المؤلفون: Naoki Kato, Kana Ebihara, Toshihiko Nogawa, Yushi Futamura, Kazue Inaba, Akiko Okano, Harumi Aono, Yuuta Fujikawa, Hideshi Inoue, Kazuhiko Matsuda, Hiroyuki Osada, Ryusuke Niwa, Shunji Takahashi

المصدر: PLoS ONE, Vol 18, Iss 8 (2023)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470909/?tool=EBI; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/005bbb16af3640c180b663d62b781f46

المؤلفون: Tomonori Hara, Manabu Toyoshima, Yasuko Hisano, Shabeesh Balan, Yoshimi Iwayama, Harumi Aono, Yushi Futamura, Hiroyuki Osada, Yuji Owada, Takeo Yoshikawa

المصدر: Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)

مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2158-3188

URL الوصول: https://doaj.org/article/a5cc49e3b8d54d4a818d9847431f0860

المؤلفون: Hiromasa Yoshioka (3128688), Tatsuro Kawamura (9323994), Makoto Muroi (1593946), Yasumitsu Kondoh (777042), Kaori Honda (839896), Makoto Kawatani (1593934), Harumi Aono (4863973), Herbert Waldmann (497871), Nobumoto Watanabe (9324000), Hiroyuki Osada (251592)

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Biotechnology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, therapeutic potential via, reducing lipid peroxides, glutathione peroxidase 4, compound named npd4928, several gpx4 inhibitors, known gpx4 inhibitors, various cancer cells, gpx4 inhibitors, cancer cells, oxidizes glutathione, cancer therapy, gpx4 inhibitor, whose cytotoxicity, target protein, study aimed, small molecule, results indicate, promising target, npd4928 enhanced, less sensitive, intracellular enzyme, exhibit cytotoxicity

Relation: https://figshare.com/articles/journal_contribution/Identification_of_a_Small_Molecule_That_Enhances_Ferroptosis_via_Inhibition_of_Ferroptosis_Suppressor_Protein_1_FSP1_/19130750

الاتاحة: https://doi.org/10.1021/acschembio.2c00028.s001

المؤلفون: Makoto Kawatani (1593934), Harumi Aono (4863973), Sayoko Hiranuma (3047643), Takeshi Shimizu (120443), Makoto Muroi (1593946), Naoko Ogawa (286886), Tomokazu Ohishi (11176574), Shun-ichi Ohba (704535), Manabu Kawada (704534), Toshihiko Nogawa (2259229), Akiko Okano (2259232), Daisuke Hashizume (1419916), Hiroyuki Osada (251592)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Genetics, Molecular Biology, Physiology, Pharmacology, Developmental Biology, Cancer, Hematology, Virology, Chemical Sciences not elsewhere classified, pentose phosphate pathway, cancer cell growth, pancreatic cancer cells, Small-molecule inhibitors, Inhibits Cancer Cell Growth Cancer ., Metabolome analysis, glycolytic pathway, cancer cells, pancreatic cancer, antiproliferative effect, DLD, ER, tumor growth, glucose uptake, Small-Molecule Glucose Transporter ., stress inducers, anticancer drugs

Relation: https://figshare.com/articles/journal_contribution/Identification_of_a_Small-Molecule_Glucose_Transporter_Inhibitor_Glutipyran_That_Inhibits_Cancer_Cell_Growth/15043280

الاتاحة: https://doi.org/10.1021/acschembio.1c00480.s001

المؤلفون: MAKOTO KAWATANI, HARUMI AONO, SAYOKO HIRANUMA, TAKESHI SHIMIZU, MAKOTO MUROI, TOSHIHIKO NOGAWA, TOMOKAZU OHISHI, SHUN-ICHI OHBA, MANABU KAWADA, KANAMI YAMAZAKI, SHINGO DAN, NAOSHI DOHMAE, HIROYUKI OSADA

المصدر: Oncology Research; 2023, Vol. 31 Issue 6, p833-844, 12p

مصطلحات موضوعية: CANCER cell growth, DIHYDROOROTATE dehydrogenase, PROTEOMICS, OROTIC acid, CELL growth

المؤلفون: Hiromasa Yoshioka, Tatsuro Kawamura, Makoto Muroi, Yasumitsu Kondoh, Kaori Honda, Makoto Kawatani, Harumi Aono, Herbert Waldmann, Nobumoto Watanabe, Hiroyuki Osada

المصدر: ACS chemical biology. 17(2)

مصطلحات موضوعية: Small Molecule Libraries, Molecular Medicine, Ferroptosis, General Medicine, Phospholipid Hydroperoxide Glutathione Peroxidase, Biochemistry, Glutathione, Oxidation-Reduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca476222ad59cd4e44ec3a3f16d0cab
https://pubmed.ncbi.nlm.nih.gov/35128925

المؤلفون: Yushi Futamura, Hiroyuki Osada, Julius Adam V Lopez, Daisuke Hashizume, Harumi Aono, Toshihiko Nogawa

المصدر: The Journal of Antibiotics. 74:477-479

مصطلحات موضوعية: 0301 basic medicine, Magnetic Resonance Spectroscopy, Stereochemistry, 030106 microbiology, Antineoplastic Agents, HL-60 Cells, Crystallography, X-Ray, Pimprinine, 01 natural sciences, High-performance liquid chromatography, Streptomyces, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Anti-Infective Agents, Cell Line, Tumor, Drug Discovery, Humans, Moiety, Cytotoxicity, Pharmacology, Biological Products, Natural product, Molecular Structure, biology, 010405 organic chemistry, Absolute configuration, Stereoisomerism, biology.organism_classification, Tryptamines, 0104 chemical sciences, chemistry, Drug Screening Assays, Antitumor, Enantiomer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d844467208d9f8ca7093929a60e80d
https://doi.org/10.1038/s41429-021-00420-7

المؤلفون: Harumi Aono, Rachael A Uson-Lopez, Hiroyuki Osada, Kai Yamamoto, Yushi Futamura, Takeshi Shimizu

المصدر: The Journal of Antibiotics. 72:986-990

مصطلحات موضوعية: 0301 basic medicine, Antifungal, Pyricularia, Antifungal Agents, Magnetic Resonance Spectroscopy, Oligomycin, medicine.drug_class, 030106 microbiology, Drug Evaluation, Preclinical, Fungus, 01 natural sciences, Streptomyces, Microbiology, 03 medical and health sciences, chemistry.chemical_compound, Ascomycota, Candida albicans, Drug Discovery, medicine, Humans, Enzyme Inhibitors, Soil Microbiology, Plant Diseases, Pharmacology, Molecular Structure, biology, 010405 organic chemistry, Chemistry, food and beverages, Oryza, biology.organism_classification, Mitochondrial respiration, Mitochondria, 0104 chemical sciences, Proton-Translocating ATPases, Macrolides, Soil microbiology, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e7d29551b93be075258eb51df0f81b
https://doi.org/10.1038/s41429-019-0239-z

المؤلفون: Harumi Aono, Haruhisa Kikuchi, Makoto Kawatani, Akiko Okano, Hiroyuki Osada, Yushi Futamura, Toshihiko Nogawa, Naoki Kato, Takeshi Shimizu

المصدر: The Journal of Antibiotics. 72:996-1000

مصطلحات موضوعية: 0301 basic medicine, Magnetic Resonance Spectroscopy, Stereochemistry, 030106 microbiology, Antineoplastic Agents, Bone Neoplasms, Stereoisomerism, Microbial Sensitivity Tests, Mass spectrometry, 01 natural sciences, Mass Spectrometry, Antimalarials, 03 medical and health sciences, Drug Discovery, Animals, Humans, Molecule, IC50, Soil Microbiology, Pharmacology, Osteosarcoma, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Tolypocladium, Biological activity, Nuclear magnetic resonance spectroscopy, biology.organism_classification, Rats, 0104 chemical sciences, Hypocreales, Diterpenes, Drug Screening Assays, Antitumor, Two-dimensional nuclear magnetic resonance spectroscopy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd2592bbce7ac672793b172aa0be599
https://doi.org/10.1038/s41429-019-0229-1

المؤلفون: Harumi Aono, Amit Subedi, Nobumoto Watanabe, Makoto Muroi, Tatsuro Kawamura, Mayuko Nishi, Yushi Futamura, Akihide Ryo, Hiroyuki Osada

المصدر: FEBS Letters. 593:763-776

مصطلحات موضوعية: Biophysics, Antineoplastic Agents, Biochemistry, Chemical library, Serine, 03 medical and health sciences, chemistry.chemical_compound, Biosynthesis, Structural Biology, Cancer stem cell, Cell Line, Tumor, Genetics, Humans, Metabolomics, Molecular Biology, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, 030302 biochemistry & molecular biology, Cell Biology, Mitochondria, Cell biology, Glucose, Enzyme, chemistry, Cancer cell, Neoplastic Stem Cells, Alkaline phosphatase, Drug Screening Assays, Antitumor, Intracellular

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09aa0b30f929861208c99cbc66a63fdc
https://doi.org/10.1002/1873-3468.13361

المؤلفون: Makoto Muroi, Harumi Aono, Daisuke Hashizume, Shun-ichi Ohba, Hiroyuki Osada, Manabu Kawada, Akiko Okano, Sayoko Hiranuma, Makoto Kawatani, Tomokazu Ohishi, Naoko Ogawa, Toshihiko Nogawa, Takeshi Shimizu

المصدر: ACS chemical biology. 16(8)

مصطلحات موضوعية: Proteomics, Glucose uptake, Glucose Transport Proteins, Facilitative, Mice, Nude, Antineoplastic Agents, Biochemistry, Cell Line, Tumor, Neoplasms, medicine, Animals, Humans, Metabolomics, Cell Proliferation, Pyrans, Mice, Inbred BALB C, biology, Cell growth, Chemistry, Glucose transporter, Cancer, Drug Synergism, General Medicine, medicine.disease, Xenograft Model Antitumor Assays, Metformin, Cell biology, Glucose, Cell culture, Cancer cell, biology.protein, Molecular Medicine, GLUT1, Female, Drug Screening Assays, Antitumor, A431 cells, Glycolysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5550367056bbd62160d0491a35f91830
https://pubmed.ncbi.nlm.nih.gov/34296611

المؤلفون: Takeo Yoshikawa, Hiroyuki Osada, Harumi Aono, Shabeesh Balan, Manabu Toyoshima, Yasuko Hisano, Yuji Owada, Tomonori Hara, Yoshimi Iwayama, Yushi Futamura

المصدر: Translational Psychiatry
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)

مصطلحات موضوعية: Physiology, Induced Pluripotent Stem Cells, Neurosciences. Biological psychiatry. Neuropsychiatry, medicine.disease_cause, Molecular neuroscience, Article, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Lactoylglutathione lyase, medicine, Humans, Respiratory function, Biological Psychiatry, Membrane potential, Neurons, biology, Catabolism, Methylglyoxal, Lactoylglutathione Lyase, Cell migration, Pyruvaldehyde, Cell biology, Mitochondria, Psychiatry and Mental health, Oxidative Stress, chemistry, biology.protein, Pyridoxamine, Oxidative stress, RC321-571

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925932433eaec17073c8f568bb2752ef
https://pubmed.ncbi.nlm.nih.gov/33966051

المؤلفون: Minami Odagi, Akiko Nagata, Kazuo Nagasawa, Fumihiro Kawagoe, Moeka Togashi, Hiroyuki Osada, Tatsuya Higashi, Shadi Sedghi Masoud, Kevin Tan Cruzado, Hayato Nakagawa, Atsushi Kittaka, Ajcharapan Tantipanjaporn, Motonari Uesugi, Makoto Kawatani, Ryota Sakamoto, Harumi Aono, Sayuri Mototani, Satoshi Okuda, Aileen Mendoza, Yasushi Takemoto

المصدر: Cell Chemical Biology. 29:660-669.e12

مصطلحات موضوعية: Metabolite, Clinical Biochemistry, TMLHE, Biology, Mitochondrion, Biochemistry, Lactones, chemistry.chemical_compound, Biosynthesis, CYP24A1, Carnitine, Drug Discovery, medicine, Animals, Vitamin D, Molecular Biology, Cholecalciferol, Pharmacology, Fatty Acids, Lipid metabolism, Vitamins, Lipid Metabolism, chemistry, Carnitine biosynthesis, Molecular Medicine, Oxidation-Reduction, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94de23364873265f9c58aecf7775abdf
https://doi.org/10.1016/j.chembiol.2021.08.008

المؤلفون: Hiroyuki Inoue, Hiroyuki Osada, Masaya Imoto, Harumi Aono, Yushi Futamura, Masaki Kiga, Yuki Shikata, Manabu Kawada

المصدر: Cancer Science

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Carcinoma, Hepatocellular, uncoupler, Blotting, Western, Apoptosis, Nonactin, Synthetic lethality, Mitochondrion, Biology, medicine.disease_cause, 03 medical and health sciences, chemistry.chemical_compound, Cell Line, Tumor, medicine, Animals, Humans, beta Catenin, Membrane Potential, Mitochondrial, Molecular Structure, Uncoupling Agents, Liver Neoplasms, Wnt signaling pathway, Wild type, Original Articles, General Medicine, Flow Cytometry, HCT116 Cells, Xenograft Model Antitumor Assays, Mitochondria, Cell biology, Drug Discovery and Delivery, 030104 developmental biology, Oncology, chemistry, A549 Cells, Mutation, β‐catenin, Original Article, Warburg effect, Macrolides, Signal transduction, Carcinogenesis, Antitumor activity, Glycolysis, HT29 Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1380435a7417a19f413969b26228e61d
https://doi.org/10.1111/cas.13172

المؤلفون: Harumi Aono, Takayuki Motoyama, Hiroyuki Osada, Makoto Kawatani, Takeo Usui, Toshiaki Hayashi, Yoko Nagumo, Hiroshi Hirota

المصدر: ChemistrySelect. 2:1533-1536

مصطلحات موضوعية: Natural product, Stereochemistry, General Chemistry, Biology, Inhibitory postsynaptic potential, chemistry.chemical_compound, chemistry, Biochemistry, Prenylation, Terpendole E, Atpase activity, Kinesin, Binding site, Mitosis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ef2220c694b9ed661cec71cf8d6bef0b
https://doi.org/10.1002/slct.201602015

المؤلفون: Hiroyuki Osada, Keisuke Morishita, Siro Simizu, Harumi Aono, Kumi Sugino, Makoto Kawatani, Shun Katsuyama, Kazuo Umezawa, Yukiko Sasazawa, Yoshihiko Nakano

المصدر: FEBS Letters. 590:1152-1162

مصطلحات موضوعية: 0301 basic medicine, Biophysics, Osteoclasts, Nucleoside Transport Proteins, Nucleoside transporter, Tritium, Biochemistry, Small Molecule Libraries, Concentrative nucleoside transporter, Mice, 03 medical and health sciences, 0302 clinical medicine, Osteogenesis, Structural Biology, Osteoclast, Cell Line, Tumor, Genetics, medicine, Animals, Humans, Molecular Biology, Mice, Inbred ICR, biology, Chemistry, RANK Ligand, Equilibrative nucleoside transporter, Transporter, Cell Biology, RAW 264.7 Cells, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, 030220 oncology & carcinogenesis, biology.protein, Female, Signal transduction, Nucleoside, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8473b935b0229f0b8b3bff3ae7f17394
https://doi.org/10.1002/1873-3468.12146

المؤلفون: Tomomi Sekine, Makoto Kawatani, Harumi Aono, Makoto Muroi, Toshihiko Nogawa, Marina Hayashida, Yushi Futamura, Hiroyuki Osada

المصدر: Biochimica et biophysica acta. Proteins and proteomics. 1867(1)

مصطلحات موضوعية: Proteomics, Macrocyclic Compounds, Phenotypic screening, Biophysics, Drug Evaluation, Preclinical, Photoaffinity Labels, 01 natural sciences, Biochemistry, Analytical Chemistry, Chemical library, Small Molecule Libraries, Two-Dimensional Difference Gel Electrophoresis, 03 medical and health sciences, chemistry.chemical_compound, Neoplasms, Drug Discovery, Animals, Humans, Molecular Biology, 030304 developmental biology, 0303 health sciences, 010405 organic chemistry, Proteomic Profiling, Chemistry, Metabolism, Electron transport chain, Small molecule, In vitro, 0104 chemical sciences, Mitochondria, Phenotype, Electron Transport Chain Complex Proteins, Cancer cell, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fcbe1f690b233e49cb7b84d5c458d89
https://pubmed.ncbi.nlm.nih.gov/29883687

المؤلفون: Harumi Aono, Hiroshi Takayama, Hiroyuki Osada, Jonathan O. Bauer, Carsten Strohmann, Herbert Waldmann, Yushi Futamura, Zhi-Jun Jia, Andrey P. Antonchick

المصدر: The Journal of organic chemistry. 83(13)

مصطلحات موضوعية: Pyrrolizidine alkaloid, Stereochemistry, Plasmodium falciparum, Stereoisomerism, 010402 general chemistry, 01 natural sciences, Catalysis, Cell Line, chemistry.chemical_compound, Antimalarials, Mice, Animals, Hedgehog Proteins, Pyrrolizidine Alkaloids, Biological evaluation, Biological Products, Mice, Inbred C3H, Cycloaddition Reaction, 010405 organic chemistry, Organic Chemistry, Enantioselective synthesis, Cycloaddition, 0104 chemical sciences, chemistry, Pyrrolizidine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8146fddebb6d8acb5262f2f1c5f67285
https://pubmed.ncbi.nlm.nih.gov/29460633

المؤلفون: Julian Wilke, Zhwan Mahmoud, Harumi Aono, Lucas Robke, Yao-Wen Wu, Nobumoto Watanabe, Yushi Futamura, Hiroyuki Osada, Herbert Waldmann, Luca Laraia, Georgios Konstantinidis

المصدر: Chemical Science

مصطلحات موضوعية: 0301 basic medicine, Organisk kemi, Phenotypic screening, Autophagy, Organic Chemistry, Biochemistry and Molecular Biology, Cancer, General Chemistry, Biology, medicine.disease, Mitochondrial respiration, Small molecule, Cell biology, 03 medical and health sciences, Metabolic pathway, 030104 developmental biology, medicine, Mitochondrial Complex I, Biokemi och molekylärbiologi

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0a2ce32855e3d4f4da555ce7922971
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158854

المؤلفون: Takeshi Shimizu, Yasuhiro Igarashi, Makoto Kawatani, Kenshirou Shimizu, Naoko Takahashi-Ando, Harumi Aono, Yushi Futamura, Hiroyuki Osada, Makoto Muroi, Gyo Inoue, Akira Wada

المصدر: Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Proteomics, Thiosemicarbazones, Metal ions in aqueous solution, Iron, Antineoplastic Agents, Iron Chelating Agents, Article, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, 2,2'-Dipyridyl, Coordination Complexes, Cell Line, Tumor, Humans, health care economics and organizations, Cell Proliferation, A549 cell, Multidisciplinary, Chemistry, Proteomic Profiling, Cell growth, Cell Cycle Checkpoints, Hypoxia-Inducible Factor 1, alpha Subunit, humanities, Streptomyces, High-Throughput Screening Assays, 030104 developmental biology, Biochemistry, Cell culture, A549 Cells, 030220 oncology & carcinogenesis, Proteome, Cancer cell, Glycolysis, Databases, Chemical, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e466db313102f2b92055a59d5e27cc