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1Academic Journal
المؤلفون: Dierckx, Tess, Vanherle, Sam, Haidar, Mansour, Grajchen, Elien, Mingneau, Fleur, Gervois, Pascal, Wolfs, Esther, Bylemans, Dany, Voet, Arnout, Nguyen, Tien, Hamad, Ibrahim, Kleinewietfeld, Markus, Bogie, Jeroen F. J., Hendriks, Jerome J. A.
المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2022 Nov . 119(46), 1-9.
URL الوصول: https://www.jstor.org/stable/27209382
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2Academic Journal
المؤلفون: Van Gaever, Femke, Mingneau, Fleur, Vanherle, Sam, Driege, Yasmine, Haegman, Mira, Van Wonterghem, Elien, Xie, Junhua, Vandenbroucke, Roosmarijn, Hendriks, Jerome J. A., Beyaert, Rudi, Staal, Jens
المصدر: FRONTIERS IN IMMUNOLOGY ; ISSN: 1664-3224
مصطلحات موضوعية: Biology and Life Sciences, Medicine and Health Sciences
وصف الملف: application/pdf
Relation: https://biblio.ugent.be/publication/01JH873BFWG96QW35EVDD0BJ0J; http://doi.org/10.3389/fimmu.2024.1500697; https://biblio.ugent.be/publication/01JH873BFWG96QW35EVDD0BJ0J/file/01JH87PQSP1JZHWJMS3DB1BBSY
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3Academic Journal
المؤلفون: McNamara, Niamh B., Munro, David A. D., Bestard-Cuche, Nadine, Uyeda, Akiko, Bogie, Jeroen F. J., Hoffmann, Alana, Holloway, Rebecca K., Molina-Gonzalez, Irene, Askew, Katharine E., Mitchell, Stephen, Mungall, William, Dodds, Michael, Dittmayer, Carsten, Moss, Jonathan, Rose, Jamie, Szymkowiak, Stefan, Amann, Lukas, McColl, Barry W., Prinz, Marco, Spires-Jones, Tara L., Stenzel, Werner, Horsburgh, Karen, Hendriks, Jerome J. A., Pridans, Clare, Muramatsu, Rieko, Williams, Anna, Priller, Josef, Miron, Veronique E.
المصدر: Nature ; volume 631, issue 8021, page E11-E11 ; ISSN 0028-0836 1476-4687
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4Academic Journal
المؤلفون: Grajchen, Elien, Loix, Melanie, Baeten, Paulien, Côrte-Real, Beatriz F., Hamad, Ibrahim, Vanherle, Sam, Haidar, Mansour, Dehairs, Jonas, Broos, Jelle Y., Ntambi, James M., Zimmermann, Robert, Breinbauer, Rolf, Stinissen, Piet, Hellings, Niels, Verberk, Sanne G. S., Kooij, Gijs, Giera, Martin, Swinnen, Johannes V., Broux, Bieke, Kleinewietfeld, Markus, Hendriks, Jerome J. A., Bogie, Jeroen F. J.
المصدر: Grajchen , E , Loix , M , Baeten , P , Côrte-Real , B F , Hamad , I , Vanherle , S , Haidar , M , Dehairs , J , Broos , J Y , Ntambi , J M , Zimmermann , R , Breinbauer , R , Stinissen , P , Hellings , N , Verberk , S G S , Kooij , G , Giera , M , Swinnen , J V , Broux , B , Kleinewietfeld , M , Hendriks , J J A & Bogie , J F J 2023 , ....
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5Academic Journal
المؤلفون: McNamara, Niamh B, Munro, David A D, Mungall, William, Dodds, Michael, Dittmayer, Carsten, Moss, Jonathan, Rose, Jamie, Szymkowiak, Stefan, Amann, Lukas, McColl, Barry W, Prinz, Marco, Spires-Jones, Tara L, Bestard-Cuche, Nadine, Stenzel, Werner, Horsburgh, Karen, Hendriks, Jerome J A, Pridans, Clare, Muramatsu, Rieko, Williams, Anna, Priller, Josef, Miron, Veronique E, Uyeda, Akiko, Bogie, Jeroen F J, Hoffmann, Alana, Holloway, Rebecca K, Molina-Gonzalez, Irene, Askew, Katharine E, Mitchell, Stephen
المصدر: Nature 613(7942), 120 - 129 (2023). doi:10.1038/s41586-022-05534-y
مصطلحات موضوعية: info:eu-repo/classification/ddc/500, Central Nervous System: cytology, Humans, Mice, Animals, Adult, Myelin Sheath: metabolism, Microglia: metabolism, Neurodegenerative Diseases: metabolism, Central Nervous System: metabolism, Axons: metabolism, Oligodendroglia, Central Nervous System: pathology, Microglia: cytology, Microglia: pathology, Myelin Sheath: pathology, Neurodegenerative Diseases: pathology, Oligodendroglia: metabolism, Oligodendroglia: pathology, Cognition, Transforming Growth Factor beta1: metabolism, Receptor, Transforming Growth Factor-beta Type I: metabolism, Lipid Metabolism, Aging: metabolism, Aging: pathology, Transforming Growth Factor beta1, Transforming Growth Factor-beta Type I
جغرافية الموضوع: DE
Relation: info:eu-repo/semantics/altIdentifier/issn/0028-0836; info:eu-repo/semantics/altIdentifier/pmid/pmid:36517604; info:eu-repo/semantics/altIdentifier/issn/1476-4687; https://pub.dzne.de/record/169135; https://pub.dzne.de/search?p=id:%22DZNE-2023-00014%22
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6Academic Journal
المؤلفون: Vanherle, Sam, Guns, Jeroen, Loix, Melanie, Mingneau, Fleur, Dierckx, Tess, Wouters, Flore, Kuipers, Koen, Vangansewinkel, Tim, Wolfs, Esther, Lins, Paula Pincela, Bronckaers, Annelies, Lambrichts, Ivo, Dehairs, Jonas, Swinnen, Johannes V., Verberk, Sanne G. S., Haidar, Mansour, Hendriks, Jerome J. A., Bogie, Jeroen F. J.
المساهمون: Fonds Wetenschappelijk Onderzoek, Interreg Vlaanderen-Nederland
المصدر: Journal of Extracellular Vesicles ; volume 12, issue 12 ; ISSN 2001-3078 2001-3078
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7Academic Journal
المؤلفون: Loix, Melanie, Vanherle, Sam, Turri, Marta, Kemp, Stephan, Fernandes, Karl J. L., Hendriks, Jerome J. A., Bogie, Jeroen F. J.
المصدر: Molecular Neurodegeneration; 11/19/2024, Vol. 19 Issue 1, p1-15, 15p
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8Academic Journal
المؤلفون: McNamara, Niamh B., Munro, David A. D., Bestard-Cuche, Nadine, Uyeda, Akiko, Bogie, Jeroen F. J., Hoffmann, Alana, Holloway, Rebecca K., Molina-Gonzalez, Irene, Askew, Katharine E., Mitchell, Stephen, Mungall, William, Dodds, Michael, Dittmayer, Carsten, Moss, Jonathan, Rose, Jamie, Szymkowiak, Stefan, Amann, Lukas, McColl, Barry W., Prinz, Marco, Spires-Jones, Tara L., Stenzel, Werner, Horsburgh, Karen, Hendriks, Jerome J. A., Pridans, Clare, Muramatsu, Rieko, Williams, Anna, Priller, Josef, Miron, Veronique E.
المصدر: Nature ; volume 613, issue 7942, page 120-129 ; ISSN 0028-0836 1476-4687
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9Academic Journal
المؤلفون: Dierckx, Tess, Haidar, Mansour, Grajchen, Elien, Wouters, Elien, Vanherle, Sam, Loix, Melanie, Boeykens, Annick, Bylemans, Dany, Hardonnière, Kévin, Kerdine-Römer, Saadia, Bogie, Jeroen F. J., Hendriks, Jerome J. A.
المساهمون: Fonds Wetenschappelijk Onderzoek, Vlaamse regering
المصدر: Journal of Neuroinflammation ; volume 18, issue 1 ; ISSN 1742-2094
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10Academic Journal
المؤلفون: Bogie, Jeroen F. J., Grajchen, Elien, Wouters, Elien, Corrales, Aida Garcia, Dierckx, Tess, Vanherle, Sam, Mailleux, Jo, Gervois, Pascal, Wolfs, Esther, Dehairs, Jonas, Van Broeckhoven, Jana, Bowman, Andrew P., Lambrichts, Ivo, Gustafsson, Jan-Ake, Remaley, Alan T., Mulder, Monique, Swinnen, Johannes, Haidar, Mansour, Ellis, Shane R., Ntambi, James M., Zelcer, Noam, Hendriks, Jerome J. A.
المصدر: Bogie , J F J , Grajchen , E , Wouters , E , Corrales , A G , Dierckx , T , Vanherle , S , Mailleux , J , Gervois , P , Wolfs , E , Dehairs , J , Van Broeckhoven , J , Bowman , A P , Lambrichts , I , Gustafsson , J-A , Remaley , A T , Mulder , M , Swinnen , J , Haidar , M , Ellis , S R , Ntambi , J M , Zelcer , N & Hendriks , J J A 2020 , ....
مصطلحات موضوعية: CHOLESTEROL EFFLUX, MYELIN PHAGOCYTOSIS, FATTY-ACIDS, ELECTROSPRAY-IONIZATION, STIMULATED MACROPHAGES, DEFICIENCY PROTECTS, GENE-EXPRESSION, FOAM CELLS, MICE, REMYELINATION
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11Academic Journal
المؤلفون: Bowman, Andrew P., Bogie, Jeroen F. J., Hendriks, Jerome J. A., Haidar, Mansour, Belov, Mikhail, Heeren, Ron M. A., Ellis, Shane R.
المصدر: Bowman , A P , Bogie , J F J , Hendriks , J J A , Haidar , M , Belov , M , Heeren , R M A & Ellis , S R 2020 , ' Evaluation of lipid coverage and high spatial resolution MALDI-imaging capabilities of oversampling combined with laser post-ionisation ' , Analytical and Bioanalytical Chemistry , vol. 412 , no. 10 , pp. 2277-2289 . https://doi.org/10.1007/s00216-019-02290-3
مصطلحات موضوعية: Mass spectrometry imaging, MALDI, Lipids, Kidney, Brain, Multiple sclerosis, MASS-SPECTROMETRY, ELECTROSPRAY-IONIZATION, DESORPTION IONIZATION, ELEVATED PRESSURE, WHITE-MATTER, TISSUE, SPHINGOLIPIDS, SUBLIMATION, SECTIONS
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12Academic Journal
المؤلفون: Grajchen, Elien, Wouters, Elien, van de Haterd, Britt, Haidar, Mansour, Hardonnière, Kévin, Dierckx, Tess, Van Broeckhoven, Jana, Erens, Celine, Hendrix, Sven, Kerdine-Römer, Saadia, Hendriks, Jerome J. A., Bogie, Jeroen F. J.
المساهمون: Fonds Wetenschappelijk Onderzoek, Belgian Charcot Foundation, Bijzonder Onderzoeksfonds UHasselt
المصدر: Journal of Neuroinflammation ; volume 17, issue 1 ; ISSN 1742-2094
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13Academic Journal
المؤلفون: Wetzels, Suzan, Vanmierlo, Tim, Scheijen, Jean L. J. M., van Horssen, Jack, Amor, Sandra, Somers, Veerle, Schalkwijk, Casper G., Hendriks, Jerome J. A., Wouters, Kristiaan
المصدر: Wetzels , S , Vanmierlo , T , Scheijen , J L J M , van Horssen , J , Amor , S , Somers , V , Schalkwijk , C G , Hendriks , J J A & Wouters , K 2019 , ' Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions ' , Frontiers in Immunology , vol. 10 , pp. 855 . https://doi.org/10.3389/fimmu.2019.00855
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14Academic Journal
المؤلفون: Wouters, Elien, de Wit, Nienke M, Vanmol, Jasmine, van der Pol, Susanne M A, van Het Hof, Bert, Sommer, Daniela, Loix, Melanie, Geerts, Dirk, Gustafsson, Jan Ake, Steffensen, Knut R, Vanmierlo, Tim, Bogie, Jeroen F J, Hendriks, Jerome J A, de Vries, Helga E
المصدر: Wouters , E , de Wit , N M , Vanmol , J , van der Pol , S M A , van Het Hof , B , Sommer , D , Loix , M , Geerts , D , Gustafsson , J A , Steffensen , K R , Vanmierlo , T , Bogie , J F J , Hendriks , J J A & de Vries , H E 2019 , ' Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function ' , Frontiers in Immunology , vol. 10 , pp. 1811 . https://doi.org/10.3389/fimmu.2019.01811
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15Academic Journal
المؤلفون: Bogie, Jeroen, Hoeks, Cindy, Schepers, Melissa, Tiane, Assia, Cuypers, Ann, Leijten, Frank, Chintapakorn, Yupyn, Suttiyut, Thiti, Pornpakakul, Surachai, Struik, Dicky, Kerksiek, Anja, Liu, Hong-Bing, Hellings, Niels, Martinez-Martinez, Pilar, Jonker, Johan W., Dewachter, Ilse, Sijbrands, Eric, Walter, Jochen, Hendriks, Jerome J. A., Groen, Albert, Staels, Bart, Lutjohann, Dieter, Vanmierlo, Tim, Mulder, Monique
وصف الملف: application/pdf
Relation: 1. Parihar, M. S. & Hemnani, T. Alzheimer’s disease pathogenesis and therapeutic interventions. Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia 11, 456–467, https://doi.org/10.1016/j.jocn.2003.12.007 (2004). 2. Jansen, D. et al. Cholesterol and synaptic compensatory mechanisms in Alzheimer’s disease mice brain during aging. Journal of Alzheimer’s disease: JAD 31, 813–826, https://doi.org/10.3233/jad-2012-120298 (2012). 3. Jones, L. et al. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer’s disease. PloS one 5, e13950, https://doi.org/10.1371/journal.pone.0013950 (2010). 4. Kolsch, H. et al. Alterations of cholesterol precursor levels in Alzheimer’s disease. Biochim Biophys Acta 1801, 945–950, https://doi. org/10.1016/j.bbalip.2010.03.001 (2010). 5. Kolsch, H. et al. Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients. Neurosci Lett 368, 303–308, https:// doi.org/10.1016/j.neulet.2004.07.031 (2004). 6. Mulder, M. Sterols in the central nervous system. Current opinion in clinical nutrition and metabolic care 12, 152–158, https://doi. org/10.1097/MCO.0b013e32832182da (2009). 7. Popp, J. et al. Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer’s disease. J Neurochem 123, 310–316, https://doi.org/10.1111/j.1471-4159.2012.07893.x (2012). 8. Shobab, L. A., Hsiung, G. Y. & Feldman, H. H. Cholesterol in Alzheimer’s disease. The Lancet. Neurology 4, 841–852, https://doi. org/10.1016/s1474-4422(05)70248-9 (2005). 9. Stefani, M. & Liguri, G. Cholesterol in Alzheimer’s disease: unresolved questions. Current Alzheimer research 6, 15–29 (2009). 10. Vanmierlo, T. et al. Alterations in brain cholesterol metabolism in the APPSLxPS1mut mouse, a model for Alzheimer’s disease. Journal of Alzheimer’s disease: JAD 19, 117–127, https://doi.org/10.3233/JAD-2010-1209 (2010). 11. Vanmierlo, T. et al. Plant sterols: friend or foe in CNS disorders? Progress in Lipid Research, https://doi.org/10.1016/j. plipres.2015.01.003 (2015). 12. Fassbender, K. et al. Simvastatin strongly reduces levels of Alzheimer’s disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc Natl Acad Sci USA 98, 5856–5861, https://doi.org/10.1073/pnas.081620098 (2001). 13. Jiang, Q. et al. ApoE Promotes the Proteolytic Degradation of Aβ. Neuron 58, 681–693, https://doi.org/10.1016/j.neuron.2008.04.010 (2008). 14. Vanmierlo, T. et al. Liver X receptor activation restores memory in aged AD mice without reducing amyloid. Neurobiology of aging 32, 1262–1272, https://doi.org/10.1016/j.neurobiolaging.2009.07.005 (2011). 15. Baez-Becerra, C. et al. Receptor Agonist GW3965 Regulates Synaptic Function upon Amyloid Beta Exposure in Hippocampal Neurons. Neurotoxicity research 33, 569–579, https://doi.org/10.1007/s12640-017-9845-3 (2018). 16. Lei, C. et al. Amelioration of amyloid beta-induced retinal inflammatory responses by a LXR agonist TO901317 is associated with inhibition of the NF-kappaB signaling and NLRP3 inflammasome. Neuroscience 360, 48–60, https://doi.org/10.1016/j. neuroscience.2017.07.053 (2017). 17. Stachel, S. J. et al. Identification and in Vivo Evaluation of Liver X Receptor beta-Selective Agonists for the Potential Treatment of Alzheimer’s Disease. Journal of medicinal chemistry 59, 3489–3498, https://doi.org/10.1021/acs.jmedchem.6b00176 (2016). 18. Sandoval-Hernandez, A. G. et al. Liver X Receptor Agonist Modifies the DNA Methylation Profile of Synapse and Neurogenesis- Related Genes in the Triple Transgenic Mouse Model of Alzheimer’s Disease. Journal of molecular neuroscience: MN 58, 243–253, https://doi.org/10.1007/s12031-015-0665-8 (2016). 19. Zelcer, N. & Tontonoz, P. Liver X receptors as integrators of metabolic and inflammatory signaling. The Journal of clinical investigation 116, 607–614, https://doi.org/10.1172/jci27883 (2006). 20. Bensinger, S. J. & Tontonoz, P. Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature 454, 470–477, https://doi.org/10.1038/nature07202 (2008). 21. Hong, C. & Tontonoz, P. Liver X receptors in lipid metabolism: opportunities for drug discovery. Nature reviews. Drug discovery 13, 433–444, https://doi.org/10.1038/nrd4280 (2014). 22. Nelissen, K. et al. Liver X receptors regulate cholesterol homeostasis in oligodendrocytes. Journal of neuroscience research 90, 60–71, https://doi.org/10.1002/jnr.22743 (2012). 23. Sodhi, R. K. & Singh, N. Liver X receptors: Emerging therapeutic targets for Alzheimer’s disease. Pharmacological Research 72, 45–51, https://doi.org/10.1016/j.phrs.2013.03.008 (2013). 24. Zelcer, N. et al. Attenuation of neuroinflammation and Alzheimer’s disease pathology by liver x receptors. Proc Natl Acad Sci USA 104, 10601–10606, https://doi.org/10.1073/pnas.0701096104 (2007). 25. Riddell, D. R. et al. The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer’s disease. Molecular and Cellular Neuroscience 34, 621–628, https://doi.org/10.1016/j.mcn.2007.01.011 (2007). 26. Vanmierlo, T. et al. Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5−/− mice. Plant Foods Hum Nutr 66, 149–156, https://doi.org/10.1007/s11130-011-0219-3 (2011). 27. Grefhorst, A. et al. Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles. J Biol Chem 277, 34182–34190, https://doi.org/10.1074/jbc.M204887200 (2002). 28. Kim, G. H. et al. Hepatic TRAP80 selectively regulates lipogenic activity of liver X receptor. The Journal of clinical investigation 125, 183–193, https://doi.org/10.1172/jci73615 (2015). 29. Repa, J. J. et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev 14, 2819–2830 (2000). 30. Schultz, J. R. et al. Role of LXRs in control of lipogenesis. Genes & Development 14, 2831–2838, https://doi.org/10.1101/gad.850400 (2000). 31. Fricke, C. B. et al. Increased plant sterol and stanol levels in brain of Watanabe rabbits fed rapeseed oil derived plant sterol or stanol esters. The British journal of nutrition 98, 890–899, https://doi.org/10.1017/s0007114507756532 (2007). 32. Jansen, P. J. et al. Dietary plant sterols accumulate in the brain. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1761, 445–453, https://doi.org/10.1016/j.bbalip.2006.03.015 (2006). 33. Vanmierlo, T. et al. Dietary intake of plant sterols stably increases plant sterol levels in the murine brain. J Lipid Res 53, 726–735, https://doi.org/10.1194/jlr.M017244 (2012). 34. Chen, Z. et al. 24(S)-Saringosterol from edible marine seaweed Sargassum fusiforme is a novel selective LXRbeta agonist. J Agric Food Chem 62, 6130–6137, https://doi.org/10.1021/jf500083r (2014). 35. El Kharrassi, Y. et al. Biological activities of Schottenol and Spinasterol, two natural phytosterols present in argan oil and in cactus pear seed oil, on murine miroglial BV2 cells. Biochem Biophys Res Commun 446, 798–804, https://doi.org/10.1016/j.bbrc.2014.02.074 (2014). 36. Hoang, M. H. et al. Fucosterol is a selective liver X receptor modulator that regulates the expression of key genes in cholesterol homeostasis in macrophages, hepatocytes, and intestinal cells. Journal of agricultural and food chemistry 60, 11567–11575, https:// doi.org/10.1021/jf3019084 (2012). 37. Kaneko, E. et al. Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist. J Biol Chem 278, 36091–36098, https://doi.org/10.1074/jbc.M304153200 (2003). 38. Plat, J., Nichols, J. A. & Mensink, R. P. Plant sterols and stanols: effects on mixed micellar composition and LXR (target gene) activation. Journal of Lipid Research 46, 2468–2476, https://doi.org/10.1194/jlr.M500272-JLR200 (2005). 39. Yang, C. et al. Disruption of cholesterol homeostasis by plant sterols. The Journal of clinical investigation 114, 813–822, https://doi. org/10.1172/jci22186 (2004). 40. Burg, V. K. et al. Plant sterols the better cholesterol in Alzheimer’s disease? A mechanistical study. J Neurosci 33, 16072–16087, https://doi.org/10.1523/jneurosci.1506-13.2013 (2013). 41. Koivisto, H. et al. Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer’s disease independent of brain amyloid deposition. J Nutr Biochem 25, 157–169, https://doi.org/10.1016/j.jnutbio.2013.09.015 (2014). 42. Shi, C. et al. beta-sitosterol inhibits high cholesterol-induced platelet beta-amyloid release. J Bioenerg Biomembr 43, 691–697, https://doi.org/10.1007/s10863-011-9383-2 (2011). 43. McDaniel, A. L. et al. Phytosterol feeding causes toxicity in ABCG5/G8 knockout mice. The American journal of pathology 182, 1131–1138, https://doi.org/10.1016/j.ajpath.2012.12.014 (2013). 44. Plat, J. et al. Protective role of plant sterol and stanol esters in liver inflammation: insights from mice and humans. PloS one 9, e110758, https://doi.org/10.1371/journal.pone.0110758 (2014). 45. Cheng, Z. Interaction of ergosterol with bovine serum albumin and human serum albumin by spectroscopic analysis. Molecular biology reports 39, 9493–9508, https://doi.org/10.1007/s11033-012-1814-6 (2012). 46. Sudhamalla, B., Gokara, M., Ahalawat, N., Amooru, D. G. & Subramanyam, R. Molecular dynamics simulation and binding studies of beta-sitosterol with human serum albumin and its biological relevance. The journal of physical chemistry. B 114, 9054–9062, https://doi.org/10.1021/jp102730p (2010). 47. Jankowsky, J. L. et al. Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomolecular Engineering 17, 157–165, https://doi.org/10.1016/S1389-0344(01)00067-3 (2001). 48. Garcia-Alloza, M. et al. Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiology of Disease 24, 516–524, https://doi.org/10.1016/j.nbd.2006.08.017 (2006). 49. Minkeviciene, R. et al. Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice. Journal of Neurochemistry 105, 584–594, https://doi.org/10.1111/j.1471-4159.2007.05147.x (2008). 50. Hooijmans, C. R. et al. DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice. Neurobiology of disease 33, 482–498, https://doi.org/10.1016/j.nbd.2008.12.002 (2009). 51. Calabro, P., Gragnano, F. & Pirro, M. Cognitive Function in a Randomized Trial of Evolocumab. The New England journal of medicine 377, 1996–1997, https://doi.org/10.1056/NEJMc1712102 (2017). 52. Mashek, D. G., Khan, S. A., Sathyanarayan, A., Ploeger, J. M. & Franklin, M. P. Hepatic lipid droplet biology: Getting to the root of fatty liver. Hepatology (Baltimore, Md.) 62, 964–967, https://doi.org/10.1002/hep.27839 (2015). 53. Rose, M. et al. Arsenic in seaweed—Forms, concentration and dietary exposure. Food and Chemical Toxicology 45, 1263–1267, https://doi.org/10.1016/j.fct.2007.01.007 (2007). 54. Bjorkhem, I. et al. Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver. Journal of lipid research 28, 1137–1143 (1987). 55. Jones, P. J. H. et al. Progress and perspectives in plant sterol and plant stanol research. Nutr Rev 76, 725–746, https://doi.org/10.1093/ nutrit/nuy032 (2018). 56. Annicotte, J. S., Schoonjans, K. & Auwerx, J. Expression of the liver X receptor alpha and beta in embryonic and adult mice. Anat Rec A Discov Mol Cell Evol Biol 277, 312–316, https://doi.org/10.1002/ar.a.20015 (2004). 57. Zhang, Y. et al. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. The Journal of neuroscience: the official journal of the Society for Neuroscience 34, 11929–11947, https://doi.org/10.1523/ JNEUROSCI.1860-14.2014 (2014). 58. Kirchgessner, T. G. et al. Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils. Cell Metab 24, 223–233, https://doi.org/10.1016/j.cmet.2016.07.016 (2016). 59. Ries, M. & Sastre, M. Mechanisms of Abeta Clearance and Degradation by Glial. Cells. Frontiers in aging neuroscience 8, 160, https:// doi.org/10.3389/fnagi.2016.00160 (2016). 60. Fu, Y. et al. Apolipoprotein E lipoprotein particles inhibit amyloid-beta uptake through cell surface heparan sulphate proteoglycan. Molecular neurodegeneration 11, 37, https://doi.org/10.1186/s13024-016-0099-y (2016). 61. Alghazwi, M., Smid, S., Musgrave, I. & Zhang, W. In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Abeta1-42) toxicity and aggregation. Neurochem Int, https://doi.org/10.1016/j.neuint.2019.01.010 (2019). 62. Oh, J. H., Choi, J. S. & Nam, T. J. Fucosterol from an Edible Brown Alga Ecklonia stolonifera Prevents Soluble Amyloid Beta-Induced Cognitive Dysfunction in Aging Rats. Mar Drugs 16, https://doi.org/10.3390/md16100368 (2018). 63. Hu, P. et al. Structural elucidation and protective role of a polysaccharide from Sargassum fusiforme on ameliorating learning and memory deficiencies in mice. Carbohydr Polym 139, 150–158, https://doi.org/10.1016/j.carbpol.2015.12.019 (2016). 64. Kenyon, E. M. et al. Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in C57BL6 mice following subchronic exposure to arsenate in drinking water. Toxicology and applied pharmacology 232, 448–455, https://doi. org/10.1016/j.taap.2008.07.018 (2008). 65. Folch, J., Lees, M. & Sloane Stanley, G. H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226, 497–509 (1957). 66. Cross, A. K. & Woodroofe, M. N. Chemokines induce migration and changes in actin polymerization in adult rat brain microglia and a human fetal microglial cell line in vitro. Journal of neuroscience research 55, 17–23, https://doi.org/10.1002/(sici)1097- 4547(19990101)55:13.0.co;2-j (1999). 67. Sun, Y., Yao, J., Kim, T. W. & Tall, A. R. Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion. J Biol Chem 278, 27688–27694, https://doi.org/10.1074/jbc.M300760200 (2003). 68. Bories, G. et al. Liver X receptor activation stimulates iron export in human alternative macrophages. Circulation research 113, 1196–1205, https://doi.org/10.1161/circresaha.113.301656 (2013). 69. van der Hoorn, J. et al. Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels. British journal of pharmacology 162, 1553–1563, https://doi.org/10.1111/j.1476-5381.2010.01168.x (2011). 70. Rutten, K. et al. The selective PDE5 inhibitor, sildenafil, improves object memory in Swiss mice and increases cGMP levels in hippocampal slices. Behavioural brain research 164, 11–16, https://doi.org/10.1016/j.bbr.2005.04.021 (2005). 71. Sik, A., van Nieuwehuyzen, P., Prickaerts, J. & Blokland, A. Performance of different mouse strains in an object recognition task. Behavioural brain research 147, 49–54 (2003). 72. Ohno, M. et al. BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer’s disease. Neuron 41, 27–33 (2004). 73. Mulder, M. et al. Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus. Neurobiology of Disease 16, 212–219, https://doi.org/10.1016/j.nbd.2004.01.015 (2004). 74. Steinerman, J. R. et al. Distinct pools of beta-amyloid in Alzheimer disease-affected brain: a clinicopathologic study. Archives of neurology 65, 906–912, https://doi.org/10.1001/archneur.65.7.906 (2008). 75. O’Meara, R. W., Ryan, S. D., Colognato, H. & Kothary, R. Derivation of enriched oligodendrocyte cultures and oligodendrocyte/ neuron myelinating co-cultures from post-natal murine tissues. Journal of visualized experiments: JoVE, https://doi.org/10.3791/3324 (2011). 76. Lütjohann, D. et al. Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain. Journal of Lipid Research 43, 1078–1085, https://doi.org/10.1194/jlr.M200071-JLR200 (2002). 77. Bogie, J. F. et al. Myelin alters the inflammatory phenotype of macrophages by activating PPARs. Acta neuropathologica communications 1, 43, https://doi.org/10.1186/2051-5960-1-43 (2013). 78. Bogie, J. F. et al. Myelin-derived lipids modulate macrophage activity by liver X receptor activation. PLoS One 7, e44998, https://doi. org/10.1371/journal.pone.0044998 (2012). 79. Akkerman, S. et al. Object recognition testing: methodological considerations on exploration and discrimination measures. Behavioural brain research 232, 335–347, https://doi.org/10.1016/j.bbr.2012.03.022 (2012). 80. Dixon, W. J. Ratios involving extreme values. Ann Math Stat 22, 68–78 (1959). 81. Dixon, W. J. Analysis of extreme values. Ann Math Stat 21, 488–506 (1959).; Scientific reports (Nature Publishing Group), 9 (Art N° 4908); http://hdl.handle.net/1942/28164; 000461762600025; https://www.ncbi.nlm.nih.gov/pubmed/30894635
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16Academic Journal
المؤلفون: Wetzels, Suzan, Wouters, Kristiaan, Miyata, Toshio, Scheijen, Jean L. J. M., Hendriks, Jerome J. A., Schalkwijk, Casper G., Vanmierlo, Tim
المصدر: Wetzels , S , Wouters , K , Miyata , T , Scheijen , J L J M , Hendriks , J J A , Schalkwijk , C G & Vanmierlo , T 2018 , ' Advanced Glycation Endproducts Are Increased in the Animal Model of Multiple Sclerosis but Cannot Be Reduced by Pyridoxamine Treatment or Glyoxalase 1 Overexpression ' , International journal of molecular sciences , vol. 19 , no. 5 , 1311 . https://doi.org/10.3390/ijms19051311
مصطلحات موضوعية: advanced glycation endproducts, pyridoxamine, glyoxalase-1, experimental autoimmune encephalomyelitis, multiple sclerosis, END-PRODUCTS AGES, CEREBROSPINAL-FLUID, INSULIN-RESISTANCE, METHYLGLYOXAL, METABOLISM, DISEASE, PLASMA, SYSTEM, MICE
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17Academic Journal
المؤلفون: Mailleux, Jo, Vanmierlo, Tim, Bogie, Jeroen F. J., Wouters, Elien, Lütjohann, Dieter, Hendriks, Jerome J. A., Van Horssen, Jack
مصطلحات موضوعية: demyelinating diseases, multiple sclerosis, myelin sheath, phagocytes, liver X receptor, 27-hydroxycholesterol
وصف الملف: application/pdf
Relation: Multiple Sclerosis Journal, 24 (3), p. 279-289; http://hdl.handle.net/1942/23716; 289; 279; 24; 000429327000009
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18Academic Journal
المؤلفون: Llufriu-Dabén, Gemma, Carrete, Alex, Chierto, Elena, Mailleux, Jo, Camand, Emeline, Simon, Anne, Vanmierlo, Tim, Rose, Christiane, Allinquant, Bernadette, Hendriks, Jerome J. A., Massaad, Charbel, Meffre, Delphine, Jafarian-Tehrania, Mehrnaz
مصطلحات موضوعية: etazolate, α-Secretase, sAPPα, myelin, oligodendrocyte, de/remyelination, white matter
وصف الملف: application/pdf
Relation: Neurobiology of disease, 109(A), p. 11-24; http://hdl.handle.net/1942/25930; 24; A; 11; 109; 000418877600002
الاتاحة: http://hdl.handle.net/1942/25930
https://doi.org/10.1016/j.nbd.2017.09.008 -
19Academic Journal
المؤلفون: Jorissen, Winde, Vanmierlo, Tim, Wens, Inez, Somers, Veerle, Van Wijmeersch, Bart, Bogie, Jeroen F. J., Remaley, Alan, Op 't Eijnde, Bert O., Hendriks, Jerome J. A.
مصطلحات موضوعية: multiple sclerosis, lipoproteins, cholesterol, training exercise
وصف الملف: application/pdf
Relation: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(1), p. 1-11 (Art N° 139); http://hdl.handle.net/1942/25968; 11; 19; 000424407200190
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20Academic Journal
المؤلفون: Bogie, Jeroen F. J., Boelen, Ellen, Louagie, Els, Delputte, Peter, Elewaut, Dirk, Van Horssen, Jack, Hendriks, Jerome J. A., Hellings, Niels
مصطلحات موضوعية: EAE, microglia, monocytes, neuroinflammation, sialoadhesin, CD169, Siglec-1, multiple sclerosis
وصف الملف: application/pdf
Relation: Multiple Sclerosis Journal, 24 (3), p. 290-300; http://hdl.handle.net/1942/23722; 300; 290; 24; 000429327000010