المؤلفون: Zhenxi Li, Xinghai Yang, Ruifeng Fu, Zhipeng Wu, Shengzhao Xu, Jian Jiao, Ming Qian, Long Zhang, Chunbiao Wu, Tianying Xie, Jiqiang Yao, Zhixiang Wu, Wenjun Li, Guoli Ma, Yu You, Yihua Chen, Han-kun Zhang, Yiyun Cheng, Xiaolong Tang, Pengfei Wu, Gewei Lian, Haifeng Wei, Jian Zhao, Jianrong Xu, Lianzhong Ai, Stefan Siwko, Yue Wang, Jin Ding, Gaojie Song, Jian Luo, Mingyao Liu, Jianru Xiao

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/f887bc7aca424cdb8d9e11b02b5c449a

المؤلفون: Zhenxi Li, Xinghai Yang, Ruifeng Fu, Zhipeng Wu, Shengzhao Xu, Jian Jiao, Ming Qian, Long Zhang, Chunbiao Wu, Tianying Xie, Jiqiang Yao, Zhixiang Wu, Wenjun Li, Guoli Ma, Yu You, Yihua Chen, Han-kun Zhang, Yiyun Cheng, Xiaolong Tang, Pengfei Wu, Gewei Lian, Haifeng Wei, Jian Zhao, Jianrong Xu, Lianzhong Ai, Stefan Siwko, Yue Wang, Jin Ding, Gaojie Song, Jian Luo, Mingyao Liu, Jianru Xiao

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/0890b5c3600c4d14b91eb72f87712feb

المؤلفون: Wei Wang, Jiacheng He, Junjie Yang, Chan Zhang, Zhiyuan Cheng, Yao Zhang, Qiansen Zhang, Peili Wang, Shuowen Tang, Xin Wang, Mingyao Liu, Weiqiang Lu, Han-Kun Zhang

المصدر: Journal of medicinal chemistry. 65(11)

مصطلحات موضوعية: Mice, Drug Discovery, Colonic Neoplasms, Tumor Microenvironment, Molecular Medicine, Animals, Immunotherapy, Receptors, Prostaglandin E, EP2 Subtype, Receptors, Prostaglandin E, EP4 Subtype, Dinoprostone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2015040ba14b76392a2c4849ab0e4874
https://pubmed.ncbi.nlm.nih.gov/35640059

المؤلفون: Jun-Jie, Yang, Wei-Wei, Yu, Long-Long, Hu, Wen-Juan, Liu, Xian-Hua, Lin, Wei, Wang, Qiansen, Zhang, Pei-Li, Wang, Shuo-Wen, Tang, Xin, Wang, Mingyao, Liu, Weiqiang, Lu, Han-Kun, Zhang

المصدر: Journal of medicinal chemistry. 63(2)

مصطلحات موضوعية: Mice, Inbred BALB C, Macrophages, Triazoles, Mice, Structure-Activity Relationship, HEK293 Cells, RAW 264.7 Cells, Cell Line, Tumor, Neoplasms, Colonic Neoplasms, Drug Discovery, Microsomes, Liver, Tumor Microenvironment, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Calcium, Female, Immunotherapy, Receptors, Prostaglandin E, EP4 Subtype, T-Lymphocytes, Cytotoxic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::c48ba4a9270319d757acda25e53cc490
https://pubmed.ncbi.nlm.nih.gov/31855426

المؤلفون: Li-Fang Yu, J. Brek Eaton, Alan P. Kozikowski, Han Kun Zhang, Ronald J. Lukas, Barbara J. Caldarone

المصدر: Journal of Medicinal Chemistry. 57:8204-8223

مصطلحات موضوعية: Drug, Chemistry, medicine.medical_treatment, media_common.quotation_subject, Pharmacology, 3. Good health, Nicotinic agonist, Drug Discovery, Cholinergic system, medicine, Molecular Medicine, Nicotinic Antagonist, Receptor, Depressive symptoms, Desensitization (medicine), media_common, Acetylcholine receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b3c32eb400ced5c1b7bce815abfedf0c
https://doi.org/10.1021/jm401937a

المؤلفون: Taleen Hanania, Han Kun Zhang, Ronald J. Lukas, Alan P. Kozikowski, J. Brek Eaton, Oluseye K. Onajole, Daniela Brunner, Li-Fang Yu, Paul Whiteaker

المصدر: Journal of Medicinal Chemistry. 56:5495-5504

مصطلحات موضوعية: Cyclopropanes, Male, Stereochemistry, Azetidine, Motor Activity, Receptors, Nicotinic, Pharmacology, Binding, Competitive, Partial agonist, Article, Cell Line, Mice, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Drug Stability, Cell Line, Tumor, Drug Discovery, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Structure–activity relationship, Nicotinic Agonists, Receptor, Swimming, Acetylcholine receptor, Mice, Inbred BALB C, Molecular Structure, Chemistry, Drug discovery, Stereoisomerism, Antidepressive Agents, Rats, Nicotinic acetylcholine receptor, Nicotinic agonist, Models, Chemical, Microsomes, Liver, Molecular Medicine, Caco-2 Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e144a9ae7f5d7f2f0ca17d84b18cfbcb
https://doi.org/10.1021/jm400510u

المؤلفون: Oluseye K. Onajole, Dani Brunner, J. Brek Eaton, Li-Fang Yu, Allison Fedolak, Hendra Gunosewoyo, Han Kun Zhang, Ronald J. Lukas, Alan P. Kozikowski

مصطلحات موضوعية: 0301 basic medicine, Male, Stereochemistry, Ether, Receptors, Nicotinic, 01 natural sciences, Partial agonist, Article, Cyclopropane, 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, Drug Discovery, medicine, Animals, Nicotinic Agonists, Swimming, Pharmacology, Behavior, Molecular Structure, 010405 organic chemistry, Chemistry, Depression, Organic Chemistry, General Medicine, Affinities, 0104 chemical sciences, Mice, Inbred C57BL, Nicotinic acetylcholine receptor, 030104 developmental biology, Nicotinic agonist, Epibatidine, Varenicline, Selectivity, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3a9f05eefcc149a307e2923ae03bd8
https://europepmc.org/articles/PMC5097879/

المؤلفون: Hendra Gunosewoyo, Han Kun Zhang, Li-Fang Yu, Alan P. Kozikowski

المصدر: ACS Medicinal Chemistry Letters. 3:1054-1058

مصطلحات موضوعية: Neurotransmitter transporter, Sigma-1 receptor, Stereochemistry, Chemistry, Organic Chemistry, Rational design, Pharmacology, Ligand (biochemistry), Biochemistry, Nicotinic acetylcholine receptor, Nicotinic agonist, Drug Discovery, Pharmacophore, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb99c04ac61e738aac181f03a40534bc
https://doi.org/10.1021/ml3002715

المؤلفون: Han-Kun Zhang, J. Brek Eaton, Allison Fedolak, Hendra Gunosewoyo, Oluseye K. Onajole, Dani Brunner, Ronald J. Lukas, Li-Fang Yu, Alan P. Kozikowski

مصطلحات موضوعية: α4β2-nAChRs, Partial agonists, Hybrids, Antidepressant-like effects

Relation: http://hdl.handle.net/10027/21453; https://figshare.com/articles/journal_contribution/Synthesis_and_biological_evaluation_of_novel_hybrids_of_highly_potent_and_selective_4_2-Nicotinic_acetylcholine_receptor_nAChR_partial_agonists/10776872

الاتاحة: http://hdl.handle.net/10027/21453
https://figshare.com/articles/journal_contribution/Synthesis_and_biological_evaluation_of_novel_hybrids_of_highly_potent_and_selective_4_2-Nicotinic_acetylcholine_receptor_nAChR_partial_agonists/10776872

المؤلفون: Yong Chang Chang, Taleen Hanania, Paul Whiteaker, Guannan Li, Jie Wu, J. Brek Eaton, Ronald J. Lukas, Richard B. van Breemen, Alan P. Kozikowski, Emily Sabath, Han Kun Zhang, Qiang Liu, Li-Fang Yu, Dani Brunner

المصدر: Pharmacology Research & Perspectives. 2

مصطلحات موضوعية: medicine.medical_specialty, business.industry, Pharmacology, Partial agonist, 3. Good health, Nicotinic acetylcholine receptor, Nicotinic agonist, Endocrinology, Neurology, Internal medicine, Medicine, Antidepressant, Cholinergic, General Pharmacology, Toxicology and Pharmaceutics, Nicotinic Antagonist, business, ADME, Behavioural despair test

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cf884747297e2fede9079e6b41fa9839
https://doi.org/10.1002/prp2.26

المؤلفون: Li-Fang, Yu, J, Brek Eaton, Han-Kun, Zhang, Emily, Sabath, Taleen, Hanania, Guan-Nan, Li, Richard B, van Breemen, Paul, Whiteaker, Qiang, Liu, Jie, Wu, Yong-Chang, Chang, Ronald J, Lukas, Dani, Brunner, Alan P, Kozikowski

المصدر: Pharmacology Research & Perspectives

مصطلحات موضوعية: Antidepressive-like behavior, selectivity, partial agonist, Original Articles, nicotinic acetylcholine receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::e91e7966687b0a771dac894883529c13
https://pubmed.ncbi.nlm.nih.gov/25505580

المؤلفون: Han Kun Zhang, Taleen Hanania, Ronald J. Lukas, J. Brek Eaton, Alan P. Kozikowski, Li-Fang Yu, Allison Fedolak, Dani Brunner

المصدر: Journal of medicinal chemistry. 55(22)

مصطلحات موضوعية: Male, Stereochemistry, Azetidine, Ether, Motor Activity, Receptors, Nicotinic, Article, chemistry.chemical_compound, Mice, Neuroblastoma, Radioligand Assay, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Nicotinic Agonists, Swimming, Acetylcholine receptor, Mice, Inbred BALB C, Stereoisomerism, Isoxazoles, Antidepressive Agents, Nicotinic acetylcholine receptor, Nicotinic agonist, chemistry, Mechanism of action, Epibatidine, Molecular Medicine, medicine.symptom, medicine.drug, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8798aa190026fe665cd03898be3e3853
https://pubmed.ncbi.nlm.nih.gov/23092294