المؤلفون: Daura, Eduard, Tegelberg, Saara, Hakala, Paula, Lehesjoki, Anna-Elina, Joensuu, Tarja

المساهمون: Medicum, Faculty of Medicine, Tutkimusryhmä Anna-Elina Lehesjoki, Department of Medical and Clinical Genetics, University of Helsinki, Research Programs Unit

مصطلحات موضوعية: Epm1, H3cs1, Brain development, cathepsin L, cystatin B, histone H3, Histone cleavage, Senescence, Neurosciences, Neurology and psychiatry

وصف الملف: application/pdf

Relation: Daura , E , Tegelberg , S , Hakala , P , Lehesjoki , A-E & Joensuu , T 2022 , ' Cystatin B deficiency results in sustained histone H3 tail cleavage in postnatal mouse brain mediated by increased chromatin-associated cathepsin L activity ' , Frontiers in Molecular Neuroscience , vol. 15 , 1069122 . https://doi.org/10.3389/fnmol.2022.1069122; ORCID: /0000-0001-5682-4787/work/125976594; http://hdl.handle.net/10138/352443; 477c6fda-5858-4903-b9d5-67a2041c3537; 000896917700001

الاتاحة: http://hdl.handle.net/10138/352443

المؤلفون: Eduard Daura, Saara Tegelberg, Paula Hakala, Anna-Elina Lehesjoki, Tarja Joensuu

المصدر: Frontiers in Molecular Neuroscience, Vol 15 (2022)

مصطلحات موضوعية: cystatin B, cathepsin L, EPM1, brain development, histone cleavage, H3cs1, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnmol.2022.1069122/full; https://doaj.org/toc/1662-5099

URL الوصول: https://doaj.org/article/bb9e8c239ab84227a67f4b49aa9c7288

المؤلفون: Daura, Eduard, Tegelberg, Saara, Yoshihara, Masahito, Jackson, Christopher, Simonetti, Francesca, Aksentjeff, Katri, Ezer, Sini, Hakala, Paula, Katayama, Shintaro, Kere, Juha, Lehesjoki, Anna-Elina, Joensuu, Tarja

المساهمون: Faculty of Medicine, Medicum, Department of Medical and Clinical Genetics, Tutkimusryhmä Anna-Elina Lehesjoki, Department of Biochemistry and Developmental Biology, Clinicum, Research Programs Unit, STEMM - Stem Cells and Metabolism Research Program, Juha Kere / Principal Investigator

مصطلحات موضوعية: Cystatin B, Histone clipping, Histone cleavage, Cathepsin, Neural differentiation, Progressive myoclonus epilepsy, EPIGENETIC REGULATORY MECHANISM, NEURAL STEM-CELLS, CATHEPSIN-L, MICROGLIAL ACTIVATION, CSTB(-/-) MOUSE, NEURONAL LOSS, DIFFERENTIATION, MUTATIONS, PROTEIN, Neurosciences

وصف الملف: application/pdf

Relation: We acknowledge Veronika Rezov for her skilled technical assistance, Katarin Gorski for technical advice and Brendan Battersby for critical reading of the manuscript. We thank the Biomedicum Functional Genomics Unit and the Biomedicum Clinical Proteomics unit for skilled scientific advice. This work has been supported by the Folkhadlsan Research Foundation, the Sigrid Juselius Foundation, the Finnish Epilepsy Association, Finska Ladkaresadllskapet (the Medical Society of Finland) , Medicinska Understoddsfodreningen Liv och Hadlsa r.f. ("Life and Health Medical Fund") , and Swedish Research Council. AE.L. is a HiLIFE Fellow at the University of Helsinki. M.Y. is supported by the ScandinaviaJapan Sasakawa Foundation, the Japan Eye Bank Association, the Astellas Foundation for Research on Metabolic Disorders, and the Japan Society for the Promotion of Science Overseas Research Fellowships. S.K. is supported by Jane and Aatos Erkko Foundation and Swedish Research Council. The computations in this work were performed on resources provided by SNIC through Uppsala Multidisciplinary Center for Advanced Computational Science (UPPMAX) under Project SNIC 2017/7-317.; Daura , E , Tegelberg , S , Yoshihara , M , Jackson , C , Simonetti , F , Aksentjeff , K , Ezer , S , Hakala , P , Katayama , S , Kere , J , Lehesjoki , A-E & Joensuu , T 2021 , ' Cystatin B-deficiency triggers ectopic histone H3 tail cleavage during neurogenesis ' , Neurobiology of Disease , vol. 156 , 105418 . https://doi.org/10.1016/j.nbd.2021.105418; ORCID: /0000-0001-5682-4787/work/108068819; ORCID: /0000-0003-1035-6417/work/108071687; http://hdl.handle.net/10138/339880; 3a16d992-7f13-484a-be47-72d9c5109280; 000670890000002

الاتاحة: http://hdl.handle.net/10138/339880

المؤلفون: Eduard Daura, Saara Tegelberg, Masahito Yoshihara, Christopher Jackson, Francesca Simonetti, Katri Aksentjeff, Sini Ezer, Paula Hakala, Shintaro Katayama, Juha Kere, Anna-Elina Lehesjoki, Tarja Joensuu

المصدر: Neurobiology of Disease, Vol 156, Iss , Pp 105418- (2021)

مصطلحات موضوعية: Cystatin B, Histone clipping, Histone cleavage, Cathepsin, Neural differentiation, Progressive myoclonus epilepsy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996121001674; https://doaj.org/toc/1095-953X

URL الوصول: https://doaj.org/article/e25ef9ea29f0476d9ed82d1d631b1cf3

المؤلفون: Yeojin Kim, Jinman Kim, Hyerim Lee, Woo-Ri Shin, Sheunghun Lee, Jisu Lee, Jae-Il Park, Byung Hak Jhun, Yang-Hoon Kim, Sun-Ju Yi, Kyunghwan Kim

المصدر: International Journal of Molecular Sciences; Volume 20; Issue 16; Pages: 4038

مصطلحات موضوعية: tigecycline, minocycline, MMP-9, osteoclast, histone cleavage, osteoporosis

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Biochemistry; https://dx.doi.org/10.3390/ijms20164038

الاتاحة: https://doi.org/10.3390/ijms20164038

المؤلفون: Eduard Daura, Saara Tegelberg, Paula Hakala, Anna-Elina Lehesjoki, Tarja Joensuu

مصطلحات موضوعية: Molecular Biology, Neuroscience, Structural Biology, Central Nervous System, Molecular Evolution, Molecular Medicine, cystatin B, cathepsin L, EPM1, brain development, histone cleavage, H3cs1, histone H3, senescence

Relation: https://figshare.com/articles/dataset/Data_Sheet_1_Cystatin_B_deficiency_results_in_sustained_histone_H3_tail_cleavage_in_postnatal_mouse_brain_mediated_by_increased_chromatin-associated_cathepsin_L_activity_docx/21645527

الاتاحة: https://doi.org/10.3389/fnmol.2022.1069122.s001
https://figshare.com/articles/dataset/Data_Sheet_1_Cystatin_B_deficiency_results_in_sustained_histone_H3_tail_cleavage_in_postnatal_mouse_brain_mediated_by_increased_chromatin-associated_cathepsin_L_activity_docx/21645527

المؤلفون: Anna-Elina Lehesjoki, Christopher B. Jackson, Saara Tegelberg, Katri Aksentjeff, Juha Kere, Masahito Yoshihara, Eduard Daura, Paula Hakala, Shintaro Katayama, Sini Ezer, Francesca Simonetti, Tarja Joensuu

المساهمون: Faculty of Medicine, Medicum, Department of Medical and Clinical Genetics, Anna-Elina Lehesjoki / Principal Investigator, Department of Biochemistry and Developmental Biology, Clinicum, Research Programs Unit, STEMM - Stem Cells and Metabolism Research Program, Juha Kere / Principal Investigator

المصدر: Neurobiology of Disease, Vol 156, Iss, Pp 105418-(2021)

مصطلحات موضوعية: 0301 basic medicine, Mice, 129 Strain, EPIGENETIC REGULATORY MECHANISM, Neurogenesis, PROTEIN, Neurosciences. Biological psychiatry. Neuropsychiatry, NEURAL STEM-CELLS, Biology, Epigenesis, Genetic, Cathepsin, Histones, Mice, 03 medical and health sciences, Histone H3, 0302 clinical medicine, Neural Stem Cells, Precursor cell, Animals, Histone cleavage, Epigenetics, Cystatin B, Cells, Cultured, Mice, Knockout, MUTATIONS, 3112 Neurosciences, Histone clipping, MICROGLIAL ACTIVATION, Neural stem cell, Chromatin, Cell biology, DIFFERENTIATION, 030104 developmental biology, CSTB(-/-) MOUSE, Neurology, CATHEPSIN-L, Progressive myoclonus epilepsy, NEURONAL LOSS, Neural differentiation, 030217 neurology & neurosurgery, RC321-571

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f517eedfee48791fda24d6b3586ad21
http://www.sciencedirect.com/science/article/pii/S0969996121001674

المؤلفون: Lluis Espinosa, Martin Floor, Anna Vert, Irene Pecharroman, Jordi Villà-Freixa, Yolanda Guillén, Gourisankar Ghosh, Laura Batlle, Joan Bertran, Daniel Álvarez-Villanueva, Luís G. Palma, Sara Arce-Gallego, Maria Carmen Mulero, Anna Bigas, Laura Marruecos

المصدر: EMBO Rep

مصطلحات موضوعية: Biochemistry, Histones, Histone H4, NF-KappaB Inhibitor alpha, Genetics, Humans, Histone cleavage, Nucleosome, News & Views, Molecular Biology, Transcription factor, biology, Chemistry, Chromatin binding, Nuclear IkappaB, Acetylation, Chromatin, Nucleosomes, Intestine, Cell biology, Histone Code, IκBα, Histone, Differentiation, biology.protein, Protein Processing, Post-Translational, Reports

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53e839b428b42295278b7a79d00334a
https://doi.org/10.15252/embr.202152649

المؤلفون: Kyunghwan Kim, Sun-Ju Yi

المصدر: BMB Reports

مصطلحات موضوعية: 0301 basic medicine, Cellular differentiation, Histone exchange, Biology, Biochemistry, Models, Biological, Chromatin remodeling, Epigenesis, Genetic, Histones, 03 medical and health sciences, Gene expression, Endopeptidases, Histone cleavage, Animals, Humans, Epigenetics, Molecular Biology, 030102 biochemistry & molecular biology, Proteolytic enzymes, General Medicine, Chromatin, Cell biology, Invited Mini Review, 030104 developmental biology, Histone, biology.protein, Histone modification

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76afbb774ba2d70191830df45570e2a
http://europepmc.org/articles/PMC5988574

المؤلفون: Cristiane Naffah de Souza, Leandro C. D. Breda, Meraj A. Khan, Sandro Rogério de Almeida, Niels Olsen Saraiva Câmara, Neil Sweezey, Nades Palaniyar

المصدر: Frontiers in Immunology
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Frontiers in Immunology, Vol 8 (2018)

مصطلحات موضوعية: lcsh:Immunologic diseases. Allergy, 0301 basic medicine, Intracellular pH, NOX-independent, Immunology, chemistry.chemical_element, Calcium, mitochondrial ROS, Calcium in biology, HIDROGÊNIO, 03 medical and health sciences, chemistry.chemical_compound, Extracellular, Immunology and Allergy, PAD4, Original Research, NADPH oxidase, calcium, biology, pH, Neutrophil extracellular traps, Cell biology, ESPÉCIES REATIVAS DE OXIGÊNIO, NET, Histone citrullination, histone 3 citrullination, 030104 developmental biology, chemistry, histone cleavage, Ionomycin, biology.protein, lcsh:RC581-607

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2aed62c9201ff21ad696cb2a7048ff6
https://pubmed.ncbi.nlm.nih.gov/29375550

المؤلفون: Tatomer, Deirdre C., Rizzardi, Lindsay F., Curry, Kaitlin P., Witkowski, Alison M., Marzluff, William F., Duronio, Robert J.

المصدر: Nucleus (Austin, Tex.), 5(6)

مصطلحات موضوعية: HCC, histone cleavage complex, PAP, poly (A) polymerase, Sym, Symplekin, cas, castor, PAS, poly A signal, SL, stem loop, yps, ypsilon schachtel, gene expression, histone mRNA, nuclear bodies, SLBP, stem loop binding protein, Rp49, ribosomal protein L32, Animals, HLB, histone locus body, Embryo, Nonmammalian, Drosophila Proteins, sop, ribosomal protein S2, Drosophila

Relation: https://doi.org/10.17615/1ran-cf75; https://cdr.lib.unc.edu/downloads/wh247119t?file=thumbnail; https://cdr.lib.unc.edu/downloads/wh247119t

الاتاحة: https://doi.org/10.17615/1ran-cf75
https://cdr.lib.unc.edu/downloads/wh247119t?file=thumbnail
https://cdr.lib.unc.edu/downloads/wh247119t

المؤلفون: Aksentjeff, Katri

المساهمون: Helsingin yliopisto, Bio- ja ympäristötieteellinen tiedekunta, University of Helsinki, Faculty of Biological and Environmental Sciences, Helsingfors universitet, Bio- och miljövetenskapliga fakulteten

مصطلحات موضوعية: EPM1, NPC, Differentiation, Histone cleavage, Histone proteolysis, Neurotieteiden maisteriohjelma, Master's Programme in Neuroscience, Magisterprogrammet i neurovetenskap, Neurotiede, Neuroscience, Neurovetenskap

وصف الملف: application/pdf

Relation: URN:NBN:fi:hulib-202006052622; http://hdl.handle.net/10138/315897

الاتاحة: http://hdl.handle.net/10138/315897