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المؤلفون: Pingping Luo, Rui Zhang, Qian Yu, George L. Tipoe, Ming Zheng, Xiaoming Sun, Yingxia Liu, Jia Xiao, Wei Li, Hong Zhang
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 668-679 (2021)مصطلحات موضوعية: Alcoholic liver disease, INSR, insulin receptor, TCF/LEF, T-cell factor/lymphoid enhancer factor, AST, aspartate aminotransferase, Pharmacology, TSA, thermal shift assay, 0302 clinical medicine, WAT, white adipose tissues, HSL, hormone sensitive lipase, FFA, free fatty acids, MTT, 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide, General Pharmacology, Toxicology and Pharmaceutics, NF-κB, nuclear factor kappa B, RER, respiratory exchange ratio, 0303 health sciences, LRP6, low-density lipoprotein receptor related protein 6, TNF, tumor necrosis factor, NAS, NAFLD activity score, biology, TG, triglyceride, Chemistry, NIAAA, National Institute on Alcohol Abuse and Alcoholism, Liver cell, CYP2E1, cytochrome P450 2E1, 030220 oncology & carcinogenesis, LDLR, low-density lipoprotein receptor, NRF2, nuclear factor erythroid 2-related factor 2, IRS, insulin receptor substrate, GTT, glucose tolerance test, Original Article, medicine.symptom, Safety, IRTK, insulin receptor tyrosine kinase, GSK3β, glycogen synthase kinase 3 beta, NAFLD, non-alcoholic fatty liver disease, ALD, alcoholic liver disease, SREBP-1c, sterol regulatory element-binding protein 1c, Inflammation, SPR, surface plasmon resonance, AMPK, adenosine 5′-monophosphate (AMP)-activated protein kinase, SAMC, S-allylmercaptocysteine, 03 medical and health sciences, ADIPOQ, adiponectin, Insulin resistance, ORF, open reading frame, PA, palmitate acid, ALT, alanine aminotransferase, medicine, CPT1, carnitine palmitoyltransferase I, IRS-1, GRB14, growth factor receptor-bound protein 14, Protein kinase B, 030304 developmental biology, ATGL, adipose triglyceride lipase, PPARα, peroxisome proliferator-activated receptor alpha, AKT, lcsh:RM1-950, ALDH2, aldehyde dehydrogenase 2, GSK3β, Lipid metabolism, medicine.disease, S-Allylmercaptocysteine, WT, wild-type, IL, interleukin, TC, total cholesterol, Insulin receptor, FDA, U.S. Food and Drug Administration, lcsh:Therapeutics. Pharmacology, biology.protein, NAC, N-acetyl-cysteine, Steatosis, IGF-1, insulin-like growth factors-1
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المؤلفون: Kazuo Inoue, Wataru Nomura, Teruo Kawada, Su-Ping Ng, Haruya Takahashi, Tsuyoshi Goto
المصدر: Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101127-(2021)
Biochemistry and Biophysics Reportsمصطلحات موضوعية: medicine.medical_specialty, Ucp1, QH301-705.5, Short Communication, p38 mitogen-activated protein kinases, ERK, extracellular receptor kinase, Biophysics, QD415-436, SEM, standard error of the mean, Biochemistry, iWAT, inguinal white adipose tissue, chemistry.chemical_compound, Beige adipocytes, Internal medicine, Methylglyoxal, NEFA, non-esterified fatty acids, medicine, Glycolysis, Protein kinase A signaling, Biology (General), Kinase, NAC, N-acetyl-l-cysteine, Metabolism, Thermogenin, Endocrinology, chemistry, MG, methylglyoxal, JNK, c-Jun N-terminal kinase, CREB, cAMP response element-binding protein, PKA, protein kinase A, JNK, BBGC, S-p-bromobenzylglutathione cyclopentyl diester, HSL, hormone-sensitive lipase, Thermogenesis
وصف الملف: application/pdf
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المؤلفون: Lucia Parlati, Catherine Postic, Marion Régnier, Hervé Guillou
المساهمون: LESUR, Hélène, Impact du métabolisme des acides gras des tissus adipeux et du foie sur l'insulinorésistance - - HepAdialogue2017 - ANR-17-CE14-0015 - AAPG2017 - VALID, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Catholique de Louvain = Catholic University of Louvain (UCL), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Toxicologie Intégrative & Métabolisme (ToxAlim-TIM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Lucia Parlati and Catherine Postic received funding from the French association for the study of the liver (AFEF). Catherine Postic and Herve Guillou received funding from the Agence Nationale de la Recherche (ANR-17-CE14-0015Hepadialogue)., ANR-17-CE14-0015,HepAdialogue,Impact du métabolisme des acides gras des tissus adipeux et du foie sur l'insulinorésistance(2017), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)
المصدر: JHEP Reports
JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, 2021, 3 (6), pp.100346. ⟨10.1016/j.jhepr.2021.100346⟩
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (6), pp.100346. ⟨10.1016/j.jhepr.2021.100346⟩مصطلحات موضوعية: HFD, high-fat diet, SREBP-1c, [SDV]Life Sciences [q-bio], Disease, Review, ACC, acetyl-CoA carboxylase, ASK1, apoptosis signal-regulating kinase 1, Chronic liver disease, Bioinformatics, ChREBP, carbohydrate responsive element–binding protein, PPARα, NEFA, TNF-α, tumour necrosis factor-α, 0302 clinical medicine, Fibrosis, Immunology and Allergy, Medicine, IL-, interleukin, VLDL, very low-density lipoprotein, 0303 health sciences, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, NEFA, non-esterified fatty acid, Fatty liver, Gastroenterology, NASH, lipotoxicity, FAS, fatty acid synthase, animal models, 3. Good health, [SDV] Life Sciences [q-bio], PY, persons/years, Lipotoxicity, FXR, Saturated fatty acid, JNK, c-Jun N-terminal kinase, 030211 gastroenterology & hepatology, LXR, CAP, controlled attenuation parameter, HSL, hormone-sensitive lipase, HSC, hepatic stellate cells, GGT, gamma glutamyltransferase, NAFLD, non-alcoholic fatty liver disease, ChREBP, NASH, non-alcoholic steatohepatitis, SFA, saturated fatty acid, TCA, tricarboxylic acid, Phf2, histone demethylase plant homeodomain finger 2, digestive system, 03 medical and health sciences, glucotoxicity, FXR, farnesoid X receptor, NAFLD, FFA, free fatty acid, Internal Medicine, RCT, randomised controlled trial, Liver X receptor, PPARa, 030304 developmental biology, FGF21, fibroblast growth factor-21, MCD, methionine- and choline-deficient, HVPG, hepatic venous pressure gradient, Hepatology, business.industry, PUFAs, polyunsaturated fatty acids, nutritional and metabolic diseases, TLR4, Toll-like receptor 4, SCD1, stearoyl-CoA desaturase-1, medicine.disease, digestive system diseases, PPARα, peroxisome proliferator-activated receptor-α, SREBP-1c, sterol regulatory element–binding protein-1c, Steatosis, LXR, liver X receptor, business, HCC, hepatocellular carcinoma, MUFA, monounsaturated fatty acids, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
وصف الملف: application/pdf
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المؤلفون: Jordi Duran, Joan J. Guinovart, Iliana López-Soldado
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Male, endocrine system diseases, medicine.medical_treatment, Biochemistry, PGC1α, proliferator-activated receptor gamma coactivator 1-α, chemistry.chemical_compound, Mice, Glycolysis, glucose, protein targeting to glycogen (PTG), Glycogen, biology, diabetes, Intracellular Signaling Peptides and Proteins, glycolysis, FAS, fatty acid synthase, Phenotype, glycogen, Female, HSL, hormone-sensitive lipase, hormones, hormone substitutes, and hormone antagonists, medicine.drug, Research Article, GK, glucokinase, medicine.medical_specialty, endocrine system, insulin, PTG, protein targeting to glycogen, liver, Diet, High-Fat, STZ, streptozotocin, TAG, triacylglyceride, Diabetes Mellitus, Experimental, 03 medical and health sciences, Insulin resistance, GS, glycogen synthase, Internal medicine, Diabetes mellitus, FFA, free fatty acid, medicine, Akita, Animals, Glycogen synthase, Molecular Biology, ATGL, adipose triglyceride lipase, 030102 biochemistry & molecular biology, Glucokinase, business.industry, Insulin, Gluconeogenesis, PP1, Protein phosphatase 1, SCD1, stearoyl-CoA desaturase-1, Cell Biology, medicine.disease, Streptozotocin, HFD, high-fat-diet, Liver Glycogen, ATP, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Endocrinology, chemistry, Diabetes Mellitus, Type 2, PK, pyruvate kinase, biology.protein, PEPCK, phosphoenolpyruvate carboxykinase, business
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المؤلفون: James G. Granneman, Stacey N Keenan, Jieqiong Lou, Ralf B. Schittenhelm, Magdalene K. Montgomery, William De Nardo, Matthew J. Watt, Elizabeth Hinde
المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100016-(2021)مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, lipid droplets, QD415-436, 030204 cardiovascular system & hematology, Carbohydrate metabolism, Biochemistry, Perilipin-5, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, HSL, hormone sensitive lipase, Internal medicine, Lipid droplet, medicine, lipase, Lipolysis, ABHD5, α-β hydrolase domain-containing 5, triglyceride, Protein kinase A, ANOVA, analysis of variance, ATGL, adipose triglyceride lipase, Chemistry, perilipins, Lipid metabolism, Cell Biology, MGL, monoacylglycerol lipase, 030104 developmental biology, Adipose triglyceride lipase, Perilipin, Phosphorylation, protein kinase A, PKA, protein kinase A, fatty acid, Research Article
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المصدر: Journal of Lipid Research, Vol 62, Iss, Pp 100093-(2021)
Journal of Lipid Researchمصطلحات موضوعية: 0301 basic medicine, Very low-density lipoprotein, Hormone-sensitive lipase, 030204 cardiovascular system & hematology, Biochemistry, Carboxylesterase, Mice, SHP, small heterodimer partner, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, RCT, reverse cholesterol transport, cardiovascular disease, cholesteryl ester hydrolase, LKO, liver-specific Ces1d KO, Cells, Cultured, AADAC, arylacetamide deacetylase, Mice, Knockout, Western-type diet, Hydrolysis, Reverse cholesterol transport, WAT, white adipose tissue, lipase activity, WTD, Western-type diet, Cholesteryl ester, lipids (amino acids, peptides, and proteins), Cholesterol Esters, HSL, hormone-sensitive lipase, VLDL, Research Article, FC, free cholesterol, LD, lipid droplet, HDL, Mice, Transgenic, QD415-436, Cholesterol 7 alpha-hydroxylase, liver, SR-BI, scavenger receptor class B type I, 03 medical and health sciences, Hydrolase, Animals, Cholesterol, Cell Biology, CYP7A1, cholesterol 7α-hydroxylase, reverse cholesterol transport, TC, total cholesterol, Lox, Ces1dflox/flox, 030104 developmental biology, chemistry, 4-MU, 4-methylumbelliferone, cholesterol metabolism, Ces1d, carboxylesterase 1d
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المؤلفون: Andrew C. McCourt, Muheeb Beg, Wei Zhang, Sven Enerbäck
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Glucose uptake, Biochemistry, chemistry.chemical_compound, Mice, Thioredoxins, AMP-activated protein kinase, DOG, 2-deoxy-d-glucose, Adipocytes, Cyclic AMP, PKA, Glucose Transporter Type 1, biology, Chemistry, HA, human influenza hemagglutinin, TXNIP, thioredoxin-interacting protein, Cell biology, GLUT, glucose transporter, hormone-sensitive lipase (HSL), triacylglycerol, HSL, hormone-sensitive lipase, TXNIP, adipose triglyceride lipase (ATGL), Research Article, Thioredoxin-Interacting Protein, TAG, triacylglycerol, Lipolysis, adipocyte, AKT, protein kinase B, 03 medical and health sciences, cAMP, 3T3-L1 Cells, FFA, free fatty acid, GSK3, glycogen synthase kinase 3, Animals, Humans, Lactic Acid, Molecular Biology, thioredoxin-interacting protein (TXNIP), ATGL, adipose triglyceride lipase, 030102 biochemistry & molecular biology, Glucose transporter, glucose transport, 8-Br-cAMP, 8-bromine-cAMP, Cell Biology, Lipase, Sterol Esterase, MGL, monoacylglycerol lipase, AMPK, AMP-activated protein kinase, 030104 developmental biology, Glucose, Proteolysis, biology.protein, GLUT1, 2-Deoxy-D-glucose, Carrier Proteins, OE, overexpression
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المؤلفون: Jelena Rajkovic, Juan A. Hermoso, José Berenguer, Elisa Beneventi, Mercedes Sánchez-Costa, Aurelio Hidalgo, Jacobo Cruces, María-Isabel González-Siso, Ana Torrado, Ivanna Rivera, Vega Miguel-Ruano, María L. Rúa, Kamila Knapik, Manuel Becerra, José M. Otero
المساهمون: ALBA Synchrotron, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), UAM. Departamento de Biología Molecular
المصدر: Investigo. Repositorio Institucional de la Universidade de Vigo
Universidade de Vigo (UVigo)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
RUC. Repositorio da Universidade da Coruña
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 1214-1232 (2021)
Computational and Structural Biotechnology Journal
RUC: Repositorio da Universidade da Coruña
Universidade da Coruña (UDC)مصطلحات موضوعية: DMSO, dimethyl sulfoxide, Biochemistry, Esterase, 0302 clinical medicine, Structural Biology, Enzime-Substrate Complex, CHCA, cyclohexane carboxylic acid, CV, column volume, chemistry.chemical_classification, 0303 health sciences, biology, Chemistry, NP, naproxen, Biología y Biomedicina / Biología, 2306 Química Orgánica, pNP, 4-nitrophenol, 3. Good health, Computer Science Applications, DSF, Differential scanning fluorimetry, 030220 oncology & carcinogenesis, Crystal structures, Enzyme-substrate complex, Crystal Structure, 2301 Química Analítica, HSL, hormone-sensitive lipase, Research Article, Biotechnology, CMC, critical micellar concentration, Hydrolase Fold, Stereochemistry, Biophysics, FLU, fluorescein, 03 medical and health sciences, Metagenomic, PPL, Porcine Pancreatic Lipase, Genetics, Lipase, ComputingMethodologies_COMPUTERGRAPHICS, 030304 developmental biology, Enzyme substrate complex, 2403 Bioquímica, Thermophilic esterase, Thermophile, Substrate (chemistry), Active site, LDAO, N,N-dimethyldodecylamine N-oxide, Enzyme, biology.protein, α/β hydrolase fold, MNP, methyl-naproxen, Linker, TP248.13-248.65
وصف الملف: application/pdf
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المؤلفون: Guohua Chen, Aaron Lotvola, Jian Wang, James G. Granneman, Guoli Zhou
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Cell cycle checkpoint, cancer metabolism, mTORC1, AMP-Activated Protein Kinases, ECL, enhanced chemiluminescence, Biochemistry, Adenosine Triphosphate, AMP-activated protein kinase, GSEA, gene set enrichment analysis, HSL, hormone sensitive lipase, OPP, O-propargyl-puromycin, RNA-Seq, ABHD5, αβ hydrolase domain containing 5, biology, LDH, lactate dehydrogenase, TG, triglyceride, Chemistry, αβ hydrolase domain containing 5 (ABHD5), mTOR, mechanistic target of rapamycin, Cell Cycle, 1-Acylglycerol-3-Phosphate O-Acyltransferase, Cell biology, mTOR, Intracellular, Research Article, LD, lipid droplet, Lipolysis, Blotting, Western, PBS, phosphate-buffered saline, Mechanistic Target of Rapamycin Complex 1, 03 medical and health sciences, AMP-activated protein kinase (AMPK), Humans, Molecular Biology, Mechanistic target of rapamycin, PI3K/AKT/mTOR pathway, Cell Proliferation, ATGL, adipose triglyceride lipase, 030102 biochemistry & molecular biology, FA, fatty acid, AMPK, Cell Biology, Adenosine Monophosphate, AMPK, AMP-activated protein kinase, 030104 developmental biology, Metabolism, PK, pyruvate kinase, Cancer cell, biology.protein
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المؤلفون: Brandyn D. Henriksbo, Kieran Kwok, Akhilesh K. Tamrakar, Wendy Chi, Yong Chen, Mark Heal, Nicole G. Barra, Kevin P. Foley, Yong Liu, Brittany M. Duggan, Jonathan D. Schertzer
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, WT, wild type, obesity, medicine.medical_treatment, immunometabolism, Adipose tissue, Hormone-sensitive lipase, White adipose tissue, Biochemistry, TKI, tyrosine kinase inhibitor, TLR4, toll-like receptor 4, Mice, PVDF, polyvinylidene difluoride, chemistry.chemical_compound, UPR, unfolded protein response, 0302 clinical medicine, ERK, extracellular signal-regulated kinase, HSL, hormone sensitive lipase, Adipocyte, Adipocytes, cytokine, Insulin, SVF, stromal vascular fraction, FK565, heptanoyl-γ-D-glutamyl-L-meso-diamino-pimelyl-D-alanine, Phosphorylation, ABL, Abelson murine leukemia viral oncogene homolog, TNF, tumor necrosis factor, 0303 health sciences, Grp78/BiP, binding immunoglobulin protein or heat shock 70 kDa protein 5, biology, PGN, peptidoglycan, Chemistry, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, NF-kappa B, WAT, white adipose tissue, BMDM, bone-marrow-derived macrophage, Il(6), interleukin, XBP1, X-box binding protein 1, Adipose Tissue, Cytokines, LPS, lipopolysaccharide, ER stress, SEAP, secreted alkaline phosphatase, Signal Transduction, Research Article, Proto-oncogene tyrosine-protein kinase Src, AKO, adipose knockout, medicine.medical_specialty, ATF6, activating transcription factor 6, Lipolysis, IRE1, inositol-requiring enzyme 1, Protein Serine-Threonine Kinases, CHOP, C/EBP homologous protein, adipocyte, metabolic syndrome, 8-Br-cAMP, 8-bromoadenosine 3′,5′-cyclic monophosphate, ER, endoplasmic reticulum, endocrinology, HEK, human embryonic kidney, 03 medical and health sciences, Insulin resistance, lipid, 3T3-L1 Cells, TUDCA, tauroursodeoxycholic acid, Internal medicine, medicine, Animals, 4-PBA, 4-phenylbutyric acid, RIPK2, receptor interacting serine/threonine kinase 2, Kinase activity, Molecular Biology, Protein kinase B, 030304 developmental biology, Inflammation, ATGL, adipose triglyceride lipase, 030102 biochemistry & molecular biology, Macrophages, Membrane Proteins, Cell Biology, medicine.disease, Insulin receptor, 030104 developmental biology, PERK, protein kinase RNA-like ER kinase, Endocrinology, KirA6, IRE1α kinase inhibiting RNase attenuator 6, Akt, protein kinase B, biology.protein, Unfolded protein response, PKA, protein kinase A, Insulin Resistance, NOD, nucleotide-binding oligomerization domain-containing protein, 030217 neurology & neurosurgery
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المؤلفون: Meiyuan Zhang, Weilan Sun, Jin Qian, Yan Tang
المصدر: Redox Biology, Vol 16, Iss, Pp 87-96 (2018)
Redox Biologyمصطلحات موضوعية: X-Box Binding Protein 1, 0301 basic medicine, IRE1α, inositol requiring enzyme 1 alpha, Acdl, acyl-Coenzyme A dehydrogenase, medicine.medical_treatment, Clinical Biochemistry, Mice, Obese, Atgl, adipose triglyceride lipase, Biochemistry, Mice, UPR, unfolded protein response, KD, ketogenic diet, Transcription (biology), Acox1, acyl-Coenzyme A oxidase 1, Ketogenesis, GDF15, growth differentiation factor 15, lcsh:QH301-705.5, Mice, Knockout, chemistry.chemical_classification, lcsh:R5-920, Fatty Acids, Ppara, peroxisome proliferator-activated receptor alpha, Fasting, XBP1, ChIP, chromatin immunoprecipitation, ERSE, ER stress-response element, Liver, Cpt1a, carnitine palmitoyltransferase 1a, lcsh:Medicine (General), Oxidation-Reduction, Hmgcs2, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2, Research Paper, medicine.medical_specialty, Growth Differentiation Factor 15, Lipid accumulation, STZ, streptozotocin, XBP1, x-box binding protein 1, 03 medical and health sciences, Mediator, NAFLD, Internal medicine, Hsl, hormone sensitive lipase, medicine, Animals, Humans, Obesity, NCD, normal chow diet, Organic Chemistry, Fatty acid, Lipid Metabolism, GDF15, 030104 developmental biology, Endocrinology, Fatty acid β-oxidation, chemistry, lcsh:Biology (General), NAFLD, nonalcoholic fatty liver disease, Energy Metabolism, Ketogenic diet
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المؤلفون: Martin Bidlingmaier, Birgit Rathkolb, Martin Hrabĕ de Angelis, Arne Hinrichs, Werner F. Blum, Sebastian Bultmann, Heinrich Leonhardt, Maik Dahlhoff, Simone Renner, Andreas Blutke, Eckhard Wolf, Barbara Kessler, Andreas Hoeflich, Hiroshi Nagashima, Maren Bernau, Mayuko Kurome, Rüdiger Wanke, Elisabeth Kemter, Armin M. Scholz
المصدر: Molecular Metabolism, Vol 11, Iss, Pp 113-128 (2018)
Molecular Metabolism
Mol. Metab. 11, 113-128 (2018)
Molecular metabolism, 11: 113-128مصطلحات موضوعية: 0301 basic medicine, Insulin-like growth factor 1, Swine, INSR, insulin receptor, medicine.medical_treatment, 4EBP1, eukaryotic initiation factor 4E binding protein 1, IGFBP3, Dwarfism, IGF1, insulin-like growth factor 1, Growth hormone receptor, PCR, polymerase chain reaction, LDL, low-density lipoprotein, Laron syndrome, STAT5 Transcription Factor, Insulin-Like Growth Factor I, LSM, least squares mean, CRISPR/Cas, clustered regularly interspaced short palindromic repeats/CRISPR-associated, JAK2, Janus kinase 2, Adiposity, mTOR, mechanistic target of rapamycin, HOMA, homeostatic model assessment, DXA, dual-energy X-ray absorptiometry, ELISA, enzyme-linked immunosorbent assay, Pig model, eIF4E, eukaryotic translation initiation factor 4E, AKT, serine-threonine protein kinase, PPARG, peroxisome proliferator-activated receptor gamma, STAT, signal transducer and activator of transcription, GHR, growth hormone receptor, LPL, lipoprotein lipase, Liver, mTORC, mTOR complex, S6K, protein S6 kinase 1, Original Article, IRS1, insulin receptor substrate 1, Growth Hormone Receptor, Laron Syndrome, Pig Model, Hypoglycemia, Insulin-like Growth Factor 1, Signaling, HSL, hormone-sensitive lipase, PI3K, phosphoinositide 3 kinase, hormones, hormone substitutes, and hormone antagonists, Signal Transduction, medicine.medical_specialty, lcsh:Internal medicine, aa, amino acid, HDL, high-density lipoprotein, IgG, immunoglobulin G, Mechanistic Target of Rapamycin Complex 2, Biology, 03 medical and health sciences, GSK3B, glycogen synthase 3 beta, Internal medicine, medicine, Animals, LS, Laron syndrome, lcsh:RC31-1245, Molecular Biology, Leptin receptor, DAB, 3,3′-diaminobenzidine, SE, standard error, Growth factor, Body Weight, sgRNA, single guide RNA, Cell Biology, Receptors, Somatotropin, Janus Kinase 2, medicine.disease, IRS1, GH, growth hormone, TBS, Tris-buffered saline, Insulin receptor, Insulin-Like Growth Factor Binding Protein 2, AMPK, AMP-activated protein kinase, 030104 developmental biology, Endocrinology, Insulin-Like Growth Factor Binding Protein 3, IGFBP, IGF-binding protein, LEPR, leptin receptor, Growth Hormone, biology.protein, RIA, radioimmunoassay, MRI, magnetic resonance imaging, MAPK, mitogen-activated protein kinase
وصف الملف: application/pdf
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المؤلفون: James G. Granneman, Victoria A. Kimler, Vanesa D. Ramseyer
المصدر: Molecular Metabolism, Vol 7, Iss, Pp 57-70 (2018)
Molecular Metabolismمصطلحات موضوعية: Male, 0301 basic medicine, beta subunit, Acadl, Vesicular Transport Proteins, LDs, lipid droplets, Adipose tissue, White adipose tissue, Brown adipose tissue, Long-chain specific acyl-CoA dehydrogenase, Ebf2, Mice, HSL, hormone sensitive lipase, Lipid droplet, Cells, Cultured, Vacuolar protein sorting, PLIN1, perilipin 1, Cox8b, Cytochrome c oxidase subunit 8B, Thermogenesis, Hadhb, hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), VPS13C, Vacuolar Protein Sorting 13C, Adipocytes, Brown, Perilipin 1, medicine.anatomical_structure, Biochemistry, Female, Original Article, ABHD5, α-β hydrolase domain-containing protein 5, lcsh:Internal medicine, Oxidative genes, Lipolysis, Nerve Tissue Proteins, Biology, Free fatty acids, ATGL, 03 medical and health sciences, Perilipin-1, estrogen related receptor, alpha, medicine, Animals, lcsh:RC31-1245, Molecular Biology, GAPDH, Glyceraldehyde 3-phosphate dehydrogenase, ATGL, adipose triglyceride lipase, Ppara, Peroxisome proliferator-activated receptor alpha, early B cell factor 2, Esrra, Lipid Droplets, Cell Biology, Ucp1, uncoupling protein 1, Mice, Inbred C57BL, BAT, brown adipose tissue, 030104 developmental biology, Cidea, cell death-inducing DNA fragmentation factor, alpha subunit-like effector A, BAs, brown adipocytes, Ppargc1a, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
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المؤلفون: Renate Schreiber, Raymond J. Owens, Monika Oberer, Roland Viertlmayr, Natalia Kulminskaya, Christoph Heier, Mariana Colaço-Gaspar, Rudolf Zechner, Peter Hofer, Robert Zimmermann, Claudia Radler
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Acylation, Gene Expression, Hormone-sensitive lipase, PNPLA, patatin-like phospholipase, Biochemistry, His6, hexahistidine tag, Mice, SMT3, small ubiquitin-like modifier, Transacylation, mATGL, mouse ATGL, Protein purification, Sf9 Cells, MAG, monoacylglycerol, CV, column volume, G0S2, NusA, transcription termination/antitermination protein, biology, Chemistry, Hydrolysis, ABHD5, Ni2+, nickel (II) ion, Recombinant Proteins, TRX, thioredoxin, MTBE, methyl tert-butyl ether, CGI-58, comparative gene identification-58, DGAT, diacylglycerol acyltransferase, NTA, nitrilotriacetic acid, HSL, hormone-sensitive lipase, Research Article, SEC, size-exclusion chromatography, LD, lipid droplet, TAG, triacylglycerol, MBP, maltose-binding protein, Spodoptera, TEV, tobacco etch virus, GST, glutathione-S-transferase, Animals, Humans, Lipase, Molecular Biology, PNPLA2, Diacylglycerol kinase, ATGL, adipose triglyceride lipase, CGI-58, OPPF, Oxford Protein Production Facility, FA, fatty acid, TCEP, Tris(2-carboxyethyl)phosphine, Cell Biology, HEK293T, human embryonic kidney 293T, Fusion protein, Monoacylglycerol lipase, ONC, overnight culture, HEK293 Cells, Adipose triglyceride lipase, lipolysis, biology.protein, BSA, bovine serum albumin, G0S2, G0/G1 switch gene 2, DAG, diacylglycerol
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المؤلفون: Hindrik Mulder
المصدر: Molecular Metabolism, Vol 6, Iss 9, Pp 1040-1051 (2017)
Molecular Metabolismمصطلحات موضوعية: 0301 basic medicine, endocrine system diseases, POLRMT, eQTL, Expression quantitative trait locus, medicine.medical_treatment, TEFM, Mitochondrial transcription elongation factor, Cell, Review, TFB1M, Transcription factor B1 mitochondrial, Disease, Mitochondrion, KATP, ATP-dependent K+-channel, POLRMT, Mitochondrial RNA polymerase, PPARγ, Peroxisome proliferator-activated receptor-γ, Insulin-Secreting Cells, Insulin, Genetics, ICDc, Cytosolic isocitrate dehydrogenase, Genome-wide association study (GWAS), Insulin secretion, OXPHOS, Oxidative phosphorylation, ATGL, adipocyte triglyceride lipase, Mitochondria, DNA-Binding Proteins, medicine.anatomical_structure, TCA, Tricarboxylic acid, Islets, PGC, Peroxisome proliferator-activated receptor-γ co-activator, Glycolysis, GWAS, Genome-wide association study, PRC, PGC1-related coactivator, β-Cell, TFB2M, Transcription factor B2 mitochondrial, lcsh:Internal medicine, TFAM, Transcription factor A mitochondrial, GSIS, Glucose-stimulated insulin secretion, SNP, Single Nucleotide Polymorphism, Biology, CYTB, Cytochrome b, SUR1, Sulphonylurea receptor-1, HSL, Hormone-sensitive lipase, MTERF, Mitochondrial transcription termination factor, Mitochondrial Proteins, COX, Cytochrome c oxidase, 03 medical and health sciences, NRF, Nuclear respiratory factor, medicine, Animals, Humans, Genetic Predisposition to Disease, Expression quantitative trait locus (eQTL), NSUN4, NOP2/Sun RNA methyltransferase family member 4, SENP1, Sentrin/SUMO-specific protease-1, lcsh:RC31-1245, GDH, Glutamate dehydrogenase, Molecular Biology, Transcription factor, TFB1M, ND, NADH dehydrogenase, nutritional and metabolic diseases, Methyltransferases, Cell Biology, TFAM, PDH, pyruvate dehydrogenase, Oxidative Stress, 030104 developmental biology, Diabetes Mellitus, Type 2, PC, Pyruvate carboxylase, POLγ, DNA polymerase-γ, ERR-α, Estrogen-related receptor-α, T2D, Type 2 Diabetes, AMPK, AMP-dependent protein kinase, Genome-Wide Association Study, Transcription Factors
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المؤلفون: Kristina M. Mueller, Frank Ruge, Doris Kaltenecker, Katrin Spirk, Florian Grebien, Anne Rupprecht, Richard Moriggl, Lukas Kenner, Elena E. Pohl, Marco Herling
المصدر: Mol. Metab. 40:101026 (2020)
Molecular Metabolism, Vol 40, Iss, Pp 101026-(2020)
Molecular Metabolismمصطلحات موضوعية: 0301 basic medicine, Male, Adipose tissue, White adipose tissue, JAK-STAT, Mice, 0302 clinical medicine, Adipose Tissue, Brown, HSL, hormone sensitive lipase, Brown adipose tissue, Adipocytes, STAT5 Transcription Factor, Mice, Knockout, Chemistry, qPCR, quantitative real-time PCR, JAK-STAT signaling pathway, WAT, white adipose tissue, Thermogenesis, Lipids, Thermogenin, Mitochondria, cAMP, cyclic adenosine monophosphate, STAT, signal transducer and activator of transcription, medicine.anatomical_structure, FCCP, carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone, H&E, haematoxylin and eosin, Female, JAK, Janus kinase, Temperature maintenance, medicine.medical_specialty, lcsh:Internal medicine, Adipose Tissue, White, Lipolysis, 030209 endocrinology & metabolism, Article, 03 medical and health sciences, β-adrenergic signalling, Internal medicine, Receptors, Adrenergic, beta, UCP1, uncoupling protein 1, medicine, NEFA, non-esterified fatty acids, Animals, ScWAT, subcutaneous WAT, Obesity, lcsh:RC31-1245, Molecular Biology, ATGL, adipose triglyceride lipase, Cold-Shock Response, FA, fatty acid, Cell Biology, EWAT, epididymal WAT, Lipid Metabolism, Jak-stat, Beta-adrenergic Signalling, Temperature Maintenance, GH, growth hormone, mtDNA, mitochondrial DNA, Mice, Inbred C57BL, BAT, brown adipose tissue, 030104 developmental biology, Endocrinology, STAT protein, PKA, protein kinase A, Energy Metabolism
وصف الملف: application/pdf
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المؤلفون: Jing Gao, Takahito Otani, Masato Hirata, Satoru Mukai, Tomoyo Kawakubo-Yasukochi, Ronghao Tang, Akiko Mizokami, Sakura Chishaki, Hiroshi Takeuchi, Eijiro Jimi, Takashi Kanematsu, Tomomi Sano, Miho Matsuda
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, eWAT, epididymal white adipose tissue, obesity, Adipose tissue, Hormone-sensitive lipase, HFS, high-fat and high-sucrose, Biochemistry, Receptors, G-Protein-Coupled, chemistry.chemical_compound, Mice, Adipocyte, Conditional gene knockout, Adipocytes, Insulin, RER, respiratory exchange ratio, GluOC, uncarboxylated form of osteocalcin, Mice, Knockout, NEFA, nonesterified fatty acid, Adipose Tissue, FoxO1, forkhead box O1, GTT, glucose tolerance test, HSL, hormone-sensitive lipase, adipose triglyceride lipase (ATGL), Research Article, medicine.medical_specialty, forkhead box O1 (FoxO1), Lipolysis, Osteocalcin, GPRC6A, adipocyte, 03 medical and health sciences, Internal medicine, 3T3-L1 Cells, medicine, Animals, Humans, db-cAMP, dibutyryl-cAMP, IRF4, interferon regulatory factor 4, Molecular Biology, Inflammation, PTT, pyruvate tolerance test, ATGL, adipose triglyceride lipase, 030102 biochemistry & molecular biology, PKI, protein kinase A inhibitor, Cell Biology, Lipase, Glucose Tolerance Test, 030104 developmental biology, Endocrinology, chemistry, G protein–coupled receptor, Adipose triglyceride lipase, PKA, protein kinase A, Adipocyte hypertrophy, Insulin Resistance
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المؤلفون: Gabriele Schoiswohl, Isabelle Strießnig-Bina, Gerald Hoefler, Zhiyuan Tang, Hao Xie, Rudolf Zechner, Martina Schweiger, Paul Vesely, Benedikt Kien, Christoph Heier, Veronika Sexl
المصدر: Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids
مصطلحات موضوعية: 0301 basic medicine, IHC, Immunohistochemistry, WAT, White adipose tissue, Proliferation, Mice, 0302 clinical medicine, Neoplasms, NSCLC, Non-small-cell lung carcinoma, shRNA, small hairpin RNA, Cancer, Gene knockdown, BM, Bone marrow, ATGL, Adipose triglyceride lipase, Chemistry, TOR Serine-Threonine Kinases, MEF, Mouse embryonic fibroblasts, DG, Diglyceride, Lipid, Cell biology, SVF, Stroma vascular fractions, 030220 oncology & carcinogenesis, H&E, Haematoxylin/eosin, MGL, Monoacylglycerol lipase, Intracellular, Signal Transduction, Cell signaling, Lipolysis, PBS, Phosphate buffered saline, CGI-58, Comparative gene identification-58, Article, Cell Line, HSL, Hormone-sensitive lipase, TG, Triglyceride, 03 medical and health sciences, ATGL, DMSO, Dimethylsulfoxid, Animals, Humans, FAO, Fatty acid oxidation, Molecular Biology, CD31, Cluster of differentiation 31, Cell Proliferation, Cell growth, Adenylate Kinase, mTOR, Mammalian target of rapamycin, Cell Biology, Lipase, Fibroblasts, Embryonic stem cell, OCR, Oxygen consumption rate, PCNA, Proliferating cell nuclear antigen, MG, Monoglyceride, 030104 developmental biology, FA, Fatty acid, Cancer cell, Adipose triglyceride lipase, AMPK, AMP activated protein kinase, ABHD6, Alpha/beta-hydrolase domain containing 6, G0S2, G0/G1 switch gene 2, HIG2, Hypoxia-inducible gene 2, ROS, Reactive oxygen species
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المؤلفون: Andreas M. Fritzen, Jørgen F. P. Wojtaszewski, Erik A. Richter, Bente Kiens, Anne-Marie Lundsgaard, Kim A. Sjøberg, Lise Madsen, Lene Secher Myrmel
المصدر: Molecular Metabolism
Lundsgaard, A, Fritzen, A M, Sjøberg, K A, Myrmel, L S, Madsen, L, Wojtaszewski, J, Richter, E A & Kiens, B 2017, ' Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates ', Molecular Metabolism, vol. 6, no. 1, pp. 22-29 . https://doi.org/10.1016/j.molmet.2016.11.001
Molecular Metabolism, Vol 6, Iss 1, Pp 22-29 (2017)مصطلحات موضوعية: Male, 0301 basic medicine, Low protein, BMI, body mass index, FGF21, fibroblast growth factor 21, BM, body mass, FGF21, HSL, hormone sensitive lipase, Faculty of Science, Insulin, chemistry.chemical_classification, FAT, fat-rich diet, AMPK, AMP-activated kinase, biology, TG, triacylglycerol, Liver, Lipogenesis, Dietary Proteins, Dietary Carbohydrates, Adult, lcsh:Internal medicine, medicine.medical_specialty, CON, control diet, Lipolysis, Carbohydrates, Brief Communication, LM, leg mass, VO2peak, maximal oxygen consumption, 03 medical and health sciences, VLDL, very low density lipoprotein, Internal medicine, medicine, Humans, CHO, carbohydrate-rich diet, lcsh:RC31-1245, Carbohydrate-responsive element-binding protein, Molecular Biology, Ra, rate of appearance, ATGL, adipose triglyceride lipase, GLUT4, glucose transporter 4, FA, fatty acid, Fatty acid, Cell Biology, Carbohydrate, Dietary Fats, BCA, bicinchoninic acid, Diet, Fibroblast Growth Factors, Glucose, 030104 developmental biology, Endocrinology, chemistry, biology.protein, PKA, protein kinase A, ChREBP, carbohydrate-responsive element binding protein, Energy Intake, Energy Metabolism, GLUT4
وصف الملف: application/pdf
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المؤلفون: Alexander M. Farberg, Whitney K. Hart, R. Jeremy Johnson
المصدر: Biochemistry and Biophysics Reports
مصطلحات موضوعية: 0301 basic medicine, Substrate specificity, 030106 microbiology, Biophysics, Virulence, Biology, DSF, differential scanning fluorimetry, Biochemistry, KEGG, Kyoto Encyclopedia of Genes and Genomes, Fluorogenic substrates, Microbiology, Conserved sequence, Tularemia, 03 medical and health sciences, HSL, hormone sensitive lipase, Catalytic triad, medicine, PDB, protein data bank, Francisella tularensis, chemistry.chemical_classification, Serine hydrolase, MWCO, molecular weight cut-off, medicine.disease, biology.organism_classification, LB, Luria-Bertani broth, FTT0941c, virulence associated serine hydrolase from Francisella tularensis, 030104 developmental biology, Enzyme, Ni-NTA, nickel-nitrilotriacetic acid, chemistry, Francisella, Research Article