المؤلفون: Francis Berthias (4556236), Hayden A. Thurman (11668155), Gayani Wijegunawardena (11933599), Haifan Wu (1566376), Alexandre A. Shvartsburg (1726948), Ole N. Jensen (187068)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Chemical Sciences not elsewhere classified, single acetyl moiety, ptm pattern encodes, proteolytic digestion obliterates, levels using chromatography, ion mobility spectrometry, ion mobility separations, dna transcription central, combinatorial language controlling, distinct ptm compositions, 3 kda ), proteoforms  proteins, intact isomeric proteoforms, acetylated h4 histones, ptms ), distinct functionalities, varied sequence, unique fragments, translational modifications, tof platform, several pairs, resolving power, proteoform characterization, preeminent example, novel capability, induced dissociation, ims )

Relation: https://figshare.com/articles/journal_contribution/Top-Down_Ion_Mobility_Separations_of_Isomeric_Proteoforms/21777201

الاتاحة: https://doi.org/10.1021/acs.analchem.2c02948.s001

المؤلفون: Chamandi S. Dampalla (11068618), Harry Nhat Nguyen (9455664), Athri D. Rathnayake (4239754), Yunjeong Kim (315112), Krishani Dinali Perera (11794426), Trent K. Madden (12695813), Hayden A. Thurman (11668155), Alexandra J. Machen (3040980), Maithri M. Kashipathy (9455670), Lijun Liu (452265), Kevin P. Battaile (418240), Scott Lovell (122251), Kyeong-Ok Chang (5282), William C. Groutas (1403371)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Plant Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, resolution cocrystal structures, highly pathogenic coronaviruses, broadly acting agents, inhibitors described herein, highly potent inhibitors, structural determinants associated, pro , 50 , potently inhibited mers, acting antivirals, based inhibitors, worldwide impact, virological studies, viral replication, validated target, urgent need, taken together, studies suggest

Relation: https://figshare.com/articles/journal_contribution/Broad-Spectrum_Cyclopropane-Based_Inhibitors_of_Coronavirus_3C-like_Proteases_Biochemical_Structural_and_Virological_Studies/21787150

الاتاحة: https://doi.org/10.1021/acsptsci.2c00206.s001

المؤلفون: Francis Berthias (4556236), Berwyck L. J. Poad (8136198), Hayden A. Thurman (11668155), Andrew P. Bowman (3951674), Stephen J. Blanksby (1284774), Alexandre A. Shvartsburg (1726948)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Sociology, Developmental Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, wide dynamic range, sup >+, one must distinguish, argentination still strikes, modern mass spectrometry, minor species often, ergodic dissociation mechanisms, ozid yield diminishes, isomeric lipids separated, identified using ozone, disentangling lipid isomers, metalated species, induced dissociation, accurate mass, ozid performance, ozid ), isomeric depth, isomeric biomolecules, steep challenge, new platform, ion around

Relation: https://figshare.com/articles/journal_contribution/Disentangling_Lipid_Isomers_by_High-Resolution_Differential_Ion_Mobility_Spectrometry_Ozone-Induced_Dissociation_of_Metalated_Species/16964916

الاتاحة: https://doi.org/10.1021/jasms.1c00251.s001

المؤلفون: Chamandi S. Dampalla (11068618), Athri D. Rathnayake (4239754), Krishani Dinali Perera (11794426), Abdul-Rahman M. Jesri (9455667), Harry Nhat Nguyen (9455664), Matthew J. Miller (7433027), Hayden A. Thurman (11668155), Jian Zheng (287758), Maithri M. Kashipathy (9455670), Kevin P. Battaile (418240), Scott Lovell (122251), Stanley Perlman (200056), Yunjeong Kim (315112), William C. Groutas (1403371), Kyeong-Ok Chang (5282)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, public health worldwide, protease may lead, based choke points, like protease, based studies, viral replication, urgent need, therapeutic intervention, studies related, specific antivirals, ray crystallography, molecule therapeutics, major impact, including vaccines, highly potent, enzyme essential, emerging variants, effective therapeutics, describe herein

Relation: https://figshare.com/articles/journal_contribution/Structure-Guided_Design_of_Potent_Inhibitors_of_SARS-CoV_2_3CL_Protease_Structural_Biochemical_and_Cell-Based_Studies/17126683

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01037.s001

المؤلفون: Chamandi S. Dampalla (11068618), Athri D. Rathnayake (4239754), Krishani Dinali Perera (11794426), Abdul-Rahman M. Jesri (9455667), Harry Nhat Nguyen (9455664), Matthew J. Miller (7433027), Hayden A. Thurman (11668155), Jian Zheng (287758), Maithri M. Kashipathy (9455670), Kevin P. Battaile (418240), Scott Lovell (122251), Stanley Perlman (200056), Yunjeong Kim (315112), William C. Groutas (1403371), Kyeong-Ok Chang (5282)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, public health worldwide, protease may lead, based choke points, like protease, based studies, viral replication, urgent need, therapeutic intervention, studies related, specific antivirals, ray crystallography, molecule therapeutics, major impact, including vaccines, highly potent, enzyme essential, emerging variants, effective therapeutics, describe herein

Relation: https://figshare.com/articles/dataset/Structure-Guided_Design_of_Potent_Inhibitors_of_SARS-CoV_2_3CL_Protease_Structural_Biochemical_and_Cell-Based_Studies/17126686

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01037.s002