المؤلفون: Asim Azhar Siddiqui, Sabrina Peter, Eve Zi Xian Ngoh, Cheng-I. Wang, Shirelle Ng, John A. Dangerfield, Walter H. Gunzburg, Peter Dröge, Harshyaa Makhija

المصدر: Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)

مصطلحات موضوعية: human cell line engineering, λ integrase, Expi293F cells, biotherapeutics, site-specific transgenesis, microencapsulation, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fbioe.2023.1198465/full; https://doaj.org/toc/2296-4185

URL الوصول: https://doaj.org/article/7d08271bf26747a0830e808c29952bae

المؤلفون: Namrata Chaudhari, Amanda M. Rickard, Suki Roy, Peter Dröge, Harshyaa Makhija

المصدر: Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-16 (2020)

مصطلحات موضوعية: Genome engineering, Gene therapy, Embryonic stem cells, Large transgene, FVIII clotting protein, Lambda integrase, Medicine (General), R5-920, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s13287-020-01890-6; https://doaj.org/toc/1757-6512

URL الوصول: https://doaj.org/article/d1b6511059e0418e83656e2597bd2673

المؤلفون: Asim Azhar Siddiqui, Sabrina Peter, Eve Zi Xian Ngoh, Cheng-I. Wang, Shirelle Ng, John A. Dangerfield, Walter H. Gunzburg, Peter Dröge, Harshyaa Makhija

مصطلحات موضوعية: Biotechnology, Biological Engineering, Genetic Engineering, Biomarkers, Biomaterials, Biomechanical Engineering, Biomedical Engineering not elsewhere classified, Synthetic Biology, Agricultural Marine Biotechnology, Bioremediation, Bioprocessing, Bioproduction and Bioproducts, Industrial Biotechnology Diagnostics (incl. Biosensors), Industrial Microbiology (incl. Biofeedstocks), Industrial Molecular Engineering of Nucleic Acids and Proteins, Industrial Biotechnology not elsewhere classified, Medical Biotechnology Diagnostics (incl. Biosensors), Medical Molecular Engineering of Nucleic Acids and Proteins, Regenerative Medicine (incl. Stem Cells and Tissue Engineering), Medical Biotechnology not elsewhere classified, human cell line engineering, λ integrase, Expi293F cells, biotherapeutics, site-specific transgenesis, microencapsulation

Relation: https://figshare.com/articles/dataset/DataSheet1_A_versatile_genomic_transgenesis_platform_with_enhanced_integrase_for_human_Expi293F_cells_pdf/23558946

الاتاحة: https://doi.org/10.3389/fbioe.2023.1198465.s001
https://figshare.com/articles/dataset/DataSheet1_A_versatile_genomic_transgenesis_platform_with_enhanced_integrase_for_human_Expi293F_cells_pdf/23558946

المؤلفون: Patcharaporn Sae-Lao, Wuan Geok Saw, Chaudhari Namrata Pradeep, Anders Poulsen, Jocelyn Hui Ling Tan, Jickky Palmae Sarathy, Pearly Shuyi Ng, Gerhard Grüber, Peter Dröge, Revathy Kalyanasundaram, Pattarakiat Seankongsuk, Priya Ragunathan, Sivaraj Anbarasu, Umayal Lakshmanan, Harshyaa Makhija, Roderick W. Bates, Kevin Pethe, Krupakar Parthasarathy, Thomas Dick, Amaravadhi Harikishore, Adam Hotra, Joon Shin, Nitin Pal Kalia

المساهمون: School of Biological Sciences, School of Physical and Mathematical Sciences, Lee Kong Chian School of Medicine (LKCMedicine), Interdisciplinary Graduate School (IGS), Nanyang Institute of Technology in Health and Medicine

المصدر: Angewandte Chemie. 132:13397-13406

مصطلحات موضوعية: Enzyme complex, medicine.drug_class, Microbial Sensitivity Tests, 010402 general chemistry, Antimycobacterial, 01 natural sciences, Catalysis, chemistry.chemical_compound, Structure-Activity Relationship, Bacterial Proteins, Drug Discovery, medicine, Structure–activity relationship, Humans, Diarylquinolines, Enzyme Inhibitors, Embryonic Stem Cells, chemistry.chemical_classification, Reporter gene, ATP synthase, biology, Molecular Structure, 010405 organic chemistry, Drug discovery, Drug Synergism, General Chemistry, Mycobacterium tuberculosis, General Medicine, 0104 chemical sciences, ATP Synthesis, Enzyme, Pyrimidines, chemistry, Biochemistry, Bacterial Proton-Translocating ATPases, Biological sciences::Biochemistry [Science], Benzamides, biology.protein, Bedaquiline

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ffd8a157e15476795321ceca37daa1
https://doi.org/10.1002/ange.202002546

المؤلفون: Namrata Chaudhari, Rickard, Amanda M., Suki Roy, Dröge, Peter, Harshyaa Makhija

مصطلحات موضوعية: Data_FILES

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05993cb7923a5df932e72b187946a46e

المؤلفون: Sharon Chee, Shree Harsha Vijaya Chandra, Farid J. Ghadessy, Harshyaa Makhija, Peter Dröge, Cho Mar Myint Wai, Jia Wei Siau, Sabrina Peter

المصدر: Protein Engineering, Design and Selection. 28:211-220

مصطلحات موضوعية: Bioengineering, Biochemistry, beta-Lactamases, Substrate Specificity, Genome engineering, Transformation, Genetic, Cell Line, Tumor, Escherichia coli, Recombinase, Humans, Molecular Biology, Gene, Derepression, Recombination, Genetic, Genetics, Recombinase activity, Base Sequence, Integrases, biology, Chemistry, Directed evolution, Integrase, Mutation, biology.protein, Directed Molecular Evolution, In vitro recombination, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ead20869fa5a5b6a9a6b0b5c5dea2b1
https://doi.org/10.1093/protein/gzv015

المؤلفون: Shawn Hoon, Harshyaa Makhija, Rahul Jaiswal, Desmond Wong, Peter Dröge, Suki Roy, Dario Campana, Farid J. Ghadessy

المساهمون: School of Biological Sciences, NTU Institute of Structural Biology

مصطلحات موضوعية: 0301 basic medicine, Transgene, Recombinant Fusion Proteins, Genetic Vectors, Protein Expression, Gene Expression, Computational biology, Genome, Genome engineering, 03 medical and health sciences, 0302 clinical medicine, Plasmid, Genome editing, Genetics, Humans, Transgenes, Gene Editing, biology, Integrases, Genetic Therapy, Bacteriophage lambda, Integrase, Science::Biological sciences [DRNTU], Transgenesis, 030104 developmental biology, Long Interspersed Nucleotide Elements, 030220 oncology & carcinogenesis, biology.protein, Human genome, Genetic Engineering

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b883945409854f93ccf9d0f4b2714191
https://hdl.handle.net/10356/103690

المؤلفون: Harshyaa Makhija

المساهمون: Peter Droge, School of Biological Sciences

مصطلحات موضوعية: Genetics, biology.protein, Biology, Genome, Recombination, Integrase, Science::Biological sciences [DRNTU]

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d8374bcf4fa7e86c58b2a5dad8afaf
http://hdl.handle.net/10356/70616

المؤلفون: Harshyaa Makhija, Stefan Lim, Tess Lu, Shyam Prabhakar, Lixia Xin, Vibhor Kumar, Huck-Hui Ng, Masafumi Muratani, Thomas Lufkin, Jeremie Poschmann, Bavani Elanggovan, Nirmala Arul Rayan

المساهمون: Department of Computational and Systems Biology [Singapore], Genome Institute of Singapore (GIS), Department of Genome Biology [Ibaraki, Japan] (Faculty of Medicine), Université de Tsukuba = University of Tsukuba, Stem Cell and Developmental Biology [Singapore, Singapore], Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Department of Biology [New York, NY, USA], Clarkson University, Department of Biological Sciences [Singapore], National University of Singapore (NUS), This work was supported by funds from the Agency for Science Technology and Research, Singapore (A∗STAR) and from grant 1R01MH094714-01 from the National Institute of Mental Health, USA., Le Bihan, Sylvie

المصدر: Genome Research
Genome Research, Cold Spring Harbor Laboratory Press, 2016, 26 (5), pp.612-623. ⟨10.1101/gr.201038.115⟩
Genome Research, 2016, 26 (5), pp.612-623. ⟨10.1101/gr.201038.115⟩

مصطلحات موضوعية: 0301 basic medicine, [SDV]Life Sciences [q-bio], Genomics, Computational biology, Cell Line, Histones, 03 medical and health sciences, Genetics, Humans, Enhancer, Promoter Regions, Genetic, Genetics (clinical), Epigenomics, Regulation of gene expression, biology, Research, Promoter, Acetylation, Chromatin, [SDV] Life Sciences [q-bio], 030104 developmental biology, Histone, Enhancer Elements, Genetic, biology.protein, Protein Processing, Post-Translational

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8ac0e99d889ab314ed01733363858a9
https://www.hal.inserm.fr/inserm-02457680

المؤلفون: Jinming Li, Zhonglu Ren, Martina Stagno d'Alcontres, Cho Mar Myint Wai, Harshyaa Makhija, Peter Dröge, Sabrina Peter, Farid J. Ghadessy, Sharon Chee, Shree Harsha Vijaya Chandra, Jindong Zhu, Jia Wei Siau

المساهمون: School of Biological Sciences

المصدر: Nucleic Acids Research

مصطلحات موضوعية: 0301 basic medicine, Transgene, Molecular Sequence Data, Gene Expression, Bacterial genome size, Biology, Genome, Genome engineering, Insertional mutagenesis, 03 medical and health sciences, Viral Proteins, Genes, Reporter, Cell Line, Tumor, Genetics, Humans, Transgenes, Gene, Embryonic Stem Cells, Single Copy Transgenesis, Base Sequence, Integrases, Genome, Human, Human Genome, Gene Transfer Techniques, Bacteriophage lambda, Science::Biological sciences [DRNTU], Transgenesis, 030104 developmental biology, Long Interspersed Nucleotide Elements, Methods Online, Human genome, Genetic Engineering, Plasmids

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3168662430c814ba3bf43b37eb48c5cb
https://pubmed.ncbi.nlm.nih.gov/26673710