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المؤلفون: Gregory Upert, Philipp Ermert, Anatol Luther, Daniel Obrecht
المصدر: Medicine in Drug Discovery
Medicine in Drug Discovery, Vol 9, Iss, Pp 100078-(2021)مصطلحات موضوعية: WT, wild type, antimicrobial peptide, CMS, colistin methane sulfonate, Polymyxin, Antibiotics, VRE, vancomycin-resistant enterococcus, lcsh:RS1-441, Peptide, Review Article, LptC, lipopolysaccharide transport protein C, Pharmacology, AMR, antimicrobial resistance, chemistry.chemical_compound, mITT population, minimal intend-to-treat population, Drug Discovery, Hpg, 4-hydroxy-phenyl glycine, Pharmacology (medical), AMP, antimicrobial peptide, CD, circular dichroism, chemistry.chemical_classification, Drug discovery, ITC, isothermal titration calorimetry, LptD, lipopolysaccharide transport protein D, ESKAPE, acronym encompassing six bacterial pathogens (often carrying antibiotic resistance): Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp, Lipopeptide, CLSI, clinical & laboratory standards institute, RBC, red blood cell, MDR, multidrug-resistant, POPC, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, i.p., intraperitoneal, MH-I, Müller-Hinton broth I, NDM-1, New Dehli metallo-β-lactamase resistant, HepG2, human hepatocellular carcinoma cell line, LPS, lipopolysaccharide, bid, bis in die (two times a day), Bacterial outer membrane, s.c., subcutaneous, MRSA, methicilline-resistant Staphylococcus aureus, FDA, U. S. Food and Drug Administration, Omp, outer membrane protein, VABP, ventilator associated bacterial pneumonia, medicine.drug_class, PBP, penicillin-binding protein, PBS, phosphate-buffered saline, ADMET, absorption, distribution, metabolism and excretion – toxicity in pharmacokinetics, HEK293, human embryonic kidney 293 cells, SPR, surface plasmon resonance, VISA, vancomycin-intermediate Staphylococcus aureus, LptA, lipopolysaccharide transport protein A, WHO, World Health Organization, lcsh:Pharmacy and materia medica, KPC, klebsiella pneumoniae metallo-β-lactamase C resistant, Antibiotic resistance, MoA, mechanism (mode) of action, SPase I, signal peptidase I, i.v., intravenous, OMPTA (outer membrane targeting antibiotic), HDP, host-defense peptide, medicine, WTA, wall teichoic acid, MIC, minimal inhibitory concentration, XDR, extremely drug-resistant, ATCC, ATCC cell collection, antimicrobial resistance, DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine, Mode of action, PBMC, peripheral mononuclear blood cell, POPG, 2-oleoyl-1-palmitoyl-sn-glycero-3-phospho-(1-glycerol), CC50, cytotoxic concentration to kill 50% of cells, ODL, odilorhabdin, HABP, hospital acquired bacterial pneumonia, Antibiotic, MH-II, Müller-Hinton broth II (cation adjusted), peptide antibiotic, CFU, colony forming unit, SAR, structure activity relationship, MSSA, methicilline-sensitive Staphylococcus aureus, chemistry, lipopeptide, NOAEL, no adverse effect level, PK, pharmacokinetics, PrAMPs, polyproline antimicrobial peptides, BAM, β-barrel assembly machinery, HK-2, human kidney 2 cells (proximal tubular cell line), OMPTA, outer membrane targeting antibiotic, VIM-1, beta-lactamase 2 (Klebsiella pneumoniae)
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المؤلفون: Wang, Bingjie, McHugh, Brian J., Qureshi, Ayub, Campopiano, Dominic J., Clarke, David J., Fitzgerald, J. Ross, Dorin, Julia R., Weller, Richard, Davidson, Donald J.
المصدر: The Journal of Investigative Dermatology
مصطلحات موضوعية: Keratinocytes, Staphylococcus aureus, beta-Defensins, Blotting, Western, Interleukin-1beta, hBD, human β-defensin, Apoptosis, Enzyme-Linked Immunosorbent Assay, Dermatology, Real-Time Polymerase Chain Reaction, Biochemistry, HDP, host defense peptide, Dermatitis, Atopic, LTA, lipoteichoic acid, Humans, OE, overexpressing, shRNA, small hairpin RNA, Molecular Biology, Cells, Cultured, Immunology/Infection, Analysis of Variance, Ssp, staphylococcus aureus serine protease, Cell Biology, AD, atopic dermatitis, HPEK, human primary epidermal keratinocyte, TJ, tight junction, Epidermal Cells, VO, vector only, LPS, lipopolysaccharide, Original Article, Staphylococcal Skin Infections, Epidermis, Peptide Hydrolases