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1Academic Journal
المؤلفون: H. James Harwood, Jr., Stephen F. Petras, Dennis J. Hoover, Dayna C. Mankowski, Victor F. Soliman, Eliot D. Sugarman, Bernard Hulin, Younggil Kwon, E. Michael Gibbs, James T. Mayne, Judith L. Treadway
المصدر: Journal of Lipid Research, Vol 46, Iss 3, Pp 547-563 (2005)
مصطلحات موضوعية: cholesterol synthesis, glycogenolysis, glycogen phosphorylase, lanosterol 14α-demethylase, CYP51, enzyme inhibition, Biochemistry, QD415-436
وصف الملف: electronic resource
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2Academic Journal
المؤلفون: Charles E. Chandler, Donald E. Wilder, Judith L. Pettini, Yvette E. Savoy, Stephen F. Petras, George Chang, John Vincent, H. James Harwood, Jr.
المصدر: Journal of Lipid Research, Vol 44, Iss 10, Pp 1887-1901 (2003)
مصطلحات موضوعية: microsomal triglyceride transfer protein, lipid transfer inhibition, very low density lipoprotein, low density lipoprotein, apolipoprotein B, apolipoprotein A-I, Biochemistry, QD415-436
وصف الملف: electronic resource
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3Academic Journal
المؤلفون: Stephen F. Petras, Saralyn Lindsey, H. James Harwood, Jr.
المصدر: Journal of Lipid Research, Vol 40, Iss 1, Pp 24-38 (1999)
مصطلحات موضوعية: cholesterol synthesis, HMG-CoA reductase, squalene synthetase, enzyme inhibition, metabolic regulation, cultured cells, Biochemistry, QD415-436
وصف الملف: electronic resource
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4Academic Journal
المؤلفون: AYUMU SUGIURA, H. JAMES HARWOOD, HIDEO HIRAI, HIROYUKI NLSHIDA, LIANG HSIUNG HUANG, NAKAO KOJIMA, NOBUJI YOSHIKAWA, SHUZO WATANABE, TAKAHITO KAMBARA, YASUHIRO KOJIMA, YUJI YAMAUCHI
المصدر: The Journal of Antibiotics. 2001, 54(12):1025
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5Academic Journal
المؤلفون: AYUMU SUGIURA, H. JAMES HARWOOD, HIDEO HIRAI, HIROYUKI NISHIDA, LIANG HSIUNG HUANG, MASARU ISHIGURO, NAKAO KOJIMA, SHUZO WATANABE, TAKAHITO KAMBARA, TOMOYUKI MATSUNAGA, YASUHIRO KOJIMA, YUMIKO SUZUKI
المصدر: The Journal of Antibiotics. 2001, 54(11):904
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6Academic Journal
المؤلفون: H. JAMES HARWOOD, JIAN-CHENG LI, LIANG H. HUANG, MICHELLE THERRIEN, NANCY D. JANKOVICH, PAUL C. WATTS, PETER M. MOSHIER, SARALYN LINDSEY, TAKUSHI KANEKO, THOMAS T. DABRAH, TIMOTHY A. SUBASHI
المصدر: The Journal of Antibiotics. 1997, 50(1):1
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7
المؤلفون: Heather Kelley, Carine Beysen, William F. Westlin, Tess Schmalbach, Kathryn Stiede, Geraldine Harriman, Rosana Kapeller, H. James Harwood, Heather S. Blanchette, Wenyan Miao
المصدر: Hepatology (Baltimore, Md.)
مصطلحات موضوعية: 0301 basic medicine, Adult, Male, medicine.medical_specialty, Administration, Oral, Biology, Placebo, Risk Assessment, Drug Administration Schedule, Body Mass Index, 03 medical and health sciences, chemistry.chemical_compound, Double-Blind Method, Non-alcoholic Fatty Liver Disease, Internal medicine, medicine, Humans, Cross-Over Studies, Hepatology, Fatty acid metabolism, Triglyceride, Dose-Response Relationship, Drug, Lipogenesis, Fatty liver, Middle Aged, Overweight, medicine.disease, Crossover study, 030104 developmental biology, Endocrinology, Treatment Outcome, chemistry, Patient Safety, Steatosis, Rapid Communication, Lipoprotein, Acetyl-CoA Carboxylase, Follow-Up Studies
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8Academic Journal
المؤلفون: Sean Ekins, Dayna C. Mankowski, Dennis J. Hoover, Michael P. Lawton, Judith L. Treadway, H. James Harwood
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.536.2633; http://dmd.aspetjournals.org/content/35/3/493.full.pdf
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9
المؤلفون: H. James Harwood
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Biochemistry, Action (philosophy), Guanidine, Guanidine derivatives
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10
المؤلفون: Gregory R. Steinberg, Robert A. Foster, Wenyan Miao, Ting Wang, Vanessa P. Houde, Naoto Fujiwara, Hailing Sun, Jeremy R. Greenwood, Jennifer Rocnik, Geraldine Harriman, Danielle K. DePeralta, Theodoros Tsakiridis, Asish K. Saha, Lan Wei, Jamie Bates, Alexander E. Anagnostopoulos, Alice Wang, Henry Liu, Kenneth K. Tanabe, Omeed Moaven, Paola Muti, Yujin Hoshida, Derek J. Erstad, William F. Westlin, Rebecca J. Ford, Ricard Masia, James S. V. Lally, Bryan C. Fuchs, Adrian S. Ray, H. James Harwood, Lindsay A. Broadfield, Sarani Ghoshal, Rosana Kapeller, Vivian Leong, Sathesh Bhat
المساهمون: daulny, anne, Cell circuits as targets and biomarkers for liver disease and cancer prevention - HEPCIR - - H20202016-01-01 - 2020-12-31 - 671231 - VALID, Department of Medicine [Hamilton, ON, Canada], McMaster University [Hamilton, Ontario], Division of Surgical Oncology [Boston, MA, USA], Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital Cancer Center [Boston, MA, USA], Department of Pathology [Boston, MA, USA], Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston], Harold C. Simmons Comprehensive Cancer Center [Dallas, TX, États-Unis], University of Texas Southwestern Medical Center [Dallas], Department of Internal Medicine [Dallas, TX, USA], Department of Oncology [Hamilton, ON, Canada], Department of Pathobiology [Guelph, ON, Canada], University of Guelph-Ontario Veterinary College [Guelph, ON, Canada], Gilead Sciences, Inc. [Foster City, CA, USA], Department of Medicine and Physiology [Boston, MA, USA], Boston University [Boston] (BU)-School of Medicine, Endocrinology, Diabetes, and Nutrition [Boston, MA, USA], Schrodinger [New York, NY, USA], Nimbus Therapeutics [Cambridge, MA, USA], Department of Biochemistry and Biomedical Sciences [Hamilton, ON, Canada], This work was supported by grants from the National Cancer Institute (T32 CA071345 to D.K.D., O.M., and K.K.T. and K01 CA140861 to B.C.F.), the Uehara Memorial Foundation (N.F.), the National Institute of Diabetes and Digestive and Kidney Diseases (DK099558 to Y.H.), the European Union (ERC-2014-AdG-671231 HEPCIR to Y.H.), the Irma T. Hirschl Trust (Y.H.), the U.S. Department of Defense (W81XWH-16-1-0363 to Y.H.), the Canadian Cancer Society Research and Innovation Fund (G.R.S.), the Canadian Institutes of Health Research (G.R.S. 125980-1, 144625-1), Nimbus Therapeutics (to B.C.F.), and Gilead Sciences (to B.C.F.). A.E.G received a scholarship from the Canadian Liver Foundation. G.R.S. is supported by a Canada Research Chair and by the J. Bruce Duncan Chair in Metabolic Diseases., European Project: 671231,H2020,ERC-2014-ADG,HEPCIR(2016)
المصدر: Cell Metabolism
Cell Metabolism, Elsevier, 2019, 29 (1), pp.174-182.e5. ⟨10.1016/j.cmet.2018.08.020⟩مصطلحات موضوعية: 0301 basic medicine, Sorafenib, Male, Carcinoma, Hepatocellular, Physiology, cancer metabolism, Article, fructose, 03 medical and health sciences, Mice, 0302 clinical medicine, malonyl-CoA, NAFLD, medicine, Animals, Humans, Phosphorylation, Rats, Wistar, Protein kinase A, Molecular Biology, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Chemistry, Lipogenesis, Fatty liver, fibrosis, Liver Neoplasms, Acetyl-CoA carboxylase, NASH, AMPK, non-alcoholic fatty liver disease, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Cell Biology, Hep G2 Cells, medicine.disease, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, 3. Good health, Rats, 030104 developmental biology, inflammation, Hepatocellular carcinoma, Cancer research, non-alcoholic steatohepatitis, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, medicine.drug, Acetyl-CoA Carboxylase
وصف الملف: application/pdf
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11
المؤلفون: Jia Wei, Salma Rafi, Silvana Leit, Byron DeLaBarre, H. James Harwood, Jun Kuai, Eric Therrien, Liang Tong
المصدر: Acta Crystallographica Section A Foundations and Advances. 75:a371-a371
مصطلحات موضوعية: Inorganic Chemistry, ATP citrate lyase, Biochemistry, Structural Biology, Chemistry, Cryo-electron microscopy, General Materials Science, Physical and Theoretical Chemistry, Condensed Matter Physics
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12
المؤلفون: Reuben J. Shaw, Sathesh Bhat, Seth J. Parker, H. James Harwood, Jeremy R. Greenwood, Portia S. Lombardo, Sonja N. Brun, Robert U. Svensson, Matthew J. Kolar, Christian M. Metallo, William F. Westlin, Amanda Hutchins, Jeanine L. Van Nostrand, Martina Wallace, Rosana Kapeller, Lillian J. Eichner, Alan Saghatelian, Laurie Gerken, Lilliana Vera, Geraldine Harriman
المصدر: Nature medicine, vol 22, iss 10
مصطلحات موضوعية: 0301 basic medicine, Lung Neoplasms, Pharmacology, AMP-Activated Protein Kinases, medicine.disease_cause, Medical and Health Sciences, chemistry.chemical_compound, Mice, Carcinoma, Non-Small-Cell Lung, Molecular Targeted Therapy, Enzyme Inhibitors, Non-Small-Cell Lung, Lung, Cancer, Mice, Knockout, Lung Cancer, Fatty Acids, General Medicine, Protein-Serine-Threonine Kinases, 3. Good health, KRAS, Knockout, Immunology, Pyrimidinones, Thiophenes, Biology, Protein Serine-Threonine Kinases, General Biochemistry, Genetics and Molecular Biology, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Rare Diseases, Allosteric Regulation, In vivo, Acetyltransferases, medicine, Animals, Humans, Lung cancer, neoplasms, Fatty acid synthesis, Cell Proliferation, Cell growth, Carcinoma, Acetyl-CoA carboxylase, medicine.disease, Lipid Metabolism, Xenograft Model Antitumor Assays, Carboplatin, respiratory tract diseases, 030104 developmental biology, chemistry, Cancer research, Tumor Suppressor Protein p53, Digestive Diseases, Acetyl-CoA Carboxylase
وصف الملف: application/pdf
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13
المؤلفون: Geraldine Harriman, Ruiying Wang, William F. Westlin, Rosana Kapeller, Sathesh Bhat, Asish K. Saha, Xinyi Huang, Liang Tong, Debamita Paul, Jeremy R. Greenwood, H. James Harwood
المصدر: Proceedings of the National Academy of Sciences. 113
مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Pyrimidinones, Thiophenes, Biology, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Insulin resistance, Internal medicine, Diabetes mellitus, medicine, Animals, Humans, Obesity, Enzyme Inhibitors, Beta oxidation, Fatty acid synthesis, Dyslipidemias, Multidisciplinary, Fatty liver, Acetyl-CoA carboxylase, Hep G2 Cells, medicine.disease, Rats, Zucker, Fatty Liver, Molecular Docking Simulation, 030104 developmental biology, Endocrinology, PNAS Plus, chemistry, 030220 oncology & carcinogenesis, Female, Insulin Resistance, Protein Multimerization, Steatosis, Metabolic syndrome, Acetyl-CoA Carboxylase
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14
المؤلفون: H. James Harwood
المصدر: Neuropharmacology. 63:57-75
مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, Adiponectin, Leptin, Neuropeptides, Adipokine, Adipose tissue, Endocrine System, Biology, medicine.disease, Energy homeostasis, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Endocrinology, Metabolic Diseases, chemistry, Adipocyte, Internal medicine, Adipocytes, medicine, Animals, Homeostasis, Humans, Resistin, Metabolic syndrome
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15
المؤلفون: Gina M. Ward, Janice D. Wagner, John R. Hadcock, Janice E. Chin, Bruce Auerbach, Kylie Kavanagh, Li Zhang, H. James Harwood
المصدر: Journal of Pharmacology and Experimental Therapeutics. 335:103-113
مصطلحات موضوعية: Blood Glucose, Leptin, Male, medicine.medical_specialty, Endpoint Determination, medicine.drug_class, media_common.quotation_subject, Rats, Sprague-Dawley, Eating, Dogs, Receptor, Cannabinoid, CB1, Weight loss, Internal medicine, Weight Loss, medicine, Animals, Obesity, Adiposity, media_common, Pharmacology, Glucose tolerance test, Dose-Response Relationship, Drug, medicine.diagnostic_test, Adiponectin, Triazines, Chemistry, Body Weight, Antagonist, Appetite, Feeding Behavior, Glucose Tolerance Test, Receptor antagonist, medicine.disease, Lipids, Diet, Rats, Macaca fascicularis, Endocrinology, Body Composition, Azetidines, Molecular Medicine, Anti-Obesity Agents, medicine.symptom
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16
المؤلفون: H. James Harwood, Kylie Kavanagh, Gina M. Ward, Melanie K. Shadoan, Omar L. Francone, Bruce Auerbach, Li Zhang, Janice D. Wagner, Lori Royer
المصدر: Journal of Pharmacology and Experimental Therapeutics. 333:844-853
مصطلحات موضوعية: Blood Glucose, medicine.medical_specialty, Apolipoprotein B, Lipoproteins, medicine.medical_treatment, Insulin resistance, Piperidines, Internal medicine, Weight Loss, medicine, Animals, Hypoglycemic Agents, PPAR alpha, Hypolipidemic Agents, Glycemic, Pharmacology, Glucose tolerance test, Dose-Response Relationship, Drug, biology, medicine.diagnostic_test, Adiponectin, Chemistry, Insulin, Glucose Tolerance Test, medicine.disease, Lipids, Macaca fascicularis, C-Reactive Protein, Endocrinology, Diabetes Mellitus, Type 2, Area Under Curve, biology.protein, Molecular Medicine, Apolipoprotein A1, Insulin Resistance, Propionates, Lipoprotein
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17
المؤلفون: Mark C. Sulavik, Debra Hanna, Bill Dunkle, Li Ann Wang, V. Hayden Thomas, Laura A. Skerlos, Tong Zhu, Chris Limberakis, Zhigang Wang, Amy Whitton, Michael Kuhn, C. Kendall Stover, Jeff Ohren, John A. Shelly, J.V.N. Vara Prasad, Steve Dunham, H. James Harwood, Michael D. Huband, J. Richard Miller, Shawn Mehrens, Alla Karnovsky, Susan Buist, W. Thomas Mueller, Jia Y. Liu, Steve Vanderroest, Craig Banotai, Adam Ogden, Lakshmi Narasimhan, Matthew Bowman, Igor Mochalkin
المصدر: Proceedings of the National Academy of Sciences. 106:1737-1742
مصطلحات موضوعية: Biotin carboxylase, Multidisciplinary, Gram-negative bacteria, biology, Drug discovery, Kinase, High-throughput screening, Small Molecule Libraries, biology.organism_classification, Biochemistry, Mechanism of action, medicine, Pharmacophore, medicine.symptom
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18
المصدر: Journal of Polymer Science Part A: Polymer Chemistry. 46:2347-2356
مصطلحات موضوعية: Polymers and Plastics, Radical, Organic Chemistry, Radical polymerization, Phenacyl, Styrene, NMR spectra database, chemistry.chemical_compound, chemistry, Polymer chemistry, Materials Chemistry, Copolymer, Methyl methacrylate, Acetophenone
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19
المؤلفون: H. James Harwood
المصدر: Journal of Polymer Science Part C: Polymer Symposia. 25:37-45
مصطلحات موضوعية: Sequence, Distribution (mathematics), medicine.anatomical_structure, Fortran, medicine, Thermodynamics, Diad, Triad (anatomy), Type (model theory), Tetrad, computer, computer.programming_language, Mathematics
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20
المؤلفون: H. James Harwood, H. Piotrowski, N. W. Johnston
المصدر: Journal of Polymer Science Part C: Polymer Symposia. 25:23-36
مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Monomer, chemistry, Polymer chemistry, Copolymer, Organic chemistry, Reactivity (chemistry), Polymer, Chemical reaction
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