المؤلفون: Shuzhi Dong, Zhiqiang Zhao, Haiqun Tang, Guoqing Li, Jianping Pan, Xin Gu, Jinlong Jiang, Li Xiao, Giovanna Scapin, David N. Hunter, Dexi Yang, Yuhua Huang, Frank Bennett, Shu-Wei Yang, Mihirbaran Mandal, Haifeng Tang, Jing Su, Clare Tudge, Reynalda Keh deJesus, Fa-Xiang Ding, Matthew Lombardo, Jacqueline D. Hicks, Thierry Fischmann, Asra Mirza, Priya Dayananth, Ronald E. Painter, Artjohn Villafania, Charles G. Garlisi, Rumin Zhang, Todd W. Mayhood, Qian Si, Nianyu Li, Rupesh P. Amin, Bhavana Bhatt, Feifei Chen, Christopher P. Regan, Hillary Regan, Xinjie Lin, Jin Wu, Andrew Leithead, Scott R. Pollack, Jack D. Scott, Ravi P. Nargund, Alex G. Therien, Todd Black, Katherine Young, Alexander Pasternak

مصطلحات موضوعية: Medicine, Microbiology, Molecular Biology, Pharmacology, Sociology, Cancer, Infectious Diseases, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, three main families, novel pan metallo, nonclinical safety profiles, bacteria expressing metallo, gn coverage spectrum, gn cell penetration, discover pan inhibitors, broad gn coverage, structure guided discovery, lactamase inhibitor combination, lactamase inhibitors, significant discovery, select compounds, preclinical candidates, key findings, infections caused, efflux challenges, based optimization, aeruginosa <

Relation: https://figshare.com/articles/journal_contribution/Structure_Guided_Discovery_of_Novel_Pan_Metallo-_-Lactamase_Inhibitors_with_Improved_Gram-Negative_Bacterial_Cell_Penetration/25270563

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01614.s001
https://figshare.com/articles/journal_contribution/Structure_Guided_Discovery_of_Novel_Pan_Metallo-_-Lactamase_Inhibitors_with_Improved_Gram-Negative_Bacterial_Cell_Penetration/25270563

المؤلفون: Mihirbaran Mandal, Li Xiao, Weidong Pan, Giovanna Scapin, Guoqing Li, Haiqun Tang, Shu-Wei Yang, Jianping Pan, Yuriko Root, Reynalda Keh de Jesus, Christine Yang, Winnie Prosise, Priya Dayananth, Asra Mirza, Alex G. Therien, Katherine Young, Amy Flattery, Charles Garlisi, Rumin Zhang, Donald Chu, Payal Sheth, Inhou Chu, Jin Wu, Carrie Markgraf, Hai-Young Kim, Ronald Painter, Todd W. Mayhood, Edward DiNunzio, Daniel F. Wyss, Alexei V. Buevich, Thierry Fischmann, Alexander Pasternak, Shuzhi Dong, Jacqueline D. Hicks, Artjohn Villafania, Lianzhu Liang, Nicholas Murgolo, Todd Black, William K. Hagmann, Jim Tata, Emma R. Parmee, Ann E. Weber, Jing Su, Haifeng Tang

المصدر: Journal of Medicinal Chemistry. 65:16234-16251

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72a226d0f459e4620537979c8da4d4d
https://doi.org/10.1021/acs.jmedchem.2c00766

المؤلفون: Katherine Young, Asra Mirza, Carl Balibar, Shuzhi Dong, Frank Bennett, Jinlong Jiang, Haiqun Tang, Claire Tudge, Jack Scott, Dexi Yang, Alexander Pasternak

المصدر: Open Forum Infectious Diseases. 9

مصطلحات موضوعية: Infectious Diseases, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e05d53410725c96796d9026a15a639b0
https://doi.org/10.1093/ofid/ofac492.1353

المؤلفون: Blair T. Lapointe, Jack D. Scott, Xin Cindy Yan, Haiqun Tang, Janice D Woodhouse, Kaleen Konrad Childers, Robert Faltus, Erin F. DiMauro, Solomon Kattar, Charles S. Yeung, Ravi Kurukulasuriya, Vladimir Simov, Hakan Gunaydin, Anmol Gulati, Joey L. Methot, Rachel L. Palte, Ellen C. Minnihan, Greg Morriello, J. Michael Ellis, Harold B. Wood, Santhosh Neelamkavil, Karin M. Otte, Michael J. Ardolino, Barbara Pio, Ping Liu, Laxminarayan G Hegde, Matthew J. Fell, Vanessa L. Rada, Peter Fuller, Paul J Ciaccio

المصدر: RSC Med Chem

مصطلحات موضوعية: Pharmacology, 0303 health sciences, Trifluoromethyl, Chemistry, Metabolite, Organic Chemistry, Pharmaceutical Science, Pyrazole, Leucine-rich repeat, Biochemistry, LRRK2, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, 030220 oncology & carcinogenesis, Drug Discovery, Molecular Medicine, Kinome, Penetrant (biochemical), Linker, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8d45ea7dd7adda70471298a4476afa
https://europepmc.org/articles/PMC8292993/

المؤلفون: Ying Zhai, De-Yi Yang, Ernest Asante-Appiah, Lei Chen, Haiqun Tang, Paul Ingravallo, Amin A. Nomeir, John P. Caldwell, Ling Tong, Guowei Zhou, Wensheng Yu, Yueheng Jiang, Oleg Selyutin, Anilkumar G. Nair, Seong Heon Kim, Rong Liu, Joseph A. Kozlowski, Qingbei Zeng, Stuart B. Rosenblum, Michael P. Dwyer, Rong Kong, Ellen Xia, Sony Agrawal, Robert Mazzola, Bandarpalle B. Shankar, Kerry Keertikar

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:1954-1957

مصطلحات موضوعية: 0301 basic medicine, Genotype, Proline, Silylation, viruses, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Pharmacology, Virus Replication, Antiviral Agents, Heterocyclic Compounds, 4 or More Rings, Biochemistry, 03 medical and health sciences, Dogs, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Pharmacokinetics, Drug Discovery, Animals, Humans, Potency, NS5A, Molecular Biology, Chemistry, Organic Chemistry, virus diseases, Haplorhini, biochemical phenomena, metabolism, and nutrition, digestive system diseases, In vitro, Rats, Regimen, 030104 developmental biology, Molecular Medicine, 030211 gastroenterology & hepatology, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd2480c8ed858188f3382243eccdd83
https://doi.org/10.1016/j.bmcl.2018.03.049

المؤلفون: Li-Kang Zhang, Younong Yu, Steven L. Colletti, Alexei V. Buevich, Haiqun Tang, Guoqing Li, Zhi-Cai Shi, Petr Vachal

المصدر: Journal of the American Chemical Society. 140:6797-6800

مصطلحات موضوعية: chemistry.chemical_classification, Peptide modification, Bioconjugation, 010405 organic chemistry, Chemistry, Molecular Conformation, Tryptophan, Proteins, Peptide, General Chemistry, Conjugated system, Photochemical Processes, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, Colloid and Surface Chemistry, Amide, Michael reaction, Chemoselectivity, Peptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d3349ea2021360c4907ac2ceef7a75
https://doi.org/10.1021/jacs.8b03973

المؤلفون: Xianhai Huang, Robert G. Aslanian, Xiao Chen, Zhidan Liu, Anandan Palani, Madhu Chintala, Haiqun Tang, Jing Su, Jun Qin, Xiaohong Zhu, Scott Greenfeder, Mckittrick Brian A, Ashwin U. Rao, Margaret van Heek, Wei Zhou, Ying Huang, Dong Xiao, Sylvia J. Degrado

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:854-858

مصطلحات موضوعية: Agonist, Pyrimidine, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Ether, Receptors, Nicotinic, Biochemistry, Lactones, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Pyrimidinedione, medicine, Humans, Molecular Biology, Molecular Structure, Organic Chemistry, In vitro, Pyrimidines, Nicotinic agonist, chemistry, Molecular Medicine, Lead compound, Ethers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171da2a13d61a0b71752fe28862ac261
https://doi.org/10.1016/j.bmcl.2011.12.041

المؤلفون: Anandan Palani, Ashwin U. Rao, Xiao Chen, Xianhai Huang, Jing Su, Haiqun Tang, Ying Huang, Jun Qin, Dong Xiao, Sylvia Degrado, Michael Sofolarides, Xiaohong Zhu, Zhidan Liu, Brian McKittrick, Wei Zhou, Robert Aslanian, William J. Greenlee, Mary Senior, Boonlert Cheewatrakoolpong, Hongtao Zhang, Constance Farley, John Cook, Stan Kurowski, Qiu Li, Margaret van Heek, Gangfeng Wang, Yunsheng Hsieh, Fangbiao Li, Scott Greenfeder, Madhu Chintala

المصدر: ACS Medicinal Chemistry Letters. 3:63-68

مصطلحات موضوعية: Agonist, business.industry, medicine.drug_class, Organic Chemistry, Pharmacology, SCH 900271, medicine.disease, Biochemistry, Beagle, Bioavailability, chemistry.chemical_compound, Nicotinic agonist, chemistry, Drug Discovery, medicine, Receptor, business, Dyslipidemia, EC50

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c5c0846188e03944198c603168e99c
https://doi.org/10.1021/ml200243g

المؤلفون: Mckittrick Brian A, Haiqun Tang, Jing Su

المصدر: Tetrahedron Letters. 52:3382-3385

مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Epoxide, Regioselectivity, Ring (chemistry), Biochemistry, Sulfone, chemistry.chemical_compound, chemistry, Suzuki reaction, Yield (chemistry), Drug Discovery, Stereoselectivity, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::24fd17d0d7c73e3a76eef49e286f8147
https://doi.org/10.1016/j.tetlet.2011.04.091

المؤلفون: William J. Greenlee, Haiqun Tang, Ruo Xu, Mckittrick Brian A, John W. Clader, Lynn A. Hyde, Lili Zhang, Jing Su

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3447-3451

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Sulfone, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Amyloid precursor protein, Animals, Sulfones, γ secretase, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Amyloid beta-Peptides, Molecular Structure, biology, Organic Chemistry, Peptide Fragments, Sulfonamide, Enzyme Activation, Disease Models, Animal, Enzyme, chemistry, Cyclization, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4530442dde753492e41fe201dfd13f54
https://doi.org/10.1016/j.bmcl.2011.03.094

المؤلفون: Haiqun Tang, Robert Mazzola, Duane A. Burnett, William J. Greenlee, Jean E. Lachowicz, Hongtao Zhang, Yuanzan Ye, Michelle Smith, Ahmad Fawzi, Zhaoning Zhu, Jing Su, Li Qiang, Mckittrick Brian A, T.K. Sasikumar

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:836-840

مصطلحات موضوعية: SCH-23390, Chemistry, Stereochemistry, Receptors, Dopamine D1, Organic Chemistry, Clinical Biochemistry, Dopamine antagonist, Pharmaceutical Science, Benzazepines, Biochemistry, Chemical synthesis, Rats, Benzazepine, chemistry.chemical_compound, Dopamine receptor D1, Dopamine, Dopamine receptor, Drug Discovery, medicine, Animals, Dopamine Antagonists, Molecular Medicine, Derivatization, Molecular Biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d019dacb2a7c725ab3c978b6558861
https://doi.org/10.1016/j.bmcl.2009.12.100

المؤلفون: Haiqun Tang, Debashis Ganguly, Michael John Rodriguez

المصدر: Synthetic Communications. 37:4219-4226

مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, chemistry, Stereochemistry, Yield (chemistry), Aryl, Caesium, Organic Chemistry, Thio, chemistry.chemical_element, Carbonate, Medicinal chemistry, Alkyl

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a1d08b78a5d9fa849f3ffaee4e79083a
https://doi.org/10.1080/00397910701575129

المؤلفون: William J. Greenlee, Brian E. Hawes, John W. Clader, Brian D. Spar, Mckittrick Brian A, Qian Gang, Jing Su, Timothy J. Kowalski, Duane A. Burnett, Steve Sorota, Haiqun Tang, Huizhong Gu, Blair Weig, Tao Guo, Kim O’Neill

المصدر: Bioorganic & Medicinal Chemistry Letters. 17:4845-4850

مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, hERG, Drug Evaluation, Preclinical, Pharmaceutical Science, Biochemistry, Chemical synthesis, Heptanes, Mice, chemistry.chemical_compound, Drug Discovery, Animals, Hexanes, Humans, Obesity, Receptors, Somatostatin, cardiovascular diseases, Receptor, Molecular Biology, Heptane, Molecular Structure, biology, Bicyclic molecule, Organic Chemistry, Fishes, In vitro, Melanin-concentrating hormone receptor, Kinetics, Models, Chemical, chemistry, Drug Design, biology.protein, Molecular Medicine, Efflux

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8cbb9f7f732117e0e0e8f97fb3c415
https://doi.org/10.1016/j.bmcl.2007.06.048

المؤلفون: William J. Greenlee, Jing Su, Kim O’Neill, Duane A. Burnett, Cheng Li, Brian E. Hawes, Brian D. Spar, John W. Clader, Timothy J. Kowalski, Haiqun Tang, Tongtong Liu, Mckittrick Brian A, Steve Sorota, Blair Weig

المصدر: Bioorganic & Medicinal Chemistry. 15:5369-5385

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, hERG, Pharmaceutical Science, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Transcriptional Regulator ERG, Drug Discovery, Animals, Structure–activity relationship, Phenyl group, Receptors, Pituitary Hormone, Cycloheptanes, Receptor, Molecular Biology, Molecular Structure, biology, Bicyclic molecule, Chemistry, Organic Chemistry, Melanin-concentrating hormone receptor, DNA-Binding Proteins, Trans-Activators, biology.protein, Molecular Medicine, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1e3f9f66fb4ce3e8e80c4d8776d754
https://doi.org/10.1016/j.bmc.2007.05.068

المؤلفون: Ying Zhai, Ellen Xia, Lei Chen, Bandarpalle B. Shankar, Qingbei Zeng, Anilkumar G. Nair, Sony Agrawal, Ronald N. Buckle, Guowei Zhou, Kannan P. Naicker, John P. Caldwell, Ling Tong, Yueheng Jiang, Stuart B. Rosenblum, Wensheng Yu, Kerry Keertikar, Haiqun Tang, Seong Heon Kim, Rong Liu, De-Yi Yang, Paul Ingravallo, Gregory Scott Martin, Samuel A. Vellekoop, Melissa L. Allard, Christian L. Holst, Michael P. Dwyer, Amin A. Nomeir, Robert Mazzola, Polivina Jolicia F Gauuan, Joseph A. Kozlowski, Oleg Selyutin, Rong Kong

المصدر: Bioorganicmedicinal chemistry letters. 26(5)

مصطلحات موضوعية: 0301 basic medicine, Silylation, Genotype, Proline, viruses, Hepacivirus, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, Pharmacology, Viral Nonstructural Proteins, Virus Replication, 01 natural sciences, Biochemistry, Antiviral Agents, 03 medical and health sciences, Structure-Activity Relationship, Drug Discovery, Potency, Structure–activity relationship, NS5A, Molecular Biology, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Drug discovery, Organic Chemistry, virus diseases, biochemical phenomena, metabolism, and nutrition, Silanes, biology.organism_classification, digestive system diseases, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85586f1ce259c9e4c3146d6078489ecd
https://pubmed.ncbi.nlm.nih.gov/26850003

المؤلفون: Haiqun Tang, William J. Greenlee, Mckittrick Brian A, Michael Czarniecki, Brian E. Hawes, Kim O’Neill, Jing Su

المصدر: Bioorganic & Medicinal Chemistry. 13:1829-1836

مصطلحات موضوعية: Food intake, Magnetic Resonance Spectroscopy, Melanin-concentrating hormone, Chemistry, Organic Chemistry, Clinical Biochemistry, Antagonist, Pharmaceutical Science, Biological activity, Biochemistry, Chemical synthesis, Melanin-concentrating hormone receptor, Structure-Activity Relationship, chemistry.chemical_compound, Hormone Antagonists, Drug Discovery, Molecular Medicine, Receptors, Pituitary Hormone, Receptor, Molecular Biology, Throughput (business)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8fd0bb98001aebca724f134c3c1f0c
https://doi.org/10.1016/j.bmc.2004.11.046

المؤلفون: Sasikumar Thavalakulamgar K, Andrew T. McPhail, Ruo Xu, Lynn A. Hyde, Ted Asberom, Wen-Lian Wu, Jing Su, Duane A. Burnett, Haiqun Tang, Josien Hubert B, Tom Bara, Lili Zhang, Hongmei Li, Martin S. Domalski, Li Qiang, Zhiqiang Zhao, Mckittrick Brian A, Dmitri A. Pissarnitski, William J. Greenlee, Murali Rajagopalan, Chad Bennett, David Cole, Mcbriar Mark D, John W. Clader

المصدر: Bioorganicmedicinal chemistry letters. 20(8)

مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Biochemistry, Mice, In vivo, Drug Discovery, Potency, Animals, Sulfones, Receptor, Molecular Biology, Gamma secretase, chemistry.chemical_classification, Receptors, Notch, Organic Chemistry, In vitro, chemistry, Drug Design, Toxicity, Molecular Medicine, Amyloid Precursor Protein Secretases, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4811174cbfc257679dcdd4619def41f9
https://pubmed.ncbi.nlm.nih.gov/20236824

المؤلفون: Debashis Ganguly, Haiqun Tang, Michael John Rodriguez

المصدر: ChemInform. 39

مصطلحات موضوعية: chemistry.chemical_classification, Addition reaction, chemistry.chemical_compound, chemistry, Yield (chemistry), Caesium, Aryl, Thio, chemistry.chemical_element, Carbonate, General Medicine, Medicinal chemistry, Alkyl

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fa748b5cbe9b4d150da73c0c16a864b0
https://doi.org/10.1002/chin.200817200

المؤلفون: Jing Su, Duane A. Burnett, Jean E. Lachowicz, Ahmad Fawzi, Haiqun Tang, Hongtao Zhang, April Smith-Torhan, Mckittrick Brian A

المصدر: Bioorganicmedicinal chemistry letters. 16(17)

مصطلحات موضوعية: Molecular Structure, Chemistry, Stereochemistry, Receptors, Dopamine D2, Receptors, Dopamine D1, fungi, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Combinatorial chemistry, Dopamine D2 Receptor Antagonists, Structure-Activity Relationship, Drug Discovery, medicine, Molecular Medicine, Dopamine Antagonists, Molecular Biology, Clozapine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1efe735d25e66ec81fd5bc622aa68ae
https://pubmed.ncbi.nlm.nih.gov/16806922