المؤلفون: Fernandez-Rozadilla, Ceres, Timofeeva, Maria, Chen, Zhishan, Law, Philip, Thomas, Minta, Bien, Stephanie, Diez-Obrero, Virginia, Li, Li, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Harris, Sarah, Svinti, Victoria, McDonnell, Kevin, Farrington, Susan, Studd, James, Vaughan-Shaw, Peter, Shu, Xiao-ou, Long, Jirong, Cai, Qiuyin, Guo, Xingyi, Lu, Yingchang, Scacheri, Peter, Huyghe, Jeroen, Harrison, Tabitha, Shibata, David, Haiman, Christopher, Devall, Mathew, Schumacher, Fredrick, Melas, Marilena, Rennert, Gad, Obon-Santacana, Mireia, Martin-Sanchez, Vicente, Moratalla-Navarro, Ferran, Oh, Jae Hwan, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Potter, John, Jenkins, Mark, Win, Aung Ko, Pai, Rish, Figueiredo, Jane, Haile, Robert, Gallinger, Steven, Woods, Michael, Newcomb, Polly, Cheadle, Jeremy, Kaplan, Richard, Maughan, Timothy, Kerr, Rachel, Kerr, David, Kirac, Iva, Boehm, Jan, Mecklin, Lukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri, Rissanen, Harri, Pukkala, Eero, Eriksson, Johan, Cajuso, Tatiana, Hanninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Zanke, Brent, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie, Ruiz-Narvaez, Edward, Palmer, Julie, Buchanan, Daniel, Platz, Elizabeth, Visvanathan, Kala, Ulrich, Cornelia, Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha, Tsilidis, Konstantinos, Schulze, Matthias, Gunter, Marc, Murphy, Neil, Castells, Antoni, Castellvi-Bel, Sergi, Moreira, Leticia, Arndt, Volker, Shcherbina, Anna, Stern, Mariana, Pardamean, Bens, Bishop, Timothy, Giles, Graham, Southey, Melissa, Idos, Gregory, Abu-Ful, Zomoroda, Greenson, Joel, Shulman, Katerina, Lejbkowicz, Flavio, Offit, Kenneth, Su, Yu-Ru, Steinfelder, Robert, Keku, Temitope, van Guelpen, Bethany, Hudson, Thomas, Hampel, Heather, Pearlman, Rachel, Berndt, Sonja, Hayes, Richard, Martinez, Marie Elena, Thomas, Sushma, Corley, Douglas, Pharoah, Paul, Larsson, Susanna, Yen, Yun, Lenz, Heinz-Josef, White, Emily, Doheny, Kimberly, Pugh, Elizabeth, Shelford, Tameka, Chan, Andrew, Cruz-Correa, Marcia, Lindblom, Annika, Joshi, Amit, Schafmayer, Clemens, Kundaje, Anshul, Nickerson, Deborah, Schoen, Robert, Hampe, Jochen, Stadler, Zsofia, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Papadopoulos, Nickolas, Edlund, Chistopher, Gauderman, William, Thomas, Duncan, Toland, Amanda, Markowitz, Sanford, Kim, Andre, Gruber, Stephen, van Duijnhoven, Franzel, Feskens, Edith, Sakoda, Lori, Gago-Dominguez, Manuela, Wolk, Alicja, Naccarati, Alessio, Pardini, Barbara, FitzGerald, Liesel, Lee, Soo Chin, Ogino, Shuji, Kooperberg, Charles, Li, Christopher, Lin, Yi, Prentice, Ross, Qu, Conghui, Bezieau, Stephane, Tangen, Catherine, Mardis, Elaine, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Le Marchand, Loic, Wu, Anna, Qu, Chenxu, McNeil, Caroline, Coetzee, Gerhard, Hayward, Caroline, Deary, Ian, Theodoratou, Evropi, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Moreno, Victor, Casey, Graham, Tomlinson, Ian, Zheng, Wei, Dunlop, Malcolm, Houlston, Richard, Peters, Ulrike

المساهمون: Lauri Antti Aaltonen / Principal Investigator, ATG - Applied Tumor Genomics, Department of Medical and Clinical Genetics, Clinicum, Research Programs Unit, Johan Eriksson / Principal Investigator, Department of General Practice and Primary Health Care, Medicum, Genome-Scale Biology (GSB) Research Program, Faculty Common Matters (Faculty of Medicine), Faculty of Medicine, HUS Abdominal Center, Department of Surgery, II kirurgian klinikka

مصطلحات موضوعية: Ld score regression, Association, Heritability, Metaanalysis, Genetics, developmental biology, physiology

وصف الملف: application/pdf

Relation: At the Institute of Cancer Research, this work was supported by Cancer Research UK (CRUK, grant no. C1298/A25514 to R.S.H.). Additional support was provided by the National Cancer Research Network. In Edinburgh, the work was supported by program grant funding from CRUK (grant nos. C348/A12076 to M.G.D. and C6199/A16459 to I.T.), EU European Research Council Advanced Grant EVOCAN, and the infrastructure and staffing of the Edinburgh CRUK Cancer Research Centre. C.F.R. was supported by a Marie Sklodowska-Curie Intra-European Fellowship Action (grant no. IEF-301077) for the INTERMPHEN project and received considerable help from many staff in the Department of Endoscopy at the John Radcliffe Hospital in Oxford. Support from the European Union (grant nos. FP7/207-2013 and 258236), FP7 collaborative project SYSCOL and COST Actions EuColonGene and TransColonCan are also acknowledged (grant nos. BM1206 and CA17118 to I.T.). We are grateful to many colleagues within UK clinical genetics departments (for CORGI) and to many collaborators who participated in the VICTOR, QUASAR2 and SCOT trials. We also thank colleagues from the UK National Cancer Research Network (for NSCCG). IT acknowledges funding from CRUK program grant no. C6199/A27327. The work at Vanderbilt University Medical Center was supported by US National Institutes of Health (NIH; grant nos. R01CA188214, R37CA070867, UM1CA182910, R01CA124558, R01CA158473 and R01CA148667), as well as Anne Potter Wilson Chair funds from the Vanderbilt University School of Medicine (to W.Z.). Sample preparation and genotyping assays at Vanderbilt University were conducted at the Survey and Biospecimen Shared Resources and Vanderbilt Microarray Shared Resource, supported in part by the Vanderbilt-Ingram Cancer Center (grant no. P30CA068485). Statistical analyses were performed on servers maintained by the Advanced Computing Center for Research and Education (ACCRE) at Vanderbilt University. Genetics and Epidemiology of Colorectal Cancer Consortium (GECCC), National Cancer Institute (NCI), NIH, US Department of Health and Human Services provided grant nos. U01 CA164930, U01 CA137088, R01 CA059045, R01201407 and R01CA206279. Genotyping services were provided by the Center for Inherited Disease Research (CIDR) contract no. HHSN268201200008I. This research was funded in part through the NIH/NCI Cancer Center support grant no. P30 CA015704. Scientific Computing Infrastructure at the Fred Hutchinson Cancer Research Center was funded by ORIP grant no. S10OD028685 (to U.P.). The Colorectal Cancer Transdisciplinary (CORECT) study was supported by the NCI/NIH, US Department of Health and Human Services (grant nos. U19 CA148107, R01 CA81488, P30 CA014089, R01 CA197350, P01 CA196569 and R01 CA201407) and National Institutes of Environmental Health Sciences, NIH (grant no. T32 ES013678). The Colon Cancer Family Registry (CCFR) participant recruitment and collection of data and biospecimens used in the present study were supported by the NCI, NIH (grant no. U01 CA167551). OFCCR was supported through funding allocated to the Ontario Registry for Studies of Familial Colorectal Cancer (grant no. U01 CA074783). The content of this manuscript does not necessarily reflect the views or policies of the NCI or any of the collaborating centers in the CCFR, and the mention of trade names, commercial products or organizations does not imply endorsement by the US Government, any cancer registry or the CCFR.; http://hdl.handle.net/10138/572963; 85144441436; 001001563800001

الاتاحة: http://hdl.handle.net/10138/572963

المؤلفون: Fernandez-Rozadilla, Ceres, Timofeeva, Maria, Chen, Zhishan, Law, Philip, Thomas, Minta, Schmit, Stephanie, Díez-Obrero, Virginia, Hsu, Li, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah, Svinti, Victoria, Donnelly, Kevin, Farrington, Susan, Blackmur, James, Vaughan-Shaw, Peter, Shu, Xiao-ou, Long, Jirong, Cai, Qiuyin, Guo, Xingyi, Lu, Yingchang, Broderick, Peter, Studd, James, Huyghe, Jeroen, Harrison, Tabitha, Conti, David, Dampier, Christopher, Devall, Mathew, Schumacher, Fredrick, Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martin-Sanchez, Vicente, Moratalla-Navarro, Ferran, Hwan Oh, Jae, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John, Jenkins, Mark, Win, Aung Ko, Pai, Rish, Figueiredo, Jane, Haile, Robert, Gallinger, Steven, Woods, Michael, Newcomb, Polly, Duggan, David, Cheadle, Jeremy, Kaplan, Richard, Maughan, Timothy, Kerr, Rachel, Kerr, David, Kirac, Iva, Bohm, Jan, Mecklin, Lukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri, Rissanen, Harri, Pukkala, Eero, Eriksson, Johan, Cajuso, Tatiana, Hanninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Zanke, Brent, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie, Ruiz-Narvaez, Edward, Palmer, Julie, Buchanan, Daniel, Platz, Elizabeth, Visvanathan, Kala, Ulrich, Cornelia, Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha

مصطلحات موضوعية: Q Science (General), R Medicine (General)

وصف الملف: application/pdf

Relation: https://orca.cardiff.ac.uk/id/eprint/153253/1/62499_2_merged_1664999669.pdf; Fernandez-Rozadilla, Ceres, Timofeeva, Maria, Chen, Zhishan, Law, Philip, Thomas, Minta, Schmit, Stephanie, Díez-Obrero, Virginia, Hsu, Li, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah, Svinti, Victoria, Donnelly, Kevin, Farrington, Susan, Blackmur, James, Vaughan-Shaw, Peter, Shu, Xiao-ou, Long, Jirong, Cai, Qiuyin, Guo, Xingyi, Lu, Yingchang, Broderick, Peter, Studd, James, Huyghe, Jeroen, Harrison, Tabitha, Conti, David, Dampier, Christopher, Devall, Mathew, Schumacher, Fredrick, Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martin-Sanchez, Vicente, Moratalla-Navarro, Ferran, Hwan Oh, Jae, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John, Jenkins, Mark, Win, Aung Ko, Pai, Rish, Figueiredo, Jane, Haile, Robert, Gallinger, Steven, Woods, Michael, Newcomb, Polly, Duggan, David, Cheadle, Jeremy https://orca.cardiff.ac.uk/view/cardiffauthors/A0702554.html orcid:0000-0001-9453-8458 orcid:0000-0001-9453-8458, Kaplan, Richard, Maughan, Timothy, Kerr, Rachel, Kerr, David, Kirac, Iva, Bohm, Jan, Mecklin, Lukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri, Rissanen, Harri, Pukkala, Eero, Eriksson, Johan, Cajuso, Tatiana, Hanninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Zanke, Brent, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie, Ruiz-Narvaez, Edward, Palmer, Julie, Buchanan, Daniel, Platz, Elizabeth, Visvanathan, Kala, Ulrich, Cornelia, Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann and Slattery, Martha 2022. Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and East Asian ancestries. Nature Genetics 10.1038/s41588-022-01222-9 https://doi.org/10.1038/s41588-022-01222-9 file https://orca.cardiff.ac.uk/id/eprint/153253/1/62499_2_merged_1664999669.pdf

الاتاحة: https://orca.cardiff.ac.uk/id/eprint/153253/
https://doi.org/10.1038/s41588-022-01222-9
https://orca.cardiff.ac.uk/id/eprint/153253/1/62499_2_merged_1664999669.pdf

المؤلفون: Katainen, Riku, Dave, Kashyap, Pitkänen, Esa, Palin, Kimmo, Kivioja, Teemu, Valimaki, Niko, Gylfe, Alexandra E., Ristolainen, Heikki, Hanninen, Ulrika A., Cajuso, Tatiana, Kondelin, Johanna, Tanskanen, Tomas, Mecklin, Jukka-Pekka, Järvinen, Heikki, Renkonen-Sinisalo, Laura, Lepisto, Anna, Kaasinen, Eevi, Kilpivaara, Outi, Tuupanen, Sari, Enge, Martin, Taipale, Jussi, Aaltonen, Lauri A.

المساهمون: Research Programs Unit, Lauri Antti Aaltonen / Principal Investigator, Genome-Scale Biology (GSB) Research Program, Department of Medical and Clinical Genetics, Medicum, Jussi Taipale / Principal Investigator, Clinicum, Heikki Järvinen / Principal Investigator, Department of Surgery, II kirurgian klinikka

مصطلحات موضوعية: Cancers, Genetics, developmental biology, physiology, Surgery, anesthesiology, intensive care, radiology

وصف الملف: application/pdf

Relation: Katainen , R , Dave , K , Pitkänen , E , Palin , K , Kivioja , T , Valimaki , N , Gylfe , A E , Ristolainen , H , Hanninen , U A , Cajuso , T , Kondelin , J , Tanskanen , T , Mecklin , J-P , Järvinen , H , Renkonen-Sinisalo , L , Lepisto , A , Kaasinen , E , Kilpivaara , O , Tuupanen , S , Enge , M , Taipale , J & Aaltonen , L A 2015 , ' CTCF/cohesin-binding sites are frequently mutated in cancer ' , Nature Genetics , vol. 47 , no. 7 , pp. 818-+ . https://doi.org/10.1038/ng.3335; Bibtex: urn:7e1eb762b31b36908d7129b19fe74646; ORCID: /0000-0002-5866-4059/work/37545773; ORCID: /0000-0002-1333-8049/work/91815971; ORCID: /0000-0001-6839-4286/work/101502711; ORCID: /0000-0001-8467-2100/work/156157827; http://hdl.handle.net/10138/326726; 7402fe51-8c1e-4593-bfdf-9bdb8b07dcc7; 84933278077; 000357090300022

الاتاحة: http://hdl.handle.net/10138/326726

المؤلفون: Tanskanen, Tomas, van den Berg, Linda, Valimaki, Niko, Aavikko, Mervi, Ness-Jensen, Eivind, Hveem, Kristian, Wettergren, Yvonne, Lindskog, Elinor Bexe, Tonisson, Neeme, Metspalu, Andres, Silander, Kaisa, Orlando, Giulia, Law, Philip J., Tuupanen, Sari, Gylfe, Alexandra E., Hanninen, Ulrika A., Cajuso, Tatiana, Kondelin, Johanna, Sarin, Antti-Pekka, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Jarvinen, Heikki, Renkonen-Sinisalo, Laura, Lepisto, Anna, Bohm, Jan, Mecklin, Jukka-Pekka, Al-Tassan, Nada A., Palles, Claire, Martin, Lynn, Barclay, Ella, Tenesa, Albert, Farrington, Susan M., Timofeeva, Maria N., Meyer, Brian F., Wakil, Salma M., Campbell, Harry, Smith, Christopher G., Idziaszczyk, Shelley, Maughan, Tim S., Kaplan, Richard, Kerr, Rachel, Kerr, David, Buchanan, Daniel D., Win, Aung K., Hopper, John, Jenkins, Mark A., Newcomb, Polly A., Gallinger, Steve, Conti, David, Schumacher, Fredrick R., Casey, Graham, Cheadle, Jeremy P., Dunlop, Malcolm G., Tomlinson, Ian P., Houlston, Richard S., Palin, Kimmo, Aaltonen, Lauri A.

المساهمون: Research Programs Unit, Lauri Antti Aaltonen / Principal Investigator, Genome-Scale Biology (GSB) Research Program, Medicum, Department of Medical and Clinical Genetics, University of Helsinki, Institute for Molecular Medicine Finland, Samuli Olli Ripatti / Principal Investigator, Biostatistics Helsinki, Aarno Palotie / Principal Investigator, Heikki Järvinen / Principal Investigator, Department of Surgery, II kirurgian klinikka, Clinicum, Centre of Excellence in Complex Disease Genetics, Centre of Excellence in Stem Cell Metabolism, Nutrient sensing laboratory, HUS Abdominal Center, Complex Disease Genetics, Genomics of Neurological and Neuropsychiatric Disorders

مصطلحات موضوعية: colorectal cancer, genetic predisposition to disease, genome-wide association study, single-nucleotide polymorphism, SUSCEPTIBILITY LOCUS, COMMON VARIATION, CHROMOSOME 8Q24, COLON-CANCER, MIXED-MODEL, EFFICIENT, SCAN, IMPUTATION, VARIANTS, DISEASE, Cancers

وصف الملف: application/pdf

Relation: Grant sponsor: Academy of Finland (Finnish Center of Excellence Program 2012-2017); Grant number: 1250345; Grant sponsor: Cancer Society of Finland; Grant sponsor: Sigrid Juselius Foundation; Grant sponsor: Jane and Aatos Erkko Foundation; Grant sponsor: SYSCOL; Grant number: 258236; Grant sponsor: Nordic Information for Action eScience Center (NIASC); Grant sponsor: Nordic Center of Excellence financed by NordForsk; Grant number: 62721; Grant sponsor: NordForsk Colorectal Cancer Pilot Project; Grant number: 07 BM 11/424; Grant sponsor: Cancer Research UK (for Edinburgh Colon Cancer Genetics Group (CCGG)); Grant number: C348/A18927; Grant sponsor: UK Medical Research Council for Edinburgh CCGG; Grant number: MR/K018647/1; Grant sponsor: Estonian RC; Grant numbers: IUT20-60, PUT736; Grant sponsor: European Regional Development Fund; Grant number: 2014-2020.4.01.15-0012; Grant sponsor: Academy of Finland; Grant number: 287665; Grant sponsor: National Cancer Institute, USA; Grant number: UM1 CA167551; Grant sponsor: Australasian Colorectal Cancer Family Registry; Grant numbers: U01 CA074778, U01/U24 CA097735; Grant sponsor: Mayo Clinic Cooperative Family Registry for Colon Cancer Studies; Grant number: U01/U24 CA074800; Grant sponsor: Ontario Familial Colorectal Cancer Registry; Grant number: U01/U24 CA074783; Grant sponsor: Seattle Colorectal Cancer Family Registry; Grant number: U01/U24 CA074794; Grant sponsor: University of Hawaii Colorectal Cancer Family Registry; Grant number: U01/U24 CA074806; Grant sponsor: USC Consortium Colorectal Cancer Family Registry; Grant number: U01/U24 CA074799; Grant sponsor: The CCFR GWASs from National Cancer Institute, USA; Grant numbers: U01 CA122839, R01 CA143237, U19 CA148107; Tanskanen , T , van den Berg , L , Valimaki , N , Aavikko , M , Ness-Jensen , E , Hveem , K , Wettergren , Y , Lindskog , E B , Tonisson , N , Metspalu , A , Silander , K , Orlando , G , Law , P J , Tuupanen , S , Gylfe , A E , Hanninen , U A , Cajuso , T , Kondelin , J , Sarin , A-P , Pukkala , E , Jousilahti , P , Salomaa , V , Ripatti , S , Palotie , A , Jarvinen , H , Renkonen-Sinisalo , L , Lepisto , A , Bohm , J , Mecklin , J-P , Al-Tassan , N A , Palles , C , Martin , L , Barclay , E , Tenesa , A , Farrington , S M , Timofeeva , M N , Meyer , B F , Wakil , S M , Campbell , H , Smith , C G , Idziaszczyk , S , Maughan , T S , Kaplan , R , Kerr , R , Kerr , D , Buchanan , D D , Win , A K , Hopper , J , Jenkins , M A , Newcomb , P A , Gallinger , S , Conti , D , Schumacher , F R , Casey , G , Cheadle , J P , Dunlop , M G , Tomlinson , I P , Houlston , R S , Palin , K & Aaltonen , L A 2018 , ' Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci ' , International Journal of Cancer , vol. 142 , no. 3 , pp. 540-546 . https://doi.org/10.1002/ijc.31076; ORCID: /0000-0002-5866-4059/work/40070217; ORCID: /0000-0002-2527-5874/work/97266252; ORCID: /0000-0001-6839-4286/work/101502579; http://hdl.handle.net/10138/327670; c40495c2-8a43-4424-b072-68e69f599a0a; 85031408086; 000417763600013

الاتاحة: http://hdl.handle.net/10138/327670

المؤلفون: Hanninen, Ulrika A., Wirta, Erkki-Ville, Katainen, Riku, Tanskanen, Tomas, Hamberg, Jiri, Taipale, Minna, Böhm, Jan, Renkonen-Sinisalo, Laura, Lepistö, Anna, Forsström, Linda M., Pitkänen, Esa, Palin, Kimmo, Seppälä, Toni T., Mäkinen, Netta, Mecklin, Jukka-Pekka, Aaltonen, Lauri A.

المساهمون: University of Helsinki, Research Programs Unit, Department of Medical and Clinical Genetics, Medicum, ATG - Applied Tumor Genomics, Lauri Antti Aaltonen / Principal Investigator, Department of Surgery, II kirurgian klinikka, Clinicum, HUS Abdominal Center

مصطلحات موضوعية: MICROSATELLITE INSTABILITY, MUTATIONAL PROCESSES, COLON, IMMUNOSCORE, PROGNOSIS, METHYLATION, SIGNATURES, CARCINOMA, FEATURES, KRAS, Cancers

وصف الملف: application/pdf

Relation: We thank Alison Ollikainen, Iina Vuoristo, Inga-Lill Aberg, Heikki Metsola, Sini Marttinen, Marjo Rajalaakso, Sirpa Soisalo, Asal Fotouhi, Lijuan Hu, Maarit Ahtiainen, Tommi Liipo, Kirsi Pylvanainen, and Marjukka Friman for excellent technical assistance. We acknowledge the computational resources provided by the ELIXIR node, hosted at the CSC-IT Center for Science, Finland. This study was supported by the Academy of Finland (Centre of Excellence in Cancer Genetics Research 2012-2017 (250345), Centre of Excellence in Tumor Genetics Research 2018-2023 (312041)), The Finnish Cancer Society, The Sigrid Juselius Foundation, and The Jane and Aatos Erkko Foundation. Personal grants for N. M. to support this work were received from the Academy of Finland (295693), for R. K. from The Ida Montin Foundation and The Juhani Aho Foundation for Medical Research, and for U. A. H. from The Biomedicum Helsinki Foundation, The Finnish Medical Society "Duodecim", The Paivikki and Sakari Sohlberg Foundation, The Ida Montin Foundation, The Einar and Karin Stroem Foundation, The Emil Aaltonen Foundation, The Oskar Oflund Foundation, The Finnish-Norwegian Medical Foundation, The Gastroenterological Research Foundation, The Maud Kuistila Memorial Foundation, The Finnish Cancer Society, The K. Albin Johansson Foundation, The Orion-Pharmos Research Foundation, and The Juhani Aho Foundation for Medical Research.; Hanninen , U A , Wirta , E-V , Katainen , R , Tanskanen , T , Hamberg , J , Taipale , M , Böhm , J , Renkonen-Sinisalo , L , Lepistö , A , Forsström , L M , Pitkänen , E , Palin , K , Seppälä , T T , Mäkinen , N , Mecklin , J-P & Aaltonen , L A 2019 , ' Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers ' , British Journal of Cancer , vol. 120 , no. 9 , pp. 922-930 . https://doi.org/10.1038/s41416-019-0427-4; ORCID: /0000-0002-5866-4059/work/57799606; ORCID: /0000-0003-0104-7794/work/57799881; ORCID: /0000-0002-4940-3498/work/57801658; ORCID: /0000-0001-6839-4286/work/101502749; http://hdl.handle.net/10138/315589; 40b1fa73-c2a8-440b-9f27-96cc22502e7c; 000466391900006

الاتاحة: http://hdl.handle.net/10138/315589

المؤلفون: Law, Philip J., Timofeeva, Maria, Fernandez-Rozadilla, Ceres, Timofeeva, Aria, Broderick, Peter, Studd, James, Fernandez-Tajes, Juan, Farrington, Susan, Svinti, Victoria, Palles, Claire, Orlando, Giulia, Sud, Amit, Holroyd, Amy, Penegar, Steven, Theodoratou, Evropi, Vaughan-Shaw, Peter, Campbell, Harry, Zgaga, Lina, Hayward, Caroline, Campbell, Archie, Harris, Sarah, Deary, Ian J., Starr, Ohn, Gatcombe, Laura, Pinna, Maria, Briggs, Sarah, Martin, Lynn, Jaeger, Emma, Sharma-Oates, Archana, East, James, Leedham, Simon, Arnold, Roland, Johnstone, Elaine, Wang, Haitao, Kerr, David, Kerr, Rachel, Maughan, Tim, Kaplan, Richard, Al-Tassan, Nada, Palin, Kimmo, Hanninen, Ulrika A., Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Eriksson, Johan G., Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Renkonen-Sinisalo, Laura, Lepisto, Anna, Bohm, Jan, Mecklin, Jukka-Pekka, Buchanan, Daniel D., Win, Aung-Ko, Hopper, John, Jenkins, Mark E., Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steven, Duggan, David, Casey, Graham, Hoffmann, Per, Nothen, Markus M., Jockel, Karl-Heinz, Easton, Douglas F., Pharoah, Paul D. P., Peto, Julian, Canzian, Federico, Swerdlow, Anthony, Eeles, Rosalind A., Kote-Jarai, Zsofia, Muir, Kenneth, Pashayan, Nora, Harkin, Andrea, Allan, Karen, McQueen, John, Paul, James, Iveson, Timothy, Saunders, Mark, Butterbach, Katja, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Kirac, Iva, Matosevic, Petar, Hofer, Philipp, Brezina, Stefanie, Gsur, Andrea, Cheadle, Jeremy P., Aaltonen, Lauri A., Tomlinson, Ian, Houlston, Richard S., Dunlop, Malcolm G., Henderson, Brian E., Haiman, Christopher A., Schumacher, Fredrick R., Al Olama, Ali Amin, Benlloch, Sara, Berndt, Sonja, I, Conti, David, V, Wiklund, Fredrik, Chanock, Stephen, Gapstur, Susan, Stevens, Victoria L., Tangen, Catherine M., Batra, Jyotsna, Clements, Judith, Gronberg, Henrik, Schleutker, Johanna, Albanes, Demetrius, Wolk, Alicja, West, Catharine, Mucci, Lorelei, Cancel-Tassin, Geraldine, Koutros, Stella, Sorensen, Karina Dalsgaard, Grindeda, Eli Marie, Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Travis, Ruth C., Hamilton, Robert J., Ingles, Sue Ann, Rosenstein, Barry S., Lu, Yong-Jie, Giles, Graham G., Kibel, Adam S., Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L., Park, Jong Y., Stanford, Janet L., Cybulski, Cezary, Nordestgaard, Borge G., Maier, Christiane, Kim, Jeri, John, Esther M., Teixeira, Manuel R., Neuhausen, Susan L., De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F., Gamulin, Marija, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A., Gago-Dominguez, Manuela, Roobol, Monique J., Menegaux, Florence, Khaw, Kay-Tee, Cannon-Albright, Lisa, Pandha, Hardev, Thibodeau, Stephen N.

المصدر: Nature Communications. 10

وصف الملف: electronic

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-387286
https://doi.org/10.1038/s41467-019-09775-w
https://uu.diva-portal.org/smash/get/diva2:1329243/FULLTEXT01.pdf

المؤلفون: Cajuso, Tatiana, Sulo, Paivi, Tanskanen, Tomas, Katainen, Riku, Taira, Aurora, Hanninen, Ulrika A., Kondelin, Johanna, Forsstrom, Linda, Valimaki, Niko, Aavikko, Mervi, Kaasinen, Eevi, Ristimaki, Ari, Koskensalo, Selja, Lepisto, Anna, Renkonen-Sinisalo, Laura, Seppala, Toni, Kuopio, Teijo, Bohm, Jan, Mecklin, Jukka-Pekka, Kilpivaara, Outi, Pitkanen, Esa, Palin, Kimmo, Aaltonen, Lauri A.

المساهمون: Genome-Scale Biology (GSB) Research Program, Research Programs Unit, Department of Medical and Clinical Genetics, Medicum, Department of Pathology, HUSLAB, Helsinki University Hospital Area, HUS Abdominal Center, Department of Surgery, Clinicum, II kirurgian klinikka, Lauri Antti Aaltonen / Principal Investigator, Machine learning in biomedicine

مصطلحات موضوعية: SOMATIC L1 RETROTRANSPOSITION, ISLAND METHYLATOR PHENOTYPE, WHOLE-GENOME, MICROSATELLITE INSTABILITY, SVA ELEMENTS, CPG, HYPOMETHYLATION, GENE, Cancers, Biomedicine

وصف الملف: application/pdf

Relation: The authors thank Alison Ollikainen, Iina Vuoristo, Inga-Lill Aberg, Sini Marttinen, Marjo Rajalaakso, Sirpa Soisalo, Jiri Hamberg, and Heikki Metsola for technical assistance and Alison Ollikainen also for proofreading the manuscript. This work was supported by grants from the Academy of Finland (Finnish Center of Excellence Program 2012-2017, 250345 and 2018-2025, 312041), The Finnish Cancer Society, The European Research Council (268648), The Sigrid Juselius Foundation; Jane and Aatos Erkko Foundation, the Nordic Information for Action eScience Center (NIASC) and Nordic Center of Excellence financed by NordForsk (Project number 62721). We also thank SYSCOL (an EU FP7 Collaborative Project, 258236) for sequencing the RNA samples. The following foundations are acknowledged for personal funding: Ida Montinin Saatio foundation, Cancer Society of Finland, Juhani Ahon Foundation for Medical Research and The Maud Kuistila Memorial Foundation. The authors wish to acknowledge CSC-IT Center for Science, Finland, for computational resources.; Cajuso , T , Sulo , P , Tanskanen , T , Katainen , R , Taira , A , Hanninen , U A , Kondelin , J , Forsstrom , L , Valimaki , N , Aavikko , M , Kaasinen , E , Ristimaki , A , Koskensalo , S , Lepisto , A , Renkonen-Sinisalo , L , Seppala , T , Kuopio , T , Bohm , J , Mecklin , J-P , Kilpivaara , O , Pitkanen , E , Palin , K & Aaltonen , L A 2019 , ' Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival ' , Nature Communications , vol. 10 , 4022 . https://doi.org/10.1038/s41467-019-11770-0; ORCID: /0000-0002-5866-4059/work/62632075; ORCID: /0000-0002-4940-3498/work/62633365; ORCID: /0000-0002-1333-8049/work/91815961; ORCID: /0000-0001-6839-4286/work/101502618; ORCID: /0000-0002-1179-8500/work/156152272; ORCID: /0000-0001-8467-2100/work/156157837; http://hdl.handle.net/10138/305752; 6eabac58-950c-4e4d-8cec-44fe540a8e99; 000484596900002

الاتاحة: http://hdl.handle.net/10138/305752

المؤلفون: Orlando, Giulia, Law, Philip J., Palin, Kimmo, Tuupanen, Sari, Gylfe, Alexandra, Hanninen, Ulrika A., Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Kaprio, Jaakko, Eriksson, Johan G., Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Järvinen, Heikki, Renkonen-Sinisalo, Laura, Lepisto, Anna, Bohm, Jan, Mecklin, Jukka-Pekka, Al-Tassan, Nada A., Palles, Claire, Martin, Lynn, Barclay, Ella, Tenesa, Albert, Farrington, Susan, Timofeeva, Maria N., Meyer, Brian F., Wakil, Salma M., Campbell, Harry, Smith, Christopher G., Idziaszczyk, Shelley, Maughan, Timothy S., Kaplan, Richard, Kerr, Rachel, Kerr, David, Buchanan, Daniel D., Win, Aung Ko, Hopper, John, Jenkins, Mark, Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steve, Conti, David, Schumacher, Fred, Casey, Graham, Taipale, Jussi, Cheadle, Jeremy P., Dunlop, Malcolm G., Tomlinson, Ian P., Aaltonen, Lauri A., Houlston, Richard S.

المساهمون: Research Programs Unit, Lauri Antti Aaltonen / Principal Investigator, Genome-Scale Biology (GSB) Research Program, Medicum, Department of Medical and Clinical Genetics, Institute for Molecular Medicine Finland, Clinicum, Johan Eriksson / Principal Investigator, Department of General Practice and Primary Health Care, Samuli Olli Ripatti / Principal Investigator, Aarno Palotie / Principal Investigator, Heikki Järvinen / Principal Investigator, Department of Surgery, II kirurgian klinikka, Jussi Taipale / Principal Investigator, Biostatistics Helsinki, Complex Disease Genetics, Genomics of Neurological and Neuropsychiatric Disorders, Genetic Epidemiology

مصطلحات موضوعية: GENOME-WIDE ASSOCIATION, SUSCEPTIBILITY LOCI, INTESTINAL INFLAMMATION, FUNCTIONAL VARIATION, CROHNS-DISEASE, COHORT PROFILE, BIRTH COHORT, METAANALYSIS, IMPUTATION, VARIANTS, Biomedicine, General medicine, internal medicine and other clinical medicine, Cancers, Surgery, anesthesiology, intensive care, radiology

وصف الملف: application/pdf

Relation: In Finland, this work was supported by grants from the Academy of Finland [Finnish Center of Excellence Program 2012-2017, 250345], the Jane and Aatos Erkko Foundation, the Finnish Cancer Society [personal grant to K.P.], the European Research Council [ERC; 268648], the Sigrid Juselius Foundation, SYSCOL, the Nordic Information for Action eScience Center (NIASC), the Nordic Center of Excellence financed by NordForsk [project 62721, personal grant to K.P.] and State Research Funding of Kuopio University Hospital [B1401]. We acknowledge the computational resources provided by the ELIXIR node, hosted at the CSC-IT Center for Science, Finland, and funded by the Academy of Finland [grants 271642 and 263164], the Ministry of Education and Culture, Finland. V.S. was supported by the Finnish Academy [grant number 139635]. Sample collection and genotyping in the Finnish Twin Cohort has been supported by the Wellcome Trust Sanger Institute, ENGAGE-European Network for Genetic and Genomic Epidemiology, FP7-HEALTH-F4-2007 [grant agreement number 201413], the National Institute of Alcohol Abuse and Alcoholism [grants AA-12502 and AA-00145 to Richard J. Rose and K02AA018755 to Danielle M. Dick] and the Academy of Finland [grants 100499, 205585, 265240 and 263278 to J.K.].; Orlando , G , Law , P J , Palin , K , Tuupanen , S , Gylfe , A , Hanninen , U A , Cajuso , T , Tanskanen , T , Kondelin , J , Kaasinen , E , Sarin , A-P , Kaprio , J , Eriksson , J G , Rissanen , H , Knekt , P , Pukkala , E , Jousilahti , P , Salomaa , V , Ripatti , S , Palotie , A , Järvinen , H , Renkonen-Sinisalo , L , Lepisto , A , Bohm , J , Mecklin , J-P , Al-Tassan , N A , Palles , C , Martin , L , Barclay , E , Tenesa , A , Farrington , S , Timofeeva , M N , Meyer , B F , Wakil , S M , Campbell , H , Smith , C G , Idziaszczyk , S , Maughan , T S , Kaplan , R , Kerr , R , Kerr , D , Buchanan , D D , Win , A K , Hopper , J , Jenkins , M , Lindor , N M , Newcomb , P A , Gallinger , S , Conti , D , Schumacher , F , Casey , G , Taipale , J , Cheadle , J P , Dunlop , M G , Tomlinson , I P , Aaltonen , L A & Houlston , R S 2016 , ' Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease ' , Human Molecular Genetics , vol. 25 , no. 11 , pp. 2349-2359 . https://doi.org/10.1093/hmg/ddw087; ORCID: /0000-0002-5866-4059/work/37545783; ORCID: /0000-0002-1333-8049/work/91815976; ORCID: /0000-0002-2527-5874/work/97266520; ORCID: /0000-0001-6839-4286/work/101502742; ORCID: /0000-0002-3716-2455/work/29958433; http://hdl.handle.net/10138/172641; 68bbf3ad-f1fb-4533-b01f-96c6922e043d; 84998636380; 000388554700019

الاتاحة: http://hdl.handle.net/10138/172641

المؤلفون: Jarvis, David, Mitchell, Jonathan S., Law, Philip J., Palin, Kimmo, Tuupanen, Sari, Gylfe, Alexandra, Hanninen, Ulrika A., Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Kaprio, Jaakko, Eriksson, Johan G., Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Järvinen, Heikki, Renkonen-Sinisalo, Laura, Lepistö, Anna, Bohm, Jan, Mecklin, Jukka-Pekka, Al-Tassan, Nada A., Palles, Claire, Martin, Lynn, Barclay, Ella, Farrington, Susan M., Timofeeva, Maria N., Meyer, Brian F., Wakil, Salma M., Campbell, Harry, Smith, Christopher G., Idziaszczyk, Shelley, Maughan, Timothy S., Kaplan, Richard, Kerr, Rachel, Kerr, David, Buchanan, Daniel D., Win, Aung K., Hopper, John L., Jenkins, Mark A., Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steve, Conti, David, Schumacher, Fred, Casey, Graham, Taipale, Jussi, Aaltonen, Lauri A., Cheadle, Jeremy P., Dunlop, Malcolm G., Tomlinson, Ian P., Houlston, Richard S.

المساهمون: Research Programs Unit, Lauri Antti Aaltonen / Principal Investigator, Genome-Scale Biology (GSB) Research Program, Medicum, Department of Medical and Clinical Genetics, Institute for Molecular Medicine Finland, Clinicum, Johan Eriksson / Principal Investigator, Department of General Practice and Primary Health Care, Samuli Olli Ripatti / Principal Investigator, Aarno Palotie / Principal Investigator, Heikki Järvinen / Principal Investigator, Department of Surgery, II kirurgian klinikka, Jussi Taipale / Principal Investigator, Biostatistics Helsinki, Complex Disease Genetics, Genomics of Neurological and Neuropsychiatric Disorders, Genetic Epidemiology

مصطلحات موضوعية: Mendelian randomisation, adiposity, colorectal cancer, BODY-MASS INDEX, OBESITY, METAANALYSIS, EPIDEMIOLOGY, INSTRUMENTS, WEIGHT, COMMON, Cancers, General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

Relation: We are grateful to all individuals who participated in the various studies. This study made use of genotyping data from the 1958 Birth Cohort, kindly made available by the Wellcome Trust Case Control Consortium 2. A full list of the investigators who contributed to the generation of the data is available at http://www.wtccc.org.uk/. At the Institute of Cancer Research, this work was supported by Cancer Research UK (C1298/A8362-Bobby Moore Fund for Cancer Research UK). Additional support was provided by the National Cancer Research Network. DJ was supported by a summer student grant from the BBRSC. In Edinburgh, the work was supported by Programme Grant funding from Cancer Research UK (C348/A12076). In Oxford, additional funding was provided by the Oxford Comprehensive Biomedical Research Centre and the EU FP7 CHIBCHA grant. Core infrastructure support to the Wellcome Trust Centre for Human Genetics, Oxford was provided by grant (090532/Z/09/Z). We are grateful to many colleagues within UK Clinical Genetics Departments (for CORGI) and to many collaborators who participated in the VICTOR and QUASAR2 trials. We also thank colleagues from the UK National Cancer Research Network (for NSCCG). Support from the European Union (FP7/207-2013, grant 258236) and FP7 collaborative project SYSCOL and COST Action in the UK is also acknowledged (BM1206). The COIN and COIN-B trials were funded by Cancer Research UK and the Medical Research Council and were conducted with the support of the National Institute of Health Research Cancer Research Network. COIN and COIN-B translational studies were supported by the Bobby Moore Fund from Cancer Research UK, Tenovus, the Kidani Trust, Cancer Research Wales and the National Institute for Social Care and Health Research Cancer Genetics Biomedical Research Unit (2011-2014). NAA, RPM and SMW were funded and supported by KFSHRC. In Finland, this work was supported by grants from the Academy of Finland (Finnish Center of Excellence Program 2012-2017, 250345), the Jane and Aatos Erkko Foundation, the Finnish Cancer Society (to KP), the European Research Council (ERC; 268648), the Sigrid Juselius Foundation, SYSCOL, the Nordic Information for Action eScience Center (NIASC), the Nordic Center of Excellence financed by NordForsk (project 62721, to KP) and State Research Funding of Kuopio University Hospital (B1401). We acknowledge the computational resources provided by the ELIXIR node, hosted at the CSC-IT Center for Science, Finland, and funded by the Academy of Finland (grants 271642 and 263164), the Ministry of Education and Culture, Finland. VS was supported by the Finnish Academy (grant number 139635). Sample collection and genotyping in the Finnish Twin Cohort has been supported by the Wellcome Trust Sanger Institute, ENGAGE-European Network for Genetic and Genomic Epidemiology, FP7-HEALTH-F4-2007 (201413), the National Institute of Alcohol Abuse and Alcoholism (grants AA-12502 and AA-00145 to Richard J Rose, and K02AA018755 to Danielle M Dick) and the Academy of Finland (100499, 205585, 265240 and 263278 to Jaakko Ka.prio (JK)).; Jarvis , D , Mitchell , J S , Law , P J , Palin , K , Tuupanen , S , Gylfe , A , Hanninen , U A , Cajuso , T , Tanskanen , T , Kondelin , J , Kaasinen , E , Sarin , A-P , Kaprio , J , Eriksson , J G , Rissanen , H , Knekt , P , Pukkala , E , Jousilahti , P , Salomaa , V , Ripatti , S , Palotie , A , Järvinen , H , Renkonen-Sinisalo , L , Lepistö , A , Bohm , J , Mecklin , J-P , Al-Tassan , N A , Palles , C , Martin , L , Barclay , E , Farrington , S M , Timofeeva , M N , Meyer , B F , Wakil , S M , Campbell , H , Smith , C G , Idziaszczyk , S , Maughan , T S , Kaplan , R , Kerr , R , Kerr , D , Buchanan , D D , Win , A K , Hopper , J L , Jenkins , M A , Lindor , N M , Newcomb , P A , Gallinger , S , Conti , D , Schumacher , F , Casey , G , Taipale , J , Aaltonen , L A , Cheadle , J P , Dunlop , M G , Tomlinson , I P & Houlston , R S 2016 , ' Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer ' , British Journal of Cancer , vol. 115 , no. 2 , pp. 266-272 . https://doi.org/10.1038/bjc.2016.188; ORCID: /0000-0002-5866-4059/work/37545787; ORCID: /0000-0002-1333-8049/work/91815964; ORCID: /0000-0002-2527-5874/work/97266381; ORCID: /0000-0001-6839-4286/work/101502649; ORCID: /0000-0002-3716-2455/work/29958428; http://hdl.handle.net/10138/167038; 19dede0f-73e9-410c-a548-2c1c74a37041; 84976273894; 000380380300016

الاتاحة: http://hdl.handle.net/10138/167038

المؤلفون: Chen, Zhishan, Guo, Xingyi, Tao, Ran, Huyghe, Jeroen R., Law, Philip J., Fernandez-Rozadilla, Ceres, Ping, Jie, Jia, Guochong, Long, Jirong, Li, Chao, Shen, Quanhu, Xie, Yuhan, Timofeeva, Maria N., Thomas, Minta, Schmit, Stephanie L., Diez-Obrero, Virginia, Devall, Matthew, Moratalla-Navarro, Ferran, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah E. W., Svinti, Victoria, Donnelly, Kevin, Farrington, Susan M., Blackmur, James, Vaughan-Shaw, Peter G., Shu, Xiao-Ou, Lu, Yingchang, Broderick, Peter, Studd, James, Harrison, Tabitha A., Conti, David V., Schumacher, Fredrick R., Melas, Marilena, Rennert, Gad, Obon-Santacana, Mireia, Martin-Sanchez, Vicente, Oh, Jae Hwan, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John L., Jenkins, Mark A., Win, Aung Ko, Pai, Rish K., Figueiredo, Janec., Haile, Robert W., Gallinger, Steven, Woods, Michael O., Newcomb, Polly A., Duggan, David, Cheadle, Jeremy P., Kaplan, Richard, Kerr, Rachel, Kerr, David, Kirac, Iva, Bohm, Jan, Mecklin, Jukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri A., Rissanen, Harri, Pukkala, Eero, Eriksson, Johan G., Cajuso, Tatiana, Hanninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Mannisto, Satu, Albanes, Demetrius, Weinstein, Stephanie J., Ruiz-Narvaez, Edward, Palmer, Julie R., Buchanan, Daniel D., Platz, Elizabeth A., Visvanathan, Kala, Ulrich, Cornelia M., Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter T., Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha L., Potter, John D., Tsilidis, Kostas K., Schulze, Matthias B., Gunter, Marc J., Murphy, Neil, Castells, Antoni, Castellvi-Bel, Sergi, Moreira, Leticia, Arndt, Volker, Shcherbina, Anna, Bishop, D. Timothy, Giles, Graham G., Southey, Melissa C., Idos, Gregory E., McDonnell, Kevin J., Abu-Ful, Zomoroda, Greenson, Joel K., Shulman, Katerina, Lejbkowicz, Flavio, Offit, Kenneth, Su, Yu-Ru, Steinfelder, Robert, Keku, Temitope O., van Guelpen, Bethany, Hudson, Thomas J., Hampel, Heather, Pearlman, Rachel, Berndt, Sonja I., Hayes, Richard B., Martinez, Marie Elena, Thomas, Sushma S., Pharoah, Paul D. P., Larsson, Susanna C., Yen, Yun, Lenz, Heinz-Josef, White, Emily, Li, Li, Doheny, Kimberly F., Pugh, Elizabeth, Shelford, Tameka, Chan, Andrew T., Cruz-Correa, Marcia, Lindblom, Annika, Hunter, David J., Joshi, Amit D., Schafmayer, Clemens, Scacheri, Peter C., Kundaje, Anshul, Schoen, Robert E., Hampe, Jochen, Stadler, Zsofia K., Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Edlund, Christopher K., Gauderman, W. James, Shibata, David, Toland, Amanda, Markowitz, Sanford, Kim, Andre, Chanock, Stephen J., van Duijnhoven, Franzel, Feskens, Edith J. M., Sakoda, Lori C., Gago-Dominguez, Manuela, Wolk, Alicja, Pardini, Barbara, Gerald, Liesel M. Fitz, Lee, Soo Chin, Ogino, Shuji, Bien, Stephanie A., Kooperberg, Charles, Li, Christopher I., Lin, Yi, Prentice, Ross, Qu, Conghui, Bezieau, Stephane, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Le Marchand, Loic, Wu, Annah., Qu, Chenxu, McNeil, Caroline E., Coetzee, Gerhard, Hayward, Caroline, Deary, Ian J., Harris, Sarah E., Theodoratou, Evropi, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Lau, Ken S., Zhao, Hongyu, Hsu, Li, Cai, Qiuyin, Dunlop, Malcolm G., Gruber, Stephen B., Houlston, Richard S., Moreno, Victor, Casey, Graham, Peters, Ulrike, Tomlinson, Ian, Zheng, Wei

المصدر: WOS ; WOS:001253611400001

Relation: NATURE COMMUNICATIONS; 15; https://www.julkari.fi/handle/10024/149501; ARTN 3557

الاتاحة: https://www.julkari.fi/handle/10024/149501

المؤلفون: Fernandez-Rozadilla, Ceres, Timofeeva, Maria, Chen, Zhishan, Law, Philip, Thomas, Minta, Bien, Stephanie, Diez-Obrero, Virginia, Li, Li, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Harris, Sarah, Svinti, Victoria, McDonnell, Kevin, Farrington, Susan, Studd, James, Vaughan-Shaw, Peter, Shu, Xiao-ou, Long, Jirong, Cai, Qiuyin, Guo, Xingyi, Lu, Yingchang, Scacheri, Peter, Huyghe, Jeroen, Harrison, Tabitha, Shibata, David, Haiman, Christopher, Devall, Mathew, Schumacher, Fredrick, Melas, Marilena, Rennert, Gad, Obon-Santacana, Mireia, Martin-Sanchez, Vicente, Moratalla-Navarro, Ferran, Oh, Jae Hwan, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Potter, John, Jenkins, Mark, Win, Aung Ko, Pai, Rish, Figueiredo, Jane, Haile, Robert, Gallinger, Steven, Woods, Michael, Newcomb, Polly, Cheadle, Jeremy, Kaplan, Richard, Maughan, Timothy, Kerr, Rachel, Kerr, David, Kirac, Iva, Boehm, Jan, Mecklin, Lukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri, Rissanen, Harri, Pukkala, Eero, Eriksson, Johan, Cajuso, Tatiana, Hanninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Zanke, Brent, Mannisto, Satu, Albanes, Demetrius, Weinstein, Stephanie, Ruiz-Narvaez, Edward, Palmer, Julie, Buchanan, Daniel, Platz, Elizabeth, Visvanathan, Kala, Ulrich, Cornelia, Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha, Tsilidis, Konstantinos, Schulze, Matthias, Gunter, Marc, Murphy, Neil, Castells, Antoni, Castellvi-Bel, Sergi, Moreira, Leticia, Arndt, Volker, Shcherbina, Anna, Stern, Mariana, Pardamean, Bens, Bishop, Timothy, Giles, Graham, Southey, Melissa, Idos, Gregory, Abu-Ful, Zomoroda, Greenson, Joel, Shulman, Katerina, Lejbkowicz, Flavio, Offit, Kenneth, Su, Yu-Ru, Steinfelder, Robert, Keku, Temitope, van Guelpen, Bethany, Hudson, Thomas, Hampel, Heather, Pearlman, Rachel, Berndt, Sonja, Hayes, Richard, Martinez, Marie Elena, Thomas, Sushma, Corley, Douglas, Pharoah, Paul, Larsson, Susanna, Yen, Yun, Lenz, Heinz-Josef, White, Emily, Doheny, Kimberly, Pugh, Elizabeth, Shelford, Tameka, Chan, Andrew, Cruz-Correa, Marcia, Lindblom, Annika, Joshi, Amit, Schafmayer, Clemens, Kundaje, Anshul, Nickerson, Deborah, Schoen, Robert, Hampe, Jochen, Stadler, Zsofia, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Papadopoulos, Nickolas, Edlund, Chistopher, Gauderman, William, Thomas, Duncan, Toland, Amanda, Markowitz, Sanford, Kim, Andre, Gruber, Stephen, van Duijnhoven, Franzel, Feskens, Edith, Sakoda, Lori, Gago-Dominguez, Manuela, Wolk, Alicja, Naccarati, Alessio, Pardini, Barbara, FitzGerald, Liesel, Lee, Soo Chin, Ogino, Shuji, Kooperberg, Charles, Li, Christopher, Lin, Yi, Prentice, Ross, Qu, Conghui, Bezieau, Stephane, Tangen, Catherine, Mardis, Elaine, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Le Marchand, Loic, Wu, Anna, Qu, Chenxu, McNeil, Caroline, Coetzee, Gerhard, Hayward, Caroline, Deary, Ian, Theodoratou, Evropi, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Moreno, Victor, Casey, Graham, Tomlinson, Ian, Zheng, Wei, Dunlop, Malcolm, Houlston, Richard, Peters, Ulrike

المصدر: WOS ; WOS:001001563800001

وصف الملف: 89-99

Relation: NATURE GENETICS; 55; https://www.julkari.fi/handle/10024/147139

الاتاحة: https://www.julkari.fi/handle/10024/147139

المؤلفون: University of Helsinki, Research Programs Unit, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Clinicum, University of Helsinki, Heikki Järvinen / Principal Investigator, University of Helsinki, II kirurgian klinikka, University of Helsinki, Medicum, Orlando, Giulia, Law, Philip J., Palin, Kimmo, Tuupanen, Sari, Gylfe, Alexandra, Hanninen, Ulrika A., Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Kaprio, Jaakko, Eriksson, Johan G., Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Järvinen, Heikki, Renkonen-Sinisalo, Laura, Lepisto, Anna, Bohm, Jan, Mecklin, Jukka-Pekka, Al-Tassan, Nada A., Palles, Claire, Martin, Lynn, Barclay, Ella, Tenesa, Albert, Farrington, Susan, Timofeeva, Maria N., Meyer, Brian F., Wakil, Salma M., Campbell, Harry, Smith, Christopher G., Idziaszczyk, Shelley, Maughan, Timothy S., Kaplan, Richard, Kerr, Rachel, Kerr, David, Buchanan, Daniel D., Win, Aung Ko, Hopper, John, Jenkins, Mark, Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steve, Conti, David, Schumacher, Fred, Casey, Graham, Taipale, Jussi, Cheadle, Jeremy P., Dunlop, Malcolm G., Tomlinson, Ian P., Aaltonen, Lauri A., Houlston, Richard S.

المصدر: Orlando , G , Law , P J , Palin , K , Tuupanen , S , Gylfe , A , Hanninen , U A , Cajuso , T , Tanskanen , T , Kondelin , J , Kaasinen , E , Sarin , A-P , Kaprio , J , Eriksson , J G , Rissanen , H , Knekt , P , Pukkala , E , Jousilahti , P , Salomaa , V , Ripatti , S , Palotie , A , Järvinen , H , Renkonen-Sinisalo , L , Lepisto , A , Bohm , J , Mecklin , J-P , Al-Tassan , N A , Palles , C , Martin , L , Barclay , E , Tenesa , A , Farrington , S , Timofeeva , M N , Meyer , B F , Wakil , S M , Campbell , H , Smith , C G , Idziaszczyk , S , Maughan , T S , Kaplan , R , Kerr , R , Kerr , D , Buchanan , D D , Win , A K , Hopper , J , Jenkins , M , Lindor , N M , Newcomb , P A , Gallinger , S , Conti , D , Schumacher , F , Casey , G , Taipale , J , Cheadle , J P , Dunlop , M G , Tomlinson , I P , Aaltonen , L A & Houlston , R S 2016 , ' Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease ' Human Molecular Genetics , vol 25 , no. 11 , pp. 2349-2359 . DOI: 10.1093/hmg/ddw087

مصطلحات الفهرس: GENOME-WIDE ASSOCIATION, SUSCEPTIBILITY LOCI, INTESTINAL INFLAMMATION, FUNCTIONAL VARIATION, CROHNS-DISEASE, COHORT PROFILE, BIRTH COHORT, METAANALYSIS, IMPUTATION, VARIANTS, 3111 Biomedicine, 3121 Internal medicine, 3122 Cancers, 3126 Surgery, anesthesiology, intensive care, radiology, A1 Refereed journal article, info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion

URL: http://hdl.handle.net/10138/172641
Human Molecular Genetics

المؤلفون: Tanskanen, Tomas, van den Berg, Linda, Valimaki, Niko, Aavikko, Mervi, Ness-Jensen, Eivind, Hveem, Kristian, Wettergren, Yvonne, Lindskog, Elinor Bexe, Tonisson, Neeme, Metspalu, Andres, Silander, Kaisa, Orlando, Giulia, Law, Philip J., Tuupanen, Sari, Gylfe, Alexandra E., Hanninen, Ulrika A., Cajuso, Tatiana, Kondelin, Johanna, Sarin, Antti-Pekka, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Jarvinen, Heikki, Renkonen-Sinisalo, Laura, Lepisto, Anna, Bohm, Jan, Mecklin, Jukka-Pekka, Al-Tassan, Nada A., Palles, Claire, Martin, Lynn, Barclay, Ella, Tenesa, Albert, Farrington, Susan M., Timofeeva, Maria N., Meyer, Brian F., Wakil, Salma M., Campbell, Harry, Smith, Christopher G., Idziaszczyk, Shelley, Maughan, Tim S., Kaplan, Richard, Kerr, Rachel, Kerr, David, Buchanan, Daniel D., Win, Aung K., Hopper, John, Jenkins, Mark A., Newcomb, Polly A., Gallinger, Steve, Conti, David, Schumacher, Fredrick R., Casey, Graham, Cheadle, Jeremy P., Dunlop, Malcolm G., Tomlinson, Ian P., Houlston, Richard S., Palin, Kimmo, Aaltonen, Lauri A.

المصدر: WOS

مصطلحات موضوعية: colorectal cancer, genetic predisposition to disease, genome-wide association study, single-nucleotide polymorphism

وصف الملف: 540-546

Relation: INTERNATIONAL JOURNAL OF CANCER; 142; FP6VC; http://www.julkari.fi/handle/10024/135769; WOS:000417763600013; BRIF1640

الاتاحة: http://www.julkari.fi/handle/10024/135769

المؤلفون: May-Wilson, Sebastian, Sud, Amit, Law, Philip J., Palin, Kimmo, Tuupanen, Sari, Gylfe, Alexandra, Hanninen, Ulrika A., Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Eriksson, Johan G., Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Renkonen-Sinisalo, Laura, Lepisto, Anna, Bohm, Jan, Mecklin, Jukka-Pekka, Al-Tassan, Nada A., Palles, Claire, Farrington, Susan M., Timofeeva, Maria N., Meyer, Brian F., Wakil, Salma M., Campbell, Harry, Smith, Christopher G., Idziaszczyk, Shelley, Maughan, Timothy S., Fisher, David, Kerr, Rachel, Kerr, David, Passarelli, Michael N., Figueiredo, Jane C., Buchanan, Daniel D., Win, Aung K., Hopper, John L., Jenkins, Mark A., Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steven, Conti, David, Schumacher, Fred, Casey, Graham, Aaltonen, Lauri A., Cheadle, Jeremy P., Tomlinson, Ian P., Dunlop, Malcolm G., Houlston, Richard S.

المصدر: WOS

مصطلحات موضوعية: Mendelian randomisation, Colorectal cancer, Risk, Plasma fatty acids, Fatty acids

وصف الملف: 228-238

Relation: EUROPEAN JOURNAL OF CANCER; 84; FH7AO; http://www.julkari.fi/handle/10024/135322; WOS:000411333300026; BRIF8901; BRIF1640

الاتاحة: http://www.julkari.fi/handle/10024/135322

المؤلفون: Rodriguez-Broadbent, Henry, Law, Philip J., Sud, Amit, Palin, Kimmo, Tuupanen, Sari, Gylfe, Alexandra, Hanninen, Ulrika A., Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Ripatti, Samuli, Eriksson, Johan G., Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Palotie, Aarno, Renkonen-Sinisalo, Laura, Lepisto, Anna, Bohm, Jan, Mecklin, Jukka-Pekka, Al-Tassan, Nada A., Palles, Claire, Martin, Lynn, Barclay, Ella, Farrington, Susan M., Timofeeva, Maria N., Meyer, Brian F., Wakil, Salma M., Campbell, Harry, Smith, Christopher G., Idziaszczyk, Shelley, Maughan, Timothy S., Kaplan, Richard, Kerr, Rachel, Kerr, David, Passarelli, Michael N., Figueiredo, Jane C., Buchanan, Daniel D., Win, Aung K., Hopper, John L., Jenkins, Mark A., Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steven, Conti, David, Schumacher, Fred, Casey, Graham, Aaltonen, Lauri A., Cheadle, Jeremy P., Tomlinson, Ian P., Dunlop, Malcolm G., Houlston, Richard S.

المصدر: WOS

مصطلحات موضوعية: Mendelian randomisation, hyperlipidaemia, cholesterol, colorectal cancer, risk

وصف الملف: 2701-2708

Relation: INTERNATIONAL JOURNAL OF CANCER; 140; 12; ET3DY; http://www.julkari.fi/handle/10024/134642; WOS:000400158800009; BRIF8901; BRIF1640

الاتاحة: http://www.julkari.fi/handle/10024/134642