المؤلفون: Harwood, Matthew D., Zettl, Katharina, Weinheimer, Manuel, Pilla-Reddy, Venkatesh, Shen, Hong, Jacobs, Frank, Chu, Xiaoyan, Huth, Felix, Nakakariya, Masanori, Chothe, Paresh P., Neuhoff, Sibylle, Wiśniewski, Jacek R.

المساهمون: Max-Planck-Gesellschaft

المصدر: Molecular Pharmaceutics ; volume 20, issue 7, page 3505-3518 ; ISSN 1543-8384 1543-8392

الاتاحة: http://dx.doi.org/10.1021/acs.molpharmaceut.3c00108
https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.3c00108

المؤلفون: Karkhanis, Aneesh V.¹ (AUTHOR) aneesh.karkhanis@certara.com, Harwood, Matthew D.¹ (AUTHOR), Stader, Felix¹ (AUTHOR), Bois, Frederic Y.¹ (AUTHOR), Neuhoff, Sibylle¹ (AUTHOR)

المصدر: Pharmaceutics. Oct2024, Vol. 16 Issue 10, p1284. 22p.

مصطلحات موضوعية: *CYTOCHROME P-450 CYP3A, *PLASMA confinement, *BIOMARKERS, *CHOLESTEROL, *PHARMACOKINETICS

المؤلفون: Al-Majdoub, Zubida, Couto, Narciso, Achour, Brahim, Harwood, Matthew D, Carlson, Gordon, Warhurst, Geoffrey, Barber, Jill, Rostami-Hodjegan, Amin

المصدر: Al-Majdoub , Z , Couto , N , Achour , B , Harwood , M D , Carlson , G , Warhurst , G , Barber , J & Rostami-Hodjegan , A 2021 , ' Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics ' , Clinical Pharmacology & Therapeutics , vol. 109 , no. 4 , pp. 1136-1146 . https://doi.org/10.1002/cpt.2097

مصطلحات موضوعية: Alkaline Phosphatase/metabolism, Cytochrome P-450 Enzyme System/metabolism, Enzymes/metabolism, Humans, Ileum/metabolism, Intestinal Mucosa/metabolism, Jejunum/metabolism, Models, Biological, Oxygenases/metabolism, Proteins/metabolism, Proteomics, Thioredoxins/metabolism, Tight Junction Proteins/metabolism, Transferases/metabolism, Xenobiotics/pharmacokinetics

Relation: https://research.manchester.ac.uk/en/publications/0c296352-0be7-45cb-bc4e-6ea13e7cb3ee

الاتاحة: https://research.manchester.ac.uk/en/publications/0c296352-0be7-45cb-bc4e-6ea13e7cb3ee
https://doi.org/10.1002/cpt.2097
http://www.scopus.com/inward/record.url?scp=85097006086&partnerID=8YFLogxK

المؤلفون: Harwood, Matthew D., Zhang, Mian, Pathak, Shriram M., Neuhoff, Sibylle

المصدر: Drug Metabolism and Disposition ; volume 47, issue 8, page 854-864 ; ISSN 0090-9556

الاتاحة: https://doi.org/10.1124/dmd.119.086959
https://api.elsevier.com/content/article/PII:S0090955624078231?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0090955624078231?httpAccept=text/plain
https://syndication.highwire.org/content/doi/10.1124/dmd.119.086959

المؤلفون: Musther, Helen, Harwood, Matthew D, Yang, Jiansong, Turner, David B, Rostami-Hochaghan, Amin, Jamei, Masoud

المصدر: Musther , H , Harwood , M D , Yang , J , Turner , D B , Rostami-Hochaghan , A & Jamei , M 2017 , ' The Constraints, Construction and Verification of a Strain-Specific Physiologically-Based Pharmacokinetic Rat Model ' , Journal of Pharmaceutical Sciences , pp. 1-13 . https://doi.org/10.1016/j.xphs.2017.05.003

وصف الملف: application/pdf

الاتاحة: https://research.manchester.ac.uk/en/publications/d1d3c02c-5639-42da-8cae-054cbae70a8f
https://doi.org/10.1016/j.xphs.2017.05.003
https://pure.manchester.ac.uk/ws/files/58383123/Harwood_2017_JPS_R1_SUBMITTED.pdf
http://ac.els-cdn.com/S0022354917303520/1-s2.0-S0022354917303520-main.pdf?_tid=a9e494fa-783a-11e7-bff7-00000aab0f6c&acdnat=1501758082_0afcf5b9d5cbf58e40c9356ee7aeaa7c

المؤلفون: Harwood, Matthew D, Achour, Brahim, Russell, Matthew R, Carlson, Gordon L, Warhurst, Geoffrey, Rostami-Hodjegan, Amin

المصدر: Harwood , M D , Achour , B , Russell , M R , Carlson , G L , Warhurst , G & Rostami-Hodjegan , A 2015 , ' Application of an LC-MS/MS Method for the Simultaneous Quantification of Human Intestinal Transporter Proteins Absolute Abundance using a QconCAT Technique ' , Journal of Pharmaceutical and Biomedical Analysis , vol. 110 , pp. 27-33 . https://doi.org/doi:10.1016/j.jpba.2015.02.043

مصطلحات موضوعية: Quantitative Targeted Absolute Proteomics, Transporter Proteins, Absolute Abundance, Human Intestine, QconCAT

وصف الملف: application/pdf

الاتاحة: https://research.manchester.ac.uk/en/publications/22868fb8-a32a-4f5c-a94c-992214ad759f
https://doi.org/10.1016/j.jpba.2015.02.043
https://pure.manchester.ac.uk/ws/files/56598619/Harwood_et_al_2015_JPBA_110_27_33.pdf

المؤلفون: Neuhoff, Sibylle, Harwood, Matthew D., Rostami-Hodjegan, Amin, Achour, Brahim

المصدر: Drug Discovery Today: Technologies ; volume 39, page 13-22 ; ISSN 1740-6749

الاتاحة: http://dx.doi.org/10.1016/j.ddtec.2021.06.002
https://api.elsevier.com/content/article/PII:S174067492100010X?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S174067492100010X?httpAccept=text/plain

المؤلفون: Couto, Narciso, Al-Majdoub, Zubida, Gibson, Stephanie L, Davies, Pamela J, Achour, Brahim, Harwood, Matthew D, Carlson, Gordon, Barber, Jill, Rostami-Hodjegan, Amin, Warhurst, Geoffrey

المصدر: Couto , N , Al-Majdoub , Z , Gibson , S L , Davies , P J , Achour , B , Harwood , M D , Carlson , G , Barber , J , Rostami-Hodjegan , A & Warhurst , G 2020 , ' Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Inter-correlations in the Human Small Intestine ' , Drug Metabolism and Disposition , vol. 48 , no. 4 , pp. 245-254 . https://doi.org/10.1124/dmd.119.089656

مصطلحات موضوعية: ASBT, BCRP, BSEP, HPLC, MATE, MCT, MRP, NTCP, OAT, OCT, PEPT, Uptake transporters (OATP, cytochrome P450, efflux transporters (P-gp, etc), etc.), gastrointestinal tract, human/clinical, mass spectrometry/MS, physiologically-based pharmacokinetic modeling/PBP, proteomics

الاتاحة: https://research.manchester.ac.uk/en/publications/0f6a6114-b735-4c11-9bf3-a74ef2991037
https://doi.org/10.1124/dmd.119.089656

المؤلفون: Harwood, Matthew D., Turner, David B., Gardner, Iain, Neuhoff, Sibylle

المصدر: Drug Metabolism and Pharmacokinetics ; volume 33, issue 1, page S89 ; ISSN 1347-4367

الاتاحة: http://dx.doi.org/10.1016/j.dmpk.2017.11.290
https://api.elsevier.com/content/article/PII:S1347436717305219?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1347436717305219?httpAccept=text/plain

المؤلفون: Harwood, Matthew D., Zhang, Mian, Pathak, Shriram, Gardner, Iain, Neuhoff, Sibylle

المصدر: Drug Metabolism and Pharmacokinetics ; volume 33, issue 1, page S88-S89 ; ISSN 1347-4367

الاتاحة: http://dx.doi.org/10.1016/j.dmpk.2017.11.289
https://api.elsevier.com/content/article/PII:S1347436717305207?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1347436717305207?httpAccept=text/plain

المؤلفون: Al‐Majdoub, Zubida M., Couto, Narciso, Achour, Brahim, Harwood, Matthew D., Carlson, Gordon, Warhurst, Geoffrey, Barber, Jill, Rostami‐Hodjegan, Amin

المصدر: Clinical Pharmacology & Therapeutics; Apr2021, Vol. 109 Issue 4, p1136-1146, 11p

مصطلحات موضوعية: XENOBIOTICS, MESSENGER RNA, PROTEINS, PROTEIN metabolism, ALKALINE phosphatase, PROTEIN microarrays, SMALL intestine, INTESTINES

المؤلفون: Harwood, Matthew D, Achour, Brahim, Neuhoff, Sibylle, Russell, Matthew R, Carlson, Gordon, Warhurst, Geoffrey, Rostami-Hodjegan, Amin

المصدر: Harwood , M D , Achour , B , Neuhoff , S , Russell , M R , Carlson , G , Warhurst , G & Rostami-Hodjegan , A 2016 , ' In vitro-in vivo extrapolation scaling factors for intestinal P-glycoprotein and breast cancer resistance protein: Part II. The impact of cross-laboratory variations of intestinal transporter relative expression factors on predicted drug disposition ' , Drug Metabolism and Disposition , vol. 44 , no. 3 , pp. 476-480 .

وصف الملف: application/pdf

الاتاحة: https://research.manchester.ac.uk/en/publications/ccaabe54-b46e-4c5b-98c9-838573a17f89
https://pure.manchester.ac.uk/ws/files/33422461/Harwood_et_al_2016_DMD_Part_II_44_476_480.pdf

المؤلفون: Harwood, Matthew D., Neuhoff, Sibylle, Rostami-Hodjegan, Amin, Warhurst, Geoffrey

المصدر: Journal of Pharmaceutical Sciences ; volume 105, issue 4, page 1370-1375 ; ISSN 0022-3549

الاتاحة: http://dx.doi.org/10.1016/j.xphs.2016.01.018
https://api.elsevier.com/content/article/PII:S0022354916003142?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0022354916003142?httpAccept=text/xml

المؤلفون: Harwood, Matthew D, Achour, Brahim, Courbebaisse, Yann, Russell, Matthew R, Neuhoff, Sibylle, Carlson, Gordon, Warhurst, Geoffry, Rostami-Hodjegan, Amin

المصدر: Harwood , M D , Achour , B , Courbebaisse , Y , Russell , M R , Neuhoff , S , Carlson , G , Warhurst , G & Rostami-Hodjegan , A 2014 , ' A Cross-Laboratory Comparison of Caco-2 and Human Intestinal Drug Transporter Protein Abundances ' , DMDG and GMP Joint Meeting , Paris, France , 22/10/14 - 24/10/14 .

الاتاحة: https://research.manchester.ac.uk/en/publications/3b385a98-a7c0-464d-8a03-f4814cb9b590

المؤلفون: Harwood, Matthew D., Rostami‐Hodjegan, Amin, Neuhoff, Sibylle

المصدر: Drug Transporters ; page 475-496 ; ISBN 9781119737551 9781119739883

الاتاحة: http://dx.doi.org/10.1002/9781119739883.ch23
https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781119739883.ch23

المؤلفون: Harwood, Matthew, Harwood, Matthew D., Russell, Matthew R., Neuhoff, Sibylle, Warhurst, Geoffrey, Rostami-Hodjegan, Amin

المصدر: Harwood , M , Harwood , M D , Russell , M R , Neuhoff , S , Warhurst , G & Rostami-Hodjegan , A 2014 , ' Lost in centrifugation: Accounting for transporter protein losses in quantitative targeted absolute proteomics ' , Drug Metabolism and Disposition , vol. 42 , no. 10 , pp. 1766-1772 . https://doi.org/10.1124/dmd.114.058446

الاتاحة: https://research.manchester.ac.uk/en/publications/4772b9d2-08d1-4e53-99b1-28c79a88caeb
https://doi.org/10.1124/dmd.114.058446
http://dmd.aspetjournals.org/content/42/10/1766.full.pdf+html

المؤلفون: Russell, Matthew R., Achour, Brahim, McKenzie, Edward A., Lopez, Ruth, Harwood, Matthew D., Rostami-Hodjegan, Amin, Barber, Jill

المصدر: Russell , M R , Achour , B , McKenzie , E A , Lopez , R , Harwood , M D , Rostami-Hodjegan , A & Barber , J 2013 , ' Alternative fusion protein strategies to express recalcitrant QconCAT proteins for quantitative proteomics of human drug metabolizing enzymes and transporters ' , Journal of Proteome Research , vol. 12 , no. 12 , pp. 5934-5942 . https://doi.org/10.1021/pr400279u

مصطلحات موضوعية: fusion construct, insoluble fusion expression protein, MetCAT, NUSa-soluble fusion expression protein, SDS-PAGE, TransCAT, triple-quadrupole mass spectrometry, ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology, name=Manchester Institute of Biotechnology

Relation: https://research.manchester.ac.uk/en/publications/05c27676-5fad-480a-a896-6b36f5d46ec1

الاتاحة: https://research.manchester.ac.uk/en/publications/05c27676-5fad-480a-a896-6b36f5d46ec1
https://doi.org/10.1021/pr400279u

المؤلفون: Couto, Narciso, Al-Majdoub, Zubida M., Gibson, Stephanie, Davies, Pamela J., Achour, Brahim, Harwood, Matthew D., Carlson, Gordon, Barber, Jill, Rostami-Hodjegan, Amin, Warhurst, Geoffrey

المصدر: Drug Metabolism and Disposition; 2020, Vol. 48 Issue: 4 p245-254, 10p

المؤلفون: Collett, Andrew, Tanianis-Hughes, Jola, Carlson, Gordon L., Harwood, Matthew D., Warhurst, Geoff

المصدر: Collett , A , Tanianis-Hughes , J , Carlson , G L , Harwood , M D & Warhurst , G 2005 , ' Comparison of P-glycoprotein-mediated drug-digoxin interactions in Caco-2 with human and rodent intestine: Relevance to in vivo prediction ' , European Journal of Pharmaceutical Sciences , vol. 26 , no. 5 , pp. 386-393 . https://doi.org/10.1016/j.ejps.2005.07.013

مصطلحات موضوعية: Caco-2, Digoxin, Drug-drug interactions, Human, P-glycoprotein, Prediction

الاتاحة: https://research.manchester.ac.uk/en/publications/f92a3a73-cfda-421c-ae50-f420630f6737
https://doi.org/10.1016/j.ejps.2005.07.013

المؤلفون: Harwood, Matthew D, Achour, Brahim, Neuhoff, Sibylle, Russell, Matthew R, Carlson, Gordon, Warhurst, Geoffrey, Rostami-Hodjegan, Amin

المصدر: Drug Metabolism and Disposition; March 2016, Vol. 44 Issue: 3 p297-307, 11p