المؤلفون: Lallo, Alice, Frese, Kristopher K, Morrow, Christopher, Szczepaniak Sloane, Robert, Gulati, Sakshi, Schenk, Maximilian W, Trapani, Francesca, Simms, Nicole, Galvin, Melanie, Brown, Stewart, Hodgkinson, Cassandra L, Priest, Lynsey, Hughes, Adina M, Lai, Zhongwu, Cadogan, Elaine B, Khandelwal, Garima, Simpson, Kathryn L, Miller, Crispin, Blackhall, Fiona H, O'Connor, Mark J, Dive, Caroline

المصدر: Lallo , A , Frese , K K , Morrow , C , Szczepaniak Sloane , R , Gulati , S , Schenk , M W , Trapani , F , Simms , N , Galvin , M , Brown , S , Hodgkinson , C L , Priest , L , Hughes , A M , Lai , Z , Cadogan , E B , Khandelwal , G , Simpson , K L , Miller , C , Blackhall , F H , O'Connor , M J & Dive , C 2018 , ' The combination of the ....

مصطلحات موضوعية: ResearchInstitutes_Networks_Beacons/mcrc, name=Manchester Cancer Research Centre

وصف الملف: application/pdf

Relation: https://research.manchester.ac.uk/en/publications/e9ade359-281d-49a0-af44-295224644b8e

الاتاحة: https://research.manchester.ac.uk/en/publications/e9ade359-281d-49a0-af44-295224644b8e
https://doi.org/10.1158/1078-0432.CCR-17-2805
https://pure.manchester.ac.uk/ws/files/75751836/1078_0432.CCR_17_2805.full.pdf
http://www.scopus.com/inward/record.url?scp=85052487038&partnerID=8YFLogxK

المؤلفون: Testoni, Ewelina, Stephenson, Natalie L, Torres-Ayuso, Pedro, Marusiak, Anna A, Trotter, Eleanor W, Hudson, Andrew, Hodgkinson, Cassandra L, Morrow, Christopher J, Dive, Caroline, Brognard, John

المصدر: Testoni , E , Stephenson , N L , Torres-Ayuso , P , Marusiak , A A , Trotter , E W , Hudson , A , Hodgkinson , C L , Morrow , C J , Dive , C & Brognard , J 2016 , ' Somatically mutated ABL1 is an actionable and essential NSCLC survival gene ' , EMBO Molecular Medicine , vol. 8 , no. 2 , pp. 105-16 . https://doi.org/10.15252/emmm.201505456

مصطلحات موضوعية: Animals, Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Cell Survival, Disease Models, Animal, Heterografts, Humans, Imatinib Mesylate, Mice, Mutant Proteins, Proto-Oncogene Proteins c-abl, Treatment Outcome, Journal Article, Research Support, Non-U.S. Gov't, ResearchInstitutes_Networks_Beacons/mcrc, Manchester Cancer Research Centre

الاتاحة: https://research.manchester.ac.uk/en/publications/8d0c2ee3-150f-4659-97b2-622d2ff2c056
https://doi.org/10.15252/emmm.201505456

المؤلفون: Greystoke, Alastair, Ayub, Mahmood, Rothwell, Dominic G., Morris, Dan, Burt, Deborah, Hodgkinson, Cassandra L., Morrow, Christopher J., Smith, Nigel, Aung, Kyaw, Valle, Juan, Carter, Louise, Blackhall, Fiona, Dive, Caroline, Brady, Ged

المساهمون: CR-UK Molecular Biology Core Facilities, Clinical and Experimental Pharmacology Group, CR-UK Manchester Institute

المصدر: Molecular Oncology ; volume 10, issue 2, page 282-291 ; ISSN 1574-7891 1878-0261

الاتاحة: http://dx.doi.org/10.1016/j.molonc.2015.10.004
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2Fj.molonc.2015.10.004
http://api.elsevier.com/content/article/PII:S1574789115001805?httpAccept=text/xml
http://api.elsevier.com/content/article/PII:S1574789115001805?httpAccept=text/plain
https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/j.molonc.2015.10.004

المؤلفون: Carter, Louise, Rothwell, Dominic G, Mesquita, Barbara, Smowton, Christopher, Leong, Hui Sun, Fernandez-Gutierrez, Fabiola, Li, Yaoyong, Burt, Deborah J, Antonello, Jenny, Morrow, Christopher J, Hodgkinson, Cassandra L, Morris, Karen, Priest, Lynsey, Carter, Mathew, Miller, Crispin, Hughes, Andrew, Blackhall, Fiona, Dive, Caroline, Brady, Ged

Relation: Carter, L. et al. (2017) Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer. Nature Medicine , 23(1), pp. 114-119. (doi:10.1038/nm.4239 ) (PMID:27869802)

الاتاحة: http://eprints.gla.ac.uk/214520/

المؤلفون: Simpson, Kathryn L, Trapani, Francesca, Metcalf, Robert, Polański, Radosław, Williamson, Stuart, Seftor, R, Seftor, E, Fusi, Alberto, Hodgkinson, Cassandra L, Nonaka, Daisuke, Morrow, Christopher J, Hendrix, Mary J C, Blackhall, Fiona H, Dive, Caroline

المساهمون: Clinical & Experimental Pharmacology Group, CRUK Manchester Institute, Manchester

Relation: Vasculogenic Mimicry in Small Cell Lung Cancer. 2015, 10(9): S222-S222 JTO; http://hdl.handle.net/10541/606625; Journal of Thoracic Oncology

الاتاحة: http://hdl.handle.net/10541/606625

المؤلفون: Carter, Louise, Rothwell, Dominic G, Mesquita, Barbara, Smowton, Christopher, Leong, Hui Sun, Fernandez-Gutierrez, Fabiola, Li, Yaoyong, Burt, Deborah J, Antonello, Jenny, Morrow, Christopher J, Hodgkinson, Cassandra L, Morris, Karen, Priest, Lynsey, Carter, Mathew, Miller, Crispin J, Hughes, A, Blackhall, Fiona H, Dive, Caroline, Brady, Ged

المساهمون: Clinical and Experimental Pharmacology Group, CRUK Manchester Institute, University of Manchester, Manchester, UK

Relation: Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer. 2016 Nat Med; http://hdl.handle.net/10541/620031; Nature Medicine

الاتاحة: http://hdl.handle.net/10541/620031
https://doi.org/10.1038/nm.4239

المؤلفون: Potter, Danielle S, Galvin, Melanie, Brown, Stewart, Lallo, Alice, Hodgkinson, Cassandra L, Blackhall, Fiona H, Morrow, Christopher J, Dive, Caroline

المساهمون: Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester

Relation: Inhibition of PI3K/BMX cell survival pathway sensitizes to BH3 mimetics in SCLC. 2016, 15 (6):1248-60 Mol Cancer Ther; http://hdl.handle.net/10541/614579; Molecular Cancer Therapeutics

الاتاحة: http://hdl.handle.net/10541/614579
https://doi.org/10.1158/1535-7163.MCT-15-0885

المؤلفون: Morrow, Christopher J, Trapani, Francesca, Metcalf, Robert, Bertolini, G, Hodgkinson, Cassandra L, Khandelwal, Garima, Kelly, Paul, Galvin, Melanie, Carter, Louise, Simpson, Kathryn L, Williamson, Stuart, Wirth, Christopher, Simms, Nicole, Franklin, Lynsey, Frese, Kristopher K, Rothwell, Dominic G, Nonaka, Daisuke, Miller, Crispin J, Brady, Ged, Blackhall, Fiona H, Dive, Caroline

المساهمون: Clinical and Experimental Pharmacology Group, University of Manchester, Manchester

Relation: Tumourigenic Non-Small Cell Lung Cancer Mesenchymal Circulating Tumour Cells - A Clinical Case Study. 2016: Ann Oncol; http://hdl.handle.net/10541/605256; Annals of Oncology

الاتاحة: http://hdl.handle.net/10541/605256
https://doi.org/10.1093/annonc/mdw122

المؤلفون: Morrow, Christopher J., Hodgkinson, Cassandra L., Li, Yaoyong, Metcalf, Robert, Rothwell, Dominic, Trapani, Francesca, Polanski, Radoslaw, Burt, Debbie, Simpson, Kathryn, Morris, Karen, Pepper, Stuart, Nonaka, Daisuke, Greystole, Alastair, Kelly, Paul, Krebs, Matthew, Antonello, Jenny, Ayub, Mahmood, Faulkner, Suzanne, Priest, Lynsey, Carter, Louise, Tate, Catriona, Miller, Crispin J., Blackhall, Fiona, Brady, Ged, Dive, Caroline

المصدر: Morrow , C J , Hodgkinson , C L , Li , Y , Metcalf , R , Rothwell , D , Trapani , F , Polanski , R , Burt , D , Simpson , K , Morris , K , Pepper , S , Nonaka , D , Greystole , A , Kelly , P , Krebs , M , Antonello , J , Ayub , M , Faulkner , S , Priest , L , Carter , L , Tate , C , Miller , C J , Blackhall , F , Brady , G & ....

مصطلحات موضوعية: ResearchInstitutes_Networks_Beacons/mcrc, name=Manchester Cancer Research Centre

Relation: https://research.manchester.ac.uk/en/publications/e16b90ea-82bb-4f51-9c30-597e9d979149

الاتاحة: https://research.manchester.ac.uk/en/publications/e16b90ea-82bb-4f51-9c30-597e9d979149
https://doi.org/10.1158/1538-7445.AM2014-3060

المؤلفون: Linnik, Inna V, Scott, Marietta L J, Holliday, Katherine F, Woodhouse, Neil, Waterton, John C, O'Connor, James P B, Barjat, Hervé, Liess, Carsten, Ulloa, Jose, Young, Helen, Dive, Caroline, Hodgkinson, Cassandra L, Ward, Tim, Roberts, Darren, Mills, Samantha J, Thompson, Gerard, Buonaccorsi, Giovanni A, Cheung, Susan, Jackson, Alan, Naish, Josephine H, Parker, Geoff J M

المصدر: Linnik , I V , Scott , M L J , Holliday , K F , Woodhouse , N , Waterton , J C , O'Connor , J P B , Barjat , H , Liess , C , Ulloa , J , Young , H , Dive , C , Hodgkinson , C L , Ward , T , Roberts , D , Mills , S J , Thompson , G , Buonaccorsi , G A , Cheung , S , Jackson , A , Naish , J H & Parker , G J M 2014 , ' ....

مصطلحات موضوعية: hypoxia, magnetic resonance imaging, oxygen-enhanced MRI, oxygenation, ResearchInstitutes_Networks_Beacons/mcrc, name=Manchester Cancer Research Centre

Relation: https://research.manchester.ac.uk/en/publications/ccbcc63e-d9be-4b01-80b9-02e1c9174a54

الاتاحة: https://research.manchester.ac.uk/en/publications/ccbcc63e-d9be-4b01-80b9-02e1c9174a54
https://doi.org/10.1002/mrm.24826
http://www.interscience.wiley.com/jpages/0740-3194

المؤلفون: Polański, Radosław, Hodgkinson, Cassandra L, Fusi, Alberto, Nonaka, Daisuke, Priest, Lynsey, Kelly, Paul, Trapani, Francesca, Bishop, Paul W, White, Anne, Critchlow, Susan E, Smith, Paul D, Blackhall, Fiona, Dive, Caroline, Morrow, Christopher J

المصدر: Polański , R , Hodgkinson , C L , Fusi , A , Nonaka , D , Priest , L , Kelly , P , Trapani , F , Bishop , P W , White , A , Critchlow , S E , Smith , P D , Blackhall , F , Dive , C & Morrow , C J 2014 , ' Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer. ' , Clinical cancer research : an official journal of the American Association for Cancer Research , vol. 20 , no. 4 , ....

الاتاحة: https://research.manchester.ac.uk/en/publications/31385279-b534-4f7e-a117-4fed1a847270
https://doi.org/10.1158/1078-0432.CCR-13-2270
http://clincancerres.aacrjournals.org/content/20/4/926.full.pdf+html

المؤلفون: Hodgkinson, Cassandra L, Morrow, Christopher J, Li, Yaoyong, Metcalf, Robert L, Rothwell, Dominic G, Trapani, Francesca, Polanski, Radoslaw, Burt, Deborah J, Simpson, Kathryn L, Morris, Karen, Pepper, Stuart D, Nonaka, Daisuke, Greystoke, Alastair, Kelly, Paul, Bola, Becky, Krebs, Matthew G, Antonello, Jenny, Ayub, Mahmood, Faulkner, Suzanne, Priest, Lynsey, Carter, Louise, Tate, Catriona, Miller, Crispin J., Blackhall, Fiona, Brady, Ged, Dive, Caroline

Relation: Hodgkinson, C. L. et al. (2014) Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer. Nature Medicine , 20(8), pp. 897-903. (doi:10.1038/nm.3600 ) (PMID:24880617)

الاتاحة: http://eprints.gla.ac.uk/214527/

المؤلفون: Cawthorne, C, Burrows, N, Gieling, R, Morrow, Christopher J, Forster, D, Gregory, J, Radigois, M, Smigova, A, Babur, M, Simpson, Kathryn L, Hodgkinson, Cassandra L, Brown, G, McMahon, A, Dive, Caroline, Hiscock, D, Wilson, I, Williams, K

المساهمون: Wolfson Molecular Imaging Centre, School of Cancer and Enabling Sciences, The University of Manchester, Manchester, United Kingdom. C.Cawthorne@hull.ac.uk

Relation: [18F]-FLT positron emission tomography can be used to image the response of sensitive tumors to PI3-kinase inhibition with the novel agent GDC-0941 2013, 12 (5):819 Mol Cancer Ther; http://hdl.handle.net/10541/297407; Molecular Cancer Therapeutics

الاتاحة: http://hdl.handle.net/10541/297407
https://doi.org/10.1158/1535-7163.MCT-12-0905

المؤلفون: Simpson, Kathryn L, Cawthorne, C, Zhou, Cong, Hodgkinson, Cassandra L, Walker, Michael J, Trapani, F, Kadirvel, M, Brown, G, Dawson, M J, Macfarlane, M, Williams, K J, Whetton, Anthony D, Dive, Caroline

المساهمون: Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, University of Manchester and Manchester Cancer Research Centre, Wilmslow Road, Withington, Manchester, UK.

Relation: A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers. 2013, 4:e613 Cell Death Dis; http://hdl.handle.net/10541/293990; Cell Death & Disease

الاتاحة: http://hdl.handle.net/10541/293990
https://doi.org/10.1038/cddis.2013.137

المؤلفون: Hitchman, Elizabeth R, Hodgkinson, Cassandra L, Roberts, Darren L, Ashton, Garry, Yunus, Zaira, Byers, R, Ward, Timothy H, Womack, Chris, Dive, Caroline

المساهمون: Paterson Institute for Cancer Research, Wilmslow Road, Manchester

مصطلحات موضوعية: Animals, Fixatives, Formaldehyde, Humans, Immunohistochemistry, Ki-67 Antigen, Mice, Neoplasms, Staining and Labeling, Tissue Fixation, Transplantation, Heterologous, Tumor Markers, Biological

Relation: Effect of prolonged formalin fixation on immunohistochemical staining for the proliferation marker Ki67. 2011, 59 (6):1261-3 Histopathology; http://hdl.handle.net/10541/231131; Histopathology

الاتاحة: http://hdl.handle.net/10541/231131
https://doi.org/10.1111/j.1365-2559.2011.03974.x

المؤلفون: Harrison, Luke R, Micha, Dimitra, Brandenburg, Martin, Simpson, Kathryn L, Morrow, Christopher J, Denneny, Olive, Hodgkinson, Cassandra L, Yunus, Zaira, Dempsey, Clare E, Roberts, Darren L, Blackhall, Fiona H, Makin, Guy W J, Dive, Caroline

المساهمون: Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom.

مصطلحات موضوعية: Animals, Anoxia, Apoptosis, Biphenyl Compounds, Cell Line, Tumor, Down-Regulation, Drug Resistance, Neoplasm, Drug Screening Assays, Antitumor, Humans, Inhibitory Concentration 50, Male, Mice, Neoplasm Transplantation, Neoplasms, Nitrophenols, Peptide Fragments, Piperazines, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, Sulfonamides

Relation: Hypoxic human cancer cells are sensitized to BH-3 mimetic–induced apoptosis via downregulation of the Bcl-2 protein Mcl-1. 2011, 121 (3):1075-87 J. Clin. Invest.; http://hdl.handle.net/10541/204710; Journal of Clinical Investigation

الاتاحة: http://hdl.handle.net/10541/204710
https://doi.org/10.1172/JCI43505

المؤلفون: Cole, Claire L, Lau, Sin, Backen, Alison C, Clamp, Andrew R, Rushton, Graham, Dive, Caroline, Hodgkinson, Cassandra L, McVey, Rhona J, Kitchener, Henry C, Jayson, Gordon C

المساهمون: Cancer Research UK and University of Manchester Dept. Translational Angiogenesis, Paterson Institute, Withington, Manchester, UK. ccole@picr.man.ac.uk.

مصطلحات موضوعية: Ovarian Cancer

Relation: Inhibition of FGFR2 and FGFR1 increases cisplatin sensitivity in ovarian cancer. 2010, 10 (5):notCancer Biol Ther; http://hdl.handle.net/10541/111178; Cancer Biology & Therapy

الاتاحة: http://hdl.handle.net/10541/111178
https://doi.org/10.4161/cbt.10.5.12585

المؤلفون: Martin-Fernandez, Cristina, Bales, Juliana, Hodgkinson, Cassandra L, Welman, Arkadiusz, Welham, Melanie J, Dive, Caroline, Morrow, Christopher J

المساهمون: Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom

مصطلحات موضوعية: Colorectal Cancer, Protein Kinases, Treatment Outcome

Relation: Blocking phosphoinositide 3-kinase activity in colorectal cancer cells reduces proliferation but does not increase apoptosis alone or in combination with cytotoxic drugs. 2009, 7(6): 955-965 Mol Cancer Res; http://hdl.handle.net/10541/85257; Molecular Cancer Research

الاتاحة: http://hdl.handle.net/10541/85257
https://doi.org/10.1158/1541-7786.MCR-08-0445

المؤلفون: Olofsson, M Hägg, Cummings, Jeffrey, Fayad, W, Brnjic, S, Herrmann, R, Berndtsson, M, Hodgkinson, Cassandra L, Dean, Emma J, Odedra, Rajesh, Wilkinson, Robert W, Mundt, Kirsten E, Busk, M, Dive, Caroline, Linder, S

المساهمون: Cancer Center Karolinska, Department of Oncology and Pathology, Karolinska Institute and Hospital, Stockholm, Sweden.

مصطلحات موضوعية: Cell Line Tumours, Colonic Cancer, Head and Neck Cancer, Experimental Cancer, Biological Tumour Markers, Amino Acid Sequence, Animals, Antineoplastic Agents, Apoptosis, Caspases, Cell Line, Tumor, Colonic Neoplasms, Doxorubicin, Enzyme-Linked Immunosorbent Assay, HT29 Cells, Head and Neck Neoplasms, Humans, Immunohistochemistry, Keratin-18, Male, Mice, SCID, Neoplasms, Experimental, Peptide Fragments, Rats, Nude, Tumor Markers, Biological

Relation: Specific demonstration of drug-induced tumour cell apoptosis in human xenografts models using a plasma biomarker. 2009, 5 (3):117-25 Cancer Biomark; http://hdl.handle.net/10541/85221; Cancer Biomarkers

الاتاحة: http://hdl.handle.net/10541/85221
https://doi.org/10.3233/CBM-2009-0597

المؤلفون: Cummings, Jeffrey, Hodgkinson, Cassandra L, Odedra, Rajesh, Sini, Patrizia, Heaton, Simon P, Mundt, Kirsten E, Ward, Timothy H, Wilkinson, Robert W, Growcott, Jim, Hughes, Andrew, Dive, Caroline

المساهمون: Clinical and Experimental Pharmacology, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK. jcummings@picr.man.ac.uk

مصطلحات موضوعية: Cancer, Tumour Markers, Experimental Cancer, Animals, Antineoplastic Agents, Apoptosis, Enzyme-Linked Immunosorbent Assay, Keratin-18, Male, Neoplasms, Experimental, Phosphoric Acid Esters, Quinazolines, Rats, Nude, Tumor Markers, Biological

Relation: Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity. 2008, 7 (3):455-63 Mol. Cancer Ther.; http://hdl.handle.net/10541/67993; Molecular Cancer Therapeutics

الاتاحة: http://hdl.handle.net/10541/67993
https://doi.org/10.1158/1535-7163.MCT-07-2136