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1Academic Journal
المؤلفون: R. Benjamin Free (1316697), Ashley N. Nilson (14312793), Noelia M. Boldizsar (14312796), Trevor B. Doyle (14312799), Ramona M. Rodriguiz (185135), Vladimir M. Pogorelov (133492), Mayako Machino (14312802), Kuo Hao Lee (8436282), Jeremiah W. Bertz (14312805), Jinbin Xu (33400), Herman D. Lim (1655842), Andrés E. Dulcey (1316673), Robert H. Mach (279778), James H. Woods (1290507), J Robert Lane (12503554), Lei Shi (8144), Juan J. Marugan (191299), William C. Wetsel (185139), David R. Sibley (1618657)
مصطلحات موضوعية: Biochemistry, Molecular Biology, Neuroscience, Pharmacology, Cancer, Science Policy, Mental Health, Infectious Diseases, Chemical Sciences not elsewhere classified, thus indicating exceptional, receptor binding rates, orthosteric binding site, human primates demonstrated, functional profiling screens, dopamine receptor antagonist, 168 different gpcrs, pet imaging studies, kinetic studies revealed, approved d2r antagonists, ml321 exhibits slow, induced locomotor activity, 2 , novel d2r antagonist, vivo <, ppi studies, taken together, selectively antagonize, restored pre, relatively ineffective, rats demonstrate
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2Academic Journal
المؤلفون: Herman D. Lim, J. Robert Lane, Meritxell Canals, Martin J. Stone
المصدر: International Journal of Molecular Sciences; Volume 22; Issue 8; Pages: 4232
مصطلحات موضوعية: chemokine, chemokine receptor, CCR4, CCR7, CCR10, GPCR, signaling pathways, partial agonism, biased agonism
جغرافية الموضوع: agris
وصف الملف: application/pdf
Relation: Molecular Pharmacology; https://dx.doi.org/10.3390/ijms22084232
الاتاحة: https://doi.org/10.3390/ijms22084232
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المؤلفون: R. Benjamin Free, Ashley N. Nilson, Noelia M. Boldizsar, Trevor B. Doyle, Ramona M. Rodriguiz, Vladimir M. Pogorelov, Mayako Machino, Kuo Hao Lee, Jeremiah W. Bertz, Jinbin Xu, Herman D. Lim, Andrés E. Dulcey, Robert H. Mach, James H. Woods, J Robert Lane, Lei Shi, Juan J. Marugan, William C. Wetsel, David R. Sibley
المصدر: ACS Pharmacology & Translational Science. 6:151-170
مصطلحات موضوعية: Pharmacology, Pharmacology (medical)
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4Academic Journal
المؤلفون: J Robert Lane, Ara M Abramyan, Pramisha Adhikari, Alastair C Keen, Kuo-Hao Lee, Julie Sanchez, Ravi Kumar Verma, Herman D Lim, Hideaki Yano, Jonathan A Javitch, Lei Shi
المصدر: eLife, Vol 9 (2020)
مصطلحات موضوعية: dopamine d2 receptor, na+ sensitivity, inverse agonism, molecular dynamics, Medicine, Science, Biology (General), QH301-705.5
وصف الملف: electronic resource
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المؤلفون: R. Benjamin Free, Ashley N. Nilson, Noelia M. Boldizsar, Trevor B. Doyle, Ramona M. Rodriguiz, Vladimir M. Pogorelov, Mayako Machino, Kuo Hao Lee, Jeremiah W. Bertz, Jinbin Xu, Herman D. Lim, Andrés E. Dulcey, Robert H. Mach, James H. Woods, J Robert Lane, Lei Shi, Juan J. Marugan, William C. Wetsel, David R. Sibley
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المؤلفون: Ram Prasad Bhusal, Pramod Aryal, Shankar Raj Devkota, Rina Pokhrel, Menachem J. Gunzburg, Simon R. Foster, Herman D. Lim, Richard J. Payne, Matthew C. J. Wilce, Martin J. Stone
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 119(9)
مصطلحات موضوعية: Inflammation, Multidisciplinary, Ticks, Protein Conformation, Animals, Receptors, Chemokine, Chemokines, Protein Engineering, Arthropod Proteins, Protein Binding
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المؤلفون: Michelle L. Halls, Julie Sanchez, Claudia Alamein, Meritxell Canals, Alexander Gillis, Frank Schmiedel, J. Robert Lane, Tristan A. Reekie, Preeti Manandhar, Michael Kassiou, Mark Connor, Andrea Kliewer, MacDonald J. Christie, Arisbel B. Gondin, Timothy A. Katte, Marina Santiago, Cornelius Krasel, Herman D. Lim, Stefan Schulz, Natasha L. Grimsey, Barrie Kellam, Sebastian Fritzwanker
المصدر: Science signaling. 13(625)
مصطلحات موضوعية: Intrinsic activity, medicine.drug_class, G protein, Oliceridine, Receptors, Opioid, mu, Thiophenes, Pharmacology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Piperidines, Opioid receptor, Functional selectivity, medicine, Humans, Urea, Spiro Compounds, Receptor, Molecular Biology, beta-Arrestins, 030304 developmental biology, 0303 health sciences, Chemistry, Cell Biology, HEK293 Cells, Opioid, Benzimidazoles, Signal transduction, 030217 neurology & neurosurgery, medicine.drug
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المؤلفون: Julie Sanchez, Herman D. Lim, Ravi Kumar Verma, Ara M. Abramyan, Kuo-Hao Lee, Hideaki Yano, Lei Shi, Pramisha Adhikari, Jonathan A. Javitch, J. Robert Lane, Alastair C. Keen
المصدر: eLife, Vol 9 (2020)
eLifeمصطلحات موضوعية: 0301 basic medicine, Protein Conformation, QH301-705.5, Structural Biology and Molecular Biophysics, inverse agonism, Science, Molecular Dynamics Simulation, 01 natural sciences, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Molecular dynamics, Eticlopride, Biochemistry and Chemical Biology, Dopamine receptor D2, None, Drug Discovery, Salicylamides, 0103 physical sciences, Binding site, Biology (General), Receptor, Binding Sites, 010304 chemical physics, General Immunology and Microbiology, Receptors, Dopamine D2, Chemistry, Drug discovery, General Neuroscience, Molecular biophysics, Receptors, Dopamine D3, General Medicine, Risperidone, molecular dynamics, 3. Good health, 030104 developmental biology, na+ sensitivity, Structural biology, Dopamine Agonists, Biophysics, Dopamine Antagonists, Medicine, dopamine d2 receptor, Research Article, Protein Binding
وصف الملف: PDF
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المؤلفون: Lei Shi, Julie Sanchez, Hideaki Yano, Ara M. Abramyan, Herman D. Lim, Kuo-Hao Lee, Alastair C. Keen, Pramisha Adhikari, Ravi Kumar Verma, J. Robert Lane, Jonathan A. Javitch
مصطلحات موضوعية: Chemistry, Dopamine receptor D2, Biophysics, Inverse, Agonism, Receptor
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المؤلفون: Arthur Christopoulos, Herman D. Lim, Carmen Klein Herenbrink, Ben Capuano, J. Robert Lane, Anitha Kopinathan, Christopher J Draper-Joyce, Jeremy Shonberg, Peter J. Scammells, Lei Shi, Ravi Kumar Verma, Alastair C. Keen, Jonathan A. Javitch
المصدر: ACS Chem Biol
مصطلحات موضوعية: 0301 basic medicine, Indoles, Intrinsic activity, Dopamine, Aripiprazole, Molecular Conformation, Phenylpiperazine, Molecular Dynamics Simulation, Pharmacology, Ligands, 01 natural sciences, Partial agonist, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, Dopamine receptor D2, medicine, Receptor, Binding Sites, Receptors, Dopamine D2, 010405 organic chemistry, General Medicine, 0104 chemical sciences, 030104 developmental biology, chemistry, Dopamine Agonists, Mutation, Mutagenesis, Site-Directed, Molecular Medicine, Pharmacophore, Antipsychotic Agents, medicine.drug
وصف الملف: PDF
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المؤلفون: Tim J, Fyfe, Barbara, Zarzycka, Herman D, Lim, Barrie, Kellam, Shailesh N, Mistry, Vsevolod, Katrich, Peter J, Scammells, J Robert, Lane, Ben, Capuano
المصدر: Journal of medicinal chemistry. 62(1)
مصطلحات موضوعية: Receptors, Dopamine D2, Molecular Conformation, CHO Cells, Tritium, Molecular Docking Simulation, Kinetics, Structure-Activity Relationship, Cricetulus, Pyrimidines, Allosteric Regulation, Cricetinae, Isotope Labeling, Animals, Haloperidol, Humans, Allosteric Site, Protein Binding
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المؤلفون: Herman D. Lim, Peter J. Scammells, Ben Capuano, Shailesh N. Mistry, J. Robert Lane, Vsevolod Katrich, Barbara Zarzycka, Tim J. Fyfe, Barrie Kellam
مصطلحات موضوعية: 0303 health sciences, Allosteric modulator, genetic structures, Chemistry, Ligand, Stereochemistry, Allosteric regulation, Dopaminergic, Cooperative binding, Cooperativity, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Dopamine receptor, Dopamine receptor D2, Drug Discovery, Molecular Medicine, 030304 developmental biology
وصف الملف: application/pdf;
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المؤلفون: Benjamin T. Porebski, Zil E Huma, Meritxell Canals, Kevin D. G. Pfleger, Martin J. Stone, Bradyn J. Parker, Herman D. Lim, Cheng Huang, J. Robert Lane, Jessica L. Bridgford, Julie Sanchez, Jiann G. Pazhamalil
المصدر: Science signaling. 10(480)
مصطلحات موضوعية: 0301 basic medicine, CCR1, Models, Molecular, CCR2, Monocyte Chemoattractant Proteins, Chemokine receptor CCR5, Receptors, CCR2, animal diseases, CCR3, Sequence Homology, CCL7, Biochemistry, 03 medical and health sciences, Chemokine receptor, parasitic diseases, Humans, Amino Acid Sequence, Chemokine CCL7, CX3CL1, Molecular Biology, Chemokine CCL2, biology, Cell Biology, Cell biology, 030104 developmental biology, biology.protein, Chemokines, Protein Binding
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المؤلفون: Herman D. Lim, Iwan J. P. de Esch, Rogier A. Smits, Karin Bessembinder, Sebastiaan Kuhne, Maikel Wijtmans, Tiffany van der Meer, Rob Leurs, Obbe P. Zuiderveld
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:461-467
مصطلحات موضوعية: Stereochemistry, Organic Chemistry, Clinical Biochemistry, Antagonist, Pharmaceutical Science, Biochemistry, Receptor–ligand kinetics, chemistry.chemical_compound, Histamine receptor, chemistry, Drug Discovery, Molecular Medicine, Histamine H4 receptor, Isoquinoline, Receptor, Molecular Biology, Histamine, G protein-coupled receptor
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المؤلفون: Herman D. Lim, Douglas S. Auld, Maria L. Webb, Jac C. H. M. Wijkmans, Jiuqiao Zhao, Luc Roumen, Rob Leurs, Chris de Graaf, Petra de Kruijf, Martine J. Smit, Véronique A. Renjaän, G.J.R. Zaman
المساهمون: Medicinal chemistry, AIMMS
المصدر: Molecular Pharmacology, 80, 1108-1118. American Society for Pharmacology and Experimental Therapeutics
de Kruijf, P, Lim, H D, Roumen, L, Renjaan, V A, Zhao, J, Webb, M J, Auld, D A, Wijkmans, J C H M, Zaman, G J R, Smit, M J, de Graaf, C & Leurs, R 2011, ' Identification of a novel allosteric binding site in the CXCR2 chemokine receptor ', Molecular Pharmacology, vol. 80, pp. 1108-1118 . https://doi.org/10.1124/mol.111.073825مصطلحات موضوعية: Pan troglodytes, Stereochemistry, Allosteric regulation, Molecular Sequence Data, Ligands, Receptors, Interleukin-8B, Chemokine receptor, Species Specificity, Pongo pygmaeus, Chlorocebus aethiops, Animals, Humans, Amino Acid Sequence, Binding site, Receptor, Pharmacology, Gorilla gorilla, biology, Rod Opsins, Cooperative binding, hemic and immune systems, respiratory system, Ligand (biochemistry), Macaca mulatta, respiratory tract diseases, Transmembrane domain, Allosteric enzyme, COS Cells, biology.protein, Molecular Medicine, Allosteric Site, Papio
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المؤلفون: Aletta D. Kraneveld, G.J.R. Zaman, Saskia A. Overbeek, Gert Folkerts, Herman D. Lim, Rob Leurs, Petra de Kruijf, Martine J. Smit
المساهمون: Medicinal chemistry, AIMMS
المصدر: De Kruijf, P, Lim, H D, Overbeek, S A, Zaman, G J R, Kraneveld, A D, Folkerts, G, Leurs, R & Smit, M J 2010, ' The collagen-breakdown product N-acetyl-Proline-Glycine-Proline (N-alpha-PGP) does not interact directly with human CXCR1 and CXCR2 ', European Journal of Pharmacology, vol. 643, no. 1, pp. 29-33 . https://doi.org/10.1016/j.ejphar.2010.06.017
European Journal of Pharmacology, 643(1), 29-33. Elsevierمصطلحات موضوعية: musculoskeletal diseases, Chemokine, Neutrophils, Cell Culture Techniques, Inflammation, Biology, Ligands, Transfection, Binding, Competitive, Receptors, Interleukin-8B, Cell Line, Receptors, Interleukin-8A, Radioligand Assay, Chemokine receptor, SDG 3 - Good Health and Well-being, medicine, Humans, Interleukin 8, CXC chemokine receptors, Receptor, Pharmacology, integumentary system, Chemotaxis, hemic and immune systems, respiratory system, respiratory tract diseases, Cell biology, Biochemistry, Cell culture, biology.protein, Collagen, medicine.symptom, Oligopeptides
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المؤلفون: Rob Leurs, Wen Jiang, Iwan J. P. de Esch, Patricia M. McGovern, Chris de Graaf, Remko A. Bakker, Enade Perdana Istyastono, Robin L. Thurmond, Herman D. Lim, Payman Sadek
المساهمون: Medicinal chemistry, AIMMS
المصدر: Lim, H D, de Graaf, C, Jiang, W, Sadek, P, McGovern, P M, Istyastono, E P, Bakker, R A, De Esch, I J, Thurmond, R L & Leurs, R 2010, ' Molecular determinants of ligand binding to H4R species variants. ', Molecular Pharmacology, vol. 77, pp. 734-743 . https://doi.org/10.1124/mol.109.063040
Molecular Pharmacology, 77, 734-743. American Society for Pharmacology and Experimental Therapeuticsمصطلحات موضوعية: Agonist, DNA, Complementary, medicine.drug_class, Guinea Pigs, Molecular Sequence Data, Biology, Transfection, Cell Line, Receptors, G-Protein-Coupled, Mice, chemistry.chemical_compound, Histamine receptor, Dogs, VUF-6002, Species Specificity, SDG 3 - Good Health and Well-being, Chlorocebus aethiops, medicine, Animals, Amino Acid Sequence, Histamine H4 receptor, Receptors, Histamine H4, JNJ-7777120, Pharmacology, Thioperamide, Sequence Homology, Amino Acid, Genetic Variation, Haplorhini, Ligand (biochemistry), Rats, Biochemistry, chemistry, COS Cells, Mutagenesis, Site-Directed, Receptors, Histamine, Molecular Medicine, VUF-8430, Sequence Alignment, Histamine, Plasmids, medicine.drug
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المؤلفون: Elena Guaita, Ralf Gutzmer, Rob Leurs, Gabriella Coruzzi, Rogier A. Smits, Herman D. Lim, Maristella Adami, Thomas Werfel, Remko A. Bakker, Iwan J. P. de Esch
المصدر: British Journal of Pharmacology. 157:34-43
مصطلحات موضوعية: Pharmacology, Agonist, medicine.medical_specialty, medicine.drug_class, Dimaprit, Histamine agonist, chemistry.chemical_compound, Histamine receptor, Endocrinology, Amthamine, chemistry, Internal medicine, medicine, VUF-8430, Histamine H4 receptor, 4-Methylhistamine
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المؤلفون: Fiona C. Shenton, Iwan J. P. de Esch, Herman D. Lim, Rob Leurs, Paul L. Chazot
المصدر: British Journal of Pharmacology. 157:14-23
مصطلحات موضوعية: Pharmacology, Histamine receptor, chemistry.chemical_compound, Immune system, chemistry, Histamine H4 receptor, Molecular Pharmacology, Biology, Signal transduction, Receptor, Biochemical Pharmacology, Histamine
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المؤلفون: Paolo Conti, Martin J. Smit, Rob Leurs, Douglas S. Auld, Petra de Kruijf, Martine J. Smit, Leontien Bosch, Miranda M. C. van der Lee, Jane van Heteren, Jac C. H. M. Wijkmans, G.J.R. Zaman, Herman D. Lim, Koc-Kan Ho, Michael Ohlmeyer
المساهمون: Medicinal chemistry
المصدر: de Kruijf, P, van Heteren, J T, Lim, H D, Conti, P, van der Lee, M M, Bosch, L, Ho, K K, Auld, D S, Ohlmeyer, M, Smit, M J, Wijkmans, J C, Zaman, G J & Leurs, R 2009, ' Nonpeptidergic allosteric antagonists differentially bind to the CXCR2 chemokine receptor ', The Journal of Pharmacology and Experimental Therapeutics, vol. 329, no. 2, pp. 783-90 . https://doi.org/10.1124/jpet.108.148387
The Journal of Pharmacology and Experimental Therapeutics, 329(2), 783-90. American Society for Pharmacology and Experimental Therapeuticsمصطلحات موضوعية: musculoskeletal diseases, Allosteric regulation, Plasma protein binding, Pharmacology, Transfection, Binding, Competitive, Receptors, Interleukin-8B, Chemokine receptor, Radioligand Assay, Structure-Activity Relationship, SDG 3 - Good Health and Well-being, Chlorocebus aethiops, Radioligand, Animals, Humans, CXC chemokine receptors, Binding site, Receptor, Chemistry, Phenylurea Compounds, hemic and immune systems, respiratory system, biological factors, respiratory tract diseases, COS Cells, Molecular Medicine, Allosteric Site, Protein Binding
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