynamics, Embolic Protection Devices, Pulmonary function testing, Surgery, law.invention, Intramedullary rod, medicine.anatomical_structure, law, medicine, Cardiology and Cardiovascular Medicine, business, Vein, Fixation (histology)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be54c8ba52e9f0e9caebd311e7bc246
https://doi.org/10.1016/j.jvsv.2012.07.012

المؤلفون: Michael B. Maron, Walter I. Horne, J. Gary Meszaros, Hans G. Folkesson, Vahagn Ohanyan, Charles F. Pilati, Shyny Koshy, Daniel J. Luther, Jon M. Walro, Tianbo Li

المصدر: American Journal of Physiology-Lung Cellular and Molecular Physiology. 297:L487-L495

مصطلحات موضوعية: Male, Pulmonary and Respiratory Medicine, Agonist, medicine.medical_specialty, Heart disease, Physiology, medicine.drug_class, Alveolar Epithelium, Terbutaline, Myocardial Infarction, Stimulation, Ion Channels, Rats, Sprague-Dawley, Physiology (medical), Internal medicine, Receptors, Adrenergic, beta, medicine, Animals, RNA, Messenger, Respiratory system, Ultrasonography, Heart Failure, Hyperplasia, business.industry, Epithelial Cells, Cell Biology, respiratory system, medicine.disease, Pulmonary edema, Hormones, Body Fluids, Rats, Pulmonary Alveoli, Endocrinology, Gene Expression Regulation, Heart failure, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5b83debaa7e9b9e989b7fbed219066
https://doi.org/10.1152/ajplung.90629.2008