المؤلفون: Kaori Tsutsumi, Thititip Tippayamontri, Mari Hayashi, Nobuto Matsuda, Yusaku Goto

المصدر: FEBS Open Bio, Vol 14, Iss 2, Pp 344-354 (2024)

مصطلحات موضوعية: adenosine triphosphate, human non‐small cell lung cancer cells, inorganic polyphosphate, mitochondria, mitochondrial membrane potential, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2211-5463

URL الوصول: https://doaj.org/article/69748490136e428589d6fb2cda107c49

المؤلفون: Holtschulte C., Borgel F., Westphalinger S., Schepmann D., Civenni G., Laurini E., Marson D., Catapano C. V., Pricl S., Wunsch B.

المساهمون: Holtschulte, C., Borgel, F., Westphalinger, S., Schepmann, D., Civenni, G., Laurini, E., Marson, D., Catapano, C. V., Pricl, S., Wunsch, B.

مصطلحات موضوعية: androgen negative human prostate cancer cells DU145, antitumor activity, cytotoxic activity, human non-small cell lung cancer cells A427, lipophilic ligand efficiency, logD, 7.4, value, molecular dynamics simulation, piperidine, selectivity over σ, receptor, structure affinity relationship, synthesi, σ, affinity, receptor ligand, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Human, Ligand, Lung Neoplasm, Male, Prostatic Neoplasm, Structure-Activity Relationship, Antineoplastic Agent, Receptors

Time: 2, 1

وصف الملف: ELETTRONICO

Relation: info:eu-repo/semantics/altIdentifier/pmid/35077612; info:eu-repo/semantics/altIdentifier/wos/WOS:000753356300001; volume:17; issue:7; firstpage:"-"; lastpage:"-"; numberofpages:17; journal:CHEMMEDCHEM; http://hdl.handle.net/11368/3018519; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85124593518

الاتاحة: http://hdl.handle.net/11368/3018519
https://doi.org/10.1002/cmdc.202100735
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202100735

المؤلفون: Jeong Yong Moon, Le Van Manh Hung, Tatsuya Unno, Somi Kim Cho

المصدر: Nutrients; Volume 10; Issue 12; Pages: 1829

مصطلحات موضوعية: Adriamycin (ADR), A549 human non-small-cell lung cancer cells, multidrug resistance-associated protein 1 (MRP1), nobiletin (NBT)

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/nu10121829

الاتاحة: https://doi.org/10.3390/nu10121829

المؤلفون: Lin, Ping-Yi, Tsai, Ching-Tsan, Chuang, Wan-Ling, Chao, Ya-Hsuan, Pan, I-Horng, Chen, Yu-Kuo, Lin, Chi-Chen, Wang, Bing-Yen

مصطلحات موضوعية: Chlorella sorokiniana, Human non-small cell lung cancer cells, Mitochondrial apoptotic pathway

Relation: http://www.biomedcentral.com/1472-6882/17/88

الاتاحة: http://www.biomedcentral.com/1472-6882/17/88

المؤلفون: Ding, Yu Chun, Chu, Yi‐Cheng, Chang, Chuan‐Hsin, Liang, Jia‐Hua, Chen, Jih‐Jung, Shih, Tzenge‐Lien

مصطلحات موضوعية: aza‐2‐styrylchromones, human non‐small‐cell lung cancer cells, pyridine N‐oxides

وصف الملف: 104 bytes; text/html

Relation: Arch. Pharm. 357(4); 1521-4184; 0365-6233; https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/125467; https://tkuir.lib.tku.edu.tw/dspace/bitstream/987654321/125467/1/index.html

الاتاحة: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/125467
https://doi.org/10.1002/ardp.202300445
https://tkuir.lib.tku.edu.tw/dspace/bitstream/987654321/125467/1/index.html

المؤلفون: Shih, Tzenge-lien

مصطلحات موضوعية: 1,2,3-triazole, benzenesulfonamide, click chemistry, flavonol, human non-small-cell lung cancer cells, hybrid molecules

وصف الملف: 104 bytes; text/html

Relation: Journal of the Chinese Chemical Society 70(10), p.1924-1936; https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/124672; https://tkuir.lib.tku.edu.tw/dspace/bitstream/987654321/124672/1/index.html

الاتاحة: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/124672
https://doi.org/10.1002/jccs.202300279
https://tkuir.lib.tku.edu.tw/dspace/bitstream/987654321/124672/1/index.html

المؤلفون: Chi-Chen Lin, Wan-Ling Chuang, Ya-Hsuan Chao, Pan I-Horng, Ching-Tsan Tsai, Bing-Yen Wang, Ping-Yi Lin, Yu-Kuo Chen

المصدر: BMC Complementary and Alternative Medicine

مصطلحات موضوعية: 0301 basic medicine, Programmed cell death, Lung Neoplasms, Apoptosis, Chlorella, Chlorella sorokiniana, Biology, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, Downregulation and upregulation, In vivo, Carcinoma, Non-Small-Cell Lung, Survivin, Animals, Humans, Human non-small cell lung cancer cells, Mice, Inbred BALB C, Plant Extracts, Mitochondrial apoptotic pathway, General Medicine, Antineoplastic Agents, Phytogenic, Xenograft Model Antitumor Assays, Mitochondria, XIAP, 030104 developmental biology, Complementary and alternative medicine, Cell culture, 030220 oncology & carcinogenesis, Immunology, Cancer research, Female, Drug Screening Assays, Antitumor, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e796f96ad82d96c40e4684d5b48f801c
https://doi.org/10.1186/s12906-017-1611-9

المؤلفون: 謝長亨, Hsieh, Chang-Heng

المساهمون: 方剛, Fang, Kang

مصطلحات موضوعية: 細胞自噬, 多麩醯胺酸, 聚集物清除, 三唑化合物, JNK訊息傳遞, 神經退化疾病, 人類非小細胞肺癌細胞, 細胞凋亡, autophagic flux, polyglutamine, aggregates clearance, triazole, JNK pathway, neuronal disorders, human non-small-cell-lung-cancer cells, apoptosis

وصف الملف: application/pdf

Relation: G080143010S; http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G080143010S%22.&%22.id.&; http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/103965

الاتاحة: http://rportal.lib.ntnu.edu.tw:80/handle/20.500.12235/103965
https://hdl.handle.net/20.500.12235/103965
http://etds.lib.ntnu.edu.tw/cgi-bin/gs32/gsweb.cgi?o=dstdcdr&s=id=%22G080143010S%22.&%22.id.&

المؤلفون: 陳尤娟

المساهمون: 生物科技系, 陳品晟

مصطلحات موضوعية: 青藤鹼, 基質金屬蛋白?, 侵入, 爬行, 人類非小細胞肺癌細胞, Sinomenine, matrix metalloproteinase, invasion, migration, human non-small cell lung cancer cells

وصف الملف: 121 bytes; text/html

Relation: 網際網路公開：2021-09-09，學年度：104，60頁; https://ir.cnu.edu.tw/handle/310902800/30046; https://ir.cnu.edu.tw/bitstream/310902800/30046/1/index.html

الاتاحة: https://ir.cnu.edu.tw/handle/310902800/30046
https://ir.cnu.edu.tw/bitstream/310902800/30046/1/index.html

المؤلفون: 林佳薇, 林銘儀, 路淑怡, 黃慧滇, 方剛

مصطلحات موضوعية: 人類非小細肺癌細胞, 玫瑰樹鹼, 凋亡, Human non-small cell lung cancer cells, Ellipticine, Apoptosis

وصف الملف: application/pdf

Relation: 42(2)，99-104; 生物學報; 12ED579C-BE1F-944B-0317-5FE309761424; http://rportal.lib.ntnu.edu.tw/handle/20.500.12235/6736

الاتاحة: http://rportal.lib.ntnu.edu.tw/handle/20.500.12235/6736
https://hdl.handle.net/20.500.12235/6736

المؤلفون: 康淵琳, 邱建智, 黃智欣, 方剛

مصطلحات موضوعية: 人類非小細肺癌細胞, 第一型皰疹病毒胸腺嘧啶激素, 基因治療, Human non-small-cell-lung cancer cells, Herpes simplex virus-thymidine kinase, Gene therapy

وصف الملف: application/pdf

Relation: 36(1)，9-15; 生物學報; 85EB5F6D-3481-D558-ED8C-093B3D94B68F; http://rportal.lib.ntnu.edu.tw/handle/20.500.12235/6956

الاتاحة: http://rportal.lib.ntnu.edu.tw/handle/20.500.12235/6956
https://hdl.handle.net/20.500.12235/6956

المؤلفون: 蔡伃婕

المساهمون: 田乃月, 郭柏麟, 嘉南藥理科技大學：生物科技系暨研究所

مصطلحات موضوعية: 人類非小細胞肺癌, Kotomolide A, 細胞凋亡, 細胞週期, 粒線體途徑, p53, ATM, Human non-small cell lung cancer cells, Apoptosis, Cell cycle, Mitochondrial pathway

وصف الملف: application/pdf; 1468117 bytes

Relation: 校內外完全公開 ，學年度：98，72頁; 參考文獻 1. Danesi R, Pasqualetti G, Giovannetti E, et al. Pharmacogenomics in non-small-cell lung cancer chemotherapy. Adv Drug Deliv Rev. 2009;61(5):408-417. 2. Spiro SG, Silvestri GA. One hundred years of lung cancer. Am J Respir Crit Care Med. 2005;172(5):523-529. 3. Peto R, Darby S, Deo H, Silcocks P, Whitley E, Doll R. Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. BMJ. 2000;321(7257):323-329. 4. Iyengar P, Tsao MS. Clinical relevance of molecular markers in lung cancer. Surg Oncol. 2002;11(4):167-179. 5. Alberg AJ, Samet JM. Epidemiology of lung cancer. Chest. 2003;123(1 Suppl):21S-49S. 6. Visbal AL, Leighl NB, Feld R, Shepherd FA. Adjuvant Chemotherapy for Early-Stage Non-small Cell Lung Cancer. Chest. 2005;128(4):2933-2943. 7. Poirier MC. Chemical-induced DNA damage and human cancer risk. Nat Rev Cancer. 2004;4(8):630-637. 8. Abraham RT. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 2001;15(17):2177-2196. 9. Wiencke JK. Impact of race/ethnicity on molecular pathways in human cancer. Nat Rev Cancer. 2004;4(1):79-84. 10. Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature. 2001;411(6835):342-348. 11.Murakami H, Nurse P. DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeasts. Biochem J. 2000;349(Pt 1):1-12. 12. Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer. 2009;9(3):153-166. 13. Bucher N, Britten CD. G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer. Br J Cancer. 2008;98(3):523-528. 14. Stewart ZA, Westfall MD, Pietenpol JA. Cell-cycle dysregulation and anticancer therapy. Trends Pharmacol Sci. 2003;24(3):139-145. 15. Senderowicz AM, Sausville EA. Preclinical and clinical development of cyclin-dependent kinase modulators. J Natl Cancer Inst. 2000;92(5):376-387. 16. Cam H, Dynlacht BD. Emerging roles for E2F: beyond the G1/S transition and DNA replication. Cancer Cell. 2003;3(4):311-316. 17. Hermeking H. The 14-3-3 cancer connection. Nat Rev Cancer. 2003;3(12):931-943. 18. Taylor WR, Stark GR. Regulation of the G2/M transition by p53. Oncogene. 2001;20(15):1803-1815. 19. Hengartner MO. The biochemistry of apoptosis. Nature. 2000;407(6805):770-776. 20. Kaufmann SH, Earnshaw WC. Induction of apoptosis by cancer chemotherapy. Exp Cell Res. 2000;256(1):42-49. 21. Ivanov VN, Bhoumik A, Ronai Z. Death receptors and melanoma resistance to apoptosis. Oncogene. 2003;22(20):3152-3161. 22. Timmer T, de Vries EG, de Jong S. Fas receptor-mediated apoptosis: a clinical application? J Pathol. 2002;196(2):125-134. 23. Schwarz M, Andrade-Navarro MA, Gross A. Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program? Apoptosis. 2007;12(5):869-876. 24. Cory S, Adams JM. The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer. 2002;2(9):647-656. 25. Bruno T, De Nicola F, Iezzi S, et al. Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint. Cancer Cell. 2006;10(6):473-486. 26. Matsuoka S, Ballif BA, Smogorzewska A, et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007;316(5828):1160-1166. 27. Srivastava N, Gochhait S, de Boer P, Bamezai RN. Role of H2AX in DNA damage response and human cancers. Mutat Res. 2009;681(2-3):180-188. 28. Lavin MF, Kozlov S. ATM activation and DNA damage response. Cell Cycle. 2007;6(8):931-942. 29. Dornan D, Shimizu H, Mah A, et al. ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage. Science. 2006;313(5790):1122-1126. 30. Stiff T, O'Driscoll M, Rief N, Iwabuchi K, Lobrich M, Jeggo PA. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res. 2004;64(7):2390-2396. 31. Bode AM, Dong Z. Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer. 2004;4(10):793-805. 32. Vousden KH, Lane DP. p53 in health and disease. Nat Rev Mol Cell Biol. 2007;8(4):275-283. 33. Lee YS, Wan J, Kim BJ, Bae MA, Song BJ. Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen. J Pharmacol Exp Ther. 2006;317(1):202-208. 34. Kulikov R, Winter M, Blattner C. Binding of p53 to the central domain of Mdm2 is regulated by phosphorylation. J Biol Chem. 2006;281(39):28575-28583. 35. Harris SL, Levine AJ. The p53 pathway: positive and negative feedback loops. Oncogene. 2005;24(17):2899-2908. 36. Fridman JS, Lowe SW. Control of apoptosis by p53. Oncogene. 2003;22(56):9030-9040. 37. Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer. 2002;2(8):594-604. 38. 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Adjuvant chemotherapy for completely resected non-small-cell lung cancer. Acta Med Okayama. 2009;63(5):223-230. 44. Bonomi PD. Implications of key trials in advanced nonsmall cell lung cancer. Cancer. 45. Kobayashi H, Uno T, Isobe K, et al. Radiation Pneumonitis Following Twice-daily Radiotherapy with Concurrent Carboplatin and Paclitaxel in Patients with Stage III Non-small-cell Lung Cancer. Jpn J Clin Oncol. 46. Saleh S, Ain-Shoka AA, El-Demerdash E, Khalef MM. Protective effects of the angiotensin II receptor blocker losartan on cisplatin-induced kidney injury. Chemotherapy. 2009;55(6):399-406. 47. Dahlberg SE, Sandler AB, Brahmer JR, Schiller JH, Johnson DH. Clinical Course of Advanced Non-Small-Cell Lung Cancer Patients Experiencing Hypertension During Treatment With Bevacizumab in Combination With Carboplatin and Paclitaxel on ECOG 4599. J Clin Oncol. 48. Hsu YL, Kuo PL, Lin CC. Isoliquiritigenin induces apoptosis and cell cycle arrest through p53-dependent pathway in Hep G2 cells. Life Sci. 2005;77(3):279-292. 49. Polager S, Ginsberg D. p53 and E2f: partners in life and death. Nat Rev Cancer. 2009;9(10):738-748. 50. Buschmann T, Adler V, Matusevich E, Fuchs SY, Ronai Z. p53 phosphorylation and association with murine double minute 2, c-Jun NH2-terminal kinase, p14ARF, and p300/CBP during the cell cycle and after exposure to ultraviolet irradiation. Cancer Res. 2000;60(4):896-900.; https://ir.cnu.edu.tw/handle/310902800/23116; https://ir.cnu.edu.tw/bitstream/310902800/23116/1/index.html

الاتاحة: https://ir.cnu.edu.tw/handle/310902800/23116
https://ir.cnu.edu.tw/bitstream/310902800/23116/1/index.html