المؤلفون: Patarrão, Rita S.¹ (AUTHOR), Meneses, Maria João¹ (AUTHOR), Ghadieh, Hilda E.^2,3 (AUTHOR), Herrera, Laura^1,4 (AUTHOR), Duarte, Sérgio⁵ (AUTHOR), Ribeiro, Rogério T.⁴ (AUTHOR), Raposo, João F.^1,4,6 (AUTHOR), Schmitt, Verena⁷ (AUTHOR), Singer, Bernhard B.⁷ (AUTHOR), Gastaldelli, Amalia⁸ (AUTHOR), Penha‐Gonçalves, Carlos⁴ (AUTHOR), Najjar, Sonia M.^2,9 (AUTHOR) najjar@ohio.edu, Macedo, M. Paula^1,4 (AUTHOR) paula.macedo@nms.unl.pt

المصدر: European Journal of Clinical Investigation. Dec2024 Supplement 1, Vol. 54, p1-11. 11p.

مصطلحات موضوعية: *HYPERINSULINISM, *TYPE 2 diabetes, *INSULIN resistance, *FATTY liver, *METABOLIC disorders

المساهمون: Miguel Pampaloni, Associate Professor of Radiology & Medicine

المصدر: 18F-Fluoro-L- DOPA PET Imaging for the Detection and Localization of Focal Congenital Hyperinsulinism

المصدر: A Phase 2, Multiple Ascending Dose, Open-label, Proof-of-concept Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of HM15136 (Efpegerglucagon) Treatment for 8 Weeks in Subjects Aged ≥2 Years With Congenital Hyperinsulinism (CHI)

المؤلفون: Chatterjee, Subhankar¹ (AUTHOR), Bhattacharjee, Rana¹ (AUTHOR) dr.r.bhatta@gmail.com, Ghosh, Ritwik² (AUTHOR), Chakraborty, Partha P.¹ (AUTHOR), Sinha, Anirban¹ (AUTHOR), Maiti, Animesh¹ (AUTHOR)

المصدر: Indian Journal of Endocrinology & Metabolism. Nov/Dec2024, Vol. 28 Issue 6, p554-561. 8p.

مصطلحات موضوعية: *HYPERINSULINISM, *TYPE 2 diabetes, *DELAYED diagnosis, *BLOOD sugar, *INSULINOMA

المؤلفون: Mitteer, Lauren M^1,2 (AUTHOR), States, Lisa^2,3 (AUTHOR), Bhatti, Tricia^2,4 (AUTHOR), Adzick, N Scott^2,5 (AUTHOR), Lord, Katherine^1,2,6 (AUTHOR), León, Diva D De^1,2,6 (AUTHOR) deleon@chop.edu

المصدر: JCEM Case Reports. Sep2024, Vol. 2 Issue 9, p1-5. 5p.

مصطلحات موضوعية: *HEALTH facilities, *HYPERINSULINISM, *GENETIC testing, *HYPOGLYCEMIA, *HOSPITAL emergency services, *INSULINOMA

المصدر: Hyperinsulinemia in Prediabetes Mediated by Interleukin-1β- The Hyper-PreDIL-Study

المصدر: Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

المؤلفون: Yakult Honsha Co., LTD

المصدر: Effect of the Replacement of Glycaemic Carbohydrates With Galacto-Oligosaccharide (GOS) Supplementation on Postprandial Glycaemic Response in Healthy Adults
Venn BJ, Green TJ. Glycemic index and glycemic load: measurement issues and their effect on diet-disease relationships. Eur J Clin Nutr. 2007 Dec;61 Suppl 1:S122-31. doi: 10.1038/sj.ejcn.1602942.
Wright E Jr, Scism-Bacon JL, Glass LC. Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia. Int J Clin Pract. 2006 Mar;60(3):308-14. doi: 10.1111/j.1368-5031.2006.00825.x.
Blaak EE, Antoine JM, Benton D, Bjorck I, Bozzetto L, Brouns F, Diamant M, Dye L, Hulshof T, Holst JJ, Lamport DJ, Laville M, Lawton CL, Meheust A, Nilson A, Normand S, Rivellese AA, Theis S, Torekov SS, Vinoy S. Impact of postprandial glycaemia on health and prevention of disease. Obes Rev. 2012 Oct;13(10):923-84. doi: 10.1111/j.1467-789X.2012.01011.x. Epub 2012 Jul 11.
Neri S, Calvagno S, Mauceri B, Misseri M, Tsami A, Vecchio C, Mastrosimone G, Di Pino A, Maiorca D, Judica A, Romano G, Rizzotto A, Signorelli SS. Effects of antioxidants on postprandial oxidative stress and endothelial dysfunction in subjects with impaired glucose tolerance and type 2 diabetes. Eur J Nutr. 2010 Oct;49(7):409-16. doi: 10.1007/s00394-010-0099-6. Epub 2010 Mar 7.
Bonora E. Postprandial peaks as a risk factor for cardiovascular disease: epidemiological perspectives. Int J Clin Pract Suppl. 2002 Jul;(129):5-11.
Levitan EB, Song Y, Ford ES, Liu S. Is nondiabetic hyperglycemia a risk factor for cardiovascular disease? A meta-analysis of prospective studies. Arch Intern Med. 2004 Oct 25;164(19):2147-55. doi: 10.1001/archinte.164.19.2147.
Lin PJ, Borer KT. Third Exposure to a Reduced Carbohydrate Meal Lowers Evening Postprandial Insulin and GIP Responses and HOMA-IR Estimate of Insulin Resistance. PLoS One. 2016 Oct 31;11(10):e0165378. doi: 10.1371/journal.pone.0165378. eCollection 2016.
Hinnen DA. Therapeutic Options for the Management of Postprandial Glucose in Patients With Type 2 Diabetes on Basal Insulin. Clin Diabetes. 2015 Oct;33(4):175-80. doi: 10.2337/diaclin.33.4.175.
Kamruzzaman M, Horowitz M, Jones KL, Marathe CS. Gut-Based Strategies to Reduce Postprandial Glycaemia in Type 2 Diabetes. Front Endocrinol (Lausanne). 2021 Apr 9;12:661877. doi: 10.3389/fendo.2021.661877. eCollection 2021.
Gill SK, Rossi M, Bajka B, Whelan K. Dietary fibre in gastrointestinal health and disease. Nat Rev Gastroenterol Hepatol. 2021 Feb;18(2):101-116. doi: 10.1038/s41575-020-00375-4. Epub 2020 Nov 18.
Jenkins DJ, Goff DV, Leeds AR, Alberti KG, Wolever TM, Gassull MA, Hockaday TD. Unabsorbable carbohydrates and diabetes: Decreased post-prandial hyperglycaemia. Lancet. 1976 Jul 24;2(7978):172-4. doi: 10.1016/s0140-6736(76)92346-1.
Bonsu NKA, Johnson S. Effects of inulin fibre supplementation on serum glucose and lipid concentration in patients with type 2 diabetes. International Journal of Diabetes and Metabolism. 2012 12;20(3):80-6. doi: 10.1159/000497730.
Dehghan P, Pourghassem Gargari B, Asgharijafarabadi M. Effects of high performance inulin supplementation on glycemic status and lipid profile in women with type 2 diabetes: a randomized, placebo-controlled clinical trial. Health Promot Perspect. 2013 Jun 30;3(1):55-63. doi: 10.5681/hpp.2013.007. eCollection 2013.
Luo J, Van Yperselle M, Rizkalla SW, Rossi F, Bornet FR, Slama G. Chronic consumption of short-chain fructooligosaccharides does not affect basal hepatic glucose production or insulin resistance in type 2 diabetics. J Nutr. 2000 Jun;130(6):1572-7. doi: 10.1093/jn/130.6.1572.
Gargari BP, Namazi N, Khalili M, Sarmadi B, Jafarabadi MA, Dehghan P. Is there any place for resistant starch, as alimentary prebiotic, for patients with type 2 diabetes? Complement Ther Med. 2015 Dec;23(6):810-5. doi: 10.1016/j.ctim.2015.09.005. Epub 2015 Sep 16.
Liu F, Li P, Chen M, Luo Y, Prabhakar M, Zheng H, He Y, Qi Q, Long H, Zhang Y, Sheng H, Zhou H. Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Increase Bifidobacterium but Reduce Butyrate Producing Bacteria with Adverse Glycemic Metabolism in healthy young population. Sci Rep. 2017 Sep 18;7(1):11789. doi: 10.1038/s41598-017-10722-2.
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المؤلفون: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of Pisa

المساهمون: Joshua Cook, Assistant Professor of Medicine

المصدر: Human Models of Selective Insulin Resistance: Graded Insulin Suppression Test (GIST) Pilot & Feasibility Study

المساهمون: Justin Gregory, Assistant Professor of Pediatric Endocrinology

المصدر: Cardiometabolic Benefit of Reducing Iatrogenic Hyperinsulinemia Using Insulin Adjunctive Therapy in Type 1 Diabetes

المؤلفون: Royal Devon University Healthcare NHS Foundation Trust

المصدر: Understanding Beta Cell Disorders Through the Study of Rare Genotypes (ENDURE)
Gupsilonemes M, Rahman SA, Kapoor RR, Flanagan S, Houghton JAL, Misra S, Oliver N, Dattani MT, Shah P. Hyperinsulinemic hypoglycemia in children and adolescents: Recent advances in understanding of pathophysiology and management. Rev Endocr Metab Disord. 2020 Dec;21(4):577-597. doi: 10.1007/s11154-020-09548-7.
De Franco E. From Biology to Genes and Back Again: Gene Discovery for Monogenic Forms of Beta-Cell Dysfunction in Diabetes. J Mol Biol. 2020 Mar 6;432(5):1535-1550. doi: 10.1016/j.jmb.2019.08.016. Epub 2019 Aug 31.
Hughes AE, De Franco E, Freathy RM; Fetal Insulin and Growth Consortium; Flanagan SE, Hattersley AT. Monogenic disease analysis establishes that fetal insulin accounts for half of human fetal growth. J Clin Invest. 2023 Mar 15;133(6):e165402. doi: 10.1172/JCI165402. No abstract available.
Wilman HR, Kelly M, Garratt S, Matthews PM, Milanesi M, Herlihy A, Gyngell M, Neubauer S, Bell JD, Banerjee R, Thomas EL. Correction: Characterisation of liver fat in the UK Biobank cohort. PLoS One. 2017 Apr 26;12(4):e0176867. doi: 10.1371/journal.pone.0176867. eCollection 2017.

المؤلفون: University of California, Berkeley, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

المساهمون: Joshua Cook, Assistant Professor of Medicine

المصدر: Human Models of Selective Insulin Resistance: Pancreatic Clamp

المؤلفون: University of California, Berkeley, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

المساهمون: Joshua Cook, Assistant Professor of Medicine

المصدر: Role of Hyperinsulinemia in Non-Alcoholic Fatty Liver Disease (NAFLD) Pathogenesis: Diazoxide Pilot & Feasibility Study

المؤلفون: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of Pisa

المساهمون: Joshua Cook, Assistant Professor of Medicine

المصدر: Human Models of Primary Hyperinsulinemia: Diazoxide Suppression Test (DzST) Pilot & Feasibility Study

المؤلفون: American Diabetes Association

المساهمون: Tracey McLaughlin, Professor of Medicine, Endocrinology

المصدر: Role of Nutrient Transit and Incretin Hormones in Hyperinsulinemic Hypoglycemia

المساهمون: Tracey McLaughlin, Associate Professor of Medicine (Endocrinology)

المصدر: Subcutaneous Injection of Exendin (9-39) in Subjects With Hyperinsulinemic Hypoglycemia Post-Bariatric Surgery

المؤلفون: McKenna, Colleen F.¹, Stierwalt, Harrison D.², Berry, Karin A. Zemski¹, Ehrlicher, Sarah E.², Robinson, Matthew M.², Zarini, Simona¹, Kahn, Darcy E.¹, Snell-Bergeon, Janet K.¹, Perreault, Leigh¹, Bergman, Bryan C.¹ bryan.bergman@cuanschutz.edu, Newsom, Sean A.² sean.newsom@oregonstate.edu

المصدر: American Journal of Physiology: Endocrinology & Metabolism. Aug2024, Vol. 327 Issue 2, pE183-E193. 11p.

مصطلحات موضوعية: *HYPERINSULINISM, *INSULIN, *PHENOTYPES, *TYPE 2 diabetes, *INSULIN sensitivity, *FATTY acid oxidation

المؤلفون: Kahlon, Harsh¹, Stanley, Joshua R.^2,3, Lineen, Cillian^2,3, Lam, Carol^2,3 carol.lam@sickkids.ca

المصدر: JCEM Case Reports. Jul2024, Vol. 2 Issue 7, p1-4. 4p.

مصطلحات موضوعية: *ACUTE kidney failure, *HYPERINSULINISM, *ACIDOSIS, *INSULIN therapy, *HOSPITAL administration

المؤلفون: Gupta, Setu¹ (AUTHOR), Goyal, Alpesh¹ (AUTHOR), Kandasamy, Devasenathipathy² (AUTHOR), Agarwal, Shipra³ (AUTHOR), Damle, Nishikant⁴ (AUTHOR), Pal, Sujoy⁵ (AUTHOR), Tandon, Nikhil¹ (AUTHOR), Jyotsna, Viveka P.¹ (AUTHOR) vivekapjyotsna@gmail.com

المصدر: Indian Journal of Endocrinology & Metabolism. Jul/Aug2024, Vol. 28 Issue 4, p363-369. 7p.

مصطلحات موضوعية: *HYPERINSULINISM, *POSITRON emission tomography, *ENDOSCOPIC ultrasonography, *OPERATIVE ultrasonography, *BLOOD sugar, *PANCREATIC beta cells

المؤلفون: National Center for Advancing Translational Sciences (NCATS)

المصدر: Reprometabolic Syndrome Mediates Subfertility in Obesity
Santoro N, Schauer IE, Kuhn K, Fought AJ, Babcock-Gilbert S, Bradford AP. Gonadotropin response to insulin and lipid infusion reproduces the reprometabolic syndrome of obesity in eumenorrheic lean women: a randomized crossover trial. Fertil Steril. 2021 Aug;116(2):566-574. doi: 10.1016/j.fertnstert.2021.03.005. Epub 2021 Apr 8.