المؤلفون: Istomin, Natalie, Härmä, Mari-Anne, Akhi, Ramin, Nissinen, Antti E., Savolainen, Markku J., Adeshara, Krishna, Lehto, Markku, Groop, Per-Henrik, Koivukangas, Vesa, Hukkanen, Janne, Hörkkö, Sohvi

المساهمون: Nefrologian yksikkö, HUS Abdominal Center, CAMM - Research Program for Clinical and Molecular Metabolism, Medicum, Clinicum, University of Helsinki, Research Programs Unit, Department of Medicine, Per Henrik Groop / Principal Investigator

مصطلحات موضوعية: Roux-en-Y gastric bypass surgery, type 2 diabetes, natural antibodies, immunoglobulins, obesity, MALONDIALDEHYDE ACETALDEHYDE-ADDUCTS, OXIDATION-SPECIFIC EPITOPES, LOW-DENSITY-LIPOPROTEIN, BARIATRIC SURGERY, APOPTOTIC CELLS, PROTEIN ADDUCTS, B-CELLS, AUTOANTIBODIES, ATHEROSCLEROSIS, INFLAMMATION, General medicine, internal medicine and other clinical medicine, 11832 Microbiology and virology

وصف الملف: application/pdf

Relation: M.J.S., V.K., S.H. contributed to the conception of the idea, design of the study and critically evaluated the manuscript. R.A., AE.N., M-A.H. and K.A. were involved with the experimental work and critically evaluated the manuscript. M.L. and P-H. G. participated in the interpretation of the results and critically evaluated the manuscript. All authors approved the final content of the manuscript. Yrj_o Jahnsson Foundation (20197174), Academy of Finland (275614, 316664, and 315568), Novo Nordisk Foundation (#NNF OC0013659), Signe and Ane Gyllenberg Foundation, Folkh_alsan Research Foundation, Helsinki University Central Hospital Research Funds, the Diabetes Research Foundation, the P_aivikki and Sakari Sohlberg Foundation, the Finnish Foundation for Cardiovascular Research, the Northern Finland Health Care Support Foundation, the Finnish Medical Foundation, and Wilhelm and Else Stockmann Foundation supported this study. We thank study nurses and coordinators for their assistance in conducting the study visits.; Istomin , N , Härmä , M-A , Akhi , R , Nissinen , A E , Savolainen , M J , Adeshara , K , Lehto , M , Groop , P-H , Koivukangas , V , Hukkanen , J & Hörkkö , S 2022 , ' Total fecal IgA levels increase and natural IgM antibodies decrease after gastric bypass surgery ' , APMIS , vol. 130 , no. 11 , pp. 637-646 . https://doi.org/10.1111/apm.13268; http://hdl.handle.net/10138/350368; 5d061f3c-492b-430e-800d-70216e899ddf; 000851311700001

الاتاحة: http://hdl.handle.net/10138/350368

المؤلفون: FinnGen, Leskelä, Jaakko, Toppila, Iiro, Härmä, Mari-Anne, Palviainen, Teemu, Salminen, Aino, Sandholm, Niina, Pietiäinen, Milla, Kopra, Elisa, Pais de Barros, Jean-Paul, Lassenius, Mariann I., Kumar, Anmol, Harjutsalo, Valma, Roslund, Kajsa, Forsblom, Carol, Loukola, Anu, Havulinna, Aki S., Lagrost, Laurent, Salomaa, Veikko, Groop, Per-Henrik, Perola, Markus, Kaprio, Jaakko, Lehto, Markku, Pussinen, Pirkko J.

المساهمون: Department of Oral and Maxillofacial Diseases, HUS Head and Neck Center, HUS Abdominal Center, Nefrologian yksikkö, Institute for Molecular Medicine Finland, Genetic Epidemiology, Clinicum, Medicum, HUS Internal Medicine and Rehabilitation, Department of Medicine, Research Programs Unit, CAMM - Research Program for Clinical and Molecular Metabolism, HUSLAB, University Management, Department of Public Health, Complex Disease Genetics, Per Henrik Groop / Principal Investigator, Helsinki University Hospital Area

مصطلحات موضوعية: coagulation, contact activation, endotoxin, gene, genome-wide association study, lipopolysaccharide, CARDIOVASCULAR-DISEASE, IDENTIFICATION, EFFICIENT, VARIANTS, HEPARIN, TARGET, LOCUS, RISK, General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

Relation: The project was supported by grants from the Academy of Finland (No. 1266053 to Dr Pussinen, No. 299200 to Dr Sandholm, and Nos. 265240, 263278, 308248, 312073, 100499, 205585, 118555, and 141054 to Dr Kaprio), the Sigrid Juselius Foundation (to Dr Pussinen), the Paulo Foundation (to Dr Pussinen), the Paivikki and Sakari Sohlberg's Foundation (to Dr Pussinen), the Finnish Dental Society Apollonia (to Dr Pussinen), and Finnish Foundation for Cardiovascular Research (to Dr Salomaa). The FinnDiane study was supported by grants from Folkhalsan Research Foundation, the Wilhelm and Else Stockmann Foundation, the Liv och Halsa Foundation, Helsinki University Central Hospital Research Funds, the Novo Nordisk Foundation (NNFOC0013659/ PROTON), European Foundation for the Study of Diabetes Young Investigator Research Award funds, and the Academy of Finland (Nos. 275614 and 316664). Genotyping of the FinnDiane genome-wide association study (GWAS) data was funded by the Juvenile Diabetes Research Foundation within the Diabetic Nephropathy Collaborative Research Initiative (grant 17-2013-7), with GWAS quality control and imputation performed at the University of Virginia. Phenotype and genotype data collection in the twin cohort has been supported by the Wellcome Trust Sanger Institute, the Broad Institute, ENGAGE-European Network for Genetic and Genomic Epidemiology, FP7-HEALTH-F4-2007 (No. 201413), the National Institute of Alcohol Abuse and Alcoholism (Nos. AA-12502, AA-00145, AA15416, and K02AA018755), and the National Heart, Lung, and Blood Institute (HL104125). GTEx Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health, and by National Cancer Institute, National Human Genome Research Institute, National Heart, Lung, and Blood Institute, National Institute on Drug Abuse, National Institute of Mental Health, and National Institute of Neurological Disorders and Stroke. The funding of the FinnGen project consists of 2 grants from Business Finland (HUS 4685/31/2016 and UH 4386/31/2016) and support from 11 industry partners: AbbVie, AstraZeneca, Biogen, Celgene, Genentech (part of Roche), GSK, Janssen, Maze Therapeutics, MSD, Pfizer, and Sanofi. The MEGASTROKE project received funding from sources specified at http:// www.megas troke.org/acknowledgments.html.; FinnGen , Leskelä , J , Toppila , I , Härmä , M-A , Palviainen , T , Salminen , A , Sandholm , N , Pietiäinen , M , Kopra , E , Pais de Barros , J-P , Lassenius , M I , Kumar , A , Harjutsalo , V , Roslund , K , Forsblom , C , Loukola , A , Havulinna , A S , Lagrost , L , Salomaa , V , Groop , P-H , Perola , M , Kaprio , J , Lehto , M & Pussinen , P J 2021 , ' Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke ' , Journal of the American Heart Association , vol. 10 , no. 21 , 022482 . https://doi.org/10.1161/JAHA.121.022482; ORCID: /0000-0003-3563-1876/work/104768694; ORCID: /0000-0003-0542-5967/work/104768850; ORCID: /0000-0003-4322-6942/work/104770199; ORCID: /0000-0002-7847-8384/work/104770538; ORCID: /0000-0002-2271-611X/work/104770676; ORCID: /0000-0001-9670-339X/work/104771079; ORCID: /0000-0001-7576-090X/work/131064498; ORCID: /0000-0002-3716-2455/work/104767385; http://hdl.handle.net/10138/337572; 062f3d3a-b1db-42ea-8621-a2667ccd84cd; 000713661400022

الاتاحة: http://hdl.handle.net/10138/337572

المؤلفون: Forsblom Carol, Sandholm Niina, Lehto Markku, on behalf of FinnDiane Study Group, Härmä Mari-Anne, Dahlström Emma H, Groop Per-Henrik

المساهمون: tyks, vsshp, tyks, vsshp, sisätautioppi, Internal Medicine, 2607318

Relation: 63; Diabetologia; https://www.utupub.fi/handle/10024/168191; URN:NBN:fi-fe2021042824185

الاتاحة: https://www.utupub.fi/handle/10024/168191