المؤلفون: Sara B. Linker, Maria C. Marchetto, Iñigo Narvaiza, Ahmet M. Denli, Fred H. Gage

المصدر: BMC Biology, Vol 15, Iss 1, Pp 1-8 (2017)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s12915-017-0409-z; https://doaj.org/toc/1741-7007

URL الوصول: https://doaj.org/article/f58c356183e54ddb8af03492e39fa759

المؤلفون: Maria C Marchetto, Branka Hrvoj-Mihic, Bilal E Kerman, Diana X Yu, Krishna C Vadodaria, Sara B Linker, Iñigo Narvaiza, Renata Santos, Ahmet M Denli, Ana PD Mendes, Ruth Oefner, Jonathan Cook, Lauren McHenry, Jaeson M Grasmick, Kelly Heard, Callie Fredlender, Lynne Randolph-Moore, Rijul Kshirsagar, Rea Xenitopoulos, Grace Chou, Nasun Hah, Alysson R Muotri, Krishnan Padmanabhan, Katerina Semendeferi, Fred H Gage

المصدر: eLife, Vol 8 (2019)

مصطلحات موضوعية: neurodevelopment, neuronal function, chimpanzee, non human primate, neuroprogenitor migration, evolution, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://elifesciences.org/articles/37527; https://doaj.org/toc/2050-084X

URL الوصول: https://doaj.org/article/8eb5b01f74684625be3abe311de8e7dd

المؤلفون: Sandra R Richardson, Iñigo Narvaiza, Randy A Planegger, Matthew D Weitzman, John V Moran

المصدر: eLife, Vol 3 (2014)

مصطلحات موضوعية: LINE-1, APOBEC3A, cytidine deaminase, retrotransposition, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://elifesciences.org/articles/02008; https://doaj.org/toc/2050-084X

URL الوصول: https://doaj.org/article/8bbe9e396ac249a28c44c58809b5568b

المؤلفون: Mikel Zaratiegui, Iñigo Narvaiza, Cheng Qian, Francisco J. Novo

المصدر: BioTechniques, Vol 28, Iss 6, Pp 1096-1100 (2000)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/0736-6205; https://doaj.org/toc/1940-9818

URL الوصول: https://doaj.org/article/baf7b0c42ea64d0d9f1145c06e99b568

المؤلفون: Iñigo Narvaiza, Daniel C Linfesty, Benjamin N Greener, Yoshiyuki Hakata, David J Pintel, Eric Logue, Nathaniel R Landau, Matthew D Weitzman

المصدر: PLoS Pathogens, Vol 5, Iss 5, p e1000439 (2009)

مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19461882/?tool=EBI; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

URL الوصول: https://doaj.org/article/c9be6e30441e4dc4b3b23d56c804e04b

المؤلفون: Sara B. Linker, Iñigo Narvaiza, Jonathan Y. Hsu, Meiyan Wang, Fan Qiu, Ana P.D. Mendes, Ruth Oefner, Kalyani Kottilil, Amandeep Sharma, Lynne Randolph-Moore, Eunice Mejia, Renata Santos, Maria C. Marchetto, Fred H. Gage

المساهمون: Martinez Rico, Clara, The Salk Institute for Biological Studies, Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut des sciences biologiques (INSB-CNRS), University of California [San Diego] (UC San Diego), University of California (UC)

المصدر: Current Biology-CB
Current Biology-CB, 2022, 32 (22), pp.4797-4807.e5. ⟨10.1016/j.cub.2022.09.028⟩

مصطلحات موضوعية: neoteny, Primates, Gorilla gorilla, Pan troglodytes, evolutionary developmental biology, nonhuman primate stem cells, evo-devo, Hominidae, Pan paniscus, Macaca mulatta, General Biochemistry, Genetics and Molecular Biology, chimpanzee, GATA3, evolution, Animals, Humans, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], General Agricultural and Biological Sciences, Transcriptome, transcription factor

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e3c94991554d42e6fb4ffe84573f8f
https://pubmed.ncbi.nlm.nih.gov/36228612

المؤلفون: Luca G. Guidotti, Matteo Iannacone, Giovanni Sitia, Iñigo Narvaiza, Zaverio M

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://cvi.asm.org/content/14/11/1532.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.551.3834; http://cvi.asm.org/content/14/11/1532.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.551.3834
http://cvi.asm.org/content/14/11/1532.full.pdf

المؤلفون: Iñigo Narvaiza, Oscar Aparicio, María Vera, Nerea Razquin, Sergia Bortolanza, Jesús Prieto, Puri Fortes

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jvi.asm.org/content/80/24/12236.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.384; http://jvi.asm.org/content/80/24/12236.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.384
http://jvi.asm.org/content/80/24/12236.full.pdf

المؤلفون: Michael H. Duyzend, Iñigo Narvaiza, Giorgia Chiatante, Osnat Penn, John Huddleston, Francesca Camponeschi, Francesca Antonacci, Nicolette Janke, Kelsi Penewit, Joshua M. Akey, Giuliana Giannuzzi, Joshua G. Schraiber, W. Joyce Tang, Laura Denman, Peter H. Sudmant, Holly A.F. Stessman, Lana Harshman, Maria C. Marchetto, Evan E. Eichler, Xander Nuttle, Carl Baker, Mario Ventura, Lucia Banci, Chris T. Amemiya, Archana Raja, Alexandre Reymond, Maika Malig, Simone Ciofi-Baffoni, Fred H. Gage, Christopher Benner

المساهمون: Sudmant, Peter

المصدر: Nature, vol 536, iss 7615
Nature
Nature, vol. 536, no. 7615, pp. 205-209
Peter Sudmant

مصطلحات موضوعية: 0301 basic medicine, Time Factors, Pan troglodytes, DNA Copy Number Variations, Evolution, General Science & Technology, Iron, Locus (genetics), Biology, Article, Chromosomes, Animals, Autistic Disorder/genetics, Chromosome Breakage, Chromosomes, Human, Pair 16/genetics, DNA Copy Number Variations/genetics, Evolution, Molecular, Gene Duplication, Genetic Predisposition to Disease, Homeostasis/genetics, Humans, Iron/metabolism, Pan troglodytes/genetics, Pongo/genetics, Proteins/analysis, Proteins/genetics, Recombination, Genetic, Species Specificity, 03 medical and health sciences, 0302 clinical medicine, Genetic, Gene duplication, Genetics, Homeostasis, Gene family, Copy-number variation, Autistic Disorder, Segmental duplication, Multidisciplinary, Pair 16, Human evolutionary genetics, Human Genome, Pongo, Proteins, Molecular, Recombination, 3. Good health, 030104 developmental biology, Homo sapiens, Iron homeostasis, Iron-sulfur proteins, Chromosome breakage, Chromosomes, Human, Pair 16, 030217 neurology & neurosurgery, Human, Biotechnology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ea85b5b82a73d3282420dfdffcdc06
https://doi.org/10.1038/nature19075

المؤلفون: Alysson R. Muotri, Ana P.D. Mendes, Grace Chou, Krishna C. Vadodaria, Diana X. Yu, Fred H. Gage, Lynne Randolph-Moore, Iñigo Narvaiza, Callie Fredlender, Renata Santos, Jonathan Cook, Ruth Oefner, Jaeson M Grasmick, Maria C. Marchetto, Ahmet M. Denli, Lauren McHenry, Katerina Semendeferi, Branka Hrvoj-Mihic, Nasun Hah, Sara B. Linker, Rea Xenitopoulos, Bilal E. Kerman, Kelly J. Heard, Rijul Kshirsagar, Krishnan Padmanabhan

المساهمون: Santos, Renata, The Salk Institute for Biological Studies, University of California [San Diego] (UC San Diego), University of California (UC), Istanbul Medipol University, Huntsman Cancer Institute, Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Rady Children's Hospital, University of Rochester [USA], REMER

المصدر: eLife, Vol 8 (2019)
eLife
eLife, 2019, 8 (pii: e37527), ⟨10.7554/eLife.37527⟩

مصطلحات موضوعية: [SDV]Life Sciences [q-bio], Regenerative Medicine, Disease susceptibility, 0302 clinical medicine, Neural Stem Cells, Cell Movement, Biology (General), Induced pluripotent stem cell, Neurons, 0303 health sciences, Stem Cell Research - Induced Pluripotent Stem Cell - Human, biology, neurodevelopment, General Neuroscience, Bonobo, Cell Differentiation, General Medicine, Pan paniscus, Phenotype, Neural stem cell, neuroprogenitor migration, 3. Good health, [SDV] Life Sciences [q-bio], Neurological, Medicine, Stem Cell Research - Nonembryonic - Non-Human, Heterochrony, Research Article, Human, Pan troglodytes, QH301-705.5, Cells, Neurogenesis, Science, Induced Pluripotent Stem Cells, Ganglionic eminence, Species-Specific, General Biochemistry, Genetics and Molecular Biology, Cell Line, developmental biology, 03 medical and health sciences, Species Specificity, chimpanzee, evolution, Animals, Humans, human, Stem Cell Research - Embryonic - Human, neuronal function, Neural, 030304 developmental biology, Stem Cell Research - Induced Pluripotent Stem Cell, General Immunology and Microbiology, Mouse cortex, Neurosciences, Dendrites, non human primate, Stem Cell Research, biology.organism_classification, Gene Expression Regulation, Biochemistry and Cell Biology, Neuroscience, Developmental biology, 030217 neurology & neurosurgery, Developmental Biology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7ad02ee0281ef8ad7a841315f271cc
https://elifesciences.org/articles/37527

المؤلفون: Bilal E. Kerman, Renata Santos, Kelly J. Heard, Callie Fredlender, Ruth Oefner, Krishnan Padmanabhan, Rea Xenitopoulos, Lynne Randolph-Moore, Rijul Kshirsagar, Krishna C. Vadodaria, Iñigo Narvaiza, Diana X. Yu, Nasun Hah, Katerina Semendeferi, Sara B. Linker, Branka Hrvoj-Mihic, Ahmet M. Denli, Lauren McHenry, Ana P.D. Mendes, Grace Chou, Jaeson M Grasmick, Alysson R. Muotri, Jonathan Cook, Fred H. Gage, Maria C. Marchetto

مصطلحات موضوعية: biology, Evolutionary biology, Bonobo, biology.organism_classification

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c8a3d92d11535c3fc864c066079e2b8f
https://doi.org/10.7554/elife.37527.024

المؤلفون: Maria C. Marchetto, Licia Selleri, Fred H. Gage, Sara L. Prescott, Irina Grishina, Iñigo Narvaiza, Rajini Srinivasan, Tomek Swigut, Joanna Wysocka

المصدر: Prescott, SL; Srinivasan, R; Marchetto, MC; Grishina, I; Narvaiza, I; Selleri, L; et al.(2015). Enhancer Divergence and cis-Regulatory Evolution in the Human and Chimp Neural Crest. Cell, 163(1), 68-84. doi: 10.1016/j.cell.2015.08.036. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/5hg5s7p6
Cell, vol 163, iss 1

مصطلحات موضوعية: Epigenomics, Pan troglodytes, Induced Pluripotent Stem Cells, Mice, Transgenic, Biology, Medical and Health Sciences, General Biochemistry, Genetics and Molecular Biology, Evolution, Molecular, Mice, 03 medical and health sciences, 0302 clinical medicine, Cranial neural crest, Species Specificity, Genetic variation, Animals, Humans, Induced pluripotent stem cell, Enhancer, Gene, 030304 developmental biology, Genetics, 0303 health sciences, Biochemistry, Genetics and Molecular Biology(all), Neural crest, Biological Sciences, Embryo, Mammalian, Embryonic stem cell, Genetic Enhancement, Neural Crest, Evolutionary biology, 030217 neurology & neurosurgery, Developmental Biology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c416658fcf491892eec6c8524a89c7da
https://doi.org/10.1016/j.cell.2015.08.036

المؤلفون: Fred H. Gage, Sara B. Linker, Ahmet M. Denli, Maria C. Marchetto, Iñigo Narvaiza

المصدر: BMC Biology
BMC Biology, Vol 15, Iss 1, Pp 1-8 (2017)

مصطلحات موضوعية: 0301 basic medicine, Primates, Retroelements, Physiology, Retrotransposon, Context (language use), Plant Science, Review, Genome, General Biochemistry, Genetics and Molecular Biology, Evolution, Molecular, 03 medical and health sciences, 0302 clinical medicine, Structural Biology, biology.animal, Animals, Primate, lcsh:QH301-705.5, Ecology, Evolution, Behavior and Systematics, Genetics, biology, Extramural, Brain, Cell Biology, Biological evolution, Biological Evolution, Primate evolution, 030104 developmental biology, lcsh:Biology (General), Evolutionary biology, Mobile genetic elements, General Agricultural and Biological Sciences, 030217 neurology & neurosurgery, Developmental Biology, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f255f245b568baea856a915c06de4a7b
https://pubmed.ncbi.nlm.nih.gov/28800766

المؤلفون: Gene W. Yeo, Alysson R. Muotri, Keval N. Desai, Apuã C. M. Paquola, Matthew D. Weitzman, Fred H. Gage, Maria C. Marchetto, Ahmet M. Denli, Christopher Benner, Roberto H. Herai, Jason L. Nathanson, Iñigo Narvaiza, Thomas A. Lazzarini

المصدر: Nature, vol 503, iss 7477

مصطلحات موضوعية: Pluripotent Stem Cells, Pan troglodytes, Evolution, General Science & Technology, Nude, Messenger, Mice, Nude, Retrotransposon, Biology, Regenerative Medicine, Germline, Cell Line, Evolution, Molecular, Minor Histocompatibility Antigens, Mice, Species Specificity, Stem Cell Research - Nonembryonic - Human, Cytidine Deaminase, Genetics, Animals, Humans, RNA, Messenger, Induced pluripotent stem cell, Cell Shape, Genome, Multidisciplinary, Stem Cell Research - Induced Pluripotent Stem Cell, Genome, Human, Sequence Analysis, RNA, Human evolutionary genetics, Human Genome, Molecular, High-Throughput Nucleotide Sequencing, Pan paniscus, Stem Cell Research, Embryonic stem cell, Phenotype, Long Interspersed Nucleotide Elements, Karyotyping, Argonaute Proteins, RNA, Human genome, Sequence Analysis, Reprogramming, Human

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4995a2d14355d0ecf6e327738e6836a5
https://doi.org/10.1038/nature12686

المؤلفون: Enrique Saez, Kenji Sasaki, Christopher G. Parker, Benjamin F. Cravatt, Arthur S. Kim, Christopher M. Joslyn, Iñigo Narvaiza, Stephen R. Johnson, Cullen L. Cavallaro, Bruno E. Correia, R. Michael Lawrence, Andrea Galmozzi, Yujia Wang

مصطلحات موضوعية: 0301 basic medicine, Proteomics, Hydrolases, Phenotypic screening, Computational biology, Biology, Crystallography, X-Ray, Ligands, 01 natural sciences, General Biochemistry, Genetics and Molecular Biology, Article, Small Molecule Libraries, 03 medical and health sciences, High-Throughput Screening Assays, Drug Discovery, Human proteome project, Adipocytes, Humans, Chemoproteomics, 010405 organic chemistry, Drug discovery, Membrane Proteins, Cell Differentiation, Small molecule, Molecular biology, 0104 chemical sciences, 030104 developmental biology, Oxidoreductases, Receptors, Progesterone, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1c382b32e8161eff4f3f6a348eca99
https://europepmc.org/articles/PMC5632530/

المؤلفون: Iñigo Narvaiza, Tobias M. Franks, Martin W. Hetzer, Janet M. Young, Harmit S. Malik, Maria C. Marchetto, Fred H. Gage, Christopher Benner

المصدر: Genes & development, vol 30, iss 10

مصطلحات موضوعية: 0301 basic medicine, Transcription, Genetic, Nuclear Localization Signals, Medical and Health Sciences, Protein Isoforms, Nuclear pore, Promoter Regions, Genetic, Genetics, Regulation of gene expression, Pom121, Membrane Glycoproteins, Nuclear Proteins, Exons, Biological Sciences, Nup98, medicine.anatomical_structure, Nucleoporin, Transcription Initiation Site, transcription, Corrigendum, Biotechnology, Evolution, 1.1 Normal biological development and functioning, Biology, Promoter Regions, Evolution, Molecular, 03 medical and health sciences, Genetic, Protein Domains, Underpinning research, nuclear pore complex, medicine, Humans, Transcription factor, Cell Nucleus, Nucleoplasm, Human Genome, Psychology and Cognitive Sciences, Cell Membrane, Molecular, Promoter, Nuclear Pore Complex Proteins, Cell nucleus, 030104 developmental biology, hominoid, Gene Expression Regulation, Solubility, Hela Cells, Mutant Proteins, Generic health relevance, Nuclear transport, 5' Untranslated Regions, Developmental Biology, HeLa Cells, Transcription Factors

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ddaf26876a4dc6c279d905300a9930
https://pubmed.ncbi.nlm.nih.gov/28512238

المؤلفون: Sébastien Landry, Matthew D. Weitzman, Iñigo Narvaiza, Daniel C. Linfesty

المصدر: EMBO reports. 12:444-450

مصطلحات موضوعية: Cell cycle checkpoint, DNA repair, DNA damage, viruses, Blotting, Western, Fluorescent Antibody Technique, Biology, Biochemistry, Cell Line, Histones, chemistry.chemical_compound, Cytidine Deaminase, APOBEC Deaminases, In Situ Nick-End Labeling, Genetics, Humans, Phosphorylation, APOBEC3A, Uracil-DNA Glycosidase, Molecular Biology, Cell Cycle, Scientific Reports, Proteins, Cytidine deaminase, Cell biology, Bromodeoxyuridine, chemistry, Nucleotide Deaminases, Uracil-DNA glycosylase, DNA, DNA Damage

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5495fe3f199145cbc9722538aeeb9ea1
https://doi.org/10.1038/embor.2011.46

المؤلفون: Nerea Razquin, Puri Fortes, Iñigo Narvaiza, Jesús Prieto, Maria Vera, Sergia Bortolanza, Oscar Aparicio

المصدر: Dadun. Depósito Académico Digital de la Universidad de Navarra
instname

مصطلحات موضوعية: ATP Binding Cassette Transporter, Subfamily B, Genetic Vectors, Molecular Sequence Data, Immunology, Oligonucleotides, Biology, Microbiology, Adenoviridae, Cell Line, Viral vector, Small hairpin RNA, Mice, RNA interference, Virology, microRNA, Gene expression, Animals, Humans, Gene silencing, Gene Silencing, Messenger RNA, Base Sequence, Bilirubin, P-Glycoproteins/metabolism, Molecular biology, Multidrug Resistance-Associated Protein 2, Virus-Cell Interactions, Cell biology, Mice, Inbred C57BL, MicroRNAs, MicroRNAs/genetics, Gene Components, Insect Science, RNA Interference, Functional genomics

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1643e37c124994bacacf6e5949eb20c9
https://doi.org/10.1128/jvi.01205-06

المؤلفون: Caroline E. Lilley, Darwin V. Lee, Hui Chen, Matthew D. Weitzman, Iñigo Narvaiza, Qin Yu, Jody Chou, Nathaniel R. Landau

المصدر: Current Biology. 16:480-485

مصطلحات موضوعية: MICROBIO, Retroelements, viruses, Retrotransposon, APOBEC-3G Deaminase, Biology, Virus Replication, medicine.disease_cause, Monocytes, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chemistry.chemical_compound, Cytidine deamination, Retrovirus, Cell Line, Tumor, Cytidine Deaminase, APOBEC Deaminases, medicine, Humans, RNA, Messenger, APOBEC3A, Adeno-associated virus, 030304 developmental biology, Cell Nucleus, Genetics, 0303 health sciences, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), Macrophages, 030302 biochemistry & molecular biology, Nuclear Proteins, Proteins, Cytidine, Dependovirus, biology.organism_classification, Virology, chemistry, General Agricultural and Biological Sciences

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d48018b11f2ea77fdae3e91bf84580
https://doi.org/10.1016/j.cub.2006.01.031

المؤلفون: Miguel Barajas, Ignacio Melero, Iñigo Narvaiza, Jesús Prieto, Ainhoa Arina, Luis Alfonso Martínez-Cruz, C Qian, Guillermo Mazzolini, Juan C. Galofré, José M. Mato

المصدر: Gene Therapy. 10:1067-1078

مصطلحات موضوعية: Receptors, CCR6, Chemokine, Genetic Vectors, Apoptosis, Adenoviridae, Interferon-gamma, Mice, Transduction, Genetic, Pancreatic cancer, Tumor Cells, Cultured, Genetics, medicine, Animals, Molecular Biology, Gene, Oligonucleotide Array Sequence Analysis, Receptors, Interferon, Mice, Inbred BALB C, Chemokine CCL20, biology, Reverse Transcriptase Polymerase Chain Reaction, Gene ontology, Genetic Therapy, Neoplasms, Experimental, Macrophage Inflammatory Proteins, medicine.disease, Interleukin-12, In vitro, Mice, Inbred C57BL, Pancreatic Neoplasms, Cell culture, Chemokines, CC, Colonic Neoplasms, Immunology, Cancer research, Interleukin 12, biology.protein, Molecular Medicine, Female, Receptors, Chemokine, Tumor Escape, Immunotherapy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067d8dc700986f0e24d23bbce5f97005
https://doi.org/10.1038/sj.gt.3301957