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1
المؤلفون: Kesti, Ella, Borgmästars, Emmy, Hagström, Jaana, Mustonen, Harri, Seppänen, Hanna, Haglund, Caj, Sund, Malin
المصدر: Pancreas. 53(9):e729-e738
مصطلحات موضوعية: collagen VI, microarray, pancreatic cancer, tumor stroma
وصف الملف: electronic
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2
المؤلفون: Gkekas, Ioannis, 1981, Novotny, Jan, Kaprio, Tuomas, Beilmann-Lehtonen, Ines, Fabian, Pavel, Tavelin, Björn, Böckelman, Camilla, Edin, Sofia, Strigård, Karin, Svoboda, Tomas, Hagström, Jaana, Barsova, Lucie, Jirasek, Tomas, Haglund, Caj, Palmqvist, Richard, Gunnarsson, Ulf
المصدر: Journal of Surgical Oncology. 129(7):1295-1304
مصطلحات موضوعية: colorectal cancer, non-colorectal malignancy, sporadic deficient mismatch repair
وصف الملف: electronic
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3
المؤلفون: Hjortborg, Mats, Edin, Sofia, Böckelman, Camilla, Kaprio, Tuomas, Li, Xingru, Gkekas, Ioannis, 1981, Hagström, Jaana, Strigård, Karin, Haglund, Caj, Gunnarsson, Ulf, Palmqvist, Richard
المصدر: Scientific Reports. 14(1)
مصطلحات موضوعية: Colorectal cancer, Immunity, Mismatch repair, Prognosis, Systemic inflammatory response
وصف الملف: electronic
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4
المؤلفون: Bertonnier-Brouty, Ludivine, Andersson, Jonas, Kaprio, Tuomas, Hagström, Jaana, Bsharat, Sara, Asplund, Olof, Hatem, Gad, Haglund, Caj, Seppänen, Hanna, Prasad, Rashmi B, Artner, Isabella
المصدر: Cancer Medicine StemTherapy: National Initiative on Stem Cells for Regenerative Therapy EXODIAB: Excellence of Diabetes Research in Sweden. 13(9)
مصطلحات موضوعية: Humans, Carcinoma, Pancreatic Ductal/genetics, Pancreatic Neoplasms/genetics, Cell Proliferation, E2F1 Transcription Factor/metabolism, Cell Line, Tumor, Cell Movement/genetics, Apoptosis, Gene Expression Regulation, Neoplastic, Animals, Repressor Proteins/genetics, Cell Survival/genetics, Mice, Medicin och hälsovetenskap, Klinisk medicin, Cancer och onkologi, Medical and Health Sciences, Clinical Medicine, Cancer and Oncology, Medicinska och farmaceutiska grundvetenskaper, Cell- och molekylärbiologi, Basic Medicine, Cell and Molecular Biology
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5Academic Journal
المؤلفون: Jauhiainen, Maria K., Pyöriä, Lari, Viitasalo, Sanna, Mohanraj, Ushanandini, Aaltonen, Leena‐Maija, Söderlund‐Venermo, Maria, Hagström, Jaana, Mäkitie, Antti A., Perdomo, Maria F., Sinkkonen, Saku T.
المساهمون: Helsingin ja Uudenmaan Sairaanhoitopiiri, Finska Läkaresällskapet, Suomen Lääketieteen Säätiö, Sigrid Juséliuksen Säätiö
المصدر: The Laryngoscope ; volume 135, issue 2, page 677-686 ; ISSN 0023-852X 1531-4995
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6Academic Journal
المؤلفون: Saraneva, Orvokki, Furuholm, Jussi, Hagström, Jaana, Sorsa, Timo, Rita, Ville, Tervahartiala, Taina, Välimaa, Hannamari, Ruokonen, Hellevi
المساهمون: Helsingin ja Uudenmaan Sairaanhoitopiiri
المصدر: Oral Diseases ; ISSN 1354-523X 1601-0825
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7Academic Journal
المؤلفون: Jauhiainen, Maria K., Markkanen, Anttoni, Atula, Timo, Aro, Katri, Haglund, Caj, Söderlund‐Venermo, Maria, Mäkitie, Antti A., Sinkkonen, Saku T., Hagström, Jaana
المصدر: APMIS ; volume 133, issue 1 ; ISSN 0903-4641 1600-0463
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8Academic Journal
المؤلفون: Brodkin, Jefim, Kaprio, Tuomas, Hagström, Jaana, Leppä, Alli, Kokkola, Arto, Haglund, Caj, Böckelman, Camilla
المساهمون: University of Helsinki
المصدر: BMC Cancer ; volume 24, issue 1 ; ISSN 1471-2407
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9Academic Journal
المؤلفون: Pakkanen, Pihla, Silvoniemi, Antti, Aro, Katri, Bäck, Leif, Irjala, Heikki, Aaltonen, Leena-Maija, Hagström, Jaana, Haglund, Caj, Laine, Jukka, Minn, Heikki, Huvila, Jutta
المساهمون: HUS Head and Neck Center, Korva-, nenä- ja kurkkutautien klinikka, University of Helsinki, Clinicum, HUSLAB, Department of Pathology, CAN-PRO - Translational Cancer Medicine Program, Faculty of Medicine, HUS Abdominal Center, II kirurgian klinikka, Department of Surgery
مصطلحات موضوعية: HPV-associated, p16, HPV-independent, Head and neck SCC, p53, Otorhinolaryngology, ophthalmology
وصف الملف: application/pdf
Relation: This work was funded by Helsinki University Hospital Research Funds (LMA), The Finnish Medical Foundation (AS), Cancer Society of Finland and Finnish Government Research Funding (MH). Roche provided the FoundationOne CDx test assays. The authors cordially thank Roche for offering the FoundationOne\u00AE CDx test assays for the study. Mikko Myllynen has been of invaluable help in test logistics.; The authors cordially thank Roche for offering the FoundationOne (R) CDx test assays for the study. Mikko Myllynen has been of invaluable help in test logistics.; http://hdl.handle.net/10138/584682; 85200674141; 001285778500001
الاتاحة: http://hdl.handle.net/10138/584682
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10Academic Journal
المؤلفون: Rytkönen, Aleksi, Laine, Hanna K., Mäkitie, Antti, Haglund, Caj, Hagström, Jaana, Almangush, Alhadi, Leivo, Ilmo
المساهمون: Department of Oral and Maxillofacial Diseases, University of Helsinki, HUS Head and Neck Center, Clinicum, Korva-, nenä- ja kurkkutautien klinikka, Research Program in Systems Oncology, Faculty of Medicine, HUS Abdominal Center, II kirurgian klinikka, Department of Surgery, Research Programs Unit, CAN-PRO - Translational Cancer Medicine Program, HUSLAB, Medicum, Department of Pathology
مصطلحات موضوعية: adenoid cystic carcinoma, survival, tumor budding, tumor-infiltrating lymphocytes, tumor-stroma ratio, Otorhinolaryngology, ophthalmology
وصف الملف: application/pdf
Relation: This study was funded by L\u00E4kares\u00E4llskapet, the Finnish Cancer Society, Turku University Hospital Fund, Maritza and Reino Salonen Foundation. Funding; http://hdl.handle.net/10138/588172; 85208794286
الاتاحة: http://hdl.handle.net/10138/588172
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11Academic Journal
المؤلفون: Punovuori, Karolina, Bertillot, Fabien, Miroshnikova, Yekaterina A., Binner, Mirjam I., Myllymäki, Satu-Marja, Follain, Gautier, Kruse, Kai, Routila, Johannes, Huusko, Teemu, Pellinen, Teijo, Hagström, Jaana, Kedei, Noemi, Ventelä, Sami, Mäkitie, Antti, Ivaska, Johanna, Wickström, Sara A.
المساهمون: STEMM - Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki Institute of Life Science HiLIFE, Research Programs Unit, Institute for Molecular Medicine Finland, Precision Systems Medicine, HUSLAB, HUS Head and Neck Center, Department of Pathology, CAN-PRO - Translational Cancer Medicine Program, Clinicum, Korva-, nenä- ja kurkkutautien klinikka, Research Program in Systems Oncology
مصطلحات موضوعية: cancer, cancer biomarker, cancer stem cell, epithelial-to-mesenchyme-transition, Biomedicine, Cancers
وصف الملف: application/pdf
Relation: We thank Franziska Peters, Hanne Ahola, and Manuela Haustein for help with experiments; Blanca Majem for advice on transplantation experiments; Elisa Piccinini for patient sample collection; Annabrita Schoonenberg, Anette Holmstr\u00F6m, and Antti Hassinen from the Institute for Molecular Medicine Finland (FIMM); the Max Planck Institute sequencing core facility; histology core facility of the Institute of Biomedicine, University of Turku; and Institute for Molecular Medicine Finland FIMM Genomics Unit for support with experiments. This work was supported by the Orion Foundation (to K.P.), Research Council of Finland (332402) and Turku Collegium for Science Medicine and Technologies postdoctoral grants (to G.F.), the Finnish Cancer Institute (K. Albin Johansson Professorship, to J.I.), Academy of Finland Center of Excellence BarrierForce (#346131 to J.I. and S.A.W.), Academy of Finland Molecular Regulatory Networks of Life (#330033, NucleoMech; to A.M., J.I., and S.A.W.), and the Sigrid Juselius Foundation, Helsinki Institute of Life Science, Wihuri Research Institute, Business Finland R2B, and the Max Planck Society (all to S.A.W.).; http://hdl.handle.net/10138/587748; 85207780386
الاتاحة: http://hdl.handle.net/10138/587748
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12Academic Journal
المؤلفون: Rusanen, Peter, Marttila, Emilia, Amatya, Sajeen Bahadur, Hagström, Jaana, Uittamo, Johanna, Reunanen, Justus, Rautemaa-Richardson , Riina, Salo, Tuula
المصدر: Rusanen , P , Marttila , E , Amatya , S B , Hagström , J , Uittamo , J , Reunanen , J , Rautemaa-Richardson , R & Salo , T 2024 , ' Expression Of Toll-like Receptors In Oral Squamous Cell Carcinoma ' , PL o S One . https://doi.org/10.1371/journal.pone.0300437
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13Academic Journal
المؤلفون: Rytkönen, Aleksi, Eray, Mine, Suominen, Auli, Mäkitie, Antti, Haglund, Caj, Hagström, Jaana, Laine, Hanna K.
المساهمون: HUSLAB, Department of Pathology, HUS Diagnostic Center, HUS Head and Neck Center, Clinicum, Korva-, nenä- ja kurkkutautien klinikka, Research Program in Systems Oncology, HUS Abdominal Center, II kirurgian klinikka, Department of Surgery, Research Programs Unit, Department of Oral and Maxillofacial Diseases
مصطلحات موضوعية: Adenoid cystic carcinoma, Immunohistochemistry, Prognosis, Toll-like receptor, Cancers
وصف الملف: application/pdf
Relation: This study was supported by the Helsinki University Hospital Research Fund and the Cancer Foundation Finland . Open access funded by Helsinki University Library .; Rytkönen , A , Eray , M , Suominen , A , Mäkitie , A , Haglund , C , Hagström , J & Laine , H K 2024 , ' Immunoexpression pattern of TLR3 and TLR7 in minor salivary gland adenoid cystic carcinoma and its role in prognosis ' , Cancer Treatment and Research Communications , vol. 40 , 100822 . https://doi.org/10.1016/j.ctarc.2024.100822; ORCID: /0000-0001-6079-7881/work/161252486; ORCID: /0000-0001-8156-6820/work/161255339; http://hdl.handle.net/10138/576656; 80cbb7f6-c17c-4165-b633-fe8ca2aa273c; 85194200771
الاتاحة: http://hdl.handle.net/10138/576656
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14Academic Journal
المؤلفون: Sjöblom, Anni, Carpen, Timo, Stenman, Ulf-Håkan, Jouhi, Lauri, Haglund, Caj, Syrjänen, Stina, Mattila, Petri, Mäkitie, Antti, Hagström, Jaana
المساهمون: HUSLAB, Department of Pathology, Clinicum, Medicum, HUS Head and Neck Center, Korva-, nenä- ja kurkkutautien klinikka, Research Program in Systems Oncology, Department of Clinical Chemistry and Hematology, HUS Abdominal Center, II kirurgian klinikka, Department of Surgery, Research Programs Unit, CAN-PRO - Translational Cancer Medicine Program
وصف الملف: application/pdf
Relation: Sjöblom , A , Carpen , T , Stenman , U-H , Jouhi , L , Haglund , C , Syrjänen , S , Mattila , P , Mäkitie , A & Hagström , J 2022 , ' The Role of Human Chorionic Gonadotropin Beta (hCG beta) in HPV-Positive and HPV-Negative Oropharyngeal Squamous Cell Carcinoma ' , Cancers , vol. 14 , no. 12 . https://doi.org/10.3390/cancers14122830; ORCID: /0000-0001-6079-7881/work/128026471; ORCID: /0000-0003-1740-4346/work/146911071; ORCID: /0000-0003-0117-8559/work/155520868; http://hdl.handle.net/10138/572218; ba7d3b9d-d8b8-4608-8c94-26c75ab952c7; 000816047600001
الاتاحة: http://hdl.handle.net/10138/572218
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15Academic Journal
المؤلفون: Pehkonen, Henna, Filippou, Artemis, Väänänen, Juho, Lindfors, Iida, Vänttinen, Mira, Ianevski, Philipp, Mäkelä, Anne, Munne, Pauliina, Klefström, Juha, Toppila-Salmi, Sanna, Grenman, Reidar, Hagström, Jaana, Mäkitie, Antti A., Karhemo, Piia-Riitta, Monni, Outi
المساهمون: Research Programs Unit, ATG - Applied Tumor Genomics, Institute for Molecular Medicine Finland, CAN-PRO - Translational Cancer Medicine Program, Digital Precision Cancer Medicine (iCAN), HUS Inflammation Center, Department of Pathology, Department of Dermatology, Allergology and Venereology, Clinicum, HUSLAB, HUS Head and Neck Center, Korva-, nenä- ja kurkkutautien klinikka, Research Program in Systems Oncology, Department of Oncology, HUS Comprehensive Cancer Center
مصطلحات موضوعية: MEK/ERK inhibitor, MEK/ERK signaling pathway, Ras, Drug screen, Head and neck squamous cell carcinoma, Liprin-alpha 1, Cancers
وصف الملف: application/pdf
Relation: HiLIFE research infrastructures namely Biomedicum Functional Genomics Unit, Finnish Genome Editing Center (FinGEEC), Biomedicum Imaging Unit, Genome Biology Unit, and High-Throughput Biomedicine Unit at the Helsinki Institute of Life Science and Biocenter Finland, University of Helsinki, Finland are thanked for excellent technical support. Dr Topi Tervonen is thanked for his crucial advice in RAS-related experiments. Dr Evgeni Kulesskiy and Dr Jani Saarela are thanked for excellent technical support in drug screening and data analysis at the Finnish Institute for Molecular Medicine, Finland. Cancer Foundation Finland, The Finnish Cultural Foundation, Luise & Henrik Kuningas Foundation, Ida Montin Foundation, The Finnish ORL-HNS Foundation, Helsinki University Hospital Research Funding, and Jane and Aatos Erkko Foundation are thanked for their financial support to this work. The graphical abstract have been created with .; Pehkonen , H , Filippou , A , Väänänen , J , Lindfors , I , Vänttinen , M , Ianevski , P , Mäkelä , A , Munne , P , Klefström , J , Toppila-Salmi , S , Grenman , R , Hagström , J , Mäkitie , A A , Karhemo , P-R & Monni , O 2024 , ' Liprin-α1 contributes to oncogenic MAPK signaling by counteracting ERK activity ' , Molecular oncology , vol. 18 , no. 3 , pp. 662-676 . https://doi.org/10.1002/1878-0261.13593; ORCID: /0000-0002-9720-9964/work/156645874; ORCID: /0000-0003-0890-6686/work/156646335; ORCID: /0000-0002-4106-1059/work/156647029; ORCID: /0000-0001-6079-7881/work/156647586; http://hdl.handle.net/10138/573595; f82d0a67-3d3b-4a05-80b3-e1090f3c2ee6; 001148095200001
الاتاحة: http://hdl.handle.net/10138/573595
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16Academic Journal
المؤلفون: Silvoniemi, Antti, Laine, Jukka, Aro, Katri, Nissi, Linda, Bäck, Leif, Schildt, Jukka, Hirvonen, Jussi, Hagström, Jaana, Irjala, Heikki, Aaltonen, Leena-Maija, Seppänen, Marko
المساهمون: HUS Head and Neck Center, Korva-, nenä- ja kurkkutautien klinikka, Clinicum, Helsinki University Hospital Area, HUS Medical Imaging Center, Department of Diagnostics and Therapeutics, HUS Diagnostic Center, HUSLAB, Medicum, Department of Pathology
مصطلحات موضوعية: Ct, Fdg-pet, cfDNA, circulating tumor DNA, ctDNA, Head and neck cancer, Liquid biopsy, Metabolic tumor volume, Next-generation sequencing, Total lesion glycolysis, Variant allele frequency, Cancers
وصف الملف: application/pdf
Relation: http://hdl.handle.net/10138/572868; 85167828295; 001045452700001
الاتاحة: http://hdl.handle.net/10138/572868
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17Academic Journal
المؤلفون: Pakkanen, Pihla, Ilmarinen, Taru, Halme, Elina, Irjala, Heikki, Koivunen, Petri, Pukkila, Matti, Ventela, Sami, Almangush, Alhadi, Birkman, Eva-Maria, Lindgren, Outi, Pohjolainen, Virva, Sjöblom, Nelli, Haglund, Caj, Hagström, Jaana, Aaltonen, Leena-Maija
المساهمون: Clinicum, HUS Head and Neck Center, Korva-, nenä- ja kurkkutautien klinikka, Faculty Common Matters (Faculty of Medicine), Department of Pathology, Medicum, HUSLAB, HUS Abdominal Center, II kirurgian klinikka, Department of Surgery
مصطلحات موضوعية: Early laryngeal cancer, Prognosis, Programmed death-ligand 1, T1 glottic cancer, Tumor-infiltrating lymphocytes, Otorhinolaryngology, ophthalmology
وصف الملف: application/pdf
Relation: Pakkanen , P , Ilmarinen , T , Halme , E , Irjala , H , Koivunen , P , Pukkila , M , Ventela , S , Almangush , A , Birkman , E-M , Lindgren , O , Pohjolainen , V , Sjöblom , N , Haglund , C , Hagström , J & Aaltonen , L-M 2023 , ' Programmed death-ligand 1 and tumor-infiltrating lymphocytes (TILs) - low TIL density may predict poorer long-term prognosis in T1 laryngeal cancer ' , Virchows Archiv . https://doi.org/10.1007/s00428-023-03586-7; ORCID: /0000-0002-3360-6645/work/154554000; ORCID: /0000-0001-6079-7881/work/154556051; http://hdl.handle.net/10138/571743; ee15c004-48ea-4e57-896f-2148764a70f7; 001031529300001
الاتاحة: http://hdl.handle.net/10138/571743
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18Academic Journal
المؤلفون: Almangush, Alhadi, Hagström, Jaana, Haglund, Caj, Kowalski, Luiz Paulo, Coletta, Ricardo D., Mäkitie, Antti A., Salo, Tuula, Leivo, Ilmo
المساهمون: Department of Pathology, Research Program in Systems Oncology, HUSLAB, Research Programs Unit, CAN-PRO - Translational Cancer Medicine Program, HUS Abdominal Center, II kirurgian klinikka, Department of Surgery, Clinicum, HUS Head and Neck Center, Korva-, nenä- ja kurkkutautien klinikka, Department of Oral and Maxillofacial Diseases
مصطلحات موضوعية: Early stage, Large nuclei, Oral tongue cancer, Single cell invasion, Survival, Otorhinolaryngology, ophthalmology, Cancers
وصف الملف: application/pdf
Relation: This study was funded by Finnish Cancer Society, the Turku University Hospital Fund, Finska Läkaresällskapet, Maritza and Reino Salonen Foundation, K. Albin Johansson Foundation, the Finnish Dental Society Apollonia, the Helsinki University Hospital Research Fund, and the Sigrid Jusélius Foundation. The funders took no part in the design or performance of the study. Funding consists of academic grants without any engagements considering the research project.; Almangush , A , Hagström , J , Haglund , C , Kowalski , L P , Coletta , R D , Mäkitie , A A , Salo , T & Leivo , I 2024 , ' The prognostic role of single cell invasion and nuclear diameter in early oral tongue squamous cell carcinoma ' , BMC Cancer , vol. 24 , no. 1 , 213 . https://doi.org/10.1186/s12885-024-11954-y; ORCID: /0000-0001-6079-7881/work/154556052; ORCID: /0000-0001-6039-0088/work/154559970; http://hdl.handle.net/10138/572041; a0672abc-4292-4154-99ce-86d7a2a68eaf; 85185242161; 001163310100004
الاتاحة: http://hdl.handle.net/10138/572041
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19Academic Journal
المؤلفون: Keski-Säntti, Noora, Waltimo, Elin, Mäkitie, Antti, Hagström, Jaana, Söderlund-Venermo, Maria, Atula, Timo, Haglund, Caj, Sinkkonen, Saku T., Jauhiainen, Maria
المساهمون: Department of Virology, HUS Head and Neck Center, Korva-, nenä- ja kurkkutautien klinikka, Department of Oral and Maxillofacial Diseases, Clinicum, Research Program in Systems Oncology, HUSLAB, Department of Pathology, Research Programs Unit, CAN-PRO - Translational Cancer Medicine Program, Human Parvoviruses: Epidemiology, Molecular Biology and Clinical Impact, HUS Abdominal Center, II kirurgian klinikka, Department of Surgery
مصطلحات موضوعية: Chronic sialadenitis, DNA viruses, immunoglobulin G4 related disease, Polymerase chain reaction, Sialolithiasis, Biomedicine, 11832 Microbiology and virology
وصف الملف: application/pdf
Relation: Open access funded by Helsinki University Library. This study recieved funding by the Finnish State Research Funding for the Helsinki University Hospital (references TYH2021338 and TYH2024327), and Finska L\u00E4kares\u00E4llskapet.; Keski-Säntti , N , Waltimo , E , Mäkitie , A , Hagström , J , Söderlund-Venermo , M , Atula , T , Haglund , C , Sinkkonen , S T & Jauhiainen , M 2024 , ' Viral DNA in submandibular gland tissue with an inflammatory disorder ' , Journal of Oral Microbiology , vol. 16 , no. 1 , 2345941 . https://doi.org/10.1080/20002297.2024.2345941; ORCID: /0000-0001-6079-7881/work/159900417; ORCID: /0000-0002-4582-8317/work/159900838; ORCID: /0000-0002-6560-1128/work/159903126; http://hdl.handle.net/10138/575321; 34032361-34ce-4ccb-94f5-4dbd75e55741; 85191392043; 001208638500001
الاتاحة: http://hdl.handle.net/10138/575321
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20Academic Journal
المؤلفون: Kasurinen, Jussi, Beilmann-Lehtonen, Ines, Kaprio, Tuomas, Hagström, Jaana, Haglund, Caj, Böckelman, Camilla
المساهمون: Research Programs Unit, CAN-PRO - Translational Cancer Medicine Program, Department of Surgery, Clinicum, HUS Helsinki and Uusimaa Hospital District, HUSLAB, HUS Head and Neck Center, Medicum, HUS Abdominal Center, II kirurgian klinikka
مصطلحات موضوعية: Cms, Phenotypic subtype, Colon cancer, Colorectal cancer, Consensus molecular subtypes, Immunohistochemistry, Rectal cancer, Cancers
وصف الملف: application/pdf
Relation: http://hdl.handle.net/10138/572290; 85149515642; 000943409200001
الاتاحة: http://hdl.handle.net/10138/572290