المؤلفون: Woo Seon Choi, Hyung‐Joon Kwon, Eunbi Yi, Haeun Lee, Jung Min Kim, Hyo Jin Park, Eun Ji Choi, Myoung Eun Choi, Young Hoon Sung, Chong Hyun Won, Chang Ohk Sung, Hun Sik Kim

المصدر: Advanced Science, Vol 11, Iss 29, Pp n/a-n/a (2024)

مصطلحات موضوعية: HPK1, Dysfunction, Lung metastasis, Melanoma, Natural killer cell, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2198-3844

URL الوصول: https://doaj.org/article/96488816109f40e28e23097a63b02c67

المؤلفون: Dazhi Feng, Bo Liu, Zhiwei Chen, Jinyi Xu, Meiyu Geng, Wenhu Duan, Jing Ai, Hefeng Zhang

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Biotechnology, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, HPK1 inhibitor, machine learning, virtual screening, free energy perturbation, structural modification

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_hematopoietic_progenitor_kinase_1_inhibitors_using_machine_learning-based_screening_and_free_energy_perturbation/24975736

الاتاحة: https://doi.org/10.6084/m9.figshare.24975736.v1
https://figshare.com/articles/journal_contribution/Discovery_of_hematopoietic_progenitor_kinase_1_inhibitors_using_machine_learning-based_screening_and_free_energy_perturbation/24975736

المؤلفون: Chenghu Xie, Bo Liu, Zilan Song, Ye Yang, Mengdi Dai, Yinglei Gao, Yujia Yao, Chunyong Ding, Jing Ai, Ao Zhang

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Virology, Chemical Sciences not elsewhere classified, structural optimization approach, promising key target, improved iv profile, important negative regulator, effectively inhibited pslp76, classic immunosuppressive factors, isoindoline structural motif, enhanced aqueous solubility, 26 tumor model, 49 , 2 , cell activity mediated, reported hpk1 inhibitor, 50 , 5 nm ), cell receptor signaling, cell receptor, tumor microenvironment, tme ), synergistically enhanced, isoindoline analogues

Relation: https://figshare.com/articles/journal_contribution/Design_Synthesis_and_Pharmacological_Evaluation_of_Isoindoline_Analogues_as_New_HPK1_Inhibitors/24610083

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01571.s001
https://figshare.com/articles/journal_contribution/Design_Synthesis_and_Pharmacological_Evaluation_of_Isoindoline_Analogues_as_New_HPK1_Inhibitors/24610083

المؤلفون: Huizhen Ge, Chunchao Tang, Yiting Pan, Xiaojun Yao

المصدر: International Journal of Molecular Sciences, Vol 24, Iss 3, p 2649 (2023)

مصطلحات موضوعية: HPK1 inhibitor, selectivity mechanism, molecular dynamics simulation, binding free energy, umbrella sampling simulations, Biology (General), QH301-705.5, Chemistry, QD1-999

Relation: https://www.mdpi.com/1422-0067/24/3/2649; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/c67f4ea365be4db790b52a025e4f1a3a

الاتاحة: https://doi.org/10.3390/ijms24032649
https://doaj.org/article/c67f4ea365be4db790b52a025e4f1a3a

المؤلفون: Ming-Shu Wang (3506888), Zhi-Zheng Wang (6056033), Zi-Long Li (1715833), Yi Gong (160525), Cheng-Xiang Duan (14290641), Qian-Hui Cheng (14290644), Wei Huang (36889), Guang-Fu Yang (364659)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, human liver microsomes, clear synergistic effect, antitumor immune therapies, hpk1 homology protein, exhibited hpk1 inhibition, conformational constraint strategy, based hpk1 inhibitors, identified candidate compound, 5i , 5 , 50 , 2 , hpk1 inhibitor design, targeting hpk1, promising strategy, f <, >< sub, ‑ cell, results showed, positive regulator, negative regulator

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Macrocycle-Based_HPK1_Inhibitors_for_T_Cell-Based_Immunotherapy/21766431

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01551.s001

المؤلفون: Huizhen Ge, Lizeng Peng, Zhou Sun, Huanxiang Liu, Yulin Shen, Xiaojun Yao

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: HPK1 inhibitor, immunotherapy, virtual screening, molecular docking, molecular dynamics simulation, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.850855/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/0318b5858d3a442191b09111a7728378

المؤلفون: Weixue Wang (1307655), Laurence Mevellec (1693495), Annie Liu (5793302), Geoff Struble (11523741), Robyn Miller (478482), Samantha J. Allen (8926661), Kelly Federowicz (11523744), Berthold Wroblowski (1340940), Jorge Vialard (3469151), Kay Ahn (1523929), Daniel Krosky (4107913)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Immunology, Cancer, Infectious Diseases, Virology, Computational Biology, Chemical Sciences not elsewhere classified, privileged chemical scaffold, targeting inactive (<, study may represent, length hpk1 utilizing, attenuates kinase autophosphorylation, unphosphorylated inactive forms, cell receptor signaling, 1 , selective hpk1 inhibitors, kinase cascade assays, allosteric hpk1 inhibitor, assays using active, cell signaling, unphosphorylated hpk1, selective inhibitor, inactive conformation, cascade assays, vs <

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_an_Allosteric_Inactive_Conformation-Selective_Inhibitor_of_Full-Length_HPK1_Utilizing_a_Kinase_Cascade_Assay/16743780

الاتاحة: https://doi.org/10.1021/acs.biochem.1c00486.s001

المؤلفون: Huai-Chia Chuang, Tse-Hua Tan

المصدر: Journal of Biomedical Science, Vol 26, Iss 1, Pp 1-8 (2019)

مصطلحات موضوعية: MAP4K3 (GLK), HPK1, Autoimmune disease, Cancer metastasis, Aging, IL-17A, Medicine

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s12929-019-0570-5; https://doaj.org/toc/1423-0127

URL الوصول: https://doaj.org/article/6cc325e4d949431fb1a9b7386c1bed23

المؤلفون: Lee, Mia Jane, Moniruzzaman, Rohan, PhD

المصدر: Summer Experience 2021

مصطلحات موضوعية: Proteasome inhibitor, xenografts, Ras pathway, HPK1

وصف الملف: application/pdf

Relation: https://openworks.mdanderson.org/sumexp21/135; https://openworks.mdanderson.org/context/sumexp21/article/1179/viewcontent/Poster.pdf

الاتاحة: https://openworks.mdanderson.org/sumexp21/135
https://openworks.mdanderson.org/context/sumexp21/article/1179/viewcontent/Poster.pdf

المؤلفون: John Morrison, Steven Sheriff, Mark D. Wittman, Gregory A. Locke, Bradley C. Pearce, Erika M. V. Araujo, Andrew P. Degnan, Christopher W. Allard, Dan You, Xin Li, Kurt Zimmermann, Anwar Murtaza, Benjamin M. Johnson, Caitlyn Stromko, Jinqi Liu, Gregory D. Vite, Godwin Kwame Kumi, Karen E. Parrish, Alan Futran, Johnson Walter Lewis

المصدر: ACS Medicinal Chemistry Letters

مصطلحات موضوعية: Letter, medicine.medical_treatment, Plasma protein binding, 01 natural sciences, Biochemistry, Hematopoetic progenitor kinase 1, Immune system, Cancer immunotherapy, Drug Discovery, Medicine, Receptor, Progenitor, cancer immunotherapy, biology, HPK1, 010405 organic chemistry, Kinase, business.industry, Organic Chemistry, T-cell receptor, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, MAP4K1, Cancer research, biology.protein, Antibody, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8d6f32c2573a82ac07636c7d82958e
https://doi.org/10.1021/acsmedchemlett.0c00660

المؤلفون: Huizhen Ge, Lizeng Peng, Zhou Sun, Huanxiang Liu, Yulin Shen, Xiaojun Yao

مصطلحات موضوعية: Pharmacology, Basic Pharmacology, Clinical Pharmacology and Therapeutics, Clinical Pharmacy and Pharmacy Practice, Pharmaceutical Sciences, Pharmacogenomics, Toxicology (incl. Clinical Toxicology), Pharmacology and Pharmaceutical Sciences not elsewhere classified, HPK1 inhibitor, immunotherapy, virtual screening, molecular docking, molecular dynamics simulation

Relation: https://figshare.com/articles/dataset/Table1_Discovery_of_Novel_HPK1_Inhibitors_Through_Structure-Based_Virtual_Screening_DOCX/19353761

الاتاحة: https://doi.org/10.3389/fphar.2022.850855.s001
https://figshare.com/articles/dataset/Table1_Discovery_of_Novel_HPK1_Inhibitors_Through_Structure-Based_Virtual_Screening_DOCX/19353761

المؤلفون: Lei Wang, Qing-Jie Meng, Jun Yuan

المصدر: Journal of Hainan Medical University, Vol 24, Iss 19, Pp 55-58 (2018)

مصطلحات موضوعية: Breast cancer, HPK1, Drug resistance gene, lcsh:R, lcsh:Medicine, skin and connective tissue diseases, Kif2a, Oncogene

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doajarticles::bca902cdde360f3d2ac4f68daf41e6be
http://www.hnykdxxb.com/PDF/201819/13.pdf

المؤلفون: Duan, Yiping, Guo, Zhichao, Zhong, Wenyi, Chen, Jichao, Xu, Shengtao, Liu, Jie, Xu, Jinyi

المصدر: Future Med Chem ; ISSN:1756-8927 ; Volume:16 ; Issue:22

مصطلحات موضوعية: HPK1 inhibitor, T cell exhaustion, anti-tumor, immunotherapy, small-molecule inhibitors

Relation: https://doi.org/10.1080/17568919.2024.2420630; https://pubmed.ncbi.nlm.nih.gov/39582317; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622775/

الاتاحة: https://doi.org/10.1080/17568919.2024.2420630
https://pubmed.ncbi.nlm.nih.gov/39582317
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622775/

المؤلفون: D. Gomika Udugamasooriya, Massimo Bellanda, Giuliano Siligardi, Luca Cesaro, Stefano Mammi, Mark R. Spaller, Andrea Borgogno, Rohanah Hussain, Arianna Donella-Deana, Chiara Rubini, Andrea Calderan, Paolo Ruzza, Anna Maria Brunati

المصدر: Biopolymers
94 (2010): 298–306. doi:10.1002/bip.21350
info:cnr-pdr/source/autori:Chiara Rubini; Paolo Ruzza; Mark R. Spaller; Giuliano Siligardi; Rohanah Hussain; D. Gomika Udugamasooriya; Massimo Bellanda; Stefano Mammi; Andrea Borgogno; Andrea Calderan; Luca Cesaro; Anna M. Brunati; Arianna Donella-Deana/titolo:Recognition of Lysine-Rich Peptide Ligands by Murine Cortactin SH3 Domain: CD, ITC, and NMR Studies/doi:10.1002%2Fbip.21350/rivista:Biopolymers (Print)/anno:2010/pagina_da:298/pagina_a:306/intervallo_pagine:298–306/volume:94

مصطلحات موضوعية: Models, Molecular, cortactin, Pro-rich peptides, protein-protein interactions, Shank2, HPK1, SH3 domain, Molecular Sequence Data, Biophysics, Peptide binding, Sequence alignment, macromolecular substances, Plasma protein binding, Calorimetry, Ligands, Biochemistry, Protein–protein interaction, protein-protein interaction, src Homology Domains, Biomaterials, Mice, pro-rich peptides, Animals, Humans, Amino Acid Sequence, Nuclear Magnetic Resonance, Biomolecular, Peptide sequence, biology, Chemistry, Circular Dichroism, Lysine, Organic Chemistry, Isothermal titration calorimetry, General Medicine, biology.protein, Peptides, Cortactin, Sequence Alignment, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ec94e5d3dd37765148939fd7021c89
https://doi.org/10.1002/bip.21350

المؤلفون: 李子健, 张幼怡, Haian Fu

المساهمون: 北京大学第三医院血管医学研究所

المصدر: 知网

مصطلحات موضوعية: 负调控, 结合蛋白, 心血管疾病, 激酶活性, 内吞, 突变体, 信号转导, HIP-55, HPK1, interacting

Relation: 中国病理生理学会第九届全国代表大会及学术会议.; 997786; http://hdl.handle.net/20.500.11897/111698

الاتاحة: https://hdl.handle.net/20.500.11897/111698

المؤلفون: Li, Zijian, Park, Hae Ryon, Shi, Zhi, Li, Zenggang, Cau Dinh Pham, Du, Yuhong, Khuri, Fadlo R., Zhang, Youyi, Han, Qide, Fu, Haian

المساهمون: Li, ZJ (reprint author), Emory Univ, Sch Med, Dept Pharmacol, Atlanta, GA 30322 USA., Emory Univ, Sch Med, Dept Pharmacol, Atlanta, GA 30322 USA., Peking Univ, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Inst Vasc Med,Minist Hlth, Key Lab Mol Cardiovasc Sci,Minst Educ,Hosp 3, Beijing 100191, Peoples R China., Beijing Key Lab Cardiovasc Receptors Res, Beijing 100191, Peoples R China., Emory Univ, Dept Hematol & Med Oncol, Sch Med, Atlanta, GA 30322 USA., Winship Canc Inst, Atlanta, GA 30322 USA.

المصدر: SCI

مصطلحات موضوعية: HIP-55, DBNL, HPK1, 14-3-3, tumorigenesis, signal transduction, HEMATOPOIETIC PROGENITOR KINASE, ACTIN-BINDING PROTEIN-1, LUNG-CANCER CELLS, PANCREATIC-CANCER, ADAPTER PROTEIN, MAMMALIAN ABP1, SIGNAL, ACTIVATION, PHOSPHORYLATION

Relation: ONCOTARGET.2014,5,(10),3197-3209.; 778481; http://hdl.handle.net/20.500.11897/389382; WOS:000336967000028

الاتاحة: https://hdl.handle.net/20.500.11897/389382

المؤلفون: Song, Xianzhou

المصدر: Dissertations and Theses (Open Access)

مصطلحات موضوعية: Pancreatic cancer, Axl, Survival, Migration, Invasion, HPK1, Endocytosis, Dynamin, Akt, Biochemistry, Biophysics, and Structural Biology, Biology, Cancer Biology, Cell Biology, Life Sciences, Medical Cell Biology, Medical Pathology, Medicine and Health Sciences, Molecular Biology

وصف الملف: application/pdf

Relation: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/204; https://digitalcommons.library.tmc.edu/context/utgsbs_dissertations/article/1233/viewcontent/Dissertation_of_Song03.pdf

الاتاحة: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/204
https://digitalcommons.library.tmc.edu/context/utgsbs_dissertations/article/1233/viewcontent/Dissertation_of_Song03.pdf

المؤلفون: Guang-Yi Zhang, Ting Li, Xiu-Ju Yu

المصدر: FEBS letters. 582(13)

مصطلحات موضوعية: Male, Biophysics, Ischemia, Biology, Protein Serine-Threonine Kinases, Biochemistry, Hippocampus, Brain Ischemia, Brain ischemia, Rats, Sprague-Dawley, chemistry.chemical_compound, Structural Biology, Mitogen-Activated Protein Kinase 10, Genetics, medicine, Animals, Phosphorylation, Molecular Biology, Protein Kinase Inhibitors, HPK1, Tyrosine phosphorylation, Cell Biology, Cerebral ischemia, medicine.disease, MAP Kinase Kinase Kinases, Neuroprotection, Rats, Neuroprotective Agents, Pyrimidines, src-Family Kinases, chemistry, Cytoprotection, Mitogen-activated protein kinase, Reperfusion Injury, biology.protein, Cancer research, Tyrosine, c-Jun NH2-terminal kinase (JNK), Signal transduction, Dizocilpine Maleate, Neuron death, N-methyl-d-aspartate receptor (NMDAR), Proto-oncogene tyrosine-protein kinase Src, Src, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d396b99c9d7cda2763598905ddd532
https://pubmed.ncbi.nlm.nih.gov/18498770

المؤلفون: Gustavus, D. (Dirk)

المساهمون: Püschel, A.W. (Andreas), Universitäts- und Landesbibliothek Münster

مصطلحات موضوعية: Multiples Myelom, HPK1, Apoptose, Proliferation, Hämatopetische Progenitor Kinase, Knochenmark, ddc:610, info:eu-repo/classification/ddc/610, Medicine and health, ddc:570, info:eu-repo/classification/ddc/570, Biology

وصف الملف: application/pdf

الاتاحة: https://nbn-resolving.org/urn:nbn:de:hbz:6-42459671009
https://miami.uni-muenster.de/Record/8a777ded-74a7-4a11-a35e-fccdcc264538
https://repositorium.uni-muenster.de/transfer/miami/8a777ded-74a7-4a11-a35e-fccdcc264538

المؤلفون: Gustavus, Dirk

مصطلحات موضوعية: Multiples Myelom, HPK1, Apoptose, Proliferation, Hämatopetische Progenitor Kinase, Knochenmark

Relation: vignette : https://noah.nrw/titlepage/urn/urn:nbn:de:hbz:6-42459671009/128; urn:nbn:de:hbz:6-42459671009; https://nbn-resolving.org/urn:nbn:de:hbz:6-42459671009; sys:HT017036628; system:muenster_miami_8a777ded-74a7-4a11-a35e-fccdcc264538

الاتاحة: https://nbn-resolving.org/urn:nbn:de:hbz:6-42459671009