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1Academic Journal
المؤلفون: Cora H. Nijboer, Cobi J. Heijnen, Vincent Degos, Hanneke L.D.M. Willemen, Pierre Gressens, Annemieke Kavelaars
المصدر: Neurobiology of Disease, Vol 54, Iss , Pp 206-215 (2013)
مصطلحات موضوعية: Ischemic brain injury, Neuroprotection, Astrocytes, G protein-coupled receptor kinase 2 (GRK2), Excitotoxicity, Glutamate transporter GLAST, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
وصف الملف: electronic resource
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المؤلفون: Hanneke L.D.M. Willemen, Patrícia Silva Santos Ribeiro, Melissa Broeks, Nils Meijer, Sabine Versteeg, Jędrzej Małecki, Pål Ø. Falnes, Judith Jans, Niels Eijkelkamp
المصدر: bioRxiv
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3
المؤلفون: Michiel van der Vlist, Ramin Raoof, Hanneke L.D.M. Willemen, Judith Prado, Sabine Versteeg, Christian Martin Gil, Martijn Vos, Roeland E. Lokhorst, R. Jeroen Pasterkamp, Toshiyuki Kojima, Hajime Karasuyama, William Khoury-Hanold, Linde Meyaard, Niels Eijkelkamp
المساهمون: Molecular cell biology and Immunology, Hematology laboratory
المصدر: van der Vlist, M, Raoof, R, Willemen, H L D M, Prado, J, Versteeg, S, Martin Gil, C, Vos, M, Lokhorst, R E, Pasterkamp, R J, Kojima, T, Karasuyama, H, Khoury-Hanold, W, Meyaard, L & Eijkelkamp, N 2022, ' Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain ', Neuron, vol. 110, no. 4, pp. 613-626.e9 . https://doi.org/10.1016/j.neuron.2021.11.020
Neuron, 110(4), 613-626.e9. Cell Press
Neuronمصطلحات موضوعية: Sensory Receptor Cells, Pain, Inflammation, Sensory system, Oxidative phosphorylation, Mitochondrion, Inflammatory bowel disease, 03 medical and health sciences, Mice, 0302 clinical medicine, Ganglia, Spinal, medicine, Animals, Humans, Receptor, 030304 developmental biology, 0303 health sciences, business.industry, General Neuroscience, Macrophages, Chronic pain, medicine.disease, 3. Good health, Mitochondria, Rheumatoid arthritis, medicine.symptom, business, Neuroscience, 030217 neurology & neurosurgery
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المؤلفون: Kaylee Keller, Niels Eijkelkamp, Hanneke L.D.M. Willemen, Thomas Valerius, Marco J.H. Jansen, Mitchell Evers, Marjolein Stip, Jeanette H. W. Leusen, Chilam Chan, Stefan Nierkens, Friederike Meyer-Wentrup, Maaike Nederend, Kevin Budding
المصدر: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Journal for Immunotherapy of Cancerمصطلحات موضوعية: Male, Cancer Research, pediatrics, Neutrophils, medicine.medical_treatment, Immunology, Mice, Neuroblastoma, Immunology and Allergy, Medicine, Animals, Humans, pain, Monoclonal antibody therapy, RC254-282, Pharmacology, Clinical/Translational Cancer Immunotherapy, biology, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immunotherapy, medicine.disease, Isotype, Complement system, Antibodies, Anti-Idiotypic, GD2 Antibody, Oncology, Neuropathic pain, biology.protein, Molecular Medicine, Female, Antibody, business
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المؤلفون: Anders Moen, Jesper V. Olsen, Lisa Schroer, Ida A. Grønsberg, Niels Eijkelkamp, Albert Jeltsch, Takehiro Suzuki, Tadahiro Shimazu, Naoshi Dohmae, Erna Davydova, Mikiko Sodeoka, Valentina Siino, Mai Akakabe, Jędrzej Małecki, Pål Ø. Falnes, Michael A. McDonough, Takashi Umehara, Yoshihiro Sohtome, Magnus E. Jakobsson, Angela Ho, Rita Pinto, Masaki Kikuchi, Sara Weirich, Christopher J. Schofield, Yoichi Shinkai, Hanneke L.D.M. Willemen, Maren Kirstin Schuhmacher, Tongri Liu
المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Davydova, E, Shimazu, T, Schuhmacher, M K, Jakobsson, M E, Willemen, H L D M, Liu, T, Moen, A, Ho, A Y Y, Małecki, J, Schroer, L, Pinto, R, Suzuki, T, Grønsberg, I A, Sohtome, Y, Akakabe, M, Weirich, S, Kikuchi, M, Olsen, J V, Dohmae, N, Umehara, T, Sodeoka, M, Siino, V, McDonough, M A, Eijkelkamp, N, Schofield, C J, Jeltsch, A, Shinkai, Y & Falnes, P 2021, ' The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes ', Nature Communications, vol. 12, 891 . https://doi.org/10.1038/s41467-020-20670-7مصطلحات موضوعية: Proteomics, 0301 basic medicine, Methyltransferase, Proteome, Science, Protein subunit, Amino Acid Motifs, General Physics and Astronomy, Peptide, Methylation, Article, General Biochemistry, Genetics and Molecular Biology, Substrate Specificity, Mice, 03 medical and health sciences, 0302 clinical medicine, Transferases, Animals, Humans, Histidine, 1-Methylhistidine, Cells, Cultured, Mammals, Mice, Knockout, chemistry.chemical_classification, Multidisciplinary, Chemistry, Methyltransferases, General Chemistry, Methylhistidines, Mitochondria, Amino acid, Mice, Inbred C57BL, Zinc, 030104 developmental biology, Biochemistry, Mutation, Protein Processing, Post-Translational, 030217 neurology & neurosurgery
وصف الملف: application/pdf
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المؤلفون: Daniel Díaz-Rodríguez, Isabel Moreno-Indias, Hanneke L.D.M. Willemen, Marta Cruces-Sande, Federico Mayor, Manuel Fresno, Cobi J. Heijnen, Alba C. Arcones, Patricia Prieto, Rafael I. Jaén, Sara Francisco, Rocío Vila-Bedmar, Annemieke Kavelaars, Carolina Gutiérrez-Repiso, Cristina Murga, Lisardo Boscá
المساهمون: Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Instituto de Salud Carlos III, Universidad de Málaga, Novo Nordisk Foundation, Comunidad de Madrid, Fundación Ramón Areces, CSIC-UAM - Centro de Biología Molecular Severo Ochoa (CBM), European Commission
المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instnameمصطلحات موضوعية: medicine.medical_specialty, Myeloid, G-Protein-Coupled Receptor Kinase 2, Adipose Tissue, White, Adipose tissue, Inflammation, Diet, High-Fat, Weight Gain, Models, Biological, Cellular and Molecular Neuroscience, Insulin resistance, Immune system, Internal medicine, Glucose Intolerance, Adipocytes, medicine, Animals, Insulin, Glucose homeostasis, Myeloid Cells, Obesity, Molecular Biology, Pharmacology, biology, Chemistry, Hypertrophy, Cell Biology, medicine.disease, Gastrointestinal Microbiome, Fatty Liver, Mice, Inbred C57BL, Insulin receptor, Glucose, medicine.anatomical_structure, Endocrinology, Adipose Tissue, Liver, Cytoprotection, Culture Media, Conditioned, Macrophages, Peritoneal, biology.protein, Molecular Medicine, Insulin Resistance, medicine.symptom, Steatosis, Signal Transduction
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المؤلفون: Angela Ho, Boudewijn M.T. Burgering, Ingrid F. Kjønstad, Niels Eijkelkamp, Fried J. T. Zwartkruis, Pål Ø. Falnes, Jędrzej Małecki, Anders Moen, Rita Pinto, Hanneke L.D.M. Willemen
المصدر: Journal of Biological Chemistry. 294:1128-1141
مصطلحات موضوعية: 0301 basic medicine, Methyltransferase, Lysine, Oxidative phosphorylation, Bioenergetics, Mitochondrion, Methylation, Biochemistry, Cell Line, Mice, 03 medical and health sciences, Protein methylation, Animals, Humans, Molecular Biology, Gene, 030102 biochemistry & molecular biology, ATP synthase, biology, Chemistry, Computational Biology, Histone-Lysine N-Methyltransferase, Cell Biology, Mitochondrial Proton-Translocating ATPases, Mitochondria, Cell biology, 030104 developmental biology, biology.protein, HeLa Cells
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المؤلفون: Niels Eijkelkamp, Pål Ø. Falnes, Angela Ho, Rita Pinto, Hanneke L.D.M. Willemen, Jędrzej Małecki, Anders Moen
المصدر: J Biol Chem
مصطلحات موضوعية: 0301 basic medicine, Methyltransferase, Mitochondrion, Bioenergetics, Biochemistry, Methylation, Mass Spectrometry, Mitochondrial Proteins, 03 medical and health sciences, chemistry.chemical_compound, Cardiolipin, Protein methylation, Animals, Humans, Amino Acid Sequence, Protein Methyltransferases, Molecular Biology, Gene, Mitochondrial transport, Chromatography, High Pressure Liquid, 030102 biochemistry & molecular biology, Chemistry, Lysine, Cell Biology, Histone-Lysine N-Methyltransferase, ANT, Cell biology, Mitochondria, Rats, 030104 developmental biology, Liver, Peptides, Mitochondrial ADP, ATP Translocases, Sequence Alignment, HeLa Cells
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المؤلفون: Niels Eijkelkamp, Hanneke L.D.M. Willemen
مصطلحات موضوعية: medicine.anatomical_structure, business.industry, Neuropathic pain, medicine, AMPK, Sensory system, Signal transduction, business, Neuroscience, PI3K/AKT/mTOR pathway, Sensory neuron
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المؤلفون: Abdella M. Habib, Annemieke Kavelaars, Judith Prado, George Posthuma, Pål Ø. Falnes, Sabine Versteeg, Niels Eijkelkamp, Lara J.J. Nellissen, Rafael Gonzalez Cano, Cobi J. Heijnen, Wenjun Zhou, Magnus E. Jakobsson, Jeshua Tromp, Mirjam Maas, Hanneke L.D.M. Willemen, Jędrzej Małecki
المصدر: PLoS Biology, Vol 16, Iss 2, p e2003452 (2018)
PLoS Biology
PLoS Biology, 16(2). Public Library of Scienceمصطلحات موضوعية: Male, 0301 basic medicine, Methyltransferase, Physiology, Sensory Physiology, Mitochondrion, Pathology and Laboratory Medicine, Bioinformatics, Nervous System, Biochemistry, Animal Cells, Medicine and Health Sciences, Biology (General), Immune Response, Energy-Producing Organelles, Neurons, Gene knockdown, Agricultural and Biological Sciences(all), Microglia, General Neuroscience, Chronic pain, Sensory Systems, Mitochondria, Enzymes, medicine.anatomical_structure, Somatosensory System, Spinal Cord, Medical Microbiology, Viral Pathogens, Gene Knockdown Techniques, Viruses, Neuropathic pain, Chromosomes, Human, Pair 5, Female, Cellular Types, Cellular Structures and Organelles, Anatomy, Pathogens, Chronic Pain, medicine.symptom, General Agricultural and Biological Sciences, Research Article, Herpesviruses, QH301-705.5, Neuroscience(all), Immunology, Glial Cells, Inflammation, Bioenergetics, Biology, Microbiology, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Signs and Symptoms, Diagnostic Medicine, Immunology and Microbiology(all), medicine, Animals, Humans, Microglial Cells, Microbial Pathogens, General Immunology and Microbiology, Biochemistry, Genetics and Molecular Biology(all), Organisms, Biology and Life Sciences, Proteins, Pain Sensation, Cell Biology, Methyltransferases, Histone-Lysine N-Methyltransferase, medicine.disease, Sensory neuron, Herpes Simplex Virus, Mice, Inbred C57BL, Neuroanatomy, HEK293 Cells, 030104 developmental biology, Cellular Neuroscience, Enzymology, Sensory Neurons, DNA viruses, Reactive Oxygen Species, Neuroscience, Genome-Wide Association Study, Genetics and Molecular Biology(all)
وصف الملف: image/pdf
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11A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia
المؤلفون: Rubén Gil-Redondo, Pedro Marset Campos, Juan Agut, Federico Mayor, Cristina Murga, Florenci V. González, Antonio Morreale, Annemieke Kavelaars, Elisa Lucas, Paula Ramos, Hanneke L.D.M. Willemen, Cobi J. Heijnen
المصدر: Biochemical Journal. 459:427-439
مصطلحات موضوعية: Male, MAPK/ERK pathway, Lipopolysaccharide, Drug Evaluation, Preclinical, Mice, Transgenic, Molecular Dynamics Simulation, Pharmacology, Biology, p38 Mitogen-Activated Protein Kinases, Biochemistry, Monocytes, Article, Cell Line, Mice, Random Allocation, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, medicine, Animals, Humans, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, Cells, Cultured, Analgesics, Oxadiazoles, Kinase, Macrophages, Anti-Inflammatory Agents, Non-Steroidal, Cell Biology, Mice, Inbred C57BL, Molecular Docking Simulation, chemistry, Hyperalgesia, Female, Tumor necrosis factor alpha, Signal transduction, medicine.symptom
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المؤلفون: Cindy T. J. van Velthoven, Hanneke L.D.M. Willemen, Cobi J. Heijnen, Luca Braccioli, Annemieke Kavelaars
المصدر: Molecular Therapy. 22:645-654
مصطلحات موضوعية: EGF Family of Proteins, Cellular differentiation, Genetic Vectors, Persephin, Nerve Tissue Proteins, Brain damage, Biology, Adenoviridae, Lesion, Cell therapy, Mice, Neural Stem Cells, Transduction, Genetic, Drug Discovery, Genetics, medicine, Animals, Hedgehog Proteins, Molecular Biology, Administration, Intranasal, Cell Proliferation, Pharmacology, Brain-derived neurotrophic factor, Brain-Derived Neurotrophic Factor, Calcium-Binding Proteins, Mesenchymal stem cell, Proteins, Cell Differentiation, Mesenchymal Stem Cells, Neural stem cell, 3. Good health, Mice, Inbred C57BL, Oligodendroglia, Treatment Outcome, Animals, Newborn, Hypoxia-Ischemia, Brain, Immunology, Cancer research, Molecular Medicine, Original Article, medicine.symptom
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المؤلفون: Elbert Geuze, Annemieke Kavelaars, Eric Vermetten, Mirjam Maas, Mirjam van Zuiden, Hanneke L.D.M. Willemen, Cobi Jacoba Johanna Heijnen, Karima Amarouchi
المصدر: Biological Psychiatry. 71:309-316
مصطلحات موضوعية: Male, Oncology, medicine.medical_specialty, Hydrocortisone, Gene Expression, Single-nucleotide polymorphism, Logistic regression, Polymorphism, Single Nucleotide, Stress Disorders, Post-Traumatic, Tacrolimus Binding Proteins, Young Adult, Receptors, Glucocorticoid, Glucocorticoid receptor, Risk Factors, Internal medicine, medicine, Humans, SNP, Genetic Predisposition to Disease, Genetic Testing, RNA, Messenger, Young adult, Prospective cohort study, Biological Psychiatry, Psychiatric Status Rating Scales, Combat Disorders, Adult Survivors of Child Abuse, Haplotype, FKBP5, Psychology, Transcription Factors, Clinical psychology
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المؤلفون: Annemieke Kavelaars, Cobi Jacoba Johanna Heijnen, Carsten Riether, Raphael Doenlen, Hanneke L.D.M. Willemen, Harald Engler, Gustavo Pacheco-López, Timo Wirth, Manfred Schedlowski
المصدر: Brain, Behavior, and Immunity. 25:59-66
مصطلحات موضوعية: medicine.medical_specialty, Endocrine and Autonomic Systems, Cell growth, T cell, Immunology, T-cell receptor, food and beverages, NFAT, Biology, Cell biology, Calcineurin, Behavioral Neuroscience, Endocrinology, medicine.anatomical_structure, Internal medicine, Second messenger system, medicine, Protein kinase A, Receptor
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المؤلفون: Hanneke L.D.M. Willemen, Keith W. Kelley, Fried J. T. Zwartkruis, Cobi Jacoba Johanna Heijnen, Annemieke Kavelaars, John N. Wood, Robert Dantzer, Anibal Garza-Carbajal, Huijing Wang, Niels Eijkelkamp
المصدر: The Journal of Neuroscience. 30:12806-12815
مصطلحات موضوعية: MAPK/ERK pathway, G-Protein-Coupled Receptor Kinase 2, Blotting, Western, Down-Regulation, Prostaglandin, Mice, Transgenic, Protein Kinase C-epsilon, Dinoprostone, Cell Line, Mice, chemistry.chemical_compound, Ganglia, Spinal, Cyclic AMP, medicine, Animals, Guanine Nucleotide Exchange Factors, Humans, Immunoprecipitation, Prostaglandin E2, Protein kinase A, Cells, Cultured, Inflammation, biology, business.industry, Kinase, General Neuroscience, Beta adrenergic receptor kinase, rap1 GTP-Binding Proteins, Articles, Cell biology, chemistry, Hyperalgesia, biology.protein, Nociceptor, Female, Mitogen-Activated Protein Kinases, medicine.symptom, business, Neuroscience, Signal Transduction, medicine.drug
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المؤلفون: Niels Eijkelkamp, Ramin Raoof, Hanneke L.D.M. Willemen
المصدر: Rheumatology (Oxford, England), 57(3), 429. Oxford University Press
Rheumatology
Rheumatology (Oxford, England)مصطلحات موضوعية: 0301 basic medicine, Nervous system, medicine.medical_specialty, animal diseases, Arthritis, Reviews, chemical and pharmacologic phenomena, Chronic pain, 03 medical and health sciences, 0302 clinical medicine, Immune system, Rheumatology, Immunity, Internal medicine, Ganglia, Spinal, Journal Article, Medicine, Humans, Pharmacology (medical), Dorsal root ganglia, Inflammatory, Immunity, Cellular, Spinal cord, business.industry, Immune cells, biochemical phenomena, metabolism, and nutrition, medicine.disease, Acute Pain, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, Immune System, bacteria, Cytokines, Neuropathic, business, Neuroscience, Free nerve ending, 030217 neurology & neurosurgery
وصف الملف: image/pdf
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المؤلفون: Annemieke Kavelaars, Hanneke L.D.M. Willemen, Cora H. Nijboer, Cobi Jacoba Johanna Heijnen, Gerald W. Dorn, Floris Groenendaal, Frank van Bel
المصدر: Brain, Behavior, and Immunity. 24:420-426
مصطلحات موضوعية: Male, medicine.medical_specialty, Pathology, G-Protein-Coupled Receptor Kinase 2, p38 mitogen-activated protein kinases, Blotting, Western, Immunology, Stimulation, Brain damage, p38 Mitogen-Activated Protein Kinases, Article, Mice, Behavioral Neuroscience, Internal medicine, medicine, Animals, Receptor, Mice, Knockout, Microglia, biology, Reverse Transcriptase Polymerase Chain Reaction, Tumor Necrosis Factor-alpha, Endocrine and Autonomic Systems, Macrophages, Beta adrenergic receptor kinase, Brain, Immunohistochemistry, Mice, Inbred C57BL, medicine.anatomical_structure, Endocrinology, Animals, Newborn, nervous system, Hypoxia-Ischemia, Brain, Forebrain, biology.protein, Female, Neuron, medicine.symptom, Calcium-Calmodulin-Dependent Protein Kinase Type 2
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المؤلفون: Joel A G van Roon, Cornelis E. Hack, Annemieke Kavelaars, Niels Eijkelkamp, C. Steen-Louws, Judith Prado, Floris P J G Lafeber, Cobi Jacoba Johanna Heijnen, Hanneke L.D.M. Willemen, Sarita A. Y. Hartgring
المصدر: Journal of Neuroscience, 36(28), 7353. Society for Neuroscience
مصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Male, Inflammatory pain, medicine.medical_treatment, Freund's Adjuvant, Carrageenan, Mice, 0302 clinical medicine, Cells, Cultured, Analgesics, General Neuroscience, Chronic pain, Articles, Interleukin-10, Allodynia, Cytokine, Treatment Outcome, Spinal Cord, Neuropathic pain, Female, medicine.symptom, Anti-inflammatory cytokines, Fusion protein, Neuroglia, Pain Threshold, Neuroscience(all), Recombinant Fusion Proteins, Inflammation, Proinflammatory cytokine, 03 medical and health sciences, Glia, Threshold of pain, medicine, Journal Article, Animals, Humans, Pain Management, business.industry, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Immunology, Neuralgia, Interleukin-4, business, 030217 neurology & neurosurgery
وصف الملف: image/pdf
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المؤلفون: John van der Oost, Andrew P. Turnbull, Jasper Akerboom, Stan J. J. Brouns, Hanneke L.D.M. Willemen
المصدر: Journal of Molecular Biology 371 (2007) 5
Journal of Molecular Biology, 371(5), 1249-1260مصطلحات موضوعية: Molecular Sequence Data, ved/biology.organism_classification_rank.species, Carbohydrates, Molecular Conformation, alternative pathway, Dehydrogenase, Reductase, Crystallography, X-Ray, Microbiology, Cofactor, cofactor-binding, glucose-dehydrogenase, evolutionary insight, Microbiologie, Structural Biology, Glucose dehydrogenase, Oxidoreductase, Catalytic Domain, Amino Acid Sequence, erythroascorbic acid, Protein Structure, Quaternary, Molecular Biology, VLAG, chemistry.chemical_classification, Cofactor binding, Binding Sites, liver alcohol-dehydrogenase, pseudomonas-aeruginosa, Sequence Homology, Amino Acid, biology, ved/biology, Sulfolobus solfataricus, Temperature, Hydrogen-Ion Concentration, thermoacidophilic archaeon, substrate-specificity, Biochemistry, chemistry, biology.protein, saccharomyces-cerevisiae, Crystallization, Sugar Alcohol Dehydrogenases, Protein Binding
وصف الملف: application/pdf; application/octet-stream
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المؤلفون: Elisa Lucas, Cristina Murga, Annemieke Kavelaars, Marta Cruces-Sande, Hanneke L.D.M. Willemen, Cobi J. Heijnen, Federico Mayor, Rocio Vila-Bedmar
المساهمون: Ministerio de Economía y Competitividad (España), Comunidad de Madrid, Instituto de Salud Carlos III, Fundación Ramón Areces, Ministerio de Educación y Ciencia (España), Universidad Autónoma de Madrid, Novo Nordisk Foundation, European Foundation for the Study of Diabetes, National Institute of Neurological Disorders and Stroke (US), University of Texas, EMBO
المصدر: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Science Signaling [E], 8(386), ra73. American Association for the Advancement of Science
Digital.CSIC. Repositorio Institucional del CSIC
instnameمصطلحات موضوعية: medicine.medical_specialty, G-Protein-Coupled Receptor Kinase 2, Type 2 diabetes, Carbohydrate metabolism, Research Support, Biochemistry, Article, Proinflammatory cytokine, N.I.H, Mice, Insulin resistance, Research Support, N.I.H., Extramural, Internal medicine, medicine, Journal Article, Glucose homeostasis, Animals, Humans, Obesity, Non-U.S. Gov't, Molecular Biology, Adiposity, Mice, Knockout, biology, Research Support, Non-U.S. Gov't, Extramural, Cell Biology, medicine.disease, Insulin receptor, Endocrinology, Glucose, biology.protein, Signal transduction, Metabolic syndrome, Insulin Resistance
وصف الملف: application/pdf; image/pdf