المؤلفون: Grigorios Nikitidis (4508872), Anna-Carin C. Carlsson (3945737), Staffan Karlsson (1443904), Andrew D. Campbell (9772366), Calum Cook (3927476), Kuangchu Dai (6904937), Hans Emtenäs (1684684), Anna C. Jonson (4007507), Hanna Leek (4007504), Marcus Malmgren (6278591), Štefan Moravčík (6933980), Subhash Pithani (6919280), Matthew R. Tatton (1304370), Hucheng Zhao (6852461), Kristina Öhlén (11326106)

مصطلحات موضوعية: Biochemistry, Pharmacology, Sociology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, multigram synthesis, drug development projects, API purification, drug candidates, Chromatographic Challenges, sequence, Multigram Manufacture, atropisomer separation, chiral axis, biaryl fragment, KRAS G 12C Inhibitors, Suzuki reaction

Relation: https://figshare.com/articles/journal_contribution/Synthetic_and_Chromatographic_Challenges_and_Strategies_for_Multigram_Manufacture_of_KRAS_sup_G12C_sup_Inhibitors/16432385

الاتاحة: https://doi.org/10.1021/acs.oprd.1c00179.s001

المؤلفون: Andrew D. Campbell, Staffan Karlsson, Štefan Moravčík, Hanna Leek, Kuangchu Dai, Matthew R. Tatton, Kristina Öhlén, Hucheng Zhao, Marcus Malmgren, Hans Emtenäs, Anna-Carin C. Carlsson, Grigorios Nikitidis, Calum Cook, Anna C. Jonson, Subhash Pithani

المصدر: Organic Process Research & Development. 26:710-729

مصطلحات موضوعية: Chromatography, Chemistry, Organic Chemistry, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::74da56bf2c792c0006f997ab45182e45
https://doi.org/10.1021/acs.oprd.1c00179

المؤلفون: Eva Lamm Bergström, Fredrik Wågberg, Christian Tyrchan, Anders Lundqvist, Ulf Andersson, Xiao-Hong Zhou, Robert Ronn, Linda Swedin, Grigorios Nikitidis, Fanyi Jiang, Victoria Ullah, Antonios Nikitidis, Petra Johannesson, Eva Björkstrand, Hui-Fang Chang, Theresa Andreasson, Lena Ripa, Magnus Munck af Rosenschöld, Pernilla Glader, Anna Pettersen, Britta Bonn, Margareta Ek, Andrew M. Davis, Euan Gordon, Helena Käck, Dave Chapman, Mattias Rohman, Anna Malmberg

المصدر: Journal of Medicinal Chemistry. 62:7769-7787

مصطلحات موضوعية: chemistry.chemical_classification, 0303 health sciences, Ligand efficiency, Leukotriene C4, Pharmacology, 01 natural sciences, Peripheral blood mononuclear cell, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, Enzyme, chemistry, In vivo, Pharmacodynamics, Drug Discovery, Molecular Medicine, Potency, IC50, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::76db67d7944baf037a5f82180c0e160c
https://doi.org/10.1021/acs.jmedchem.9b00555

المؤلفون: Marcus Malmgren, Grigorios Nikitidis, Carl-Johan Aurell, Subhash Pithani, Stig D. Friis

المصدر: Organic Process Research & Development. 23:1752-1757

مصطلحات موضوعية: Green chemistry, chemistry.chemical_compound, chemistry, Ligand, Aryl, Process chemistry, Organic Chemistry, Substrate (chemistry), Physical and Theoretical Chemistry, Weak base, Combinatorial chemistry, Amination, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a665e3f2d66de7f7b4906f1c46c50dd3
https://doi.org/10.1021/acs.oprd.9b00237

المؤلفون: Kenneth L. Granberg, Zhong-Qing Yuan, Bo Lindmark, Karl Edman, Johan Kajanus, Anders Hogner, Marcus Malmgren, Gavin O’Mahony, Anneli Nordqvist, Jan Lindberg, Stefan Tångefjord, Michael Kossenjans, Christian Löfberg, Jonas Brånalt, Dongmei Liu, Nidhal Selmi, Grigorios Nikitidis, Peter Nordberg, Ahlke Hayen, Anna Aagaard, Eva Hansson, Majlis Hermansson, Ida Ivarsson, Rasmus Jansson-Löfmark, Ulla Karlsson, Ulrika Johansson, Lena William-Olsson, Judith Hartleib-Geschwindner, Krister Bamberg

المصدر: Journal of Medicinal Chemistry. 62:1385-1406

مصطلحات موضوعية: Male, 0301 basic medicine, Molecular Structure, Sodium, Heart, 030204 cardiovascular system & hematology, Kidney, Protective Agents, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, Receptors, Mineralocorticoid, 030104 developmental biology, 0302 clinical medicine, Oxazines, Drug Discovery, Potassium, Animals, Homeostasis, Humans, Molecular Medicine, Rats, Wistar, Renal Insufficiency, Chronic, Mineralocorticoid Receptor Antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f3415ae30a4bd17f715f083a4fc37e
https://doi.org/10.1021/acs.jmedchem.8b01523

المؤلفون: Tor Svensson, Marika Lindhagen, Grigorios Nikitidis, Staffan Karlsson, Cristina Gardelli

المصدر: Organic Process Research & Development. 22:1174-1187

مصطلحات موضوعية: Agonist, chemistry.chemical_classification, Ketone, 010405 organic chemistry, medicine.drug_class, Chemistry, Organic Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Desymmetrization, 0104 chemical sciences, Hydroboration, chemistry.chemical_compound, Yield (chemistry), medicine, Ghrelin, Physical and Theoretical Chemistry, Cyclopentane, Curtius rearrangement

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7f0d3623b957eece79ff498e8acebaa4
https://doi.org/10.1021/acs.oprd.8b00179

المؤلفون: Magnus, Munck Af Rosenschöld, Petra, Johannesson, Antonios, Nikitidis, Christian, Tyrchan, Hui-Fang, Chang, Robert, Rönn, Dave, Chapman, Victoria, Ullah, Grigorios, Nikitidis, Pernilla, Glader, Helena, Käck, Britta, Bonn, Fredrik, Wågberg, Eva, Björkstrand, Ulf, Andersson, Linda, Swedin, Mattias, Rohman, Theresa, Andreasson, Eva Lamm, Bergström, Fanyi, Jiang, Xiao-Hong, Zhou, Anders J, Lundqvist, Anna, Malmberg, Margareta, Ek, Euan, Gordon, Anna, Pettersen, Lena, Ripa, Andrew M, Davis

المصدر: Journal of medicinal chemistry. 62(17)

مصطلحات موضوعية: Dose-Response Relationship, Drug, Molecular Structure, Administration, Oral, Asthma, Rats, Disease Models, Animal, Structure-Activity Relationship, Pyrazines, Drug Discovery, Animals, Humans, Anti-Asthmatic Agents, Enzyme Inhibitors, Glutathione Transferase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::14a2759a1fc1e1a9c5c1ce4c83ae3c85
https://pubmed.ncbi.nlm.nih.gov/31415176

المؤلفون: Markus Berger, Ramon Hendrickx, Martin Lindsjö, Stinabritt Nilsson, Tina Jellesmark Jensen, Tomas Klingstedt, Wayne Russell, Hartmut Rehwinkel, Martin Hemmerling, Thomas Hansson, Nafizal Hossain, Stefan Eirefelt, Balint Gabos, Henrik Johansson, Grigorios Nikitidis, Svetlana Ivanova, John Steele, Matti Lepistö, Eskil Johnsson, Anne-Helene Jansson, Anna Abrahamsson, Carina Kärrman Mårdh, Krister Henriksson, Jan Dahmén, Karl Edman, Anders Eriksson, Ulrika Tehler, Anders Jerre, Irene Mile, Lisa Wissler

المصدر: Journal of medicinal chemistry. 60(20)

مصطلحات موضوعية: 0301 basic medicine, Drug, medicine.medical_specialty, Indazoles, medicine.drug_class, media_common.quotation_subject, Proton Magnetic Resonance Spectroscopy, Pulmonary Edema, Pharmacology, Fluticasone propionate, Mass Spectrometry, 03 medical and health sciences, Glucocorticoid receptor, Therapeutic index, Receptors, Glucocorticoid, Internal medicine, Drug Discovery, Acetamides, Administration, Inhalation, medicine, Animals, Humans, Receptor, media_common, Aged, Thymic involution, Inhalation, Dose-Response Relationship, Drug, Chemistry, Rats, 030104 developmental biology, Endocrinology, Molecular Medicine, Corticosteroid, Powders, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f24c66ce17b946cd661fe6628c9bfcc
https://pubmed.ncbi.nlm.nih.gov/28937774

المؤلفون: Antonio Llinas, Göran Duker, Annika Åstrand, Victoria Ullah, Qing-Dong Wang, Fabrizio Giordanetto, Grigorios Nikitidis, Fredrik Thorstensson, Emma Lindhardt, Anders Lindqvist, Staffan Karlsson, Nidhal Selmi, Got Högberg, Andreas Wållberg, Laurent Knerr, Åsa Lindelöf

المصدر: Bioorganicmedicinal chemistry letters. 23(1)

مصطلحات موضوعية: Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, Biochemistry, chemistry.chemical_compound, Calcium Channels, T-Type, Structure-Activity Relationship, Dogs, Heart Rate, Drug Discovery, medicine, Animals, Humans, Hydroxymethyl, Benzamide, Molecular Biology, Ion channel, Mibefradil, Voltage-dependent calcium channel, Calcium channel, Organic Chemistry, T-type calcium channel, Calcium Channel Inhibition, Calcium Channel Blockers, chemistry, Benzamides, Molecular Medicine, medicine.drug, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d91b9b81d442c16ed0609d98d792fd
https://pubmed.ncbi.nlm.nih.gov/23200256

المؤلفون: Anders Hallberg, Niels Harrit, Grigorios Nikitidis, I. Trabjerg, Lars Ivar Elding, Salo Gronowitz

المصدر: Acta Chemica Scandinavica. 45:632-635

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Bicyclic molecule, General Chemical Engineering, Thiophene, Medicinal chemistry, Sulfone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1a6f41e1dbe819b7b5f5607b54b346dd
https://doi.org/10.3891/acta.chem.scand.45-0632

المؤلفون: Salo Gronowitz, Grigorios Nikitidis, Anders Hallberg, Claes Stålhandske, Lars I. Elding, I. Trabjerg

المصدر: Acta Chemica Scandinavica. 45:636-643

مصطلحات موضوعية: chemistry.chemical_compound, Decalin, Bicyclic molecule, Chemistry, General Chemical Engineering, Thiophene, Crystal structure, 3-Bromothiophene, Aliphatic compound, Medicinal chemistry, Bond cleavage, Sulfone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bea63ae7dfac76abd800ab4effc5ddf9
https://doi.org/10.3891/acta.chem.scand.45-0636

المؤلفون: Salo Gronowitz, Claes Staalhandske, Grigorios Nikitidis, Anders Hallberg

المصدر: The Journal of Organic Chemistry. 56:4064-4066

مصطلحات موضوعية: chemistry.chemical_compound, Deuterium, chemistry, Reagent, Organic Chemistry, Grignard reagent, Medicinal chemistry, Derivative (chemistry), Sulfone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::90ba9c1eec63bb54a42a24a03208d08f
https://doi.org/10.1021/jo00012a052

المؤلفون: Grigorios Nikitidis, Salo Gronowitz, Anders Hallberg, Claes Stålhandske, Rolf Norrestam

المصدر: Acta Chemica Scandinavica. :297-301

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, General Chemical Engineering, X-ray crystallography, X-ray, Organic chemistry, Molecule, Crystal structure, Piperidine, Benzene, Medicinal chemistry, Toluene, Sulfone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f4b58d69de1653b79f09aac8ab014f05
https://doi.org/10.3891/acta.chem.scand.41b-0297

المؤلفون: Anders Hallberg, Salo Gronowitz, Grigorios Nikitidis, Rolf Servin

المصدر: The Journal of Organic Chemistry. 53:3351-3353

مصطلحات موضوعية: chemistry.chemical_compound, Tandem, chemistry, Stereochemistry, Organic Chemistry, Nuclear magnetic resonance spectroscopy, Halo, Ring (chemistry), Cycloaddition, Sulfone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::312d8bd1daad75d2f5b8bba279f67516
https://doi.org/10.1021/jo00249a041