نتائج البحث - "Halladay, Jason S"

1

Academic Journal

Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates

مصطلحات موضوعية: Drug development, Parasite biology, Parasitic infection, Target identification

وصف الملف: application/pdf

Relation: Padilla, A.M., Wang, W., Akama, T. et al. Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates. Nat Microbiol 7, 1536–1546 (2022). https://doi.org/10.1038/s41564-022-01211-y; http://hdl.handle.net/1808/33957; orcid:0000-0002-7907-5667; orcid:0000-0003-3164-9147; orcid:0000-0003-0025-1400; orcid:0000-0003-0837-6953; orcid:0000-0002-4955-048X; orcid:0000-0003-4113-7081; orcid:0000-0002-0441-1355; orcid:0000-0003-0844-088X; orcid:0000-0002-0392-6824; orcid:0000-0003-2494-4172; orcid:0000-0001-9669-2862; orcid:0000-0002-9589-5243; PMC9519446

الاتاحة: http://hdl.handle.net/1808/33957
https://doi.org/10.1038/s41564-022-01211-y

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2

Conference

Inhibitory Effect of Trapping Agents of Reactive Intermediates of Sulfur-containing Drugs Against Major Human Cytochrome P450 ; Effets inhibiteurs sur les cytochromes P450 humains majeursdes agents de piègeage d'intermédiaires métaboliques réactifs concernant les médicaments contenant du soufre.

المؤلفون: Dansette, Patrick, M, Sodhi, Jasleen, K, Delarosa, Marie, Halladay, Jason, S, Driscoll, James, P, Mulder, Teresa, Cyrus Khojasteh, S

المساهمون: Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (LCBPT - UMR 8601), Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Pr Vlada Urlacher

المصدر: 20th International Conference on Cytochrome P450 (ICCP 20)
https://hal.science/hal-03539866
20th International Conference on Cytochrome P450 (ICCP 20), Aug 2017, Dusseldorf, Germany.
https://www.biochemistry2.hhu.de/en/news/iccp450

جغرافية الموضوع: Dusseldorf, Germany

Relation: hal-03539866; https://hal.science/hal-03539866; https://hal.science/hal-03539866/document; https://hal.science/hal-03539866/file/TrappingAgentP450inhibition5.ppt.pdf

الاتاحة: https://hal.science/hal-03539866
https://hal.science/hal-03539866/document
https://hal.science/hal-03539866/file/TrappingAgentP450inhibition5.ppt.pdf

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3

Book

Case Study 9: Probe-Dependent Binding Explains Lack of CYP2C9 Inactivation by 1-Aminobenzotriazole (ABT)

المؤلفون: Sodhi, Jasleen K., Halladay, Jason S.

المصدر: Methods in Molecular Biology ; Enzyme Kinetics in Drug Metabolism ; page 765-779 ; ISSN 1064-3745 1940-6029 ; ISBN 9781071615539 9781071615546

الاتاحة: http://dx.doi.org/10.1007/978-1-0716-1554-6_28
https://link.springer.com/content/pdf/10.1007/978-1-0716-1554-6_28

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4

Academic Journal

For a series of methylindole analogs, reactive metabolite formation is a poor predictor of intrinsic cytotoxicity in human hepatocytes

المؤلفون: Zhang, Chenghong, Ma, Shuguang, Delarosa, Erlie Marie, Tay, Suzanne, Sodhi, Jasleen, Musinipally, Vivek, Chang, Patricia, Pai, Rama, Halladay, Jason S., Misner, Dinah, Kenny, Jane R., Hop, Cornelis E. C. A., Khojasteh, S. Cyrus

المصدر: Toxicology Research ; volume 3, issue 3, page 184 ; ISSN 2045-452X 2045-4538

الاتاحة: https://doi.org/10.1039/c3tx50062d

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5

Academic Journal

The Effects of Drug Metabolizing Enzyme Inhibitors on Hepatic Efflux and Uptake Transporters

المؤلفون: Cheong, Jonathan, Halladay, Jason S., Plise, Emile, Sodhi, Jasleen K., Salphati, Laurent

المصدر: Drug Metabolism Letters ; volume 11, issue 2 ; ISSN 1872-3128

الاتاحة: http://dx.doi.org/10.2174/1872312811666171010101248
http://eurekaselect.com/article/download/156306

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6

Academic Journal

A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834

المؤلفون: Sodhi, Jasleen K, Wong, Susan, Kirkpatrick, Donald S, Liu, Lichuan, Khojasteh, S Cyrus, Hop, Cornelis E C A, Barr, John T, Jones, Jeffrey P, Halladay, Jason S

مصطلحات موضوعية: Liver - enzymology, Protein-Tyrosine Kinases - metabolism, Humans, Molecular Conformation, Drugs, Investigational - pharmacokinetics, Substrate Specificity, Anti-Inflammatory Agents, Non-Steroidal - chemistry, Thiophenes - metabolism, Investigational - metabolism, Gene Expression Profiling, Pyrimidinones - metabolism, Non-Steroidal - blood, Investigational - analysis, Thiophenes - blood, Pyrimidinones - chemistry, Cytosol - enzymology, Investigational - chemistry, Protein Kinase Inhibitors - chemistry, Aldehyde Oxidase - chemistry, Protein-Tyrosine Kinases - chemistry, Non-Steroidal - metabolism, Protein Kinase Inhibitors - pharmacokinetics, Catalytic Domain, Biocatalysis, Drug Stability, Liver - metabolism, Models, Molecular

Relation: ispartof: Drug metabolism and disposition spage 908 epage 915 issue 6 vol 43; PMC4429680; WOS:000354187500013; 2376/101366; https://doi.org/10.1124/dmd.114.061804; 99900546534301842; alma:01ALLIANCE_WSU/bibs/99900546534301842

الاتاحة: https://doi.org/10.1124/dmd.114.061804
https://rex.libraries.wsu.edu/esploro/outputs/journalArticle/A-novel-reaction-mediated-by-human/99900546534301842

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