المؤلفون: Alexandra E. Gould, Courtney Cullis, Lee Hong Myung, David Lok, Rachel E. Gershman, Scott R. Rowland, Miho Mizutani, Dave Janowick, Gipson Krista E, Vihren Kolev, Robert J. Griffin, Joe Conlon, Steve Stroud, Akito Hata, Jeffrey Ciavarri, Dylan Bradley England, Cardin David P, Sandeep Pusalkar, Paul D. Greenspan, Adnan O Abu-Yousif, Jenna Malley, Doanh Mai, Michael Shaw, Ji Zhang, Robert J. Skene, Hu Zhigen, Matthew A. Jones, Atsushi Matsuda, Shih-Chung Huang, Nina Molchanova, Xu Tianlin, Jian Huang, He Xu, Stepan Vyskocil, Nanda Gulavita, Francois Soucy, Gang Li, Yongbo Hu, Liting Ma, Steven P. Langston, Zhan Shi, Christelle C. Renou, Luhua Shen, Sean Harrison, Elise Nunes, Kenneth M. Gigstad, Yosuke Sato, Hirotake Mizutani

المصدر: Journal of Medicinal Chemistry. 64:6902-6923

مصطلحات موضوعية: Transplantation, Heterologous, Inflammation, 01 natural sciences, Phosphates, Mice, Structure-Activity Relationship, 03 medical and health sciences, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Animals, Humans, 030304 developmental biology, 0303 health sciences, Tumor microenvironment, Binding Sites, Innate immune system, Chemistry, Membrane Proteins, Type I interferon production, Acquired immune system, eye diseases, Rats, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Sting, Pyrimidines, Stimulator of interferon genes, Cancer research, Molecular Medicine, Administration, Intravenous, Cytokine secretion, Immunotherapy, Nucleotides, Cyclic, medicine.symptom, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f642868da1ca20f638998dc8a616442f
https://doi.org/10.1021/acs.jmedchem.1c00374

المؤلفون: Toshio Honda, Hidenori Namiki, Hiromasa Nagase, Hirotake Mizutani

المصدر: ARKIVOC, Vol 2003, Iss 8, Pp 188-198 (2003)

مصطلحات موضوعية: Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.0004.819; https://doaj.org/toc/1551-7004; https://doaj.org/toc/1551-7012

URL الوصول: https://doaj.org/article/b66e6135095b4fe986730b7eef6301af

المؤلفون: Stanley C, Xie, Riley D, Metcalfe, Hirotake, Mizutani, Tanya, Puhalovich, Eric, Hanssen, Craig J, Morton, Yawei, Du, Con, Dogovski, Shih-Chung, Huang, Jeffrey, Ciavarri, Paul, Hales, Robert J, Griffin, Lawrence H, Cohen, Bei-Ching, Chuang, Sergio, Wittlin, Ioanna, Deni, Tomas, Yeo, Kurt E, Ward, Daniel C, Barry, Boyin, Liu, David L, Gillett, Benigno F, Crespo-Fernandez, Sabine, Ottilie, Nimisha, Mittal, Alisje, Churchyard, Daniel, Ferguson, Anna Caroline C, Aguiar, Rafael V C, Guido, Jake, Baum, Kirsten K, Hanson, Elizabeth A, Winzeler, Francisco-Javier, Gamo, David A, Fidock, Delphine, Baud, Michael W, Parker, Stephen, Brand, Lawrence R, Dick, Michael D W, Griffin, Alexandra E, Gould, Leann, Tilley

المصدر: Proceedings of the National Academy of Sciences of the United States of America

مصطلحات موضوعية: Boron Compounds, Models, Molecular, Proteasome Endopeptidase Complex, Plasmodium, Plasmodium falciparum, Administration, Oral, Mice, SCID, Biological Sciences, Biochemistry, Mice, proteasome, Mice, Inbred NOD, Catalytic Domain, parasitic diseases, Animals, Humans, cryo-EM, Malaria, Falciparum, Proteasome Inhibitors, peptide boronate, antimalarial drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::a17d17dad9983ee3c287198b34e727b8
https://pubmed.ncbi.nlm.nih.gov/34548400

المؤلفون: Xingyue He, Mark G. Qian, Matthew O. Duffey, Larry Cohen, Michael D. Sintchak, Mi-Sook Kim, Jessica Riceberg, Vaishali Shindi, Kelly Connolly, Jianping Guo, Agatha Zawadzka, Rachel E. Gershman, Teresa A. Soucy, Neil Bence, Zhigen Hu, Xiaofeng Yang, Shumet A. Hailu, Nina Molchinova, Nanda Gulavita, Ji Zhang, Hirotake Mizutani, Keli Song, A D Patil, Scott Freeze, Jessica Grieves, Dylan Bradley England, Roushan Afroze, James J. Minissale, Anya Lublinsky, Mitsuhiro Ito, David Lok, Scott Weston Lane, William D. Mallender, Stephen Grossman, Kara Hoar, Nitya Durvasula, Bei-Ching Chuang, Yongbo Hu, Steven P. Langston, Sai M. Pulukuri, Miho Mizutani, Ryan Chau, Nancy Bump, Katherine M. Galvin, Christopher F. Claiborne, Paul D. Greenspan, He Xu, Gaulin Jeffrey L, Melissa Gallery, Douglas Bowman, Yana Wang, Koji Ono, Mcintyre Charles

المصدر: Journal of medicinal chemistry. 64(5)

مصطلحات موضوعية: Adenosine, SUMO protein, Antineoplastic Agents, Plasma protein binding, Ubiquitin-Activating Enzymes, 01 natural sciences, Adduct, 03 medical and health sciences, Mice, Structure-Activity Relationship, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Enzyme Inhibitors, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Molecular Structure, Chemistry, Cancer, Sumoylation, medicine.disease, Xenograft Model Antitumor Assays, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, Biochemistry, Cell culture, Covalent bond, Molecular Medicine, Sulfonic Acids, Protein Processing, Post-Translational, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5159f216a3701336ba4dda4e3a9836
https://pubmed.ncbi.nlm.nih.gov/33631934

المؤلفون: Benigno F. Crespo-Fernandez, Eric Hanssen, Elizabeth A. Winzeler, Ioanna Deni, Lawrence Cohen, Du Yawei, Daniel C. Barry, Leann Tilley, Riley D. Metcalfe, David L. Gillett, Kurt E. Ward, Bei-Ching Chuang, Hirotake Mizutani, Lawrence R. Dick, Anna Caroline Campos Aguiar, David A. Fidock, Kirsten K. Hanson, Boyin Liu, Alexandra E. Gould, Stanley C. Xie, Rafael Victorio Carvalho Guido, Francisco-Javier Gamo, Tanya Puhalovich, Shih-Chung Huang, Daniel Ferguson, Paul Hales, Con Dogovski, Sabine Ottilie, Nimisha Mittal, Craig J. Morton, Sergio Wittlin, Robert J. Griffin, Delphine Baud, Tomas Yeo, Michael D. W. Griffin, Jake Baum, Stephen Brand, Alisje Churchyard, Jeffrey Ciavarri, Michael W. Parker

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

مصطلحات موضوعية: 0303 health sciences, Multidisciplinary, biology, 010405 organic chemistry, Chemistry, Bortezomib, Plasmodium vivax, Active site, Plasmodium falciparum, QUÍMICA MÉDICA, Pharmacology, biology.organism_classification, 01 natural sciences, 3. Good health, 0104 chemical sciences, 03 medical and health sciences, Proteasome, In vivo, parasitic diseases, biology.protein, medicine, Potency, Selectivity, 030304 developmental biology, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1732262eee41ce63468baae5797862

المؤلفون: Steven P. Langston (2219188), Stephen Grossman (10198133), Dylan England (10198136), Roushan Afroze (2219245), Neil Bence (720479), Douglas Bowman (2125528), Nancy Bump (10198139), Ryan Chau (1359909), Bei-Ching Chuang (4057621), Christopher Claiborne (10198142), Larry Cohen (10198145), Kelly Connolly (10198148), Matthew Duffey (10198151), Nitya Durvasula (10198154), Scott Freeze (10198157), Melissa Gallery (4797807), Katherine Galvin (841559), Jeffrey Gaulin (10198160), Rachel Gershman (10198163), Paul Greenspan (10198166), Jessica Grieves (10198169), Jianping Guo (299686), Nanda Gulavita (10198172), Shumet Hailu (10198175), Xingyue He (720471), Kara Hoar (1359942), Yongbo Hu (2252653), Zhigen Hu (10198178), Mitsuhiro Ito (213512), Mi-Sook Kim (733644), Scott Weston Lane (6663500), David Lok (10198181), Anya Lublinsky (10198184), William Mallender (10198187), Charles McIntyre (5875838), James Minissale (10198190), Hirotake Mizutani (2219254), Miho Mizutani (10198193), Nina Molchinova (10198196), Koji Ono (352024), Ashok Patil (10198199), Mark Qian (10198202), Jessica Riceberg (720472), Vaishali Shindi (10198205), Michael D. Sintchak (2125567), Keli Song (10198208), Teresa Soucy (10198211), Yana Wang (1485724), He Xu (147776), Xiaofeng Yang (168148), Agatha Zawadzka (10198214), Ji Zhang (70438), Sai M. Pulukuri (10198217)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Pharmacology, Immunology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, adduct, protein function, Cancer SUMOylation, pharmacodynamic effect, First-in-Class Inhibitor, tumor models, covalent attachment, ATP-dependent process, ubiquitin-like modifier, SUMOylating proteins, SUMO protein, SAE, identification, SUMO-activating enzyme, TAK, mechanism-based inhibitor, pathway inhibition

Relation: https://figshare.com/articles/dataset/Discovery_of_TAK-981_a_First-in-Class_Inhibitor_of_SUMO-Activating_Enzyme_for_the_Treatment_of_Cancer/14120909

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c01491.s001

المؤلفون: Xie, Stanley C., Metcalfe, Riley D., Hirotake Mizutani, Puhalovich, Tanya, Hanssen, Eric, Morton, Craig J., Yawei Du, Con Dogovski, Shih-Chung Huang, Ciavarri, Jeffrey, Hales, Paul, Griffin, Robert J., Cohen, Lawrence H., Bei-Ching Chuang, Wittlin, Sergio, Deni, Ioanna, Yeo, Tomas, Ward, Kurt E., Barry, Daniel C., Boyin Liu

المصدر: Proceedings of the National Academy of Sciences of the United States of America; 9/28/2021, Vol. 118 Issue 39, p1-9, 9p

مصطلحات موضوعية: PROTEASOME inhibitors, PLASMODIUM falciparum, DRUG target, LABORATORY mice, PLASMODIUM vivax

المؤلفون: Hidenori Namiki, Hirotake Mizutani, Kyousuke Kaneda, Toshio Honda, 双木 秀紀, 本多 利雄, 水谷 尋丈, 金田 京介

المصدر: Proceedings of the Symposium on Progress in Organic Reactions and Syntheses. 2003, :216

المؤلفون: Hirotake MIZUTANI, 水谷 尋丈

المصدر: ファルマシア / Farumashia. 2003, 39(3):253

المؤلفون: Mi-Sook Kim, Mansoureh Rezaei, Jouhara Chouitar, Katherine Brewer, Michael D. Smith, Alexandra E. Gould, Katherine Galvin, Shih-Chung Huang, Dong Mei Zhang, Sharmila Adhikari, Hirotake Mizutani, Steven P. Langston, Dylan England, Paul D. Greenspan, Emily F. Calderwood, Craig Fisher, Sean J. Harrison, Li-Ting Ma, Saurabh Menon, Roushan Afroze, Jeffery Gaulin

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:1156-1160

مصطلحات موضوعية: Male, Proto-Oncogene Proteins B-raf, 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Tetrahydronaphthalenes, Stereochemistry, Transplantation, Heterologous, Clinical Biochemistry, hERG, Pharmaceutical Science, Ether, Biochemistry, Rats, Sprague-Dawley, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Cell Line, Tumor, Neoplasms, Amide, Drug Discovery, Animals, Humans, Structure–activity relationship, cardiovascular diseases, Protein Kinase Inhibitors, Molecular Biology, biology, Chemistry, Organic Chemistry, Ether-A-Go-Go Potassium Channels, Potassium channel, Rats, 030104 developmental biology, Mutagenesis, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Selectivity, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6930550d409a9ac05c6295b259baab57
https://doi.org/10.1016/j.bmcl.2016.01.049

المؤلفون: Sai M Pulukuri, James Minissale, Neil F. Bence, Matt Duffey, Hirotake Mizutani, He Xu, Hu Zhigen, Lawrence R. Dick, Xingyue He, Dylan England, Erik Koenig, Pooja Shah, Xiaofeng Yang, Hua Liao, Teresa A. Soucy, James E. Brownell, Melissa Gallery, Claudia Rabino, John Newcomb, Hugues Bernard, John Bradley, Jianping Guo, Mike Sintchak, Zhong-Hua Yan, Kristina Xega, Steve Langston, Ryan Chau, Jessica Riceberg, Eric S. Lightcap

المصدر: Nature chemical biology. 13(11)

مصطلحات موضوعية: 0301 basic medicine, Mutant, SUMO protein, Genes, myc, Mitosis, Biology, 03 medical and health sciences, Small Ubiquitin-Related Modifier Proteins, Chromosome Segregation, Neoplasms, parasitic diseases, Tumor Cells, Cultured, Humans, Enzyme Inhibitors, Molecular Biology, Cell Proliferation, Regulation of gene expression, Oncogene, Cell growth, Sumoylation, Cell Biology, Cell biology, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Cancer cell, Protein Processing, Post-Translational, DNA Damage

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9174b996cee052b2dfda9c4bae1d2e1a
https://pubmed.ncbi.nlm.nih.gov/28892090

المؤلفون: Emily F. Calderwood, Kathleen Aertgeerts, Michael D. Smith, Dylan Bradley England, Roushan Afroze, Ryan Chau, Stepan Vyskocil, Nancy E. Forsyth, Dong Mei Zhang, Ruth Adams, Stephen G. Stroud, O. P. Veiby, Christelle C. Renou, R. Scott Rowland, Erin Paske, Jane X. Liu, Ming Tregay, Michael D. Sintchak, Juliet A Williams, Shih-Chung Huang, Xu Tianlin, Bheemashankar Kulkarni, Sharmila Adhikari, Yuan Tian, Jason Yano, Christopher Blackburn, Paul D. Greenspan, Cheryl A. Farrer, Matthew O. Duffey, Liting Ma, Mi-Sook Kim, Qin Zhang, Sean Harrison, Hirotake Mizutani, Katherine M. Galvin, Alexandra E. Gould, Johnny J. Yang, Steven P. Langston, Dave Janowick, Natalia Iartchouk, Mansoureh Rezaei, Jeffery Gaulin, Khristofer Garcia, Hongbo Zeng, Ribo Guo, Tricia J. Vos, Jouhara Chouitar, Saurabh Menon

المصدر: Journal of Medicinal Chemistry. 54:1836-1846

مصطلحات موضوعية: Models, Molecular, Proto-Oncogene Proteins B-raf, Tetrahydronaphthalenes, Mutant, Melanoma, Experimental, Administration, Oral, Biological Availability, Mice, Nude, Antineoplastic Agents, Pharmacology, Crystallography, X-Ray, Mice, Structure-Activity Relationship, Pharmacokinetics, Mouse xenograft, In vivo, Drug Discovery, medicine, Animals, chemistry.chemical_classification, Chemistry, Melanoma, Stereoisomerism, medicine.disease, Xenograft Model Antitumor Assays, In vitro, Bioavailability, Enzyme, Drug Design, Mutation, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48918d40f47903a78da39dee5fa5f8e
https://doi.org/10.1021/jm101479y

المؤلفون: Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen, Allison J. Berger, James M. Gavin, Sharmila Adhikari, James E. Brownell, Kristine E. Burke, David P. Cardin, Stephen Critchley, Courtney A. Cullis, Amanda Doucette, James J. Garnsey, Jeffrey L. Gaulin, Rachel E. Gershman, Anna R. Lublinsky, Alice McDonald, Hirotake Mizutani, Usha Narayanan, Edward J. Olhava, Stephane Peluso, Mansoureh Rezaei, Michael D. Sintchak, Tina Talreja, Michael P. Thomas, Tary Traore, Stepan Vyskocil, Gabriel S. Weatherhead, Jie Yu, Julie Zhang, Lawrence R. Dick, Christopher F. Claiborne, Mark Rolfe, Joseph B. Bolen, Steven P. Langston

المصدر: Nature. 458:732-736

مصطلحات موضوعية: NEDD8 Protein, Ubiquitin-activating enzyme, Transplantation, Heterologous, Antineoplastic Agents, Cyclopentanes, Ubiquitin-Activating Enzymes, NEDD8, Mice, Ubiquitin, Cell Line, Tumor, Neoplasms, Animals, Humans, Enzyme Inhibitors, Ubiquitins, Cells, Cultured, Multidisciplinary, biology, Cullin Proteins, Cell biology, Pyrimidines, Pevonedistat, Proteasome, Cancer cell, biology.protein, Female, Neddylation, Proteasome Inhibitors, Cullin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f238daefd87e22eb7816dddaf60362e3
https://doi.org/10.1038/nature07884

المؤلفون: Makoto Ushiwata, Hirotake Mizutani, Toshio Honda

المصدر: Tetrahedron Letters. 47:6251-6254

مصطلحات موضوعية: Pandamarilactonine B, chemistry.chemical_compound, Enantiopure drug, Stereochemistry, Chemistry, Organic Chemistry, Drug Discovery, Stereoselectivity, One-Step, Ruthenium catalyst, Metathesis, Biochemistry, Derivative (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b4ddc4c3613b108b7cf231332131c46c
https://doi.org/10.1016/j.tetlet.2006.06.142

المؤلفون: Hirotake Mizutani, Toshio Honda, Masayuki Watanabe

المصدر: Tetrahedron. 58:8929-8936

مصطلحات موضوعية: biology, Stereochemistry, Chemistry, Organic Chemistry, Enantioselective synthesis, Total synthesis, Malyngolide, General Medicine, biology.organism_classification, Metathesis, Biochemistry, Tanikolide, Ring-closing metathesis, Drug Discovery, Salt metathesis reaction, Organic chemistry, Lyngbya majuscula

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd648637b5dae6de32467808bbd359d
https://doi.org/10.1016/s0040-4020(02)01160-2

المؤلفون: Hirotake Mizutani, Yukio Soeda, Jun Takayama, Toshio Honda

المصدر: Tetrahedron Letters. 43:2411-2414

مصطلحات موضوعية: chemistry.chemical_compound, Enantiopure drug, Chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Iodobenzene, Antagonist, Total synthesis, Muscarinic acetylcholine receptor M1, Bond formation, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c93987d5f6a7bfd5c378bc0ded021b1e
https://doi.org/10.1016/s0040-4039(02)00296-4

المؤلفون: Sai M Pulukuri, Eric S. Lightcap, Teresa A. Soucy, James E. Brownell, John Newcomb, Keli Song, Erik Koenig, Katherine Galvin, Anna Kreshock, Dylan England, Stephen Grossman, Steve Langston, Xingyue He, Hirotake Mizutani, Jessica Riceberg, Larry Dick

المصدر: Cancer Research. 77:1147-1147

مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, SUMO protein, SUMO enzymes, Biology, Cell cycle, Enzyme assay, Cell biology, Enzyme, Death-associated protein 6, Oncology, chemistry, Transcription (biology), Cancer cell, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f928c916562b6df5e7fefef64962f1fa
https://doi.org/10.1158/1538-7445.am2017-1147

المؤلفون: Courtney A. Luchaco-Cullis, Amir H. Hoveyda, Hirotake Mizutani, Kerry E. Murphy

المصدر: Angewandte Chemie International Edition. 40:1456-1460

مصطلحات موضوعية: Substitution reaction, chemistry.chemical_classification, Allylic rearrangement, Stereochemistry, organic chemicals, Enantioselective synthesis, chemistry.chemical_element, Peptide, General Medicine, General Chemistry, Copper, Catalysis, chemistry, Reagent, Reactivity (chemistry), Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20723e94572b637ed523e2f4a5ef82d0
https://doi.org/10.1002/1521-3773(20010417)40:8<1456::aid-anie1456>3.0.co;2-t

المؤلفون: Toshio Honda, Hirotake Mizutani, Naofumi Watanabe, Hidenori Namiki, Mika Kudoh, Hiromasa Nagase

المصدر: Tetrahedron Letters. 41:5927-5930

مصطلحات موضوعية: biology, Stereochemistry, Organic Chemistry, Total synthesis, biology.organism_classification, Biochemistry, Securinega, Enol, Formal synthesis, chemistry.chemical_compound, chemistry, Intramolecular force, Drug Discovery, Diels alder, Organic chemistry, Diels–Alder reaction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::737ca4be8ec5f1b3d6236a684997d5cf
https://doi.org/10.1016/s0040-4039(00)00976-x

المؤلفون: Mai Ohta, Hirotake Mizutani, Toshio Honda

المصدر: Journal of the Chemical Society, Perkin Transactions 1. :23-30

مصطلحات موضوعية: Chemistry, Stereochemistry, Octadecadienoic Acid, Organic chemistry, Blast disease

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::316ad04ef09d02ddda86cceca518b40e
https://doi.org/10.1039/a808114j