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المؤلفون: Shaheen Akhtar, Joanna Bottomley, Edward Ryder, Daniel M Barrett, Michaela Bruntraeger, Sanger Mouse Genetics, James Bussell, Jonathan Burvill, Radka Platte, Debarati Sethi, Diane Gleeson
المصدر: Methods (San Diego, Calif.)
مصطلحات موضوعية: FASTQ format, Genotyping, Genotype, Genotyping Techniques, Mouse, Computational biology, Biology, Polymerase Chain Reaction, Genome, Article, General Biochemistry, Genetics and Molecular Biology, DNA sequencing, Mice, 03 medical and health sciences, PCR, polymerase chain reaction, Animals, CRISPR, CRISPR, clustered regularly interspaced short palindromic repeat, hom, homozygous, Allele, Molecular Biology, Alleles, QC, 030304 developmental biology, 0303 health sciences, fungi, 030302 biochemistry & molecular biology, sgRNA, single guide RNA, Mutant, food and beverages, High-Throughput Nucleotide Sequencing, NGS, next generation sequencing, het, heterozygous, Amplicon, WT, wild-type, Mice, Mutant Strains, QC, quality control, NHEJ, non-homologous end joining, NGS
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المؤلفون: Chakera, Ali J., Hurst, Paul S., Spyer, Gill, Ogunnowo-Bada, Emmanuel O., Marsh, William J., Riches, Christine H., Yueh, Chen-Yu, Markkula, S. Pauliina, Dalley, Jeffrey W., Cox, Roger D., Macdonald, Ian A., Amiel, Stephanie A., MacLeod, Kenneth M., Heisler, Lora K., Hattersley, Andrew T., Evans, Mark L.
المساهمون: Dalley, Jeffrey [0000-0002-2282-3660], Evans, Mark [0000-0001-8122-8987], Apollo - University of Cambridge Repository
المصدر: Molecular Metabolism, Vol 17, Iss, Pp 17-27 (2018)
Chakera, A J, Hurst, P S, Spyer, G, Ogunnowo-Bada, E O, Marsh, W J, Riches, C H, Yueh, C Y, Markkula, S P, Dalley, J W, Cox, R D, Macdonald, I A, Amiel, S A, MacLeod, K M, Heisler, L K, Hattersley, A T & Evans, M L 2018, ' Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes ', Molecular Metabolism . https://doi.org/10.1016/j.molmet.2018.08.001
Molecular Metabolismمصطلحات موضوعية: Adult, Blood Glucose, Male, lcsh:Internal medicine, ARC, Arcuate nucleus, Epinephrine, β-cells, HET, Heterozygous, HOM, Homozygous, Mice, Hyperinsulinism, Insulin-Secreting Cells, Glucokinase, Diabetes Mellitus, Animals, Humans, Hypoglycemic Agents, Insulin, Insulin clamp, lcsh:RC31-1245, VMN, Ventromedial hypothalamus, GE, Glucose excited, Mice, Inbred BALB C, SF1, steroidogenic factor 1, Counter-regulation, GI, Glucose inhibited, STZ, Streptozotocin, Middle Aged, Glucagon, Hypoglycemia, GCK, Glucokinase, Disease Models, Animal, Glucose, Glucose Clamp Technique, Original Article, Female, Maturity onset diabetes of young (MODY), WT, Wild type
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