المؤلفون: Kathrin Gnoth, Joachim Wolfgang Bär, Fred Rosche, Jens-Ulrich Rahfeld, Hans-Ulrich Demuth

المصدر: PLoS ONE, Vol 19, Iss 4 (2024)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11020753/?tool=EBI; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/6af1ab80da134924975ebef387f8b17f

المؤلفون: Susan Barendrecht, An Schreurs, Stefanie Geissler, Victor Sabanov, Victoria Ilse, Vera Rieckmann, Rico Eichentopf, Anja Künemund, Benjamin Hietel, Sebastian Wussow, Katrin Hoffmann, Kerstin Körber-Ferl, Ravi Pandey, Gregory W. Carter, Hans-Ulrich Demuth, Max Holzer, Steffen Roßner, Stephan Schilling, Christoph Preuss, Detlef Balschun, Holger Cynis

المصدر: Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-23 (2023)

مصطلحات موضوعية: Alzheimer’s disease, Animal model, Tau, Knock-in, Amyloid, Gene expression, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1758-9193

URL الوصول: https://doaj.org/article/a9c1be2cbfd647cb8dd039ae107ce4ee

المؤلفون: Kathrin Gnoth, Anke Piechotta, Martin Kleinschmidt, Sandra Konrath, Mathias Schenk, Nadine Taudte, Daniel Ramsbeck, Vera Rieckmann, Stefanie Geissler, Rico Eichentopf, Susan Barendrecht, Maike Hartlage-Rübsamen, Hans-Ulrich Demuth, Steffen Roßner, Holger Cynis, Jens-Ulrich Rahfeld, Stephan Schilling

المصدر: Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-20 (2020)

مصطلحات موضوعية: Passive immunotherapy, Isoaspartate, Amyloid beta, 5xFAD mouse model, Alzheimer’s disease, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s13195-020-00719-x; https://doaj.org/toc/1758-9193

URL الوصول: https://doaj.org/article/2c961e761ce84b74a60f7925a3750699

المؤلفون: Maike Hartlage-Rübsamen, Veronika Ratz, Ulrike Zeitschel, Lukas Finzel, Lisa Machner, Janett Köppen, Anja Schulze, Hans-Ulrich Demuth, Stephan von Hörsten, Corinna Höfling, Steffen Roßner

المصدر: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-19 (2019)

مصطلحات موضوعية: Huntingtin, Cranial nerve nuclei, Alzheimer’s disease, Animal model, Amyloid precursor protein, Astrocytes, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s40478-019-0726-2; https://doaj.org/toc/2051-5960

URL الوصول: https://doaj.org/article/a1306f3f0a4543f58627dc1ea08af327

المؤلفون: Sharon C. Yates, Nicolaas E. Groeneboom, Christopher Coello, Stefan F. Lichtenthaler, Peer-Hendrik Kuhn, Hans-Ulrich Demuth, Maike Hartlage-Rübsamen, Steffen Roßner, Trygve Leergaard, Anna Kreshuk, Maja A. Puchades, Jan G. Bjaalie

المصدر: Frontiers in Neuroinformatics, Vol 13 (2019)

مصطلحات موضوعية: rodent brain analysis, Alzheimer’s disease, quantification, workflow, APP—amyloid precursor protein, beta-amyloid, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fninf.2019.00075/full; https://doaj.org/toc/1662-5196

URL الوصول: https://doaj.org/article/5dc24db4c0df4d0ba8ee4846c5996928

المؤلفون: Janett Köppen, Anja Schulze, Lisa Machner, Michael Wermann, Rico Eichentopf, Max Guthardt, Angelika Hähnel, Jessica Klehm, Marie-Christin Kriegeskorte, Maike Hartlage-Rübsamen, Markus Morawski, Stephan von Hörsten, Hans-Ulrich Demuth, Steffen Roßner, Stephan Schilling

المصدر: Molecules, Vol 25, Iss 3, p 580 (2020)

مصطلحات موضوعية: alpha-synuclein (α-synuclein), alzheimer’s disease, amyloid-beta (aβ), dementia with lewy bodies, parkinson’s disease, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/3/580; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/7da9d0773fc1416584614e4190644c3e

المؤلفون: Maike Hartlage-Rübsamen, Alexandra Bluhm, Anke Piechotta, Miriam Linnert, Jens-Ulrich Rahfeld, Hans-Ulrich Demuth, Inge Lues, Peer-Hendrik Kuhn, Stefan F. Lichtenthaler, Steffen Roßner, Corinna Höfling

المصدر: Molecules, Vol 23, Iss 4, p 924 (2018)

مصطلحات موضوعية: Alzheimer’s disease, animal model, human APP expression, glutaminyl cyclase, pyroglutamate-Abeta, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1420-3049/23/4/924; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/b60fbbff8b6b44548f4086d7a40380b3

المؤلفون: Christina Dammers, Lothar Gremer, Philipp Neudecker, Hans-Ulrich Demuth, Melanie Schwarten, Dieter Willbold

المصدر: PLoS ONE, Vol 10, Iss 10, p e0139710 (2015)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC4593648?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/44d40b340307452ba230d5099657ff41

المؤلفون: Christina Dammers, Lothar Gremer, Kerstin Reiß, Antonia N Klein, Philipp Neudecker, Rudolf Hartmann, Na Sun, Hans-Ulrich Demuth, Melanie Schwarten, Dieter Willbold

المصدر: PLoS ONE, Vol 10, Iss 11, p e0143647 (2015)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC4658145?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/6c54de1f07bb45dab81589101289ead2

المؤلفون: Stephanie Hielscher-Michael, Carola Griehl, Mirko Buchholz, Hans-Ulrich Demuth, Norbert Arnold, Ludger A. Wessjohann

المصدر: Marine Drugs, Vol 14, Iss 11, p 203 (2016)

مصطلحات موضوعية: glutaminyl cyclase (QC) inhibitor, microalgae, sulfolipids, AD, reverse metabolomics, Scenedesmus sp., natural product, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1660-3397/14/11/203; https://doaj.org/toc/1660-3397

URL الوصول: https://doaj.org/article/220f62f3723643dea6ecd9177e396cc2

المؤلفون: Deutscher Ethikrat, Prof. Dr. med. Alena Buyx (Vorsitzende) Prof. Dr. iur. Dr. h. c. Volker Lipp (Stellvertretender Vorsitzender) Prof. Dr. phil. Dr. h. c. Julian Nida-Rümelin (Stellvertretender Vorsitzender) Prof. Dr. rer. nat. Susanne Schreiber (Stellvertretende Vorsitzende) Prof. Dr. iur. Steffen Augsberg Regionalbischöfin Dr. phil. Petra Bahr Prof. Dr. theol. Franz-Josef Bormann Prof. Dr. rer. nat. Hans-Ulrich Demuth Prof. Dr. iur. Helmut Frister Prof. Dr. theol. Elisabeth Gräb-Schmidt Prof. Dr. rer. nat. Dr. phil. Sigrid Graumann Prof. Dr. rer. nat. Armin Grunwald Prof. Dr. med. Wolfram Henn Prof. Dr. rer. nat. Ursula Klingmüller Stephan Kruip Prof. Dr. theol. Andreas Lob-Hüdepohl Prof. Dr. iur. Stephan Rixen Prof. Dr. iur. Dr. phil. Frauke Rostalski Prof. Dr. theol. Kerstin Schlögl-Flierl Prof. Dr. phil. Mark Schweda Prof. Dr. phil. Judith Simon Prof. Dr. phil. Muna Tatari Externer Experte Prof. Dr. phil. habil. Dr. phil. h. c. lic. phil. Carl Friedrich Gethmann (Ratsmitglied bis 13. Februar 2021, danach Mitarbeit als externer Experte)

مصطلحات موضوعية: info:eu-repo/classification/ddc

وصف الملف: application/pdf

Relation: https://mediatum.ub.tum.de/1753389; https://mediatum.ub.tum.de/doc/1753389/document.pdf

الاتاحة: https://mediatum.ub.tum.de/1753389
https://mediatum.ub.tum.de/doc/1753389/document.pdf

المؤلفون: Prof. Dr. med. Alena Buyx (Vorsitzende) Prof. Dr. iur. Dr. h. c. Volker Lipp (Stellvertretender Vorsitzender) Prof. Dr. phil. Dr. h. c. Julian Nida-Rümelin (Stellvertretender Vorsitzender) Prof. Dr. rer. nat. Susanne Schreiber (Stellvertretende Vorsitzende) Prof. Dr. iur. Steffen Augsberg Regionalbischöfin Dr. phil. Petra Bahr Prof. Dr. theol. Franz-Josef Bormann Prof. Dr. rer. nat. Hans-Ulrich Demuth Prof. Dr. iur. Helmut Frister Prof. Dr. theol. Elisabeth Gräb-Schmidt Prof. Dr. rer. nat. Dr. phil. Sigrid Graumann Prof. Dr. rer. nat. Armin Grunwald Prof. Dr. med. Wolfram Henn Prof. Dr. rer. nat. Ursula Klingmüller Stephan Kruip Prof. Dr. theol. Andreas Lob-Hüdepohl Prof. Dr. iur. Stephan Rixen Prof. Dr. iur. Dr. phil. Frauke Rostalski Prof. Dr. theol. Kerstin Schlögl-Flierl Prof. Dr. phil. Mark Schweda Prof. Dr. phil. Judith Simon Prof. Dr. phil. Muna Tatari Externer Experte Prof. Dr. phil. habil. Dr. phil. h. c. lic. phil. Carl Friedrich Gethmann (Ratsmitglied bis 13. Februar 2021, danach Mitarbeit als externer Experte

مصطلحات موضوعية: info:eu-repo/classification/ddc

وصف الملف: application/pdf

Relation: https://mediatum.ub.tum.de/1753390; https://mediatum.ub.tum.de/doc/1753390/document.pdf

الاتاحة: https://mediatum.ub.tum.de/1753390
https://mediatum.ub.tum.de/doc/1753390/document.pdf

المؤلفون: Miriam Linnert, Claudia Fritz, Christian Jäger, Dagmar Schlenzig, Daniel Ramsbeck, Martin Kleinschmidt, Michael Wermann, Hans-Ulrich Demuth, Christoph Parthier, Stephan Schilling

المصدر: International Journal of Molecular Sciences; Volume 22; Issue 11; Pages: 5651

مصطلحات موضوعية: Meprin B, Meprin beta, metalloproteinase, astacin, hydroxamate, SAR (structure activity relationship), MWT-S-270

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Biochemistry; https://dx.doi.org/10.3390/ijms22115651

الاتاحة: https://doi.org/10.3390/ijms22115651

المؤلفون: Franziska Seifert, Stephan Schilling, Oliver Kupski, Hans-Ulrich Demuth, Lisa-Marie Funk, Viktor Sautner, Franc Meyer, Ulf Diederichsen, Brigitte Worbs, Daniel Ramsbeck, Mirko Buchholz, Kai Tittmann

المصدر: Biochemistry. 59:2585-2591

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, Druggability, Peptide, Crystallography, X-Ray, Hydrazide, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Alzheimer Disease, In vivo, Humans, Molecular Targeted Therapy, Enzyme Inhibitors, Deamidation, Neurotensin, chemistry.chemical_classification, 0303 health sciences, 030302 biochemistry & molecular biology, Glutamate receptor, Aminoacyltransferases, 3. Good health, Hydrazines, Enzyme, chemistry, Cyclization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7744ff16652a4699ae8ab2f5632ec2e
https://doi.org/10.1021/acs.biochem.0c00337

المؤلفون: Daniel Ramsbeck, Christoph Parthier, Hans-Ulrich Demuth, Stephan Schilling, Miriam Linnert, Michael Wermann, Martin Kleinschmidt, Claudia Fritz, Dagmar Schlenzig, Christian Jäger

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5651, p 5651 (2021)
Volume 22
Issue 11

مصطلحات موضوعية: 0301 basic medicine, Proteases, Arginine, QH301-705.5, medicine.medical_treatment, Drug design, Molecular Dynamics Simulation, hydroxamate, Hydroxamic Acids, 01 natural sciences, Isozyme, Catalysis, Article, MWT-S-270, Inorganic Chemistry, 03 medical and health sciences, Structure-Activity Relationship, 0103 physical sciences, medicine, Humans, Protease Inhibitors, Physical and Theoretical Chemistry, Biology (General), Molecular Biology, QD1-999, Meprin B, Spectroscopy, Metalloproteinase, Protease, 010304 chemical physics, biology, Chemistry, Organic Chemistry, SAR (structure activity relationship), Active site, Metalloendopeptidases, General Medicine, Meprin beta, Computer Science Applications, 030104 developmental biology, Biochemistry, biology.protein, metalloproteinase, Astacin, astacin

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7feb43d2e744a3a88ac52c537574ae1
http://europepmc.org/articles/PMC8197800

المؤلفون: Stephan Schilling, Michael Wermann, Miriam Linnert, Martin Kleinschmidt, Claudia Fritz, Hans-Ulrich Demuth, Christian Jäger, Daniel Ramsbeck, Dagmar Schlenzig

مصطلحات موضوعية: Metalloproteinase, Stereochemistry, Chemistry, Dynamics (mechanics), biochemistry, Astacin

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ec0001f5a64dcafc469baf1f2cb3c4

المؤلفون: Miriam Linnert, Stephan Schilling, Hans-Ulrich Demuth, Mirko Buchholz, Jens-Ulrich Rahfeld, John A. Houston, Christoph Parthier, Florian Veillard, Nadine Taudte, Anke Piechotta, Milton T. Stubbs, Petr Kolenko, Jan Potempa, Daniel Ramsbeck, Sigrun Eick

المساهمون: Publica

المصدر: The Journal of Biological Chemistry
Taudte, Nadine; Linnert, Miriam; Rahfeld, Jens-Ulrich; Piechotta, Anke; Ramsbeck, Daniel; Buchholz, Mirko; Kolenko, Petr; Parthier, Christoph; Houston, John A; Veillard, Florian; Eick, Sigrun; Potempa, Jan; Schilling, Stephan; Demuth, Hans-Ulrich; Stubbs, Milton T (2021). Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis. The journal of biological chemistry, 296, p. 100263. American Society for Biochemistry and Molecular Biology 10.1016/j.jbc.2021.100263 <http://dx.doi.org/10.1016/j.jbc.2021.100263>

مصطلحات موضوعية: 0301 basic medicine, glutaminyl cyclase, periodontal disease, TRH, thyrotropin-releasing hormone, Crystallography, X-Ray, Biochemistry, Prevotella intermedia, Catalytic Domain, bacterial pathogens, Tannerella forsythia, 610 Medicine & health, ACAP, auto-antibodies against citrullinated peptides, Bibliographie, chemistry.chemical_classification, biology, Chemistry, Aminoacyltransferases, Glutaminyl cyclase, Enzyme structure, Pyrrolidonecarboxylic Acid, enzyme structure, AD, Alzheimer's disease, Bacterial outer membrane, Porphyromonas gingivalis, Research Article, crystal structure, drug design, PPAD, P. gingivalis peptidylarginine deiminase, FRIL, freeze-fracture replica immunolabeling, 03 medical and health sciences, ORF, open reading frame, medicine, GnRH, gonadotropin-releasing hormone, Humans, Periodontitis, Molecular Biology, 030102 biochemistry & molecular biology, Cell Biology, Periplasmic space, NMM, N-methylmorpholine, medicine.disease, biology.organism_classification, Protein Structure, Tertiary, 030104 developmental biology, Enzyme

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b44849e5bf631c10995725a3bbf87c2
https://publica.fraunhofer.de/handle/publica/267517

المؤلفون: Mirko Buchholz, Holger Cynis, Hans-Ulrich Demuth, Claudia Spahn, Ulrike Zeitschel, Daniel Ramsbeck, Michael Wermann, Maike Hartlage-Rübsamen, Steffen Roßner, Katja Menge, Dagmar Schlenzig, Anja Fothe, Stephan Schilling

المصدر: Journal of Alzheimer's Disease. 66:359-375

مصطلحات موضوعية: Male, 0301 basic medicine, Proteases, Dipeptidyl-peptidase activity, CHO Cells, Dipeptidyl peptidase, 03 medical and health sciences, Cricetulus, 0302 clinical medicine, Cricetinae, Animals, Humans, Amino Acid Sequence, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases, Protein precursor, Peptide sequence, Aged, Aged, 80 and over, Exopeptidase activity, Amyloid beta-Peptides, biology, Chemistry, General Neuroscience, Brain, Metalloendopeptidases, General Medicine, Aminoacyltransferases, Peptide Fragments, Endopeptidase, Enzyme Activation, Psychiatry and Mental health, Clinical Psychology, HEK293 Cells, 030104 developmental biology, Biochemistry, biology.protein, Female, Geriatrics and Gerontology, Amyloid precursor protein secretase, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94ec447859ba4fdfdc0d846dcf89a41
https://doi.org/10.3233/jad-171183

المؤلفون: An Tanghe, Annelies Termont, Pascal Merchiers, Stephan Schilling, Hans-Ulrich Demuth, Louise Scrocchi, Fred Van Leuven, Gerard Griffioen, Tom Van Dooren

المصدر: International Journal of Alzheimer's Disease, Vol 2010 (2010)

مصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Geriatrics, RC952-954.6

Relation: http://dx.doi.org/10.4061/2010/417314; https://doaj.org/toc/2090-0252; https://doaj.org/article/a5197c7e75b44c5e80b34ab6b80b4a30

الاتاحة: https://doi.org/10.4061/2010/417314
https://doaj.org/article/a5197c7e75b44c5e80b34ab6b80b4a30

المؤلفون: An Tanghe, Annelies Termont, Pascal Merchiers, Stephan Schilling, Hans-ulrich Demuth, Louise Scrocchi, Fred Van Leuven, Gerard Griffioen, Tom Van Dooren

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f5/c3/Int_J_Alzheimers_Dis_2010_Sep_2_2010_417314.tar.gz

وصف الملف: application/zip

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.351.5068

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.351.5068