نتائج البحث - "Hellström‐Lindberg, Eva"

المساهمون: HUS Children and Adolescents, Children's Hospital, University of Helsinki, Faculty of Medicine, Department of Medical and Clinical Genetics, Medicum, ATG - Applied Tumor Genomics, HUS Diagnostic Center, HUS Comprehensive Cancer Center, Research Programs Unit, Clinicum, Department of Medicine, Hematologian yksikkö

مصطلحات موضوعية: Cancers

وصف الملف: application/pdf

Relation: Baliakas , P , Tesi , B , Cammenga , J , Stray-Pedersen , A , Jahnukainen , K , Andersen , M K , Ågerstam , H , Creignou , M , Dybedal , I , Raaschou-Jensen , K , Grønbæk , K , Kilpivaara , O , Hellström Lindberg , E & Wartiovaara-Kautto , U 2024 , ' How to manage patients with germline DDX41 variants : Recommendations from the Nordic working group on germline predisposition for myeloid neoplasms ' , Hemasphere , vol. 8 , no. 8 , e145 . https://doi.org/10.1002/hem3.145; ORCID: /0000-0001-8467-2100/work/166166457; http://hdl.handle.net/10138/584839; 9cfc40db-80fb-4d1e-9ae3-ad86830886f6; 85201123864; 001289786300001

الاتاحة: http://hdl.handle.net/10138/584839

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12

Academic Journal

Somatic mutations associate with clonal expansion of CD8+ T cells

المؤلفون: Lundgren, Sofie, Myllymäki, Mikko, Järvinen, Timo, Keränen, Mikko A.I., Theodoropoulos, Jason, Smolander, Johannes, Kim, Daehong, Salmenniemi, Urpu, Walldin, Gunilla, Savola, Paula, Kelkka, Tiina, Rajala, Hanna, Hellström-Lindberg, Eva, Itälä-Remes, Maija, Kankainen, Matti, Mustjoki, Satu

المساهمون: TRIMM - Translational Immunology Research Program, Department of Clinical Chemistry and Hematology, HUS Comprehensive Cancer Center, Department of Oncology, Myllymaki_lab, Hematologian yksikkö, Research Programs Unit, Department of Medical and Clinical Genetics, Faculty Common Matters (Faculty of Medicine), Medicum, Clinicum, HUS Diagnostic Center, HUSLAB, Digital Precision Cancer Medicine (iCAN)

وصف الملف: application/pdf

Relation: Acknowledgments: this research was funded with research grants from the european Research council (M-iMM and StRAtiFY projects), Academy of Finland, Sigrid Juselius Foundation, cancer Foundation Finland, Blood disease Research Foundation, and instrumentarium Science Foundation. S.L. was supported by Biomedicum helsinki Foundation and Finnish Medical Foundation. We acknowledge P. ellonen from the institute of Molecular Medicine Finland (FiMM) for advice on gene panel design. We thank h. L\u00E4hteenm\u00E4ki, t. Kasanen, and J. Klievink from the hematology Research Unit helsinki for excellent technical assistance. We acknowledge J. huuhtanen for expertise and advice with tcR data analysis. Single-cell sequencing and immunogene panel sequencing were performed at FiMM Single-cell Analytics and Sequencing units supported by hiLiFe and Biocenter Finland. We acknowledge the Finnish Red cross Blood Service for providing healthy control samples. the authors thank all the patients for their generous participation. We acknowledge the it center for Science Ltd. for data storage and computational resources and Aalto Science-it project for computational resources. Author contributions: conceptualization: S.L., M.A.i.K., P.S., t.K., and S.M. Methology: S.L., M.A.i.K., t.K., P.S., and J.S. validation: S.L., P.S., and M.K. Formal analysis: S.L., t.J., J.t., M.K., and J.S. investigation: S.L., M.A.i.K., P.S., d.K., h.R., and J.S. Resources: M.A.i.K., U.S., G.W., P.S., h.R., e.h.-L., M.i.-R., and S.M. data curation: S.L., M.A.i.K., U.S., G.W., P.S., h.R., and M.i.-R. visualization: S.L. Supervision: S.M., M.M., and M.K. Writing\u2014original draft: S.L. Writing\u2014review and editing: All authors. Funding acquisition: S.M. Competing interests: S.M. has received honoraria and research funding from BMS and novartis, research funding from Pfizer, and honoraria from dren-Bio (none of these are related to this project). the other authors declare that they have no competing interests. Data and materials availability: the scRnA + tcR\u03B1\u03B2-seq raw data and immunogene panel sequencing raw data have been deposited at the european Genome-phenome Archive (eGA; https://ega-archive.org), which are hosted by the eBi and the cRG, under accession numbers eGAd00001012121 and eGAd50000000352. the access is restricted and can be requested on the eGA website through the data Access committee, due to data privacy concerns. the processed scRnA + tcR\u03B1\u03B2-seq data are available in the Arrayexpress database at eMBL-eBi (www.ebi.ac.uk/arrayexpress) under accession number e-MtAB-13419. tcR\u03B2 sequencing data are available at Zenodo under 10.5281/zenodo.11106370 and 10.5281/ zenodo.11106372. All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials.; Lundgren , S , Myllymäki , M , Järvinen , T , Keränen , M A I , Theodoropoulos , J , Smolander , J , Kim , D , Salmenniemi , U , Walldin , G , Savola , P , Kelkka , T , Rajala , H , Hellström-Lindberg , E , Itälä-Remes , M , Kankainen , M & Mustjoki , S 2024 , ' Somatic mutations associate with clonal expansion of CD8 + T cells ' , Science Advances , vol. 10 , no. 23 , eadj0787 . https://doi.org/10.1126/sciadv.adj0787; http://hdl.handle.net/10138/577711; 6f5f246b-97aa-4174-a803-20409d83f3a7; 85195534106

الاتاحة: http://hdl.handle.net/10138/577711

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13

Academic Journal

Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option

المساهمون: HUS Comprehensive Cancer Center, Department of Clinical Chemistry and Hematology, Clinicum, TRIMM - Translational Immunology Research Program, Digital Precision Cancer Medicine (iCAN), Hematologian yksikkö

مصطلحات موضوعية: Cancers

وصف الملف: application/pdf

Relation: The authors thank Johannis Klang and Monika Jansson for their technical assistance. All major computations were performed on resources provided by the Swedish National Infrastructure for Computing through Uppsala Multidisciplinary Center for Advanced Computational Science under project b2014299 migrated to sens2018540. The authors also thank the core facility at NEO, BEA, Bioinformatics and Expression Analysis, which is supported by the board of research at the Karolinska Institute (KI) and the research committee at the Karolinska University Hospital . FACS analysis and cell sorting were performed at MedH Flow Cytometry core facility (KI), supported by KI/Stockholms läns landsting. The authors thank Johannis Klang and Monika Jansson for their technical assistance. All major computations were performed on resources provided by the Swedish National Infrastructure for Computing through Uppsala Multidisciplinary Center for Advanced Computational Science under project b2014299 migrated to sens2018540. The authors also thank the core facility at NEO, BEA, Bioinformatics and Expression Analysis, which is supported by the board of research at the Karolinska Institute (KI) and the research committee at the Karolinska University Hospital. FACS analysis and cell sorting were performed at MedH Flow Cytometry core facility (KI), supported by KI/Stockholms läns landsting. This work was supported by the Swedish Research Council (2019-01361, 2022-01228), Swedish Childhood Society (PR2015-0142, FoAss13/015, PR2017/0154, and PR2020-0166), Swedish Cancer Society (CAN2017/774, 19 0092 SIA, and 20 1222 PjF), Åke Olsson foundation, Radiumhemmets Forskningsfonder and Karolinska Institute Wallenberg Institute for Regenerative Medicine, Karolinska Institute Doctoral Education (KID) funding (2-1293/2014, 2021-00480), Stiftelsen Clas Groschinskys Minnesfond (M16 50), the Knut and Alice Wallenberg Foundation (KAW 2020.0102), Cancer Research KI (Karolinska Institute), Incyte Biosciences Nordic, and Blodcancerfonden (H.Q.), and Nordic Cancer Union and Cancer Foundation Finland (S.M.). Contribution: M.D. H.C. and A.M. participated in experimental design, performing experiments, collection and assembly of data, data analysis and interpretation, and figure preparation; J.S. E.L. J.P.M. P.X. Y.G. M.C. L. Sandhow, M.K. T.B. and A.-S.J. performed experiments, collected data, and analyzed data; X.L. L. Stenke, U.O.-S. S.M. and M.E. contributed to data analysis and interpretation; S.S. M.J. K.L.B. S.D. J.U. E.H.-L. S.L. and M.T. contributed to sample collection and data analysis; A.O. contributed to the NIH3-CXCL14 cells and provided scientific input; M.S. contributed to the RNA sequencing; H.Q. designed the study, performed some experiments, collected and analyzed data, prepared figures, and wrote the manuscript; and all authors approved the final version of the manuscript. This work was supported by the Swedish Research Council ( 2019-01361 , 2022-01228 ), Swedish Childhood Society ( PR2015-0142 , FoAss13/015 , PR2017/0154 , and PR2020-0166 ), Swedish Cancer Society ( CAN2017/774 , 19 0092 SIA, and 20 1222 PjF), Åke Olsson foundation , Radiumhemmets Forskningsfonder and Karolinska Institute Wallenberg Institute for Regenerative Medicine , Karolinska Institute Doctoral Education (KID) funding ( 2-1293/2014, 2021-00480 ), Stiftelsen Clas Groschinskys Minnesfond ( M16 50 ), the Knut and Alice Wallenberg Foundation ( KAW 2020.0102 ), Cancer Research KI (Karolinska Institute), Incyte Biosciences Nordic, and Blodcancerfonden (H.Q.), and Nordic Cancer Union and Cancer Foundation Finland (S.M.).; Dolinska , M , Cai , H , Månsson , A , Shen , J , Xiao , P , Bouderlique , T , Li , X , Leonard , E , Chang , M , Gao , Y , Medina , J P , Kondo , M , Sandhow , L , Johansson , A S , Deneberg , S , Söderlund , S , Jädersten , M , Ungerstedt , J , Tobiasson , M , Östman , A , Mustjoki , S , Stenke , L , Le Blanc , K , Hellström-Lindberg , E , Lehmann , S , Ekblom , M , Olsson-Strömberg , U , Sigvardsson , M & Qian , H 2023 , ' Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option ' , Blood , vol. 142 , no. 1 , pp. 73-89 . https://doi.org/10.1182/blood.2022016896; ORCID: /0000-0002-0816-8241/work/153473758; http://hdl.handle.net/10138/578868; 1f776a37-fd59-4aa1-8d6d-feb18c2d53e1; 85163377077; 001159707400001

الاتاحة: http://hdl.handle.net/10138/578868

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14

Academic Journal

Inflammatory profile of lower risk myelodysplastic syndromes

المساهمون: Kennedy Trust for Rheumatology Research, Cancer Research UK, National Institute for Health and Care Research, Leeds Biomedical Research Centre, Janssen Pharmaceutica, Takeda Pharmaceuticals International

المصدر: British Journal of Haematology ; volume 205, issue 3, page 1044-1054 ; ISSN 0007-1048 1365-2141

الاتاحة: https://doi.org/10.1111/bjh.19530
https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.19530

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15

Academic Journal

Competition of dual SF3B1mt clones in MDS-RS is associated with distinct RNA mis-splicing in hematopoietic stem cells

المؤلفون: Moura, Pedro Luis, Nannya, Yasuhito, Aliouat, Affaf, Hofman, Isabel Juliana, Mortera Blanco, Teresa, Yoshizato, Tetsuichi, Saiki, Ryunosuke, Nakagawa, Masahiro M, Creignou, Maria, Björklund, Ann-Charlotte, Walldin, Gunilla, Barbosa, Indira, Jansson, Monika, Grasso, Francesca, Elvarsdottir, Edda M, Woll, Petter S, Eirik W Jacobsen, Sten, Ogawa, Seishi, Hellström-Lindberg, Eva

المساهمون: Centrum for innovativ medicin, Knut Och Alice Wallenbergs Stiftelse, Bloodwise, Medical Research Council, Vetenskapsradet, Cancerfonden, Torsten Söderbergs Stiftelse

المصدر: Blood Neoplasia ; page 100011 ; ISSN 2950-3280

الاتاحة: http://dx.doi.org/10.1016/j.bneo.2024.100011
https://api.elsevier.com/content/article/PII:S2950328024000116?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2950328024000116?httpAccept=text/plain

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