المؤلفون: Yoshihiro Konno, Shunsuke Kamigaso, Hidetoh Toki, Shuichi Terasaka, Hirohiko Hikichi, Hiromi Endo, Jun‐Ichi Yamaguchi, Akiko Mizuno‐Yasuhira

المصدر: Pharmacology Research & Perspectives, Vol 12, Iss 2, Pp n/a-n/a (2024)

مصطلحات موضوعية: disposition, half‐life, metabolism, orexin, pharmacokinetic, TS‐142, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2052-1707

URL الوصول: https://doaj.org/article/f0fdc42495644a57a4587a112985bc33

المؤلفون: Hirohiko Hikichi, Tetsuaki Hiyoshi, Toshiyuki Marumo, Yasumitsu Tomishima, Ayaka Kaku, Izumi Iida, Hiroki Urabe, Tomoko Tamita, Akito Yasuhara, Jun-ichi Karasawa, Shigeyuki Chaki

المصدر: Journal of Pharmacological Sciences, Vol 127, Iss 3, Pp 352-361 (2015)

مصطلحات موضوعية: TASP0443294, mGlu2 receptor positive allosteric modulator, Hyperlocomotion, Social memory, EEG, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861315000158; https://doaj.org/toc/1347-8613

URL الوصول: https://doaj.org/article/b56722cac0fc4fd59c23db537c537189

المؤلفون: Hirohiko Hikichi, Ayaka Kaku, Jun-ichi Karasawa, Shigeyuki Chaki

المصدر: Journal of Pharmacological Sciences, Vol 122, Iss 1, Pp 10-16 (2013)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861319303391; https://doaj.org/toc/1347-8613

URL الوصول: https://doaj.org/article/64f65c83271e477c8d44d5feecae42fb

المؤلفون: Ayaka Kaku-Fukumoto, Noriko Hino, Hirohiko Hikichi, Dai Nozawa, Jun-ichi Karasawa, Toshio Nakamura, Emi Tatsuda, Shigeyuki Chaki, Yasumitsu Tomishima, Toshiyuki Marumo, Toshiharu Shimazaki, Makiko Kotani, Hiroko Komiyama

المصدر: Journal of Pharmacology and Experimental Therapeutics. 375:276-285

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Agonist, Chemistry, medicine.drug_class, Histaminergic, Antagonist, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Competitive antagonist, medicine, Molecular Medicine, Inverse agonist, Histamine H3 receptor, Receptor, 030217 neurology & neurosurgery, Histamine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1cf1b46a58c5f29e719fa092f8a420ec
https://doi.org/10.1124/jpet.120.000185

المؤلفون: Kohnosuke Kinoshita, Misako Fukasawa, Shigeru Okuyama, Brian Marcy, Shigeru Yoshida, Hakop Gevorkyan, Hirohiko Hikichi, Shigeyuki Chaki, Mai Watanabe

المصدر: British Journal of Clinical Pharmacology

مصطلحات موضوعية: Male, Agonist, medicine.drug_class, Cmax, Administration, Oral, Pharmacology, MGS0274, 030226 pharmacology & pharmacy, cerebrospinal fluid, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Glutamates, Pharmacokinetics, Oral administration, medicine, Humans, TS‐134, Prodrugs, Pharmacology (medical), 030212 general & internal medicine, mGlu2/3 agonist, Adverse effect, Dose-Response Relationship, Drug, business.industry, Nausea, Original Articles, Prodrug, Healthy Volunteers, Bioavailability, schizophrenia, Area Under Curve, Vomiting, Original Article, Female, MGS0008, medicine.symptom, business, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4710244ebf18b7ec5bb0dd9b7ab86279
https://doi.org/10.1111/bcp.14331

المؤلفون: Gentaroh Suzuki, Hiroko Kawagoe-Takaki, Takao Inoue, Toshifumi Kimura, Hirohiko Hikichi, Takashi Murai, Akio Satow, Mikiko Hata, Shunsuke Maehara, Satoru Ito, Hiroshi Kawamoto, Satoshi Ozaki, Hisashi Ohta

المصدر: Journal of Pharmacological Sciences, Vol 110, Iss 3, Pp 315-325 (2009)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861319311806; https://doaj.org/toc/1347-8613

URL الوصول: https://doaj.org/article/6bf604453a04428db2000bdf467daf44

المؤلفون: Noriko, Hino, Toshiyuki, Marumo, Makiko, Kotani, Toshiharu, Shimazaki, Ayaka, Kaku-Fukumoto, Hirohiko, Hikichi, Jun-Ichi, Karasawa, Yasumitsu, Tomishima, Hiroko, Komiyama, Emi, Tatsuda, Dai, Nozawa, Toshio, Nakamura, Shigeyuki, Chaki

المصدر: The Journal of pharmacology and experimental therapeutics. 375(2)

مصطلحات موضوعية: Male, Mice, Neurotransmitter Agents, Cognition, Histamine Antagonists, Animals, Receptors, Histamine H3, Electroencephalography, Wakefulness, Locomotion, Rats

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::d4bb83aca81af8a17a5879f4ee7f1340
https://pubmed.ncbi.nlm.nih.gov/32862143

المؤلفون: Naoki Miyakoshi, Motoki Ochi, Toshiyuki Marumo, Misako Fukasawa, Takashi Hashihayata, Hiroki Urabe, Akiko Nozoe, Junichi Yamaguchi, Kohnosuke Kinoshita, Shigeyuki Chaki, Norikazu Ohtake, Hirohiko Hikichi

المصدر: European journal of medicinal chemistry. 203

مصطلحات موضوعية: Agonist, medicine.drug_class, Administration, Oral, Biological Availability, Pharmacology, Receptors, Metabotropic Glutamate, 01 natural sciences, 03 medical and health sciences, Pharmacokinetics, Drug Discovery, medicine, Animals, Prodrugs, 030304 developmental biology, 0303 health sciences, 010405 organic chemistry, Chemistry, Organic Chemistry, Glutamate receptor, Esters, Stereoisomerism, General Medicine, Haplorhini, Prodrug, 0104 chemical sciences, Bioavailability, Metabotropic glutamate receptor, Drug Design, Lipophilicity, Metabotropic glutamate receptor 2

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd7fdcf1e674d170275b8838d244759
https://pubmed.ncbi.nlm.nih.gov/32698110

المؤلفون: Yuichi Tokumaru, Daiji Kambe, Noriko Hino, Y Konno, Hirohiko Hikichi, Mari Ohmichi

المصدر: Sleep. 43:A2-A2

مصطلحات موضوعية: Pharmacy (field), Chemistry, Physiology (medical), Orexin Receptor Antagonists, Antagonist, Wakefulness, Neurology (clinical), Pharmacology, Sleep in non-human animals, Orexin receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::776824c6e1745ef2ad0d67c182ef5bee
https://doi.org/10.1093/sleep/zsaa056.003

المؤلفون: Hiroyuki Koike, Daiji Kambe, Jun-ichi Karasawa, Hirohiko Hikichi, Kohnosuke Kinoshita, Ayaka Kaku, Shigeyuki Chaki, Kazuaki Kawaura

المصدر: Behavioural Brain Research. 278:186-192

مصطلحات موضوعية: Male, Agonist, Imipramine, medicine.drug_class, Glycine, Motor Activity, Pharmacology, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Serine, Behavioral Neuroscience, Glycine Plasma Membrane Transport Proteins, Haloperidol, Animals, Medicine, Clozapine, Swimming, biology, business.industry, Sarcosine, Antidepressive Agents, Rats, Disease Models, Animal, Glycine transporter 1, Schizophrenia, biology.protein, NMDA receptor, Dizocilpine Maleate, business, Locomotion, Antipsychotic Agents, Behavioural despair test, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f151be3c0d0495da9517aa12771517
https://doi.org/10.1016/j.bbr.2014.09.046

المؤلفون: Jun-ichi Karasawa, Hirohiko Hikichi, Ayaka Kaku, Shigeyuki Chaki

المصدر: Journal of Pharmacological Sciences, Vol 122, Iss 1, Pp 10-16 (2013)

مصطلحات موضوعية: Male, Agonist, medicine.drug_class, Pharmacology, Receptors, Metabotropic Glutamate, Rats, Sprague-Dawley, Animals, Medicine, Amino Acids, Memory Disorders, Metabotropic glutamate receptor 5, business.industry, Metabotropic glutamate receptor 4, Metabotropic glutamate receptor 7, lcsh:RM1-950, Recognition, Psychology, Bridged Bicyclo Compounds, Heterocyclic, Rats, lcsh:Therapeutics. Pharmacology, Xanthenes, Competitive antagonist, Quinolines, Molecular Medicine, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 3, Dizocilpine Maleate, Metabotropic glutamate receptor 2, business, Excitatory Amino Acid Antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed0678b5425e90b93c63c7cc71f7a2e
http://www.sciencedirect.com/science/article/pii/S1347861319303391

المؤلفون: Hisashi Ohta, Akio Satow, Hirohiko Hikichi, Shunsuke Maehara

المصدر: European Journal of Pharmacology. 667:242-249

مصطلحات موضوعية: Male, medicine.medical_specialty, medicine.drug_class, Scopolamine, Pharmacology, Dopamine agonist, Rats, Sprague-Dawley, Internal medicine, Muscarinic acetylcholine receptor, medicine, Animals, Receptor, Serotonin, 5-HT2A, Clozapine, Prepulse inhibition, Behavior, Animal, Chemistry, Receptor, Muscarinic M1, Antagonist, Sensory Gating, Methamphetamine, Receptor antagonist, Prolactin, Rats, Dopamine D2 Receptor Antagonists, Endocrinology, Serotonin 5-HT2 Receptor Antagonists, Ketamine, Serotonin, Antipsychotic Agents, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26512ed5966c28044a464acd3cb1c66e
https://doi.org/10.1016/j.ejphar.2011.05.063

المؤلفون: Hirohiko Hikichi, Shigeyuki Chaki

المصدر: Current Pharmaceutical Design. 17:94-102

مصطلحات موضوعية: Psychosis, Glutamic Acid, Pharmacology, Receptors, Metabotropic Glutamate, Synaptic Transmission, Mice, Glutamatergic, APICA, Drug Discovery, medicine, Animals, Humans, Molecular Targeted Therapy, Receptor, business.industry, Glutamate receptor, Brain, Potentiator, medicine.disease, Rats, Metabotropic receptor, Metabotropic glutamate receptor, Schizophrenia, business, Neuroscience, Antipsychotic Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584bddfd45f8f52955c6078383ae6473
https://doi.org/10.2174/138161211795049570

المؤلفون: Akio Satow, Shoki Okuda, Miho Nishino, Hiroshi Takehana, Shunsuke Maehara, Hisashi Ohta, Mikiko Hata, Takeshi Murai, Satoko Ise, Gentaroh Suzuki, Hirohiko Hikichi

المصدر: European Journal of Pharmacology. 639:106-114

مصطلحات موضوعية: Central Nervous System, Male, Allosteric modulator, Fever, Pyridones, Central nervous system, Electric Countershock, Rodentia, Pharmacology, Receptors, Metabotropic Glutamate, Inhibitory postsynaptic potential, Rats, Sprague-Dawley, Mice, Cognition, Allosteric Regulation, medicine, Animals, Ultrasonics, Maze Learning, Prepulse inhibition, Mice, Inbred ICR, Behavior, Animal, Chemistry, Metabotropic glutamate receptor 7, Glutamate receptor, Tail suspension test, Rats, Metabotropic receptor, medicine.anatomical_structure, Pentylenetetrazole, Vocalization, Animal, Excitatory Amino Acid Antagonists, Locomotion

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c9763e05a5b7c5ebb998829e6e3b19
https://doi.org/10.1016/j.ejphar.2009.08.047

المؤلفون: Hiroshi Kawamoto, Miho Nishino, Shunsuke Maehara, Hirohiko Hikichi, Miyuki Fukushima, Hisashi Ohta, Akio Satow

المصدر: European Journal of Pharmacology. 639:99-105

مصطلحات موضوعية: Male, Agonist, medicine.medical_specialty, medicine.drug_class, Pharmacology, Ligands, Receptors, Metabotropic Glutamate, Mice, chemistry.chemical_compound, AMN082, Internal medicine, medicine, Animals, DCPG, Prepulse inhibition, Dose-Response Relationship, Drug, Chemistry, Glutamate receptor, Neural Inhibition, Receptor antagonist, Endocrinology, Metabotropic receptor, Mice, Inbred DBA, Metabotropic glutamate receptor, Schizophrenia, Excitatory Amino Acid Antagonists, Antipsychotic Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d0d37c25b2ee5ce04824f4114bd71c3
https://doi.org/10.1016/j.ejphar.2010.03.046

المؤلفون: Mikiko Hata, Hirohiko Hikichi, Atsushi Satoh, Akio Satow, Toshifumi Kimura, Gentaroh Suzuki, Yasushi Nagatomi, Shunsuke Maehara, Hiroshi Kawamoto, Yukari Hirata, Satoru Ito, Hisashi Ohta

المصدر: Bioorganic & Medicinal Chemistry Letters. 19:5464-5468

مصطلحات موضوعية: Stereochemistry, Chemistry, Organic Chemistry, Clinical Biochemistry, Glutamate receptor, Antagonist, Pharmaceutical Science, Receptors, Metabotropic Glutamate, Biochemistry, In vitro, Rats, Mice, Structure-Activity Relationship, Metabotropic receptor, In vivo, Benzamides, Drug Discovery, Animals, Humans, Molecular Medicine, Structure–activity relationship, Metabotropic glutamate receptor 1, Receptor, Molecular Biology, Antipsychotic Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c059ff09da4348b24419cec5ab71fa4d
https://doi.org/10.1016/j.bmcl.2009.07.097

المؤلفون: Takao Inoue, Akio Satow, Hiroshi Kawamoto, Mikiko Hata, Satoru Ito, Takashi Murai, Hisashi Ohta, Hiroko Kawagoe-Takaki, Toshifumi Kimura, Hirohiko Hikichi, Satoshi Ozaki, Gentaroh Suzuki, Shunsuke Maehara

المصدر: Journal of Pharmacological Sciences, Vol 110, Iss 3, Pp 315-325 (2009)

مصطلحات موضوعية: Male, Allosteric regulation, Glycine, CHO Cells, In Vitro Techniques, Pharmacology, Biology, Receptors, Metabotropic Glutamate, Mice, Cricetulus, Allosteric Regulation, In vivo, Cricetinae, Radioligand, Animals, Receptor, Mice, Knockout, Mice, Inbred ICR, Behavior, Animal, Metabotropic glutamate receptor 5, lcsh:RM1-950, Brain, Resorcinols, Triazoles, Recombinant Proteins, lcsh:Therapeutics. Pharmacology, Metabotropic glutamate receptor, Molecular Medicine, Metabotropic glutamate receptor 1, Ex vivo, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db5771127ecab16634ead57a9390379
https://doi.org/10.1254/jphs.09011fp

المؤلفون: Jun-ichi Karasawa, Kazuaki Kawaura, Hirohiko Hikichi

المصدر: Pharmacological reports : PR. 68(1)

مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, Allosteric modulator, medicine.drug_class, Stimulation, Pharmacology, Motor Activity, Receptors, Metabotropic Glutamate, Rats, Sprague-Dawley, 03 medical and health sciences, Immobilization, 0302 clinical medicine, medicine, Animals, Amino Acids, Rats, Wistar, Receptor, Swimming, Dose-Response Relationship, Drug, business.industry, Glutamate receptor, General Medicine, Bridged Bicyclo Compounds, Heterocyclic, Rats, 030104 developmental biology, Metabotropic receptor, NMDA receptor, Dizocilpine Maleate, business, Excitatory Amino Acid Antagonists, 030217 neurology & neurosurgery, Behavioural despair test

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426c9bbf7ba3b86a0849c644acfd139a
https://pubmed.ncbi.nlm.nih.gov/26721357

المؤلفون: Izumi Iida, Yasumitsu Tomishima, Hiroki Urabe, Ayaka Kaku, Toshiyuki Marumo, Akito Yasuhara, Hirohiko Hikichi, Jun-ichi Karasawa, Tomoko Tamita, Shigeyuki Chaki, Tetsuaki Hiyoshi

المصدر: Journal of Pharmacological Sciences, Vol 127, Iss 3, Pp 352-361 (2015)

مصطلحات موضوعية: Male, Allosteric modulator, Administration, Oral, Prefrontal Cortex, Sleep, REM, Pharmacology, Motor Activity, Social memory, Receptors, Metabotropic Glutamate, Rats, Sprague-Dawley, Allosteric Regulation, Hyperlocomotion, Animals, Humans, EEG, Rats, Wistar, Oxazoles, Cells, Cultured, Chemistry, Metabotropic glutamate receptor 5, lcsh:RM1-950, TASP0443294, Metabotropic glutamate receptor 6, Imidazoles, Electroencephalography, Stimulation, Chemical, Disease Models, Animal, lcsh:Therapeutics. Pharmacology, Metabotropic receptor, Metabotropic glutamate receptor, mGlu2 receptor positive allosteric modulator, Schizophrenia, Molecular Medicine, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 3, Metabotropic glutamate receptor 2, Antipsychotic Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be2658fe1040fdd06d6fcdcee854dd1
https://pubmed.ncbi.nlm.nih.gov/25837934

المؤلفون: Yasumitsu Tomishima, Izumi Iida, Tetsuaki Hiyoshi, Hirohiko Hikichi, Akito Yasuhara, Toshiyuki Marumo, Shigeyuki Chaki, Tomoko Tamita, Hiroki Urabe, Jun-ichi Karasawa

المصدر: The Journal of pharmacology and experimental therapeutics. 351(3)

مصطلحات موضوعية: Male, Pharmacology, Biology, Motor Activity, Receptors, Metabotropic Glutamate, Rats, Sprague-Dawley, Mice, Cricetulus, Organ Culture Techniques, Allosteric Regulation, Dopamine receptor D2, Cricetinae, Animals, Humans, Rats, Wistar, Oxazoles, Dose-Response Relationship, Drug, Metabotropic glutamate receptor 5, Metabotropic glutamate receptor 7, Imidazoles, Excitatory Postsynaptic Potentials, Rats, Mice, Inbred C57BL, Metabotropic receptor, Metabotropic glutamate receptor, Molecular Medicine, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 3, Metabotropic glutamate receptor 2, Antipsychotic Agents, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23feca1a5e64c92cff6f8b573ebde77e
https://pubmed.ncbi.nlm.nih.gov/25277141