المؤلفون: Francis, Laura, Harrell, Andrew, Hallifax, David, Galetin, Aleksandra

المصدر: Francis , L , Harrell , A , Hallifax , D & Galetin , A 2020 , ' Utilising magnetically isolated lysosomes for direct quantification of intralysosomal drug concentrations by LC MS/MS analysis: An investigatory study with imipramine ' , Journal of Pharmaceutical Sciences , vol. 109 , no. 9 , pp. 2891-2901 . https://doi.org/10.1016/j.xphs.2020.05.026

مصطلحات موضوعية: cell biology, in vitro model(s), pH, pharmacokinetics, super paramagentic iron oxide nanoparticles

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

الاتاحة: https://research.manchester.ac.uk/en/publications/cf0e99ed-82e3-43a4-b4d8-4454c9626c22
https://doi.org/10.1016/j.xphs.2020.05.026
https://pure.manchester.ac.uk/ws/files/165402590/FrancisEtAl_JPharmSci_2020_ManuscriptForReview_revised_20_391.docx

المؤلفون: Godoy, Patricio, Hewitt, Nicola J., Albrecht, Ute, Andersen, Melvin E., Ansari, Nariman, Bhattacharya, Sudin, Bode, Johannes Georg, Bolleyn, Jennifer, Borner, Christoph, Boettger, Jan, Braeuning, Albert, Budinsky, Robert A., Burkhardt, Britta, Cameron, Neil R., Camussi, Giovanni, Cho, Chong-Su, Choi, Yun-Jaie, Rowlands, J. Craig, Dahmen, Uta, Damm, Georg, Dirsch, Olaf, Teresa Donato, Maria, Dong, Jian, Dooley, Steven, Drasdo, Dirk, Eakins, Rowena, Ferreira, Karine Sa, Fonsato, Valentina, Fraczek, Joanna, Gebhardt, Rolf, Gibson, Andrew, Glanemann, Matthias, Goldring, Chris E. P., Jose Gomez-Lechon, Maria, Groothuis, Geny M. M., Gustavsson, Lena, Guyot, Christelle, Hallifax, David, Hammad, Seddik, Hayward, Adam, Haeussinger, Dieter, Hellerbrand, Claus, Hewitt, Philip, Hoehme, Stefan, Holzhuetter, Hermann-Georg, Houston, J. Brian, Hrach, Jens, Ito, Kiyomi, Jaeschke, Hartmut, Keitel, Verena, Kelm, Jens M., Park, B. Kevin, Kordes, Claus, Kullak-Ublick, Gerd A., LeCluyse, Edward L., Lu, Peng, Luebke-Wheeler, Jennifer, Lutz, Anna, Maltman, Daniel J., Matz-Soja, Madlen, McMullen, Patrick, Merfort, Irmgard, Messner, Simon, Meyer, Christoph, Mwinyi, Jessica, Naisbitt, Dean J., Nussler, Andreas K., Olinga, Peter, Pampaloni, Francesco, Pi, Jingbo, Pluta, Linda, Przyborski, Stefan A., Ramachandran, Anup, Rogiers, Vera, Rowe, Cliff, Schelcher, Celine, Schmich, Kathrin, Schwarz, Michael, Singh, Bijay, Stelzer, Ernst H. K., Stieger, Bruno, Stoeber, Regina, Sugiyama, Yuichi, Tetta, Ciro, Thasler, Wolfgang E., Vanhaecke, Tamara, Vinken, Mathieu, Weiss, Thomas S., Widera, Agata, Woods, Courtney G., Xu, Jinghai James, Yarborough, Kathy M., Hengstler, Jan G.

المصدر: Archives of Toxicology. 87(8):1315-1530

مصطلحات موضوعية: Non-parenchymal cells, Mechanisms of gene regulation, DILI, 3D Models, Cryopreservation, Clearance, Mathematical modeling, Medicin och hälsovetenskap, Medicinska och farmaceutiska grundvetenskaper, Farmakologi och toxikologi, Medical and Health Sciences, Basic Medicine, Pharmacology and Toxicology

وصف الملف: electronic

URL الوصول: https://lup.lub.lu.se/record/4063481
https://portal.research.lu.se/files/3322378/4589277
http://dx.doi.org/10.1007/s00204-013-1078-5

المؤلفون: Hallifax, David, Houston, James

المصدر: Hallifax , D & Houston , J 2019 , ' Use of segregated hepatocyte scaling factors and cross-species relationships to resolve clearance dependence in the prediction of human hepatic clearance ' , Drug Metabolism and Disposition -Bethesda- , vol. 47 , no. 3 , pp. 320-327 . https://doi.org/10.1124/dmd.118.085191

وصف الملف: application/pdf

الاتاحة: https://research.manchester.ac.uk/en/publications/d98e9932-bc8e-4857-91e9-e47a17543892
https://doi.org/10.1124/dmd.118.085191
https://pure.manchester.ac.uk/ws/files/84784031/dmd.118.085191.full.pdf
http://www.mendeley.com/research/segregated-hepatocyte-scaling-factors-crossspecies-relationships-resolve-clearance-dependence-predic

المؤلفون: Chinnadurai, Rajkumar, Al-Qassabi, Jokha, Darwich, Adam, Murphy, Susan, Hallifax, David, Rostami, Amin, Kalra, Philip

المصدر: Nephrology Dialysis Transplantation ; volume 34, issue Supplement_1 ; ISSN 0931-0509 1460-2385

الاتاحة: https://doi.org/10.1093/ndt/gfz103.sp268
http://academic.oup.com/ndt/article-pdf/34/Supplement_1/gfz103.SP268/28823011/gfz103.sp268.pdf

المؤلفون: Francis, Laura, Ogungbenro, Kayode, De Bruyn, Tom, Houston, J Brian, Hallifax, David

المصدر: Francis , L , Ogungbenro , K , De Bruyn , T , Houston , J B & Hallifax , D 2023 , ' Exploring the boundaries for in vitro-in vivo extrapolation : Use of isolated hepatocytes in co-culture and impact of albumin binding properties in the prediction of clearance of various drug types. ' , Drug Metabolism and Disposition . https://doi.org/10.1124/dmd.123.001309

الاتاحة: https://research.manchester.ac.uk/en/publications/aa2d7dff-2346-41fc-ba3c-d7f5e808f05f
https://doi.org/10.1124/dmd.123.001309

المؤلفون: Wood, Francesca, Houston, James, Hallifax, David

المصدر: Wood , F , Houston , J & Hallifax , D 2018 , ' Importance of the unstirred water layer and hepatocyte membrane integrity in vitro for quantification of intrinsic metabolic clearance ' , Drug Metabolism and Disposition , vol. 46 , no. 1 . https://doi.org/10.1124/dmd.117.078949

الاتاحة: https://research.manchester.ac.uk/en/publications/52e047e4-3649-4b08-8214-e7e5853d93a4
https://doi.org/10.1124/dmd.117.078949
http://europepmc.org/abstract/MED/29233818

المؤلفون: Foster, Joanne A., Houston, J. Brian, Hallifax, David

المصدر: Xenobiotica ; volume 41, issue 2, page 124-136 ; ISSN 0049-8254 1366-5928

الاتاحة: http://dx.doi.org/10.3109/00498254.2010.530700
http://www.tandfonline.com/doi/pdf/10.3109/00498254.2010.530700

المؤلفون: Francis, Laura, Ogungbenro, Kayode, De Bruyn, Tom, Houston, J. Brian, Hallifax, David

المصدر: Drug Metabolism and Disposition; 2023, Vol. 51 Issue: 11 p1463-1473, 11p

المؤلفون: Hallifax, David, Houston, J. Brian

المصدر: Drug Metabolism and Disposition ; volume 35, issue 8, page 1325-1332 ; ISSN 0090-9556

الاتاحة: https://doi.org/10.1124/dmd.107.015131
https://api.elsevier.com/content/article/PII:S0090955624013795?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0090955624013795?httpAccept=text/plain
https://syndication.highwire.org/content/doi/10.1124/dmd.107.015131

المؤلفون: Francis, Laura, Houston, James, Hallifax, David

المصدر: Francis , L , Houston , J & Hallifax , D 2020 , ' Impact of plasma protein binding in drug clearance prediction: a database analysis of published studies and implications for in vitro in vivo extrapolation ' , Drug Metabolism and Disposition .

الاتاحة: https://research.manchester.ac.uk/en/publications/09456c11-3623-4cfd-8809-c0b9517cab35

المؤلفون: Francis, Laura, Hallifax, David, Harrell, Andrew, Galetin, Aleksandra

المصدر: Drug Metabolism and Pharmacokinetics ; volume 35, issue 1, page S64 ; ISSN 1347-4367

الاتاحة: http://dx.doi.org/10.1016/j.dmpk.2020.04.138
https://api.elsevier.com/content/article/PII:S1347436720301634?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1347436720301634?httpAccept=text/plain

المؤلفون: Galetin, Aleksandra, Ito, Kiyomi, Hallifax, David, Houston, J. Brian

المصدر: The Journal of Pharmacology and Experimental Therapeutics ; volume 314, issue 1, page 180-190 ; ISSN 0022-3565

الاتاحة: https://doi.org/10.1124/jpet.104.082826
https://api.elsevier.com/content/article/PII:S0022356524320725?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0022356524320725?httpAccept=text/plain
https://syndication.highwire.org/content/doi/10.1124/jpet.104.082826

المؤلفون: Musther, Helen, Ghosh, Avijit, Gardner, Iain, Rostami-Hodjegan, Amin, Hallifax, David

المصدر: Musther , H , Ghosh , A , Gardner , I , Rostami-Hodjegan , A & Hallifax , D 2017 , ' Revisiting human tissue drug distribution: Limitations of current prediction models and potential impact of lipid contributions in fraction unbound ' .

الاتاحة: https://research.manchester.ac.uk/en/publications/9a21faab-9743-476c-ad27-b0e22f9b25c9

المؤلفون: Francis, Laura, Ufuk, Ayse, Harrell, Andy, Hallifax, David, Galetin, Aleksandra

المصدر: Francis , L , Ufuk , A , Harrell , A , Hallifax , D & Galetin , A 2017 , ' Novel Methodology for the Isolation of Lysosomes and Measurement of Intralysosomal Drug Accumulation ' .

الاتاحة: https://research.manchester.ac.uk/en/publications/2d8cd7e6-205f-4d49-85b3-a688e0ededcf

المؤلفون: Ufuk, Ayşe, Matsunaga, Norikazu, Hallifax, David, Galetin, Aleksandra

المصدر: Drug Metabolism and Pharmacokinetics ; volume 33, issue 1, page S46 ; ISSN 1347-4367

الاتاحة: http://dx.doi.org/10.1016/j.dmpk.2017.11.162
https://api.elsevier.com/content/article/PII:S1347436717303932?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1347436717303932?httpAccept=text/plain

المؤلفون: Rowland, Andrew, Hallifax, David, Nussio, Matthew R., Shapter, Joseph G., Mackenzie, Peter I., Houston, J. Brian, Knights, Kathleen M., Miners, John O.

مصطلحات موضوعية: Drug distribution, drug-protein binding, surface plasmon resonance

Relation: orcid:0000-0002-4000-2751

الاتاحة: https://espace.library.uq.edu.au/view/UQ:728208

المؤلفون: Wood, Francesca, Hallifax, David, Houston, Brian

المصدر: Wood , F , Hallifax , D & Houston , B 2015 , Assessing metabolic competence in isolated hepatocytes: Exploring the relationship between enzyme function and plasma membrane integrity via Saponin treatment . in host publication . vol. P10 , 13th European ISSX Meeting , Glasgow, Scotland , 22/06/15 .

الاتاحة: https://research.manchester.ac.uk/en/publications/23a552ec-b700-4463-862d-784dd5d64258

المؤلفون: Wood, Francesca, Hallifax, David, Houston, James

المصدر: Wood , F , Hallifax , D & Houston , J 2014 , Intrinsic Clearance Predictions from Freshly Isolated Rat Hepatocytes : Effects of Assay Format and Cofactor Supplementation . in Proceedings of 20th international symposium on microsomes and drug oxidations . 20th International Symposium on Microsomes and Drug Oxidations (MDO) , Stuttgart , Germany , 18/05/14 .

الاتاحة: https://research.manchester.ac.uk/en/publications/3fefe35a-df90-49ac-947a-4bd06672d22e

المؤلفون: Zanelli, Ugo, Caradonna, Nicola Pasquale, Hallifax, David, Turlizzi, Elisa, Houston, J. Brian

المصدر: Zanelli , U , Caradonna , N P , Hallifax , D , Turlizzi , E & Houston , J B 2012 , ' Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs ' , Drug Metabolism and Disposition , vol. 40 , no. 1 , pp. 104-110 . https://doi.org/10.1124/dmd.111.042309

الاتاحة: https://research.manchester.ac.uk/en/publications/73eabd58-b556-41c4-9df5-1c1d4f5661fb
https://doi.org/10.1124/dmd.111.042309
http://dmd.aspetjournals.org/content/40/1/104.full.pdf+html

المؤلفون: Hallifax, David, Turlizzi, Elisa, Zanelli, Ugo, Houston, J. Brian

المصدر: Hallifax , D , Turlizzi , E , Zanelli , U & Houston , J B 2012 , ' Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: Comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs ' , European Journal of Pharmaceutical Sciences , vol. 45 , no. 5 , pp. 570-574 . https://doi.org/10.1016/j.ejps.2011.12.010

مصطلحات موضوعية: Diffusion, Hepatocytes, In vitro/in vivo, Metabolic clearance, Permeability

الاتاحة: https://research.manchester.ac.uk/en/publications/62ba6723-d30a-45c8-8f20-afb0ad73268c
https://doi.org/10.1016/j.ejps.2011.12.010