-
1Academic Journal
المؤلفون: De-La-Torre Pedro, Gutierrez Margarita, Caballero Julio, Trilleras Jorge, Astudillo Luis, Cardenas Alejandro, Brito Ivan
المصدر: Zeitschrift für Kristallographie - New Crystal Structures, Vol 231, Iss 1, Pp 171-173 (2016)
مصطلحات موضوعية: 1441735, Physics, QC1-999, Crystallography, QD901-999
وصف الملف: electronic resource
-
2Academic Journal
المؤلفون: Duarte Yorley, Gutierrez Margarita, Astudillo Luis, Brito Iván, Cárdenas Alejandro, Bolte Michael, López-Rodríguez Matías
المصدر: Zeitschrift für Kristallographie - New Crystal Structures, Vol 228, Iss 3, Pp 371-372 (2013)
مصطلحات موضوعية: Physics, QC1-999, Crystallography, QD901-999
وصف الملف: electronic resource
-
3Academic JournalUnexpected discovery: “A new 3,3′-bipyrazolo[3,4-b]pyridine scaffold and its comprehensive analysis”
المؤلفون: Polo-Cuadrado, Efraín, Ferrer, Karoll, Sánchez-Márquez, Jesús, Charris-Molina, Andrés, Rodríguez-Núñez, Yeray A., Espinoza-Catalán, Luis, Gutiérrez, Margarita
المساهمون: Fondo Nacional de Desarrollo Científico y Tecnológico
المصدر: Heliyon ; volume 10, issue 11, page e32573 ; ISSN 2405-8440
-
4Academic Journal
المؤلفون: Pino-Ramos, Liudis L., Farias, Dafne Reyes, Olivares-Caro, Lia, Mitsi, Christina, Mardones, Claudia, Echeverria, Javier, Avila, Felipe, Gutierrez, Margarita
المساهمون: National Agency for Research and Development
المصدر: Heliyon ; volume 10, issue 19, page e38837 ; ISSN 2405-8440
-
5Academic Journal
المؤلفون: Legoas, Jorge, Zeisser, Maite, Gutiérrez, Margarita
المصدر: Revista Educación, Política y Sociedad; Vol. 9 No. 2 (2024): Indigenous Knowledge and Education: Experiences and Perspectives in the Americas; 71-106 ; Revista Educación, Política y Sociedad; Vol. 9 Núm. 2 (2024): Saberes y educación indígenas: experiencias y perspectivas en las Américas; 71-106 ; 2445-4109 ; 10.15366/10.15366/reps2024.9.2
مصطلحات موضوعية: Learning, pedagogy, indigenous ontologies, radio, intangible heritage, Aprendizaje, pedagogía, ontologías indígenas, medio radial, patrimonio cultural inmaterial
وصف الملف: application/pdf
-
6Academic Journal
المؤلفون: Portillo Peñuelas, Samuel Alejandro, Enríquez Félix, Misael, Reynoso González, Oscar Ulises, Valenzuela Santoyo, Alba del Carmen, Carranza Gutiérrez, Margarita, Tovar Cedillo, Erick Arnoldo
المصدر: Dilemas contemporáneos: Educación, Política y Valores; Año XI, Publicación #3, Mayo 2024 ; Dilemas contemporáneos: Educación, Política y Valores; Year XI, Publication #3, May 2024 ; 2007-7890
مصطلحات موضوعية: self-perceived teacher competence, teacher training, undergraduate, graduate, Mexico, competencia autopercibida docente, formación docente, licenciatura, posgrado, México
وصف الملف: application/pdf
Relation: https://www.dilemascontemporaneoseducacionpoliticayvalores.com/index.php/dilemas/article/view/4116/4011; https://www.dilemascontemporaneoseducacionpoliticayvalores.com/index.php/dilemas/article/view/4116
-
7Academic Journal
المصدر: Ciencia Latina Revista Científica Multidisciplinar; Vol. 8 Núm. 3 (2024); 4452-4471 ; 2707-2215 ; 2707-2207 ; 10.37811/cl_rcm.v8i3
مصطلحات موضوعية: fractions, algorithms, students, artificial intelligence, mathematics, fracciones, algoritmos, estudiantes, inteligencia artificial, matemáticas
وصف الملف: application/pdf; text/html
Relation: https://ciencialatina.org/index.php/cienciala/article/view/11661/16999; https://ciencialatina.org/index.php/cienciala/article/view/11661/17000; https://ciencialatina.org/index.php/cienciala/article/view/11661
-
8Academic Journal
المؤلفون: Camargo-Ayala, Lorena, Bedoya, Mauricio, Prent-Peñaloza, Luis, Polo-Cuadrado, Efraín, Osorio, Edison, Brito, Iván, Delgado, Gerzon E., González, Wendy, Gutierrez, Margarita
المساهمون: Universidad de Ibagué
المصدر: RSC Advances ; volume 14, issue 8, page 5222-5233 ; ISSN 2046-2069
-
9Academic Journal
المؤلفون: Polo-Cuadrado, Efraín, Osorio, Edison, Acosta-Quiroga, Karen, Camargo-Ayala, Paola Andrea, Brito, Iván, Rodriguez, Jany, Alderete, Joel B., Forero-Doria, Oscar, Blanco-Acuña, Edgard Fabián, Gutiérrez, Margarita
المساهمون: Universidad de Talca, Fondo Nacional de Desarrollo Científico y Tecnológico, Universidad de Ibagué
المصدر: RSC Advances ; volume 14, issue 15, page 10199-10208 ; ISSN 2046-2069
-
10Academic Journal
المصدر: Encuentros. Revista de Ciencias Humanas, Teoría Social y Pensamiento Crítico, 17(Universidad Nacional Experimental Rafael María Baralt), 217-227, (2023-01-12)
مصطلحات موضوعية: Pedagogía afectiva, Aprendizaje, Universidad
Relation: https://encuentros.unermb.web.ve/index.php/encuentros; https://doi.org/10.5281/zenodo.7527644; https://doi.org/10.5281/zenodo.7527645; oai:zenodo.org:7527645
-
11Academic Journal
المؤلفون: Lopez Muñoz, Diego Fernando, Duque, Leidy, Quiceno, Yexuan, Gutiérrez, Margarita, Solarte, Andrés Felipe
المصدر: Ciencia Latina Revista Científica Multidisciplinar; Vol. 7 Núm. 1 (2023); 9099-9107 ; 2707-2215 ; 2707-2207 ; 10.37811/cl_rcm.v7i1
مصطلحات موضوعية: multiple mieloma, immunoglobulin kappa-chains, immunoglobulin a, paraproteinemias, mieloma múltiple, cadenas kappa de inmunoglobulina, inmunoglobulina a, gammapatía monoclonal
وصف الملف: application/pdf; text/html
Relation: https://ciencialatina.org/index.php/cienciala/article/view/5107/7743; https://ciencialatina.org/index.php/cienciala/article/view/5107/7745; https://ciencialatina.org/index.php/cienciala/article/view/5107
-
12Academic Journal
المؤلفون: Polo-Cuadrado, Efraín, López-Cuellar, Lorena, Acosta-Quiroga, Karen, Rojas-Peña, Cristian, Brito, Iván, Cisterna, Jonathan, Trilleras, Jorge, Alderete, Joel B., Duarte, Yorley, Gutiérrez, Margarita
المصدر: RSC Advances ; volume 13, issue 43, page 30118-30128 ; ISSN 2046-2069
-
13Academic Journal
المؤلفون: Polo-Cuadrado, Efraín, Ferrer, Karoll, Osorio, Edison, Brito, Iván, Cisterna, Jonathan, Espinoza, Luis, Alderete, Joel B., Gutiérrez, Margarita
المساهمون: Fondo Nacional de Desarrollo Científico y Tecnológico
المصدر: RSC Advances ; volume 13, issue 8, page 5197-5207 ; ISSN 2046-2069
-
14Academic Journal
المؤلفون: González, Ricelia, Murillo-López, Juliana, Rabanal-León, Walter, Prent-Peñaloza, Luis, Concepción, Odette, Olivares, Pedro, Duarte, Yorley, de la Torre, Alexander F., Gutiérrez, Margarita, Caballero, Julio
المصدر: Frontiers in Chemistry ; volume 11 ; ISSN 2296-2646
-
15Academic Journal
المؤلفون: Amaya, Alejandra, Gutiérrez, Margarita, Garzón, Martín, Villalba, Fabiola, Mendez, Yanet, Beltran, Oscar, Hernández, Geovanny, Salinas, Carolina, Torres, Cristina, Ponce, Enrique, Jorge, Ceballos, Adriana, Varón
المصدر: Annals of Hepatology ; volume 28, page 100983 ; ISSN 1665-2681
-
16Academic Journal
-
17Academic Journal
المؤلفون: Camargo-Ayala, Lorena, Polo-Cuadrado, Efraín, Osorio, Edison, Soto-Delgado, Jorge, Duarte, Yorley, Prent-Peñaloza, Luis, Gutiérrez, Margarita
مصطلحات موضوعية: Alzheimer's disease, Butyrylcholinesterase inhibitors, IMCR
وصف الملف: application/pdf
Relation: 10; 133307; 1264; Journal of Molecular Structure; I. Ugi, A. Dömling, W. Hörl Multicomponent reactions in organic chemistry Endeavour, 18 (1994), pp. 115-122, 10.1016/S0160-9327(05)80086-9; E. Ruijter, R. Orru Multicomponent reactions in drug discovery and medicinal chemistry Drug Discov. Today Technol., 29 (2018), pp. 1-2, 10.1016/j.ddtec.2018.11.002; A. Shaabani, R. Mohammadian, R. Afshari, S.E. Hooshmand, M.T. Nazeri, S. Javanbakht The status of isocyanide-based multi-component reactions in Iran (2010–2018) Mol. Divers., 252 (25) (2020), pp. 1145-1210, 10.1007/S11030-020-10049-7; I. Ugi, R. Meyr, I Isonitrile Darstellung von isonitrilen aus monosubstituierten formamiden durch wasserabspaltung Chem. Ber., 93 (1960), pp. 239-248, 10.1002/cber.19600930136; I. Ugi, R. Meyr Neue Darstellungsmethode für Isonitrile Angew. Chem., 70 (1958), pp. 702-703, 10.1002/ange.19580702213; B. Banerjee Recent developments on ultrasound-assisted one-pot multicomponent synthesis of biologically relevant heterocycles Ultrason. Sonochem., 35 (2017), pp. 15-35, 10.1016/j.ultsonch.2016.10.010; A. Dömling* Recent developments in isocyanide based multicomponent reactions in applied chemistry† Chem. Rev., 106 (2005), pp. 17-89, 10.1021/CR0505728; I. Pachón-Angona, H. Martin, S. Chhor, M.J. Oset-Gasque, B. Refouvelet, J. Marco-Contelles, L. Ismaili Synthesis of new ferulic/lipoic/comenic acid-melatonin hybrids as antioxidants and Nrf2 activators via Ugi reaction Future Med. Chem., 11 (2019), pp. 3097-3108, 10.4155/fmc-2019-0191; M. Ingold, L. Colella, P. Hernández, C. Batthyány, D. Tejedor, A. Puerta, F. García-Tellado, J.M. Padrón, W. Porcal, G.V. López A focused library of no-donor compounds with potent antiproliferative activity based on green multicomponent reactions ChemMedChem, 14 (2019), pp. 1669-1683, 10.1002/cmdc.201900385; E. Avilés, J. Prudhomme, K.G. Le Roch, S.G. Franzblau, K. Chandrasena, A.M.S. Mayer, A.D. Rodríguez Synthesis and preliminary biological evaluation of a small library of hybrid compounds based on Ugi isocyanide multicomponent reactions with a marine natural product scaffold Bioorganic Med. Chem. Lett., 25 (2015), pp. 5339-5343, 10.1016/j.bmcl.2015.09.033; A.H. Rezayan, S. Hariri, P. Azerang, G. Ghavami, I. Portugal, S. Sardari Synthesis of novel fluorene bisamide derivatives via ugi reaction and evaluation their biological activity against mycobacterium species Iran. J. Pharm. Res. IJPR., 16 (2017), p. 745; L. Prent-Peñaloza, A.F. De La Torre, J.L. Velázquez-Libera, M. Gutiérrez, J. Caballero Synthesis of DiN-substituted glycyl-phenylalanine derivatives by using Ugi four component reaction and their potential as acetylcholinesterase inhibitors Molecules (2019), p. 24, 10.3390/molecules24010189; N. Cankařová, V. Krchňák Isocyanide multicomponent reactions on solid phase: state of the art and future application Int. J. Mol. Sci., 21 (2020), pp. 1-48, 10.3390/IJMS21239160; R. Munir, M. Zia-ur-Rehman, S. Murtaza, S. Zaib, N. Javid, S.J. Awan, K. Iftikhar, M.M. Athar, I. Khan Microwave-assisted synthesis of (piperidin-1-yl)quinolin-3-yl)methylene)hydrazinecarbothioamides as potent inhibitors of cholinesterases: a biochemical and in silico approach Molecules, 26 (2021), p. 656, 10.3390/molecules26030656; Z. Breijyeh, R. Karaman Comprehensive review on alzheimer's disease: causes and treatment Molecules (2020), p. 25, 10.3390/MOLECULES25245789; D. Munoz-Torrero Acetylcholinesterase inhibitors as disease-modifying therapies for alzheimers disease Curr. Med. Chem., 15 (2008), pp. 2433-2455, 10.2174/092986708785909067; R.T. Bartus, R.L. Dean, B. Beer, A.S. Lippa The cholinergic hypothesis of geriatric memory dysfunction Science (80-.), 217 (1982), pp. 408-417, 10.1126/science.7046051; T. Zhao, K.M. Ding, L. Zhang, X.M. Cheng, C.H. Wang, Z.T. Wang Acetylcholinesterase and butyrylcholinesterase inhibitory activities of β -carboline and quinoline alkaloids derivatives from the plants of genus peganum J. Chem. (2013), p. 2013, 10.1155/2013/717232; N.H. Greig, T. Utsuki, Q. Yu, X. Zhu, H.W. Holloway, T. Perry, B. Lee, D.K. Ingram, D.K. Lahiri A New Therapeutic Target in Alzheimer's Disease Treatment: attention to Butyrylcholinesterase Curr. Med. Res. Opin, 17 (2001), pp. 159-165, 10.1185/0300799039117057; Q. Li, H. Yang, Y. Chen, H. Sun Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease Eur. J. Med. Chem., 132 (2017), pp. 294-309, 10.1016/j.ejmech.2017.03.062; N.H. Greig, T. Utsuki, D.K. Ingram, Y. Wang, G. Pepeu, C. Scali, Q.S. Yu, J. Mamczarz, H.W. Holloway, T. Giordano, D. Chen, K. Furukawa, K. Sambamurti, A. Brossi, D.K. Lahiri Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent Proc. Natl. Acad. Sci. U. S. A., 102 (2005), pp. 17213-17218, 10.1073/pnas.0508575102; P. Brandão, Ó. López, L. Leitzbach, H. Stark, J.G. Fernández-Bolaños, A.J. Burke, M. Pineiro Ugi reaction synthesis of oxindole–lactam hybrids as selective butyrylcholinesterase inhibitors ACS Med. Chem. Lett. (2021), 10.1021/ACSMEDCHEMLETT.1C00344; Schrödinger, D. E. Shaw Research, New York, NY Release 2021-2:, Desmond Molecular Dynamics System 2021 Maestro-Desmond Interoperability Tools, Schrödinger, New York, NY (2021); T. Tubiana, J.C. Carvaillo, Y. Boulard, S. Bressanelli TTClust: a versatile molecular simulation trajectory clustering program with graphical summaries J. Chem. Inf. Model., 58 (2018), pp. 2178-2182, 10.1021/ACS.JCIM.8B00512/SUPPL_FILE/CI8B00512_SI_001.PDF; H. Chermette Chemical reactivity indexes in density functional theory J. Comput. Chem., 20 (1999), pp. 129-154, 10.1002/(SICI)1096-987X(19990115)20:13.0.CO;2-A; A. Daina, O. Michielin, V. Zoete SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules Sci. Rep., 7 (2017), p. 42717, 10.1038/srep42717; G.L. Ellman, K.D. Courtney, V. Andres, R.M. Featherstone A new and rapid colorimetric determination of acetylcholinesterase activity Biochem. Pharmacol., 7 (1961), pp. 88-95, 10.1016/0006-2952(61)90145-9; H.M. Greenblatt, G. Kryger, T. Lewis, I. Silman, J.L. Sussman Structure of acetylcholinesterase complexed with (−)-galanthamine at 2.3Å resolution FEBS Lett, 463 (1999), pp. 321-326, 10.1016/S0014-5793(99)01637-3; F. Nachon, E. Carletti, C. Ronco, M. Trovaslet, Y. Nicolet, L. Jean, P.Y. Renard Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase Biochem. J., 453 (2013), pp. 393-399, 10.1042/BJ20130013; A.D. Becke Density-functional thermochemistry. III. The role of exact exchange J. Chem. Phys., 98 (1993), pp. 5648-5652, 10.1063/1.464913; C. Lee, W. Yang, R.G. Parr Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density Phys. Rev. B., 37 (1988), pp. 785-789, 10.1103/PhysRevB.37.785; R. Krishnan, J.S. Binkley, R. Seeger, J.A. Pople Self-consistent molecular orbital methods. XX. A basis set for correlated wave functions J. Chem. Phys., 72 (1980), pp. 650-654, 10.1063/1.438955; A.D. McLean, G.S. Chandler Contracted Gaussian basis sets for molecular calculations. I. Second row atoms, Z=11-18 J. Chem. Phys., 72 (1980), pp. 5639-5648, 10.1063/1.438980; G. Frisch, H. Trucks, G. Schlegel, M. Scuseria, J. Robb, J. Cheeseman, T. Montgomery, K. Vreven, J. Kudin, J. Burant, S. Millam, J. Iyengar, V. Tomasi, B. Barone, M. Mennucci, G. Cossi, N. Scalmani, G. Rega, H. Petersson, M. Nakatsuji, M. Hada, K. Ehara, R. Toyota, J. Fukuda, M. Hasegawa, T. Ishida, Y. Nakajima, O. Honda, H. Kitao, M. Nakai, X. Klene, J. Li, H. Knox, J. Hratchian, V. Cross, C. Bakken, J. Adamo, R. Jaramillo, R. Gomperts, O. Stratmann, A. Yazyev, R. Austin, C. Cammi, J. Pomelli, P. Ochterski, K. Ayala, G. Morokuma, P. Voth, J. Salvador, V. Dannenberg, S. Zakrzewski, A. Dapprich, M. Daniels, O. Strain, D. Farkas, A. Malick, K. Rabuck, J. Raghavachari, J. Foresman, Q. Ortiz, A. Cui, S. Baboul, J. Clifford, B. Cioslowski, G. Stefanov, A. Liu, P. Liashenko, I. Piskorz, R. Komaromi, D. Martin, T. Fox, A. Keith, C. Laham, A. Peng, M. Nanayakkara, P. Challacombe, B. Gill, W. Johnson, M. Chen, C. Wong, J. Gonzalez Pople, Gaussian 09, Revision D.01 Gaussian, Inc., Wallingford CT (2009); G.M. Morris, H. Ruth, W. Lindstrom, M.F. Sanner, R.K. Belew, D.S. Goodsell, A.J. Olson Software news and updates AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility J. Comput. Chem., 30 (2009), pp. 2785-2791, 10.1002/jcc.21256; G.M. Morris, D.S. Goodsell, R.S. Halliday, R. Huey, W.E. Hart, R.K. Belew, A.J. Olson Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function J. Comput. Chem., 19 (1998), pp. 1639-1662, 10.1002/(SICI)1096-987X(19981115)19:143.0.CO;2-B; W.L. DeLano, The PyMOL molecular graphics system, (2002). http://www.pymol.org.; S. Salentin, S. Schreiber, V.J. Haupt, M.F. Adasme, M. Schroeder PLIP: fully automated protein–ligand interaction profiler Nucleic Acids Res., 43 (2015), pp. W443-W447, 10.1093/NAR/GKV315; M.P. Jacobson, D.L. Pincus, C.S. Rapp, T.J.F. Day, B. Honig, D.E. Shaw, R.A. Friesner A hierarchical approach to all-atom protein loop prediction Proteins Struct. Funct. Bioinforma., 55 (2004), pp. 351-367, 10.1002/prot.10613; https://hdl.handle.net/20.500.12313/3834
-
18Academic Journal
المؤلفون: De-La-Torre, Pedro, Osorio, Edison, Alzate-Morales, Jans H., Caballero, Julio, Trilleras, Jorge, Astudillo-Saavedra, Luis, Brito, Ivan, Cardenas, Alejandro, Quiroga, Jairo, Gutierrez, Margarita
جغرافية الموضوع: OXFORD
Relation: instname: Conicyt; reponame: Repositorio Digital RI2.0; info:eu-repo/grantAgreement/Fondecyt/1100481; info:eu-repo/semantics/dataset/hdl.handle.net/10533/93477; https://doi.org/10.1016/j.ultsonch.2014.02.021; 1100481; WOS:000337776800010; https://hdl.handle.net/10533/131722
الاتاحة: https://hdl.handle.net/10533/131722
-
19Academic Journal
المؤلفون: Rodriguez-Azua, Rosio, Treuer, Adriana, Moore-Carrasco, Rodrigo, Cortacans, Daniel, Gutierrez, Margarita, Astudillo, Luis, Fuentes, Eduardo, Palomo, Ivan
جغرافية الموضوع: NEW YORK
Relation: instname: Conicyt; reponame: Repositorio Digital RI2.0; info:eu-repo/grantAgreement/Fondecyt/1130216; info:eu-repo/semantics/dataset/hdl.handle.net/10533/93477; https://doi.org/10.1089/jmf.2012.0243; 1130216; WOS:000336217200013; https://hdl.handle.net/10533/133896
الاتاحة: https://hdl.handle.net/10533/133896
-
20Academic Journal
المؤلفون: Polo-Cuadrado, Efraín, Rojas-Peña, Cristian, Acosta-Quiroga, Karen, Camargo-Ayala, Lorena, Brito, Iván, Cisterna, Jonathan, Moncada, Félix, Trilleras, Jorge, Rodríguez-Núñez, Yeray A., Gutierrez, Margarita
المساهمون: Universidad de Talca
المصدر: RSC Advances ; volume 12, issue 51, page 33032-33048 ; ISSN 2046-2069