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المؤلفون: Samir A. Mahgoub, Abdulrahman I. Almansour, Salha M Aljubiri, Kamel H. Shaker, Mohamed Shaaban
المصدر: Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences, Vol 28, Iss 1, Pp 417-426 (2021)مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, HSQC, Heteronuclear single quantum coherence spectroscopy, J, Coupling Constant, MTT, Colorimetric assay for measuring cell metabolic activity as an indicator of cell viability, proliferation, and cytotoxicity, HePG2, Human hepatocellular carcinoma cell line, Isoorientin, Cytotoxicity, dd, Doublet of doublet, HMQC, Hetero-nuclear multiple quantum correlation spectroscopy, Ethyl acetate, Ether, Euphorbia balsamifera, 01 natural sciences, HCT116, Colon cell line, δ, Chemical shift (in ppm), Enterococcus faecalis, GC–MS, Gas Chromatogrphy/ Mass Spectrometry, Isolation, 03 medical and health sciences, chemistry.chemical_compound, d, Doublet, ESIMS, Electrospray Ionization Mass Spectrometry, 1H–1H COSY, Proton Correlation Spectrometry, HMBC, Hetero-nuclear multiple bond correlation spectroscopy, TLC, Thin-layer Chromatography, GC–MS, E. balsamifera, Euphorbia balsamifera, lcsh:QH301-705.5, Spectroscopy, MCF7, Human Caucasian breast adenocarcinoma, Chromatography, biology, Chemistry, biology.organism_classification, Antibacterial, 030104 developmental biology, lcsh:Biology (General), Original Article, DEPT, Distortionless enhancement by polarization transfer, Gas chromatography–mass spectrometry, General Agricultural and Biological Sciences, Antibacterial activity, Asir region, Bacteria, 010606 plant biology & botany
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المؤلفون: Gregory Upert, Philipp Ermert, Anatol Luther, Daniel Obrecht
المصدر: Medicine in Drug Discovery
Medicine in Drug Discovery, Vol 9, Iss, Pp 100078-(2021)مصطلحات موضوعية: WT, wild type, antimicrobial peptide, CMS, colistin methane sulfonate, Polymyxin, Antibiotics, VRE, vancomycin-resistant enterococcus, lcsh:RS1-441, Peptide, Review Article, LptC, lipopolysaccharide transport protein C, Pharmacology, AMR, antimicrobial resistance, chemistry.chemical_compound, mITT population, minimal intend-to-treat population, Drug Discovery, Hpg, 4-hydroxy-phenyl glycine, Pharmacology (medical), AMP, antimicrobial peptide, CD, circular dichroism, chemistry.chemical_classification, Drug discovery, ITC, isothermal titration calorimetry, LptD, lipopolysaccharide transport protein D, ESKAPE, acronym encompassing six bacterial pathogens (often carrying antibiotic resistance): Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp, Lipopeptide, CLSI, clinical & laboratory standards institute, RBC, red blood cell, MDR, multidrug-resistant, POPC, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, i.p., intraperitoneal, MH-I, Müller-Hinton broth I, NDM-1, New Dehli metallo-β-lactamase resistant, HepG2, human hepatocellular carcinoma cell line, LPS, lipopolysaccharide, bid, bis in die (two times a day), Bacterial outer membrane, s.c., subcutaneous, MRSA, methicilline-resistant Staphylococcus aureus, FDA, U. S. Food and Drug Administration, Omp, outer membrane protein, VABP, ventilator associated bacterial pneumonia, medicine.drug_class, PBP, penicillin-binding protein, PBS, phosphate-buffered saline, ADMET, absorption, distribution, metabolism and excretion – toxicity in pharmacokinetics, HEK293, human embryonic kidney 293 cells, SPR, surface plasmon resonance, VISA, vancomycin-intermediate Staphylococcus aureus, LptA, lipopolysaccharide transport protein A, WHO, World Health Organization, lcsh:Pharmacy and materia medica, KPC, klebsiella pneumoniae metallo-β-lactamase C resistant, Antibiotic resistance, MoA, mechanism (mode) of action, SPase I, signal peptidase I, i.v., intravenous, OMPTA (outer membrane targeting antibiotic), HDP, host-defense peptide, medicine, WTA, wall teichoic acid, MIC, minimal inhibitory concentration, XDR, extremely drug-resistant, ATCC, ATCC cell collection, antimicrobial resistance, DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine, Mode of action, PBMC, peripheral mononuclear blood cell, POPG, 2-oleoyl-1-palmitoyl-sn-glycero-3-phospho-(1-glycerol), CC50, cytotoxic concentration to kill 50% of cells, ODL, odilorhabdin, HABP, hospital acquired bacterial pneumonia, Antibiotic, MH-II, Müller-Hinton broth II (cation adjusted), peptide antibiotic, CFU, colony forming unit, SAR, structure activity relationship, MSSA, methicilline-sensitive Staphylococcus aureus, chemistry, lipopeptide, NOAEL, no adverse effect level, PK, pharmacokinetics, PrAMPs, polyproline antimicrobial peptides, BAM, β-barrel assembly machinery, HK-2, human kidney 2 cells (proximal tubular cell line), OMPTA, outer membrane targeting antibiotic, VIM-1, beta-lactamase 2 (Klebsiella pneumoniae)
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المؤلفون: Di Shao, Richard A. Cohen, Mark E. McComb, Chunxiang Yao, Maya H. Kim, Markus Bachschmid, Jessica L. Fry, Reiko Matsui, Francesca Seta, Catherine E. Costello
المصدر: Redox Biology, Vol 22, Iss, Pp-(2019)
Redox Biologyمصطلحات موضوعية: 0301 basic medicine, Male, endocrine system diseases, GSH, reduced glutathione, Clinical Biochemistry, Endogeny, Resveratrol, medicine.disease_cause, Biochemistry, B6J, C57BL/6J mouse strain, Mass Spectrometry, chemistry.chemical_compound, Mice, HPHG, high palmitate high glucose medium, 0302 clinical medicine, SRT1720, Sirtuin 1, NAD+, nicotinamide adenine dinucleotide, Drug Discovery, lcsh:QH301-705.5, lcsh:R5-920, biology, Chemistry, GSSG, oxidized glutathione, food and beverages, Hep G2 Cells, HFHS, high fat high sucrose diet, HEK-293, human embryonic kidney cell-293, p53, tumor suppressor p53, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, HPLC, high performance liquid chromatography, Sirtuin, HepG2, human hepatocellular carcinoma cell line, IAM, iodoacetamide, lipids (amino acids, peptides, and proteins), IP, immuno-precipitation, lcsh:Medicine (General), hormones, hormone substitutes, and hormone antagonists, IgG, immunoglobulin G, Antineoplastic Agents, Mice, Transgenic, ND, chow diet, Article, RONS, reactive oxygen and nitrogen species, 03 medical and health sciences, Stress, Physiological, medicine, Animals, Humans, Metabolomics, CysNO, S-nitrosocysteine, DBC-1, deleted in breast cancer 1, Organic Chemistry, SirT1, Sirtuin-1, Enzyme Activation, Oxidative Stress, enzymes and coenzymes (carbohydrates), 030104 developmental biology, Mitochondrial biogenesis, LacZ, beta-galactosidase, MS, mass spectrometry, lcsh:Biology (General), SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis, biology.protein, BSA, bovine serum albumin, NAD+ kinase, SirBACO, Sirtuin-1 Bacterial Artificial Chromosome Overexpressor, 030217 neurology & neurosurgery, Oxidative stress