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1
المؤلفون: James S. Scott, Darren Stead, Bernard Barlaam, Jason Breed, Rodrigo J. Carbajo, Elisabetta Chiarparin, Natalie Cureton, Paul R. J. Davey, David I. Fisher, Eric T. Gangl, Tyler Grebe, Ryan D. Greenwood, Sudhir Hande, Holia Hatoum-Mokdad, Samantha J. Hughes, Thomas A. Hunt, Tony Johnson, Stefan L. Kavanagh, Teresa C. M. Klinowska, Carrie J. B. Larner, Mandy Lawson, Andrew S. Lister, David Longmire, Stacey Marden, Thomas M. McGuire, Caroline McMillan, Lindsay McMurray, Christopher J. Morrow, J. Willem M. Nissink, Thomas A. Moss, Daniel H. O’Donovan, Radoslaw Polanski, Stephen Stokes, Kumar Thakur, Dawn Trueman, Caroline Truman, Michael J. Tucker, Haixia Wang, Nicky Whalley, Dedong Wu, Ye Wu, Bin Yang, Wenzhan Yang
المصدر: Journal of Medicinal Chemistry. 66:2918-2945
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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2
المؤلفون: Michael J. Tucker, Thomas A. Moss, James S. Scott, Barlaam Bernard Christophe, Paul R. J. Davey, Ryan Greenwood, Stephen Stokes, Gary Fairley, Radoslaw Polanski, Holia Hatoum-Mokdad, David Longmire, Eric Gangl, Bin Yang, Andrew Lister, Jeffrey G. Varnes
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Chemistry, Organic Chemistry, Drug Discovery, Advanced stage, Lipophilicity, Late stage, Fluorine, Surface modification, chemistry.chemical_element, Biochemistry, Combinatorial chemistry
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3
المؤلفون: Haixia Wang, Lakshmaiah Gingipalli, Bo Peng, Xiaolan Zheng, Jeffrey Boerth, Ye Wu, Sharon Tentarelli, Ariamala Gopalsamy, Scott D. Edmondson, Li Sha, Tyler Grebe, David Emmons, Holia Hatoum-Mokdad
المصدر: Organic Letters. 22:3418-3422
مصطلحات موضوعية: Decarboxylation, Chemistry, Radical, Organic Chemistry, Photoredox catalysis, Electron, Physical and Theoretical Chemistry, Bond formation, Biochemistry, Medicinal chemistry, Catalysis, Conjugate
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4
المؤلفون: Haixia Wang, Stefan Kavanagh, Radoslaw Polanski, Eric Gangl, Michael J. Tucker, Jason Breed, Thomas Anthony Hunt, Paul R. J. Davey, Mandy Lawson, Darren Stead, Oona Delpuech, Ye Wu, J. Willem M. Nissink, Barlaam Bernard Christophe, Dedong Wu, Sudhir M. Hande, Amber Balazs, Dermot F. McGinnity, Wenzhan Yang, Thomas A. Moss, Bin Yang, Sladjana Gagrica, Kumar Thakur, Stacey Marden, Tyler Grebe, Daniel Hillebrand O'donovan, Teresa Klinowska, Samantha Jayne Hughes, Kara Herlihy, David I Fisher, Stephen Stokes, Holia Hatoum-Mokdad, Tony Johnson, James S. Scott, Elisabetta Chiarparin, Bo Peng, Sophie L. M. Janbon, Scott Throner, Ryan Greenwood, David Matthew Wilson, Andrew Lister, Stephen Fawell, Hoan Huynh, Jeffrey G. Varnes, Christopher J. Morrow, Rodrigo J. Carbajo
المصدر: Journal of medicinal chemistry. 63(23)
مصطلحات موضوعية: Selective Estrogen Receptor Modulators, Estrogen receptor, Administration, Oral, Biological Availability, Antineoplastic Agents, Breast Neoplasms, Pharmacology, Crystallography, X-Ray, 01 natural sciences, 03 medical and health sciences, Structure-Activity Relationship, In vivo, Oral administration, Cell Line, Tumor, Drug Discovery, medicine, Structure–activity relationship, Humans, 030304 developmental biology, Cell Proliferation, 0303 health sciences, Fulvestrant, Molecular Structure, Chemistry, Drug discovery, Antagonist, Lipids, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Cyclization, Lipophilicity, Molecular Medicine, Female, medicine.drug
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5
المؤلفون: Lakshmaiah, Gingipalli, Jeffrey, Boerth, David, Emmons, Tyler, Grebe, Holia, Hatoum-Mokdad, Bo, Peng, Li, Sha, Sharon, Tentarelli, Haixia, Wang, Ye, Wu, XiaoLan, Zheng, Scott, Edmondson, Ariamala, Gopalsamy
المصدر: Organic letters. 22(9)
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6
المؤلفون: Jacques Dumas, Laszlo L. Musza, Holia Hatoum-Mokdad, Robert Schoenleber, William Stirtan, William Carley, Robert Sibley, Hong Xiao, Diana Marrero
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:1919-1922
مصطلحات موضوعية: Agonist, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Subtype selectivity, Pharmaceutical Science, Estrogen receptor, Alkenes, Ligands, Biochemistry, Inhibitory Concentration 50, Cell Line, Tumor, Presenilin-2, Drug Discovery, Functional selectivity, medicine, Humans, Receptor, Molecular Biology, chemistry.chemical_classification, Estradiol, Bicyclic molecule, Chemistry, Ligand, Raloxifene Hydrochloride, Organic Chemistry, Membrane Proteins, General Medicine, Bridged Bicyclo Compounds, Heterocyclic, Ligand (biochemistry), In vitro, Receptors, Estrogen, Molecular Medicine, Template based, Bridged compounds, hormones, hormone substitutes, and hormone antagonists
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7
المؤلفون: David E. Ehmann, Mark Zambrowski, Adam B. Shapiro, Pratik R. Bhagunde, Beesan Tan, Kerry E. Murphy-Benenato, Li Sha, Olga Quiroga, Vincent Galullo, Hajnalka E. Davis, M. R. Manjunatha, Holia Hatoum-Mokdad, Mark Sylvester, Aryun Kim, Haris Jahic, Shannon X. Zhao, Ye Wu, April Chen, Andy S. Tsai, Jennifer J. Harris, Sara A. Patey, Michael T. Rooney, Erika L. Manyak, Thomas F. Durand-Reville, Maria Uria-Nickelsen, John P. Mueller
المصدر: Journal of medicinal chemistry. 58(5)
مصطلحات موضوعية: Male, Siderophore, Siderophores, Pharmacology, medicine.disease_cause, beta-Lactamases, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Potency, Structure–activity relationship, Animals, Humans, Pseudomonas Infections, Rats, Wistar, Chemistry, Pseudomonas aeruginosa, Drug discovery, In vitro, Anti-Bacterial Agents, Rats, Free fraction, Molecular Medicine, Monobactams
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8
المؤلفون: Robert Sibley, Dixon Brian R, David R. Brittelli, Gerhard Konig, Stephen K.-F. Wong, Jinshan Chen, Jacques Dumas, James A. Witowsky, Holia Hatoum-Mokdad
المصدر: Bioorganic & Medicinal Chemistry Letters. 9:2531-2536
مصطلحات موضوعية: medicine.drug_class, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Cathepsin D, Carboxamide, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Drug Discovery, medicine, Humans, Protease Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Small molecule, In vitro, Enzyme, Liver, Enzyme inhibitor, biology.protein, Molecular Medicine
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9
المؤلفون: Jacques Dumas, Romulo Romero, Roger A. Smith, Ajay Bhargava, Jinshan Chen, Christopher Browe, Holia Hatoum-Mokdad
المصدر: Bioorganicmedicinal chemistry letters. 11(22)
مصطلحات موضوعية: medicine.drug_class, Peptidomimetic, Stereochemistry, Clinical Biochemistry, Cathepsin K, Pharmaceutical Science, Carboxamide, Cysteine Proteinase Inhibitors, Biochemistry, Chemical synthesis, Aminoketone, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Molecular Biology, chemistry.chemical_classification, biology, Organic Chemistry, Molecular Mimicry, Ketones, Cathepsins, Kinetics, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine
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10
المؤلفون: Gerald Ranges, Catherine Brennan, Bernd Riedl, Tiffany Turner, Timothy B. Lowinger, Timothy J Housley, William J. Scott, Scott Wilhelm, Jacques Dumas, Monahan Mary-Katherine, Holia Hatoum-Mokdad, Alka Shrikhande, Ajay Bhargava, Robert Schoenleber, Jeffrey Johnson, Robert Sibley, Reina Natero
المصدر: Bioorganicmedicinal chemistry letters. 10(18)
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, p38 Mitogen-Activated Protein Kinases, Inhibitory Concentration 50, Structure-Activity Relationship, Heterocyclic Compounds, Drug Discovery, Hydrocarbons, Chlorinated, Structure–activity relationship, Combinatorial Chemistry Techniques, Humans, Urea, Enzyme Inhibitors, Protein kinase A, Molecular Biology, IC50, chemistry.chemical_classification, biology, Chemistry, Phenylurea Compounds, Organic Chemistry, Enzyme, Solubility, Enzyme inhibitor, Mitogen-activated protein kinase, Antirheumatic Agents, biology.protein, Molecular Medicine, Osteoporosis, Pyrazoles, Signal transduction, Mitogen-Activated Protein Kinases