المؤلفون: Oktora, Siskarossa Ika, Wulansari, Ika Yuni, Siagian, Tiodora Hadumaon, Laksono, Bagaskoro Cahyo, Sugiandewi, Ni Nyoman Ria, Anindita, Nabila

المصدر: International Journal of Disaster Resilience in the Built Environment, 2022, Vol. 15, Issue 2, pp. 177-192.

URL الوصول: http://www.emeraldinsight.com/doi/10.1108/IJDRBE-04-2022-0034

المؤلفون: Matiar Madanchi, Riccardo Curatolo, Hazem A. Juratli, Cristina Mangas, Carlo Mainetti

المصدر: Acta Dermato-Venereologica, Vol 104 (2024)

مصطلحات موضوعية: Ultra-high potency topical corticosteroids, reactive perforating collagenosis, trigger, Dermatology, RL1-803

وصف الملف: electronic resource

Relation: https://medicaljournalssweden.se/actadv/article/view/40950; https://doaj.org/toc/0001-5555; https://doaj.org/toc/1651-2057

URL الوصول: https://doaj.org/article/b2d4d0310f7c43e48c2f5d0c3a70bab9

المؤلفون: Austin-Zimmerman, Isabelle, Spinazzola, Edoardo, Quattrone, Diego, Wu-Choi, Beatrice, Trotta, Giulia, Li, Zhikun, Johnson, Emma, Richards, Alexander L, Freeman, Tom P, Tripoli, Giada, Gayer-Anderson, Charlotte, Rodriguez, Victoria, Jongsma, Hannah E, Ferraro, Laura, La Cascia, Caterina, Tosato, Sarah, Tarricone, Ilaria, Berardi, Domenico, Bonora, Elena, Seri, Marco, D'Andrea, Giuseppe, Szöke, Andrei, Arango, Celso, Bobes, Julio, Sanjuán, Julio, Santos, Jose Luis, Arrojo, Manuel, Velthorst, Eva, Bernardo, Miguel, Del-Ben, Cristina Marta, Rossi Menezes, Paulo, Selten, Jean-Paul, Jones, Peter B, Kirkbride, James B, Rutten, Bart P F, Tortelli, Andrea, Llorca, Pierre-Michel, de Haan, Lieuwe, Stilo, Simona, La Barbera, Daniele, Lasalvia, Antonio, Schurnhoff, Franck, Pignon, Baptiste, van Os, Jim, Lynskey, Michael, Morgan, Craig, O' Donovan, Michael, Lewis, Cathryn M, Sham, Pak C

المصدر: Austin-Zimmerman , I , Spinazzola , E , Quattrone , D , Wu-Choi , B , Trotta , G , Li , Z , Johnson , E , Richards , A L , Freeman , T P , Tripoli , G , Gayer-Anderson , C , Rodriguez , V , Jongsma , H E , Ferraro , L , La Cascia , C , Tosato , S , Tarricone , I , Berardi , D , Bonora , E , Seri , M , D'Andrea , G , Szöke , A , Arango , C , Bobes , J ....

مصطلحات موضوعية: cannabis, first-episode psychosis, high-potency cannabis, polygenic risk score, psychosis, schizophrenia

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/f02b2414-20e0-4063-a982-ef0aaeb6d2a0
https://doi.org/10.1017/S0033291724002058

المؤلفون: Yahong Liu, Ying Cheng, Gongchao Huang, Xiangying Xia, Xingkai Wang, Hongqi Tian

المصدر: Frontiers in Pharmacology, Vol 14 (2023)

مصطلحات موضوعية: mek inhibitor, RAF/RAS mutant cancer, tunlametinib, drug combination, high potency, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1271268/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/b974c78211d44fed8927e24c4cefca76

المؤلفون: He, Yuanzheng, Shi, Jingjing, Nguyen, Quang Tam, You, Erli, Liu, Hongbo, Ren, Xin, Wu, Zhongshan, Li, Jianshuang, Qiu, Wenli, Khoo, Sok Kean, Yang, Tao, Yi, Wei, Sun, Feng, Xi, Zhijian, Huang, Xiaozhu, Melcher, Karsten, Min, Booki, Xu, H Eric

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 116(14)

مصطلحات موضوعية: Lung, Asthma, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Respiratory, Animals, Anti-Asthmatic Agents, Disease Models, Animal, Drug Development, Female, Glucocorticoids, Male, Mice, Receptors, Glucocorticoid, Severity of Illness Index, steroid resistant asthma, glucocorticoid, high potency, VSG158, VSG159, steroid-resistant asthma

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6kt3p9fk

المؤلفون: Chethan, C.R.^{1, 1}, Dubey, R.P.¹, Chander, Subhash², Pawar, Deepak V.¹, Ghosh, Dibakar³, Singh, P.K.¹

المصدر: 54(2):146-150

المؤلفون: Qun Li, Yang Zang, Dan An, Lifei Liu, Wen Jiang, Rongchen Liu, Jiangtao Su, Jun Yang, Lie Li, Xuejun Zhang

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Pharmacology, Biotechnology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, synthetic lethal target, received significant interest, methionine adenosyltransferase 2a, favorable pharmacokinetic profile, deleted xenograft model, deleted tumors inhibition, novel mat2a inhibitors, exhibited high potency, current clinical compound, 30 , mat2a inhibition, vivo <, h <, c <, showed better, selected compound, one derivatives, methylthioadenosine phosphorylase, >] pyrimidin, >- pyrido, 2 -<

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Potent_and_Oral_Bioavailable_MAT2A_Inhibitors_for_the_Treatment_of_MTAP-Deleted_Tumors/24721366

الاتاحة: https://doi.org/10.1021/acsmedchemlett.3c00488.s001
https://figshare.com/articles/journal_contribution/Discovery_of_Potent_and_Oral_Bioavailable_MAT2A_Inhibitors_for_the_Treatment_of_MTAP-Deleted_Tumors/24721366

المؤلفون: Spinazzola, Edoardo, Quattrone, Diego, Rodriguez, Victoria, Trotta, Giulia, Alameda, Luis, Tripoli, Giada, Gayer-Anderson, Charlotte, Freeman, Tom P., Johnson, Emma C., Jongsma, Hannah E., Stilo, Simona, La Cascia, Caterina, Ferraro, Laura, La Barbera, Daniele, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, D'Andrea, Giuseppe, Galatolo, Michela, Tortelli, Andrea, Tagliabue, Ilaria, Turco, Marco, Pompili, Maurizio, Selten, Jean-Paul, de Haan, Lieuwe, Rossi Menezes, Paulo, Del Ben, Cristina M., Santos, Jose Luis, Arrojo, Manuel, Bobes, Julio, Sanjuan, Julio, Bernardo, Miguel, Arango, Celso, Kirkbride, James B., Jones, Peter B., O'Donovan, Michael, Rutten, Bart P., Van Os, Jim, Morgan, Craig, Sham, Pak C., Austin-Zimmerman, Isabelle, Li, Zhikun, Vassos, Evangelos, Murray, Robin M., Di Forti, Marta

المصدر: Spinazzola , E , Quattrone , D , Rodriguez , V , Trotta , G , Alameda , L , Tripoli , G , Gayer-Anderson , C , Freeman , T P , Johnson , E C , Jongsma , H E , Stilo , S , La Cascia , C , Ferraro , L , La Barbera , D , Lasalvia , A , Tosato , S , Tarricone , I , D'Andrea , G , Galatolo , M , Tortelli , A , Tagliabue , I , Turco , M , Pompili , M , Selten , ....

مصطلحات موضوعية: Cannabis use, path analysis, psychotic disorders, HIGH-POTENCY CANNABIS, SYMPTOMS, SCHIZOPHRENIA, DISORDERS, ONSET, RELIABILITY, EXPERIENCES, ENVIRONMENT, EPISODE

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/05c848fa-c322-4044-afcc-1bb4a9c486da
https://doi.org/10.1017/S0033291723001071

المؤلفون: Muralinath E., Pooja Devi, Prasanta Chbukdhara, Sanjib Borah, Kalyan C., Archana Jain, Guruprasad M.

المصدر: Research and Reviews in Intensive and Critical Care Nursing, 2(1), 1-8, (2023-12-06)

مصطلحات موضوعية: Skin derivatives, topical corticosteroids, eczema, dermatitis, psoriasis, pro_ inflammatory substances, low as well as high_potency corticosteroids, skin discoloration, skin thinning, athletes foot, fungal nail infections, clotrimazole, fluconazole, keroconazole, miconazole, terbinafine, jock itch, yeast infections, cephalexin, doxycyclin, neomycin, impetigo, folliculitis, diarrhea, stomach upset, retinoids, tretinoin, adapalene, calcineurin inhibitors, methotrexate

Relation: https://zenodo.org/communities/nurse; https://doi.org/10.5281/zenodo.10276018; https://doi.org/10.5281/zenodo.10276019; oai:zenodo.org:10276019

الاتاحة: https://doi.org/10.5281/zenodo.10276019

المؤلفون: Hans-Peter Gerber, Leonard G. Presta

المصدر: Frontiers in Oncology, Vol 12 (2022)

مصطلحات موضوعية: TCR mimic compounds, high potency modalities, protein binder scaffolds, targeted cancer therapy, cancer testis antigen, Antibody Drug Conjugates, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.1027548/full; https://doaj.org/toc/2234-943X

URL الوصول: https://doaj.org/article/3d9bcbd576b6440697b903d4530142d0

المؤلفون: Theunissen, Eef Lien, Kuypers, Kim Paula Colette, Mason, Natasha Leigh, Ramaekers, Johannes Gerardus

المصدر: Theunissen , E L , Kuypers , K P C , Mason , N L & Ramaekers , J G 2022 , ' A Comparison of Acute Neurocognitive and Psychotomimetic Effects of a Synthetic Cannabinoid and Natural Cannabis at Psychotropic Dose Equivalence ' , Frontiers in Psychiatry , vol. 13 , 891811 . https://doi.org/10.3389/fpsyt.2022.891811

مصطلحات موضوعية: ALCOHOL, BEHAVIORAL MEASURES, COCAINE, DELTA-9-TETRAHYDROCANNABINOL, HIGH-POTENCY CANNABIS, IMPULSIVITY, JWH-018, PERFORMANCE, PSYCHOSIS, SMOKED MARIJUANA, THC, cannabinoids, neurocognitive effects, psychotomimetic effects, psychotropic dose equivalence

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/a01685e1-8d2a-4c0b-88de-6d292d818f2c
https://doi.org/10.3389/fpsyt.2022.891811

المؤلفون: Huda Zahid (8823089), Caroline R. Buchholz (8413125), Manjulata Singh (3906433), Michael F. Ciccone (11425803), Alice Chan (1823551), Stanley Nithianantham (11425806), Ke Shi (154717), Hideki Aihara (277567), Marcus Fischer (44253), Ernst Schönbrunn (1319238), Camila O. dos Santos (11425809), Joseph W. Landry (11425812), William C. K. Pomerantz (8053445)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Developmental Biology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, useful starting points, nucleosome remodeling factor, new design rules, guide future designs, good physicochemical properties, emerging anticancer target, developing potent cell, alters chromatin accessibility, bptf knockdown cells, bptf bromodomain presents, high potency (<, chemical tool development, based bptf inhibitors, high potency, several cancers, potential strategy

Relation: https://figshare.com/articles/journal_contribution/New_Design_Rules_for_Developing_Potent_Cell-Active_Inhibitors_of_the_Nucleosome_Remodeling_Factor_NURF_via_BPTF_Bromodomain_Inhibition/16611261

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01294.s002

المؤلفون: Athandwe M. Paca, Peter A. Ajibade, Fartisincha P. Andrew, Nirasha Nundkumar, Moganavelli Singh

المصدر: Arabian Journal of Chemistry, Vol 14, Iss 9, Pp 103326- (2021)

مصطلحات موضوعية: Dithiocarbamate, Pd(II), Molecular structure, Cytotoxic evaluation, High potency, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1878535221003415; https://doaj.org/toc/1878-5352

URL الوصول: https://doaj.org/article/e4d8aba842eb478d829ce29224f30bb9

المؤلفون: Hannon, E., Dempster, E.L., Mansell, G., Burrage, J., Bass, N., Bohlken, M.M., Corvin, A., Curtis, C.J., Dempster, D., Di Forti, M., Dinan, T.G., Donohoe, G., Gaughran, F., Gill, M., Gillespie, A., Gunasinghe, C., Hulshoff, H.E., Hultman, C.M., Johansson, V., Kahn, R.S., Kaprio, J., Kenis, G., Kowalec, K., MacCabe, J., McDonald, C., McQuillin, A., Morris, D.W., Murphy, K.C., Mustard, C.J., Nenadic, I., O'Donovan, M.C., Quattrone, D., Richards, A.L., Rutten, B.P., St Clair, D., Therman, S., Toulopoulou, T., Van Os, J., Waddington, J.L., Sullivan, P., Vassos, E., Breen, G., Collier, D.A., Murray, R.M., Schalkwyk, L.S., Mill, J.

المصدر: Hannon , E , Dempster , E L , Mansell , G , Burrage , J , Bass , N , Bohlken , M M , Corvin , A , Curtis , C J , Dempster , D , Di Forti , M , Dinan , T G , Donohoe , G , Gaughran , F , Gill , M , Gillespie , A , Gunasinghe , C , Hulshoff , H E , Hultman , C M , Johansson , V , Kahn , R S , Kaprio , J , Kenis , G , Kowalec , K ....

مصطلحات موضوعية: 1ST-EPISODE PSYCHOSIS, BLOOD, BURDEN, DISEASE, HIGH-POTENCY CANNABIS, HUMAN BRAIN-TISSUE, METHYLOMIC VARIATION, RISK, TRAIT, WIDE ASSOCIATION

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/e452989f-7ebb-418e-a9c2-3e58be83b568
https://doi.org/10.7554/eLife.58430

المؤلفون: Xiaoyu Wang (182979), Rui Zhao (43391), Wenming Ji (9370959), Jie Zhou (28945), Quan Liu (486219), Linxiang Zhao (1338357), Zhufang Shen (4126459), Shuainan Liu (4126456), Bailing Xu (2303065)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, ray crystal structures, novel antidiabetic agents, distinct binding features, carboxylic acid scaffold, >- acylsulfonamide moiety, novel indole derivatives, 50 , 22f , n <, three x, submicromolar levels, structural basis, new indole, like properties, key enzyme, inhibitory activity, high potency, chemoinformatics analysis, benzofuran analogues

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Novel_Indole_Derivatives_as_Fructose-1_6-bisphosphatase_Inhibitors_and_X_ray_Cocrystal_Structures_Analysis/17303817

الاتاحة: https://doi.org/10.1021/acsmedchemlett.1c00613.s001

المؤلفون: Kai Yuan (289810), Minghui Ji (11879571), Shengnan Xie (9970522), Zhixia Qiu (5535824), Weijiao Chen (11879574), Wenjian Min (11560191), Fei Xia (256985), Mingming Zheng (718716), Xiao Wang (19312), Jiaxing Li (113609), Yi Hou (148620), Wenbin Kuang (1404673), Liping Wang (33601), Wanjian Gu (8306460), Zhiyu Li (10983), Peng Yang (296696)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Biotechnology, Cancer, Hematology, Infectious Diseases, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, increasingly important role, great pharmacokinetic properties, generate synergistic effects, excellent safety profile, dependent kinase 6, acute myeloid leukemia, great lead compound, based virtual screening, aml preclinical studies, 51 , 1 , displayed stronger potency, balanced dual cdk6, cancer treatment due, vivo <, via <, novel lead, high potency, dual cdk6, targeting cdk6

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Dual_CDK6_PIM1_Inhibitors_with_a_Novel_Structure_High_Potency_and_Favorable_Druggability_for_the_Treatment_of_Acute_Myeloid_Leukemia/17695128

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c02019.s001

المؤلفون: Hiroki Anzai (747844), Takuya Terai (1521961), Kanako Wakabayashi-Nakao (11349778), Taro Noguchi (698875), Shigefumi Kumachi (2867351), Masayuki Tsuchiya (11349781), Naoto Nemoto (2867348)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Physiology, Biotechnology, Cancer, Chemical Sciences not elsewhere classified, physiological heterogenous environments, attractive new modality, cdna may play, heterogenous conditions peptide, cyclic peptide aptamers, cdna display system, 12 , 17a peptide aptamers, cdna display, vitro <, peptide specificity, selected molecules, select molecules, powerful way, pivotal role, nanomolar affinity, high potency, high percentage, dna linker, conventional screenings, biological context, based drugs, approximately 10

Relation: https://figshare.com/articles/journal_contribution/Interleukin-17A_Peptide_Aptamers_with_an_Unexpected_Binding_Moiety_Selected_by_cDNA_Display_under_Heterogenous_Conditions/16528021

الاتاحة: https://doi.org/10.1021/acsmedchemlett.1c00217.s001

المؤلفون: Brian T. Hopkins (2723545), Eris Bame (7038266), Bekim Bajrami (230244), Cheryl Black (11647791), Tonika Bohnert (2700703), Carrie Boiselle (11647794), Doug Burdette (8379867), Jeremy C. Burns (9903441), Luisette Delva (11647797), Douglas Donaldson (6387041), Richard Grater (11647800), Chungang Gu (1638805), Marc Hoemberger (11647803), Josh Johnson (831725), Sudarshan Kapadnis (3829360), Kris King (11647806), Mukesh Lulla (11647809), Bin Ma (219839), Isaac Marx (11647812), Tom Magee (11647815), Robert Meissner (384997), Claire M. Metrick (9214871), Michael Mingueneau (4182721), Paramasivam Murugan (8042474), Kevin L. Otipoby (9214862), Evelyne Polack (9025907), Urjana Poreci (9214874), Robin Prince (11647818), Allie M. Roach (11647821), Chris Rowbottom (11647824), Joseph C. Santoro (8042477), Patricia Schroeder (647768), Hao Tang (44155), Eric Tien (424500), Fengmei Zhang (836324), Joseph Lyssikatos (1577434)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Genetics, Neuroscience, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, treating autoimmune diseases, tolerability profile suitable, important phosphorylation site, high potency molecule, central nervous system, axonal injury leading, superior safety profiles, inflammation processes leading, selective btk inhibitor, highly selective, reversible inhibitor, unmet need, sequester tyr, primary driver, preclinical characterization, like properties, inactive conformation, good drug, excellent affinity

Relation: https://figshare.com/articles/journal_contribution/Discovery_and_Preclinical_Characterization_of_BIIB091_a_Reversible_Selective_BTK_Inhibitor_for_the_Treatment_of_Multiple_Sclerosis/16930248

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00926.s001

المؤلفون: Shilin Gong (11581313), Yue Zhuo (311893), Shengshuang Chen (6114155), Xiaolan Hu (128041), Xing-Xing Fan (7011782), Jian-Lin Wu (2707027), Na Li (6550)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Pharmacology, Biotechnology, Inorganic Chemistry, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sensitive liquid chromatography, protein adducts formed, mixed hydrolysis method, covalent modification potential, covalent drugs, vivo <, target organs, successful therapies, small molecules, results interpreted, quantitative objects, quantitative approach, past decades, noninvasive monitoring, mass spectrometry, low abundance, lasting modifications, high potency, established based, blood testing

Relation: https://figshare.com/articles/journal_contribution/Quantification_of_Osimertinib_and_Metabolite_Protein_Modification_Reveals_Its_High_Potency_and_Long_Duration_of_Effects_on_Target_Organs/16832900

الاتاحة: https://doi.org/10.1021/acs.chemrestox.1c00195.s001

المؤلفون: Yangbo Feng (1346307), HaJeung Park (1346313), Jae Cheon Ryu (9763966), Sung OK Yoon (9763969)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, studies utilizing various, one lead compound, good oral bioavailability, 92 min ), vivo assays led, substituted indazole derivatives, selective jnk3 inhibitor, 50 , 29 , high brain penetration, 2 , based assays, n <, high stability, high potency, >< sub, plasma ratio, panel profiling, orally bioavailable

Relation: https://figshare.com/articles/journal_contribution/_i_N_i_Aromatic-Substituted_Indazole_Derivatives_as_Brain-Penetrant_and_Orally_Bioavailable_JNK3_Inhibitors/16652982

الاتاحة: https://doi.org/10.1021/acsmedchemlett.1c00334.s001