المؤلفون: Gahbauer, Stefan, DeLeon, Chelsea, Braz, Joao, Craik, Veronica, Kang, Hye, Wan, Xiaobo, Huang, Xi-Ping, Billesbølle, Christian, Liu, Yongfeng, Che, Tao, Deshpande, Ishan, Fink, Elissa, Kondratov, Ivan, Moroz, Yurii, Roth, Bryan, Basbaum, Allan, Shoichet, Brian, Jewell, Madison, Irwin, John

المصدر: Nature Communications. 14(1)

مصطلحات موضوعية: Humans, Mice, Animals, Dinoprostone, Receptors, Prostaglandin, Phagocytosis, Anti-Inflammatory Agents, Pain, Anti-Inflammatory Agents, Non-Steroidal

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4xz106d7
https://escholarship.org/content/qt4xz106d7/qt4xz106d7.pdf

المؤلفون: Singh, Isha, Seth, Anubha, Billesbølle, Christian B, Braz, Joao, Rodriguiz, Ramona M, Roy, Kasturi, Bekele, Bethlehem, Craik, Veronica, Huang, Xi-Ping, Boytsov, Danila, Pogorelov, Vladimir M, Lak, Parnian, O'Donnell, Henry, Sandtner, Walter, Irwin, John J, Roth, Bryan L, Basbaum, Allan I, Wetsel, William C, Manglik, Aashish, Shoichet, Brian K, Rudnick, Gary

المصدر: Cell. 186(10)

مصطلحات موضوعية: Animals, Mice, Serotonin, Fluoxetine, Ibogaine, Molecular Conformation, Serotonin Plasma Membrane Transport Proteins, Small Molecule Libraries, Selective Serotonin Reuptake Inhibitors, depression, docking, functional selectivity, serotonin transporter, ultra-large libraries, Substance Misuse, Neurosciences, Drug Abuse (NIDA only), Biological Sciences, Medical and Health Sciences, Developmental Biology

URL الوصول: https://escholarship.org/uc/item/5cg0t59n

المؤلفون: Kaplan, Anat Levit, Confair, Danielle N, Kim, Kuglae, Barros-Álvarez, Ximena, Rodriguiz, Ramona M, Yang, Ying, Kweon, Oh Sang, Che, Tao, McCorvy, John D, Kamber, David N, Phelan, James P, Martins, Luan Carvalho, Pogorelov, Vladimir M, DiBerto, Jeffrey F, Slocum, Samuel T, Huang, Xi-Ping, Kumar, Jain Manish, Robertson, Michael J, Panova, Ouliana, Seven, Alpay B, Wetsel, Autumn Q, Wetsel, William C, Irwin, John J, Skiniotis, Georgios, Shoichet, Brian K, Roth, Bryan L, Ellman, Jonathan A

المصدر: Nature. 610(7932)

مصطلحات موضوعية: Theory Of Computation, Information and Computing Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, Brain Disorders, Women's Health, 1.1 Normal biological development and functioning, Animals, Mice, Antidepressive Agents, Cryoelectron Microscopy, Fluoxetine, Hallucinogens, Ligands, Pyrrolidines, Receptor, Serotonin, 5-HT2A, Small Molecule Libraries, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/87f9q9sd
https://escholarship.org/content/qt87f9q9sd/qt87f9q9sd.pdf

المؤلفون: Fink, Elissa A, Xu, Jun, Hübner, Harald, Braz, Joao M, Seemann, Philipp, Avet, Charlotte, Craik, Veronica, Weikert, Dorothee, Schmidt, Maximilian F, Webb, Chase M, Tolmachova, Nataliya A, Moroz, Yurii S, Huang, Xi-Ping, Kalyanaraman, Chakrapani, Gahbauer, Stefan, Chen, Geng, Liu, Zheng, Jacobson, Matthew P, Irwin, John J, Bouvier, Michel, Du, Yang, Shoichet, Brian K, Basbaum, Allan I, Gmeiner, Peter

المصدر: Science. 377(6614)

مصطلحات موضوعية: Adrenergic alpha-2 Receptor Agonists, Analgesics, Non-Narcotic, Animals, Dexmedetomidine, Drug Design, Drug Discovery, Humans, Ligands, Mice, Molecular Docking Simulation, Pain, Pain Management, Structure-Activity Relationship, Neurosciences, Pain Research, Chronic Pain, General Science & Technology

URL الوصول: https://escholarship.org/uc/item/6r0990sd

المؤلفون: Alon, Assaf, Lyu, Jiankun, Braz, Joao M, Tummino, Tia A, Craik, Veronica, O’Meara, Matthew J, Webb, Chase M, Radchenko, Dmytro S, Moroz, Yurii S, Huang, Xi-Ping, Liu, Yongfeng, Roth, Bryan L, Irwin, John J, Basbaum, Allan I, Shoichet, Brian K, Kruse, Andrew C

المصدر: Nature. 600(7890)

مصطلحات موضوعية: Theory Of Computation, Biomedical and Clinical Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, Information and Computing Sciences, Neurosciences, Neurodegenerative, Chronic Pain, Pain Research, Peripheral Neuropathy, 5.1 Pharmaceuticals, Animals, Ligands, Mice, Neuralgia, Receptors, sigma, Structure-Activity Relationship, General Science & Technology

URL الوصول: https://escholarship.org/uc/item/9gp7838k

المؤلفون: Cao, Can, Kang, Hye Jin, Singh, Isha, Chen, He, Zhang, Chengwei, Ye, Wenlei, Hayes, Byron W, Liu, Jing, Gumpper, Ryan H, Bender, Brian J, Slocum, Samuel T, Krumm, Brian E, Lansu, Katherine, McCorvy, John D, Kroeze, Wesley K, English, Justin G, DiBerto, Jeffrey F, Olsen, Reid HJ, Huang, Xi-Ping, Zhang, Shicheng, Liu, Yongfeng, Kim, Kuglae, Karpiak, Joel, Jan, Lily Y, Abraham, Soman N, Jin, Jian, Shoichet, Brian K, Fay, Jonathan F, Roth, Bryan L

المصدر: Nature. 600(7887)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Chemical Sciences, Chronic Pain, Pain Research, 2.1 Biological and endogenous factors, Generic health relevance, Cryoelectron Microscopy, Drug Inverse Agonism, GTP-Binding Protein alpha Subunits, Gi-Go, GTP-Binding Protein alpha Subunits, Gq-G11, Humans, Models, Molecular, Nerve Tissue Proteins, Pruritus, Receptors, G-Protein-Coupled, Receptors, Neuropeptide, General Science & Technology

URL الوصول: https://escholarship.org/uc/item/78f5d3k9

المؤلفون: Bedard, Madigan L., Huang, Xi-Ping, Murray, Jackson G., Nowlan, Alexandra C., Conley, Sara Y., Mott, Sarah E., Loyack, Samuel J., Cline, Calista A., Clodfelter, Caroline G., Dasgupta, Nabarun, Krumm, Brian, Roth, Bryan L., McElligott, Zoe A.

المصدر: Addiction Neuroscience, 11

مصطلحات موضوعية: politicians, decision, policy, considerations, health crisis, naloxone precipitated withdrawal, drug supply, naloxone efficacy, behavior, ongoing health crisis, withdrawal, public health officials, opioid antagonism, sensitivity, impact, combination, effect, drug, supply, fentanyl, agonists, public health considerations, rate, pharmacology, kappa, officials, potential mechanisms, xylazine, data, opioid receptors

Relation: https://cdr.lib.unc.edu/downloads/ww72br769?file=thumbnail; https://cdr.lib.unc.edu/downloads/ww72br769

الاتاحة: https://doi.org/10.17615/g2dk-3k56
https://cdr.lib.unc.edu/downloads/ww72br769?file=thumbnail
https://cdr.lib.unc.edu/downloads/ww72br769

المؤلفون: Huang, Xi-Ping, Kenakin, Terrence P, Gu, Shuo, Shoichet, Brian K, Roth, Bryan L

المصدر: Biochemistry. 59(38)

مصطلحات موضوعية: Biochemistry and Cell Biology, Chemical Sciences, Biological Sciences, Allosteric Regulation, Amino Acid Sequence, Calcium, HEK293 Cells, Histidine, Humans, Hydrogen-Ion Concentration, Magnesium, Metals, Heavy, Mutation, Protons, Receptors, G-Protein-Coupled, Medicinal and Biomolecular Chemistry, Medical Biochemistry and Metabolomics, Biochemistry & Molecular Biology, Biochemistry and cell biology, Medical biochemistry and metabolomics, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9bg4r1x9

المؤلفون: Pottel, Joshua, Armstrong, Duncan, Zou, Ling, Fekete, Alexander, Huang, Xi-Ping, Torosyan, Hayarpi, Bednarczyk, Dallas, Whitebread, Steven, Bhhatarai, Barun, Liang, Guiqing, Jin, Hong, Ghaemi, S Nassir, Slocum, Samuel, Lukacs, Katalin V, Irwin, John J, Berg, Ellen L, Giacomini, Kathleen M, Roth, Bryan L, Shoichet, Brian K, Urban, Laszlo

المصدر: Science. 369(6502)

مصطلحات موضوعية: 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Animals, Drug Compounding, Drug Evaluation, Preclinical, Excipients, Humans, Molecular Targeted Therapy, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/27x6b8vj

المؤلفون: Gordon, David E, Jang, Gwendolyn M, Bouhaddou, Mehdi, Xu, Jiewei, Obernier, Kirsten, White, Kris M, O’Meara, Matthew J, Rezelj, Veronica V, Guo, Jeffrey Z, Swaney, Danielle L, Tummino, Tia A, Hüttenhain, Ruth, Kaake, Robyn M, Richards, Alicia L, Tutuncuoglu, Beril, Foussard, Helene, Batra, Jyoti, Haas, Kelsey, Modak, Maya, Kim, Minkyu, Haas, Paige, Polacco, Benjamin J, Braberg, Hannes, Fabius, Jacqueline M, Eckhardt, Manon, Soucheray, Margaret, Bennett, Melanie J, Cakir, Merve, McGregor, Michael J, Li, Qiongyu, Meyer, Bjoern, Roesch, Ferdinand, Vallet, Thomas, Mac Kain, Alice, Miorin, Lisa, Moreno, Elena, Naing, Zun Zar Chi, Zhou, Yuan, Peng, Shiming, Shi, Ying, Zhang, Ziyang, Shen, Wenqi, Kirby, Ilsa T, Melnyk, James E, Chorba, John S, Lou, Kevin, Dai, Shizhong A, Barrio-Hernandez, Inigo, Memon, Danish, Hernandez-Armenta, Claudia, Lyu, Jiankun, Mathy, Christopher JP, Perica, Tina, Pilla, Kala Bharath, Ganesan, Sai J, Saltzberg, Daniel J, Rakesh, Ramachandran, Liu, Xi, Rosenthal, Sara B, Calviello, Lorenzo, Venkataramanan, Srivats, Liboy-Lugo, Jose, Lin, Yizhu, Huang, Xi-Ping, Liu, YongFeng, Wankowicz, Stephanie A, Bohn, Markus, Safari, Maliheh, Ugur, Fatima S, Koh, Cassandra, Savar, Nastaran Sadat, Tran, Quang Dinh, Shengjuler, Djoshkun, Fletcher, Sabrina J, O’Neal, Michael C, Cai, Yiming, Chang, Jason CJ, Broadhurst, David J, Klippsten, Saker, Sharp, Phillip P, Wenzell, Nicole A, Kuzuoglu-Ozturk, Duygu, Wang, Hao-Yuan, Trenker, Raphael, Young, Janet M, Cavero, Devin A, Hiatt, Joseph, Roth, Theodore L, Rathore, Ujjwal, Subramanian, Advait, Noack, Julia, Hubert, Mathieu, Stroud, Robert M, Frankel, Alan D, Rosenberg, Oren S, Verba, Kliment A, Agard, David A, Ott, Melanie, Emerman, Michael, Jura, Natalia

المصدر: Nature. 583(7816)

مصطلحات موضوعية: Biological Sciences, Bioinformatics and Computational Biology, Biomedical and Clinical Sciences, Coronaviruses Therapeutics and Interventions, Emerging Infectious Diseases, Infectious Diseases, Coronaviruses, 5.1 Pharmaceuticals, Infection, Good Health and Well Being, Animals, Antiviral Agents, Betacoronavirus, COVID-19, Chlorocebus aethiops, Cloning, Molecular, Coronavirus Infections, Drug Evaluation, Preclinical, Drug Repositioning, HEK293 Cells, Host-Pathogen Interactions, Humans, Immunity, Innate, Mass Spectrometry, Molecular Targeted Therapy, Pandemics, Pneumonia, Viral, Protein Binding, Protein Biosynthesis, Protein Domains, Protein Interaction Mapping, Protein Interaction Maps, Receptors, sigma, SARS-CoV-2, SKP Cullin F-Box Protein Ligases, Vero Cells, Viral Proteins, COVID-19 Drug Treatment, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/2gt3q50x
https://escholarship.org/content/qt2gt3q50x/qt2gt3q50x.pdf

المؤلفون: Stein, Reed M, Kang, Hye Jin, McCorvy, John D, Glatfelter, Grant C, Jones, Anthony J, Che, Tao, Slocum, Samuel, Huang, Xi-Ping, Savych, Olena, Moroz, Yurii S, Stauch, Benjamin, Johansson, Linda C, Cherezov, Vadim, Kenakin, Terry, Irwin, John J, Shoichet, Brian K, Roth, Bryan L, Dubocovich, Margarita L

المصدر: Nature. 579(7800)

مصطلحات موضوعية: Sleep Research, Neurosciences, Underpinning research, 1.1 Normal biological development and functioning, Animals, Circadian Rhythm, Darkness, Drug Evaluation, Preclinical, Drug Inverse Agonism, Female, Humans, Ligands, Light, Male, Mice, Mice, Knockout, Molecular Docking Simulation, Receptor, Melatonin, MT1, Receptor, Melatonin, MT2, Receptors, Melatonin, Small Molecule Libraries, Substrate Specificity, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3sp0d3rw

المؤلفون: Weiss, Dahlia R, Karpiak, Joel, Huang, Xi-Ping, Sassano, Maria F, Lyu, Jiankun, Roth, Bryan L, Shoichet, Brian K

المصدر: Journal of Medicinal Chemistry. 61(15)

مصطلحات موضوعية: Neurosciences, Drug Evaluation, Preclinical, Ligands, Molecular Docking Simulation, Protein Conformation, Receptor, Serotonin, 5-HT2A, Receptors, Dopamine D2, Substrate Specificity, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/96n832dt

المؤلفون: Salas-Estrada, Leslie, Provasi, Davide, Qiu, Xing, Kaniskan, Husnu Ümit, Huang, Xi-Ping, DiBerto, Jeffrey F., Lamim Ribeiro, João Marcelo, Jin, Jian, Roth, Bryan L., Filizola, Marta

المساهمون: National Institute on Drug Abuse

المصدر: Journal of Chemical Information and Modeling ; volume 63, issue 16, page 5056-5065 ; ISSN 1549-9596 1549-960X

الاتاحة: https://doi.org/10.1021/acs.jcim.3c00651
https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.3c00651

المؤلفون: Wang, Sheng, Wacker, Daniel, Levit, Anat, Che, Tao, Betz, Robin M, McCorvy, John D, Venkatakrishnan, AJ, Huang, Xi-Ping, Dror, Ron O, Shoichet, Brian K, Roth, Bryan L

المصدر: Science. 358(6361)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Chemical Sciences, Biological Psychology, Psychology, Pharmacology and Pharmaceutical Sciences, Mental Health, Neurosciences, 5.1 Pharmaceuticals, Allosteric Site, Antipsychotic Agents, Benzamides, Dopamine Agonists, Humans, Protein Conformation, Receptors, Dopamine D4, Structure-Activity Relationship, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6662k2z4
https://escholarship.org/content/qt6662k2z4/qt6662k2z4.pdf

المؤلفون: Axen, Seth D, Huang, Xi-Ping, Cáceres, Elena L, Gendelev, Leo, Roth, Bryan L, Keiser, Michael J

المصدر: Journal of Medicinal Chemistry. 60(17)

مصطلحات موضوعية: Medicinal and Biomolecular Chemistry, Chemical Sciences, Machine Learning and Artificial Intelligence, Good Health and Well Being, Computer-Aided Design, Drug Design, Ligands, Models, Molecular, Molecular Conformation, Small Molecule Libraries, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, Pharmacology and pharmaceutical sciences, Medicinal and biomolecular chemistry, Organic chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3t3870bb
https://escholarship.org/content/qt3t3870bb/qt3t3870bb.pdf

المؤلفون: Lansu, Katherine, Karpiak, Joel, Liu, Jing, Huang, Xi-Ping, McCorvy, John D, Kroeze, Wesley K, Che, Tao, Nagase, Hiroshi, Carroll, Frank I, Jin, Jian, Shoichet, Brian K, Roth, Bryan L

المصدر: Nature Chemical Biology. 13(5)

مصطلحات موضوعية: Medicinal and Biomolecular Chemistry, Chemical Sciences, Opioids, Biotechnology, Substance Misuse, Neurosciences, 5.1 Pharmaceuticals, Generic health relevance, Calcium, Cell Degranulation, Cell Line, Computer Simulation, Dose-Response Relationship, Drug, Drug Design, Drug Evaluation, Preclinical, Humans, Ligands, Mast Cells, Molecular Docking Simulation, Molecular Probes, Molecular Structure, Nerve Tissue Proteins, Pyrazoles, Pyrimidines, Receptors, G-Protein-Coupled, Receptors, Neuropeptide, Structure-Activity Relationship, Biochemistry and Cell Biology, Biochemistry & Molecular Biology, Biochemistry and cell biology, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/7kk0c31w
https://escholarship.org/content/qt7kk0c31w/qt7kk0c31w.pdf

المؤلفون: Manglik, Aashish, Lin, Henry, Aryal, Dipendra K, McCorvy, John D, Dengler, Daniela, Corder, Gregory, Levit, Anat, Kling, Ralf C, Bernat, Viachaslau, Hübner, Harald, Huang, Xi-Ping, Sassano, Maria F, Giguère, Patrick M, Löber, Stefan, Da Duan, Scherrer, Grégory, Kobilka, Brian K, Gmeiner, Peter, Roth, Bryan L, Shoichet, Brian K

المصدر: Nature. 537(7619)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Opioid Misuse and Addiction, Opioids, Chronic Pain, Drug Abuse (NIDA only), Pain Research, Neurosciences, Brain Disorders, Substance Misuse, Lung, 5.1 Pharmaceuticals, Good Health and Well Being, Analgesia, Analgesics, Opioid, Animals, Drug Discovery, GTP-Binding Protein alpha Subunits, Gi-Go, HEK293 Cells, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Molecular Docking Simulation, Pain, Receptors, Opioid, mu, Spiro Compounds, Structure-Activity Relationship, Thiophenes, Urea, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/41j4g4rn
https://escholarship.org/content/qt41j4g4rn/qt41j4g4rn.pdf

المؤلفون: Farrell, Martilias S, McCorvy, John D, Huang, Xi-Ping, Urban, Daniel J, White, Kate L, Giguere, Patrick M, Doak, Allison K, Bernstein, Alison I, Stout, Kristen A, Park, Su Mi, Rodriguiz, Ramona M, Gray, Bradley W, Hyatt, William S, Norwood, Andrew P, Webster, Kevin A, Gannon, Brenda M, Miller, Gary W, Porter, Joseph H, Shoichet, Brian K, Fantegrossi, William E, Wetsel, William C, Roth, Bryan L

المصدر: PLOS ONE. 11(3)

مصطلحات موضوعية: Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Mental Health, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Mental health, Good Health and Well Being, Animals, Antipsychotic Agents, Aporphines, Behavior, Animal, HEK293 Cells, Humans, Mice, Receptors, Dopamine D4, Serotonin 5-HT1 Receptor Agonists, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/998966pm
https://escholarship.org/content/qt998966pm/qt998966pm.pdf

المؤلفون: Mao, Qi, Zhang, Bingjie, Tian, Sheng, Qin, Wangzhi, Chen, Jiaojiao, Huang, Xi-Ping, Xin, Ye, Yang, Huicui, Zhen, Xue-Chu, Shui, Wenqing, Ye, Na

المساهمون: National Natural Science Foundation of China

المصدر: Bioorganic Chemistry ; volume 123, page 105795 ; ISSN 0045-2068

الاتاحة: http://dx.doi.org/10.1016/j.bioorg.2022.105795
https://api.elsevier.com/content/article/PII:S0045206822002000?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0045206822002000?httpAccept=text/plain

المؤلفون: Huang, Xi-Ping, Karpiak, Joel, Kroeze, Wesley K, Zhu, Hu, Chen, Xin, Moy, Sheryl S, Saddoris, Kara A, Nikolova, Viktoriya D, Farrell, Martilias S, Wang, Sheng, Mangano, Thomas J, Deshpande, Deepak A, Jiang, Alice, Penn, Raymond B, Jin, Jian, Koller, Beverly H, Kenakin, Terry, Shoichet, Brian K, Roth, Bryan L

المصدر: Nature. 527(7579)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, 5.1 Pharmaceuticals, 1.1 Normal biological development and functioning, Inflammatory and immune system, Generic health relevance, Allosteric Regulation, Allosteric Site, Animals, Anti-Anxiety Agents, Benzyl Alcohols, Conditioning, Classical, Drug Discovery, Fear, Female, HEK293 Cells, Humans, Ligands, Lorazepam, Male, Memory, Mice, Mice, Knockout, Models, Molecular, Receptors, G-Protein-Coupled, Signal Transduction, Triazines, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9qh2x85w
https://escholarship.org/content/qt9qh2x85w/qt9qh2x85w.pdf