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    المساهمون: The research was carried out at the expense of the grant of the Russian Science Foundation No. 23-25-00144 (https://rscf.ru/project/23-25-00144).

    المصدر: Translational Medicine; Том 11, № 1 (2024); 19-27 ; Трансляционная медицина; Том 11, № 1 (2024); 19-27 ; 2410-5155 ; 2311-4495

    وصف الملف: application/pdf

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    المصدر: Meditsinskiy sovet = Medical Council; № 1 (2024); 144–151 ; Медицинский Совет; № 1 (2024); 144–151 ; 2658-5790 ; 2079-701X

    وصف الملف: application/pdf

    Relation: https://www.med-sovet.pro/jour/article/view/8090/7150; Ogden CL, Carroll MD, Lawman HG, Fryar CD, Kruszon-Moran D, Kit BK, Flegal KM. Trends in Obesity Prevalence Among Children and Adolescents in the United States, 1988–1994 Through 2013–2014. JAMA. 2016;315(21):2292–2299. https://doi.org/10.1001/jama.2016.6361.; Васюкова ОВ. Ожирение у детей и подростков: критерии диагноза. Ожирение и метаболизм. 2019;16(1):70–73. https://doi.org/10.14341/omet10170.; Никитина ИЛ, Тодиева АМ, Каронова ТЛ, Буданова МВ. Ожирение у детей и подростков: особенности фенотипа, ассоциации с компонентами метаболического синдрома. Вопросы детской диетологии. 2012;10(5):23–30. Режим доступа: https://www.phdynasty.ru/katalog/zhurnaly/voprosy-detskoy-dietologii/2012/tom-10-nomer-5/9131.; Darvison KK, Susman EJ, Birch LL. Percent body fat at age 5 predicts earlier pubertal development among girls at age 9. Pediatrics. 2003;111(4):815–821. https://doi.org/10.1542/peds.111.4.815.; Hochberg Z. Evolutionary perspective in child growth. Rambam Maimonides Med J. 2011;2(3):e0057. https://doi.org/10.5041%2FRMMJ.10057.; Chodick G, Huerta M, Balicer RD, Davidovitch N, Grotto I. Secular trends in age at menarche, smoking, and oral contraceptive use among Israeli girls. Prev Chronic Dis. 2005;2(2):A12. Available at: https://pubmed.ncbi.nlm.nih.gov/15888223.; Soni A, Siddiqui NI, Wadhwani R. Relative influence of body mass index and socioeconomic class on blood pressure levels and health. Eur J Clin Exp Med. 2019;(17):131–135. https://doi.org/10.15584/ejcem.2019.2.4.; Di Bonito P, Pacifico L, Chiesa C, Valerio G, Miraglia Del Giudice E, Maffeis C et al. Impaired fasting glucose and impaired glucose tolerance in children and adolescents with overweight/obesity. J Endocrinol Invest. 2017;40(4):409–416. https://doi.org/10.1007/s40618-016-0576-8.; Brix N, Ernst A, Lauridsen LLB, Parner ET, Arah OA, Olsen J et al. Childhood overweight and obesity and timing of puberty in boys and girls: cohort and sibling-matched analyses. Int J Epidemiol. 2020;49(3):834–844. https://doi.org/10.1093/ije/dyaa056.; Lee JM, Appugliese D, Kaciroti N, Corwyn RF, Bradley RH, Lumeng JC. Weight status in young girls and the onset of puberty. Pediatrics. 2007;119(3):e624–630. https://doi.org/10.1542/peds.2006-2188.; Лискина АС, Васильева ЕЮ, Зазерская ИЕ, Никитина ИЛ. Кисспептиновый сигналинг при нарушении менструального цикла у девочек-подростков с ожирением. Трансляционная медицина. 2023;10(3):154–165. https://doi.org/10.18705/2311-4495-2023-10-3-154-165; Лискина АС, Зазерская ИЕ, Антошина ТИ, Сафиуллина СР, Джамиева ША, Никитина ИЛ. К вопросу о характеристике менструального цикла у девочек-подростков с ожирением. Педиатрия. Сonsilium Medicum. 2022;(3):249–254. https://doi.org/10.26442/26586630.2022.3.201778.; Ju H, Jones M, Mishra GD. Premenstrual syndrome and dysmenorrhea: symptom trajectories over 13 years in young adults. Maturitas. 2014;78(2):99–105. https://doi.org/10.1016/j.maturitas.2014.03.008.; Адамян ЛВ, Андреева ЕН, Артымук НВ, Белокриницкая ТЕ, Гусев ДВ, Марченко ЛА и др. Аменорея и олигоменорея: клинические рекомендации. М.; 2021. Режим доступа: https://cr.minzdrav.gov.ru/schema/644_1.; Петеркова ВА, Безлепкина ОБ, Васюкова ОВ, Окороков ПЛ, Богова ЕА, Нагаева ЕВ и др. Ожирение у детей: клинические рекомендации. М.; 2021. Режим доступа: https://cr.minzdrav.gov.ru/schema/229_2.; Navarro DJ, Foxcroft DR. Learning statistics with jamovi: a tutorial for psychology students and other beginners. 2022. https://doi.org/10.24384/hgc3-7p15.; Quennell JH, Mulligan AC, Tups A, Liu X, Phipps SJ, Kemp CJ et al. Leptin indirectly regulates gonadotropin-releasing hormone neuronal function. Endocrinology. 2009;150(6):2805–2812. https://doi.org/10.1210/en.2008-1693.; Elizondo Montemayor L, Hernández-Escobar C, Lara-Torre E, Nieblas B, Gómez-Carmona M. Gynecologic and obstetric consequences of obesity in adolescent girls. J Pediatr Adolesct Gynecol. 2017;30(2):156–168. https://doi.org/10.1016/j.jpag.2016.02.007.; Hillman JB, Miller RJ, Inge TH. Menstrual concerns and intrauterine contraception among adolescent bariatric surgery patients. J Womens Health (Larchmt). 2011;20(4):533–538. https://doi.org/10.1089/jwh.2010.2462.; Ibanez L, Oberfield ShE, Witchel SF, Auchus RJ, Chang RJ, Codner E et al. An international consortium apdate: pathophysiology, diagnosis, and treatment of polycystic ovarian syndrome in adolescence. Horm Res Paediatr. 2017;88(6):371–395. https://doi.org/10.1159/000479371.; https://www.med-sovet.pro/jour/article/view/8090

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    المساهمون: The work was carried out with financial support from the Ministry of Science and Higher Education of the Russian Federation (agreement No. 075-15-2022-301). The work by Evgeny N. Imyanitov was supported by the Russian Science Foundation grant No. 23-45-10038., Работа выполнена при финансовой поддержке Министерства науки и высшего образования Российской Федерации (соглашение №075-15-2022-301). Работа Е.Н. Имянитова поддержана грантом Российского научного фонда №23-45-10038.

    المصدر: Meditsinskiy sovet = Medical Council; № 22 (2023); 122-128 ; Медицинский Совет; № 22 (2023); 122-128 ; 2658-5790 ; 2079-701X

    وصف الملف: application/pdf

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Annu Rev Pharmacol Toxicol. 2021;61:679–699. https://doi.org/10.1146/annurev-pharmtox-031320-104151.; Forrest SJ, Geoerger B, Janeway KA. Precision medicine in pediatric oncology. Curr Opin Pediatr. 2018;30(1):17–24. https://doi.org/10.1097/MOP.0000000000000570.; Lee J, Gillam L, Visvanathan K, Hansford JR, McCarthy MC. Clinical Utility of Precision Medicine in Pediatric Oncology: A Systematic Review. JCO Precis Oncol. 2021;(5):1088–1102. https://doi.org/10.1200/PO.20.00405.; Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C et al. Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro Oncol. 2017;19(5):699–709. https://doi.org/10.1093/neuonc/now254.; Zhong Y, Xu F, Wu J, Schubert J, Li MM. Application of Next Generation Sequencing in Laboratory Medicine. Ann Lab Med. 2021;41(1):25–43. https://doi.org/10.3343/alm.2021.41.1.25.; Barsan V, Paul M, Gorsi H, Malicki D, Elster J, Kuo DJ, Crawford J. Clinical Impact of Next-generation Sequencing in Pediatric Neuro-Oncology Patients: A Single-institutional Experience. Cureus. 2019;11(12):e6281. https://doi.org/10.7759/cureus.6281.; Ahmed AA, Vundamati DS, Farooqi MS, Guest E. Precision Medicine in Pediatric Cancer: Current Applications and Future Prospects. High Throughput. 2018;7(4):39. https://doi.org/10.3390/ht7040039.; Hill RM, Richardson S, Schwalbe EC, Hicks D, Lindsey JC, Crosier S et al. Time, pattern, and outcome of medulloblastoma relapse and their association with tumour biology at diagnosis and therapy: a multicentre cohort study. Lancet Child Adolesc Health. 2020;4(12):865–874. https://doi.org/10.1016/S2352-4642(20)30246-7.; Sharma T, Schwalbe EC, Williamson D, Sill M, Hovestadt V, Mynarek M et al. Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes. Acta Neuropathol. 2019;138(2):309–326. https://doi.org/10.1007/s00401-019-02020-0.; Northcott PA, Korshunov A, Witt H, Hielscher T, Eberhart CG, Mack S et al. Medulloblastoma comprises four distinct molecular variants. J Clin Oncol. 2011;29(11):1408–1414. https://doi.org/10.1200/JCO.2009.27.4324.; Simon T, Hero B, Schulte JH, Deubzer H, Hundsdoerfer P, von Schweinitz D et al. 2017 GPOH Guidelines for Diagnosis and Treatment of Patients with Neuroblastic Tumors. Klin Padiatr. 2017;229(3):147–167. https://doi.org/10.1055/s-0043-103086.; Lee JW, Cho B. Prognostic factors and treatment of pediatric acute lymphoblastic leukemia. Korean J Pediatr. 2017;60(5):129–137. https://doi.org/10.3345/kjp.2017.60.5.129.; Ramkissoon SH, Bandopadhayay P, Hwang J, Ramkissoon LA, Greenwald NF, Schumacher SE et al. Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors. Neuro Oncol. 2017;19(7):986–996. https://doi.org/10.1093/neuonc/now294.; Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. 2021;23(8):1231–1251. https://doi.org/10.1093/neuonc/noab106.; Trubicka J, Grajkowska W, Dembowska-Bagińska B. Molecular Markers of Pediatric Solid Tumors-Diagnosis, Optimizing Treatments, and Determining Susceptibility: Current State and Future Directions. Cells. 2022;11(7):1238. https://doi.org/10.3390/cells11071238.; Mosaab A, El-Ayadi M, Khorshed EN, Amer N, Refaat A, El-Beltagy M et al. Histone H3K27M Mutation Overrides Histological Grading in Pediatric Gliomas. 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Precision-guided treatment improves outcomes for children with high-risk cancers. Research Square. 2023. https://doi.org/10.21203/rs.3.rs-3376668/v1.; Strzebonska K, Wasylewski MT, Zaborowska L, Polak M, Slugocka E, Stras J et al. Risk and Benefit for Targeted Therapy Agents in Pediatric Phase II Trials in Oncology: A Systematic Review with a Meta-Analysis. Target Oncol. 2021;16(4):415–424. https://doi.org/10.1007/s11523-021-00822-5.; Nelson MR, Johnson T, Warren L, Hughes AR, Chissoe SL, Xu CF, Waterworth DM. The genetics of drug efficacy: opportunities and challenges. Nat Rev Genet. 2016;17(4):197–206. https://doi.org/10.1038/nrg.2016.12.; Van Tilburg CM, Pfaff E, Pajtler KW, Langenberg KPS, Fiesel P, Jones BC et al. The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets. 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Cancers (Basel). 2020;12(1):230. https://doi.org/10.3390/cancers12010230.; Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, Sivachenko A et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 2013;499(7457):214–218. https://doi.org/10.1038/nature12213.; Campbell BB, Light N, Fabrizio D, Zatzman M, Fuligni F, de Borja R et al. Comprehensive Analysis of Hypermutation in Human Cancer. Cell. 2017;171(5):1042–1056.e10. https://doi.org/10.1016/j.cell.2017.09.048.; Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A et al. Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1–2 trial. Lancet Oncol. 2020;21(1):121–133. https://doi.org/10.1016/S1470-2045(19)30671-0.; https://www.med-sovet.pro/jour/article/view/7987

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    Academic Journal

    المساهمون: State task number 2021-42 “Development of a new drug for the treatment of male hypogonadism” of the Research Laboratory of Pediatric Endocrinology of the Institute of Endocrinology, Federal Almazov National Medical Research Center, Saint-Petersburg, Russia., Государственное задание номер 2021-42 «Разработка нового лекарственного препарата для лечения мужского гипогонадизма» Научно-исследовательской лаборатории детской эндокринологии Института эндокринологии, Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр им. В. А. Алмазова» Министерства здравоохранения Российской Федерации, Санкт-Петербург, Россия.

    المصدر: Translational Medicine; Том 10, № 3 (2023); 154-165 ; Трансляционная медицина; Том 10, № 3 (2023); 154-165 ; 2410-5155 ; 2311-4495

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    المصدر: Meditsinskiy sovet = Medical Council; № 17 (2023); 109-114 ; Медицинский Совет; № 17 (2023); 109-114 ; 2658-5790 ; 2079-701X

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    المصدر: Meditsinskiy sovet = Medical Council; № 19 (2022); 96-103 ; Медицинский Совет; № 19 (2022); 96-103 ; 2658-5790 ; 2079-701X

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