المؤلفون: Ameen, S Sadia, Griem-Krey, Nane, Dufour, Antoine, Hossain, M Iqbal, Hoque, Ashfaqul, Sturgeon, Sharelle, Nandurkar, Harshal, Draxler, Dominik F, Medcalf, Robert L, Kamaruddin, Mohd Aizuddin, Lucet, Isabelle S, Leeming, Michael G, Liu, Dazhi, Dhillon, Amardeep, Lim, Jet Phey, Basheer, Faiza, Zhu, Hong-Jian, Bokhari, Laita, Roulston, Carli L, Paradkar, Prasad N, Kleifeld, Oded, Clarkson, Andrew N, Wellendorph, Petrine, Ciccotosto, Giuseppe D, Williamson, Nicholas A, Ang, Ching-Seng, Cheng, Heung-Chin

المصدر: Molecular & cellular proteomics : MCP. 22(5)

مصطلحات موضوعية: Neurons, Cells, Cultured, Animals, Mice, Rats, Nervous System Diseases, Calpain, Glutamic Acid, Proteolysis, Neuroprotection, CRMP2, CaM kinase IIa, CaM kinase IIb, Src, calpains, excitotoxicity, neuronal death, neuroprotection, proteolytic processing, synaptic damage, Neurosciences, Stroke, Genetics, Brain Disorders, Underpinning research, Aetiology, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Neurological, Biochemistry & Molecular Biology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/1wq8b98r
https://escholarship.org/content/qt1wq8b98r/qt1wq8b98r.pdf

المؤلفون: Leurs, Ulrike, Klein, Anders B, McSpadden, Ethan D, Griem-Krey, Nane, Solbak, Sara MØ, Houlton, Josh, Villumsen, Inge S, Vogensen, Stine B, Hamborg, Louise, Gauger, Stine J, Palmelund, Line B, Larsen, Anne Sofie G, Shehata, Mohamed A, Kelstrup, Christian D, Olsen, Jesper V, Bach, Anders, Burnie, Robert O, Kerr, D Steven, Gowing, Emma K, Teurlings, Selina MW, C., Chris, Gee, Christine L, Frølund, Bente, Kornum, Birgitte R, van Woerden, Geeske M, Clausen, Rasmus P, Kuriyan, John, Clarkson, Andrew N, Wellendorph, Petrine

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 118(31)

مصطلحات موضوعية: Medicinal and Biomolecular Chemistry, Chemical Sciences, Brain Disorders, Neurosciences, 1.1 Normal biological development and functioning, 5.1 Pharmaceuticals, Neurological, Binding Sites, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Carboxylic Acids, Crystallography, X-Ray, Cyclopentanes, Gene Expression Regulation, Enzymologic, HEK293 Cells, Humans, Neuroprotection, Protein Binding, Protein Domains, Signal Transduction, Sodium Oxybate, photoaffinity labeling, x-ray crystallography, HOCPCA, excitotoxicity, photothrombotic storke, photothrombotic stroke

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6fq63908
https://escholarship.org/content/qt6fq63908/qt6fq63908.pdf

المؤلفون: Narayanan, Dilip, Larsen, Anne Sofie G, Gauger, Stine Juul, Adafia, Ruth, Hammershøi, Rikke Bartschick, Hamborg, Louise, Bruus-Jensen, Jesper, Griem-Krey, Nane, Gee, Christine L, Frølund, Bente, Stratton, Margaret M, Kuriyan, John, Kastrup, Jette Sandholm, Langkilde, Annette E, Wellendorph, Petrine, Solbak, Sara M Ø

المصدر: Narayanan , D , Larsen , A S G , Gauger , S J , Adafia , R , Hammershøi , R B , Hamborg , L , Bruus-Jensen , J , Griem-Krey , N , Gee , C L , Frølund , B , Stratton , M M , Kuriyan , J , Kastrup , J S , Langkilde , A E , Wellendorph , P & Solbak , S M Ø 2024 , ' Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking, and modulation of kinase activity ' , Protein science : a publication of the Protein ....

مصطلحات موضوعية: Calcium-Calmodulin-Dependent Protein Kinase Type 2/chemistry, Crystallography, X-Ray, Humans, Protein Domains, Ligands, Models, Molecular, Scattering, Small Angle, Tryptophan/chemistry, Pyridazines/chemistry, Phosphorylation

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/ligandinduced-camkii-hub-trp403-flip-hub-domain-stacking-and-modulation-of-kinase-activity(7601808a-7564-411f-89d8-48472b085a65).html
https://doi.org/10.1002/pro.5152
https://curis.ku.dk/ws/files/407791133/Protein_Science_2024_Narayanan_Ligand_induced_CaMKII_hub_Trp403_flip_hub_domain_stacking_and_modulation_of_kinase_1_.pdf

المؤلفون: Andersen, Jens V., Westi, Emil W., Griem-Krey, Nane, Skotte, Niels H., Schousboe, Arne, Aldana, Blanca I., Wellendorph, Petrine

المصدر: Andersen , J V , Westi , E W , Griem-Krey , N , Skotte , N H , Schousboe , A , Aldana , B I & Wellendorph , P 2024 , ' Deletion of CaMKIIα disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex ' , Journal of Neurochemistry , vol. 168 , no. 5 , pp. 704-718 . https://doi.org/10.1111/jnc.15814

مصطلحات موضوعية: astrocytes, Ca/calmodulin-dependent protein kinase II alpha, energy and neurotransmitter metabolism, long-term potentiation, mitochondria, neurotransmitter recycling

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/deletion-of-camkii-disrupts-glucose-metabolism-glutamate-uptake-and-synaptic-energetics-in-the-cerebral-cortex(ce588ea3-ff29-4fc1-baba-53b272917f42).html
https://doi.org/10.1111/jnc.15814
https://curis.ku.dk/ws/files/392872260/Journal_of_Neurochemistry_2023_Andersen_Deletion_of_CaMKII_disrupts_glucose_metabolism_glutamate_uptake_and.pdf

المؤلفون: Griem-Krey, Nane, Klein, Anders B., Clausen, Bettina H., Namini, Mathias R.J., Nielsen, Pernille V., Bhuiyan, Mozammel, Nagaraja, Raghavendra Y., De Silva, T. Michael, Sobey, Christopher G., Cheng, Heung Chin, Orset, Cyrille, Vivien, Denis, Lambertsen, Kate L., Clarkson, Andrew N., Wellendorph, Petrine

المصدر: Griem-Krey , N , Klein , A B , Clausen , B H , Namini , M R J , Nielsen , P V , Bhuiyan , M , Nagaraja , R Y , De Silva , T M , Sobey , C G , Cheng , H C , Orset , C , Vivien , D , Lambertsen , K L , Clarkson , A N & Wellendorph , P 2023 , ' The GHB analogue HOCPCA improves deficits in cognition and sensorimotor function after MCAO via CaMKIIα ' , Journal of Cerebral Blood Flow and Metabolism , ....

مصطلحات موضوعية: CaMKII, excitotoxicity, functional recovery, HOCPCA, MCAO, Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism, Stroke, Animals, Mice, Cognition, Sodium Oxybate/metabolism

وصف الملف: application/pdf

الاتاحة: https://portal.findresearcher.sdu.dk/da/publications/1b0c9b8a-cf88-4d53-8c89-e505cd998e6b
https://doi.org/10.1177/0271678X231167920
https://findresearcher.sdu.dk/ws/files/243708423/Open_Access_Version.pdf

المؤلفون: Ameen, S. Sadia, Griem-Krey, Nane, Dufour, Antoine, Hossain, M. Iqbal, Hoque, Ashfaqul, Sturgeon, Sharelle, Nandurkar, Harshal, Draxler, Dominik F., Medcalf, Robert L., Kamaruddin, Mohd Aizuddin, Lucet, Isabelle S., Leeming, Michael G., Liu, Dazhi, Dhillon, Amardeep, Lim, Jet Phey, Basheer, Faiza, Zhu, Hong Jian, Bokhari, Laita, Roulston, Carli L., Paradkar, Prasad N., Kleifeld, Oded, Clarkson, Andrew N., Wellendorph, Petrine, Ciccotosto, Giuseppe D., Williamson, Nicholas A., Ang, Ching Seng, Cheng, Heung Chin

المصدر: Ameen , S S , Griem-Krey , N , Dufour , A , Hossain , M I , Hoque , A , Sturgeon , S , Nandurkar , H , Draxler , D F , Medcalf , R L , Kamaruddin , M A , Lucet , I S , Leeming , M G , Liu , D , Dhillon , A , Lim , J P , Basheer , F , Zhu , H J , Bokhari , L , Roulston , C L , Paradkar , P N , Kleifeld , O , Clarkson , A N ....

مصطلحات موضوعية: calpains, CaM kinase IIa, CaM kinase IIb, CRMP2, excitotoxicity, neuronal death, neuroprotection, proteolytic processing, Src, synaptic damage

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/nterminomic-changes-in-neurons-during-excitotoxicity-reveal-proteolytic-events-associated-with-synaptic-dysfunctions-and-potential-targets-for-neuroprotection(d21e44f0-9566-4d49-893b-fb63f48af858).html
https://doi.org/10.1016/j.mcpro.2023.100543
https://curis.ku.dk/ws/files/357280187/1_s2.0_S1535947623000531_main.pdf

المؤلفون: Griem-Krey, Nane, Clarkson, Andrew N., Wellendorph, Petrine

المصدر: Griem-Krey , N , Clarkson , A N & Wellendorph , P 2022 , ' CaMKIIα as a Promising Drug Target for Ischemic Grey Matter ' , Brain Sciences , vol. 12 , no. 12 , 1639 . https://doi.org/10.3390/brainsci12121639

مصطلحات موضوعية: CaMKII, excitotoxicity, GHB analogues, glutamate, HOCPCA, ischemia, neuroprotection, stroke

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/camkii-as-a-promising-drug-target-for-ischemic-grey-matter(d174ab5b-7df2-4003-bc0a-b7d47a7856ec).html
https://doi.org/10.3390/brainsci12121639
https://curis.ku.dk/ws/files/332687471/brainsci_12_01639_v2.pdf

المؤلفون: Griem-Krey, Nane, Gauger, Stine J., Gowing, Emma K., Thiesen, Louise, Frølund, Bente, Clarkson, Andrew N., Wellendorph, Petrine

المصدر: Griem-Krey , N , Gauger , S J , Gowing , E K , Thiesen , L , Frølund , B , Clarkson , A N & Wellendorph , P 2022 , ' The CaMKIIα hub ligand Ph-HTBA promotes neuroprotection after focal ischemic stroke by a distinct molecular interaction ' , Biomedicine and Pharmacotherapy , vol. 156 , 113895 . https://doi.org/10.1016/j.biopha.2022.113895

مصطلحات موضوعية: Autophosphorylation, Baclofen (PubChem CID: 44602), KN93 (PubChem CID: 5312122), CaMKII, GHB (PubChem CID: 23663870), HOCPCA (PubChem CID: 21750168), Hub domain, Motor behavior, Photothrombotic stroke

وصف الملف: application/pdf

الاتاحة: https://curis.ku.dk/portal/da/publications/the-camkii-hub-ligand-phhtba-promotes-neuroprotection-after-focal-ischemic-stroke-by-a-distinct-molecular-interaction(3ee80d1d-a021-4021-a788-305209948489).html
https://doi.org/10.1016/j.biopha.2022.113895
https://curis.ku.dk/ws/files/323978490/1_s2.0_S0753332222012847_main.pdf

المؤلفون: L'Estrade, Elina T., Hansen, Hanne D., Falk-Petersen, Christina, Haugaard, Anne, Griem-Krey, Nane, Jung, Sascha, Lueddens, Hartmut, Schirmeister, Tanja, Erlandsson, Maria, Ohlsson, Tomas, Knudsen, Gitte M., Herth, Matthias M., Wellendorph, Petrine, Frolund, Bente

المصدر: L'Estrade , E T , Hansen , H D , Falk-Petersen , C , Haugaard , A , Griem-Krey , N , Jung , S , Lueddens , H , Schirmeister , T , Erlandsson , M , Ohlsson , T , Knudsen , G M , Herth , M M , Wellendorph , P & Frolund , B 2019 , ' Synthesis and Pharmacological Evaluation of [C-11]4-Methoxy-N-[2-(thiophen-2-yl) imidazo[1,2-a] pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the delta-Subunit-Containing gamma-Aminobutyric Acid Type A Receptors ' , ACS Omega , vol. 4 , no. 5 , pp. 8846-8851 . ....

وصف الملف: application/pdf

الاتاحة: https://curis.ku.dk/portal/da/publications/synthesis-and-pharmacological-evaluation-of-c114methoxyn2thiophen2yl-imidazo12a-pyridin3ylbenzamide-as-a-brain-penetrant-pet-ligand-selective-for-the-deltasubunitcontaining-gammaaminobutyric-acid-type-a-receptors(bf583b78-d2d4-4141-9fe6-64a5e59809e0).html
https://doi.org/10.1021/acsomega.9b00434
https://curis.ku.dk/ws/files/227570870/acsomega.9b00434.pdf

المؤلفون: Griem-Krey, Nane, Klein, Anders B, Clausen, Bettina H, Namini, Mathias RJ, Nielsen, Pernille V, Bhuiyan, Mozammel, Nagaraja, Raghavendra Y, De Silva, T Michael, Sobey, Christopher G, Cheng, Heung-Chin, Orset, Cyrille, Vivien, Denis, Lambertsen, Kate L, Clarkson, Andrew N, Wellendorph, Petrine

مصطلحات موضوعية: 110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::26d955954437b281207627cfffc71b35

المؤلفون: Griem-Krey, Nane, Klein, Anders B, Clausen, Bettina H, Namini, Mathias RJ, Nielsen, Pernille V, Bhuiyan, Mozammel, Nagaraja, Raghavendra Y, De Silva, T Michael, Sobey, Christopher G, Cheng, Heung-Chin, Orset, Cyrille, Vivien, Denis, Lambertsen, Kate L, Clarkson, Andrew N, Wellendorph, Petrine

مصطلحات موضوعية: 110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cfa738ac1e06e6b98169fe32013b25e7

المؤلفون: Lie, Maria Elena Klibo, Falk-Petersen, Christina Birkedahl, Petersen, Louise Piilgaard, Griem-Krey, Nane, Wellendorph, Petrine, Kornum, Birgitte Rahbek

المصدر: Lie , M E K , Falk-Petersen , C B , Petersen , L P , Griem-Krey , N , Wellendorph , P & Kornum , B R 2021 , ' GABAA receptor β1-subunit knock-out mice show increased delta power in NREM sleep and decreased theta power in REM sleep ' , European Journal of Neuroscience , vol. 54 , no. 2 , pp. 4445-4455 . https://doi.org/10.1111/ejn.15267

الاتاحة: https://researchprofiles.ku.dk/da/publications/gabaa-receptor-1subunit-knockout-mice-show-increased-delta-power-in-nrem-sleep-and-decreased-theta-power-in-rem-sleep(16924398-a9dc-473d-b3e1-a414ab243790).html
https://doi.org/10.1111/ejn.15267

المؤلفون: Griem-Krey, Nane, Frolund, Bente, Marek, Ales, Wellendorph, Petrine

المصدر: Griem-Krey , N , Frolund , B , Marek , A & Wellendorph , P 2021 , ' Radiolabeled HOCPCA as a highly useful tool in drug discovery and pharmacology ' , Journal of Labelled Compounds and Radiopharmaceuticals , vol. 64 , no. 2 . https://doi.org/10.1002/jlcr.3870

مصطلحات موضوعية: GHB high-affinity binding sites, MCT1 uptake, radioligand binding, selective GHB ligand, GAMMA-HYDROXYBUTYRIC ACID, AFFINITY BINDING-SITE, ETHANOIC ACID, GHB

الاتاحة: https://researchprofiles.ku.dk/da/publications/radiolabeled-hocpca-as-a-highly-useful-tool-in-drug-discovery-and-pharmacology(828ba3e8-422b-458c-b8e4-c257f76d3f45).html
https://doi.org/10.1002/jlcr.3870

المؤلفون: Thiesen, Louise, Belew, Zeinu Mussa, Griem-Krey, Nane, Pedersen, Stine Falsig, Crocoll, Christoph, Nour-Eldin, Hussam Hassan, Wellendorph, Petrine

المصدر: Thiesen , L , Belew , Z M , Griem-Krey , N , Pedersen , S F , Crocoll , C , Nour-Eldin , H H & Wellendorph , P 2020 , ' The γ-hydroxybutyric acid (GHB) analogue NCS-382 is a substrate for both monocarboxylate transporters subtypes 1 and 4 ' , European Journal of Pharmaceutical Sciences , vol. 143 , 105203 , pp. 1-9 . https://doi.org/10.1016/j.ejps.2019.105203

مصطلحات موضوعية: BCECF, Brain uptake, GHB, MCT, NCS-382 transport

الاتاحة: https://curis.ku.dk/portal/da/publications/the-hydroxybutyric-acid-ghb-analogue-ncs382-is-a-substrate-for-both-monocarboxylate-transporters-subtypes-1-and-4(2922a576-a045-47b8-9cab-83a367552804).html
https://doi.org/10.1016/j.ejps.2019.105203

المؤلفون: Griem-Krey, Nane, Klein, Anders Bue, Herth, Matthias, Wellendorph, Petrine

المصدر: Griem-Krey , N , Klein , A B , Herth , M & Wellendorph , P 2019 , ' Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets ' , Journal of visualized experiments : JoVE , no. 145 , e58879 . https://doi.org/10.3791/58879

الاتاحة: https://researchprofiles.ku.dk/da/publications/autoradiography-as-a-simple-and-powerful-method-for-visualization-and-characterization-of-pharmacological-targets(dbb80930-2924-4064-b724-41b836c4bd8e).html
https://doi.org/10.3791/58879

المؤلفون: Lie, Maria Elena Klibo, Falk‐Petersen, Christina Birkedahl, Piilgaard, Louise, Griem‐Krey, Nane, Wellendorph, Petrine, Kornum, Birgitte Rahbek, Adamantidis, Antoine

المصدر: European Journal of Neuroscience; Jul2021, Vol. 54 Issue 2, p4445-4455, 11p, 1 Black and White Photograph, 1 Chart, 2 Graphs

مصطلحات موضوعية: RAPID eye movement sleep, THETA rhythm, LABORATORY mice, SLEEP, MICE

المؤلفون: Griem‐Krey, Nane, Frølund, Bente, Marek, Aleš, Wellendorph, Petrine

المصدر: Journal of Labelled Compounds & Radiopharmaceuticals; Feb2021, Vol. 64 Issue 2, p77-81, 5p

مصطلحات موضوعية: PHARMACOLOGY, BINDING sites, GAMMA-hydroxybutyrate, SMALL molecules, AUTORADIOGRAPHY, NARCOLEPSY, DRUG discovery

المؤلفون: Griem-Krey, Nane

مصطلحات الفهرس: person

URL: https://curis.ku.dk/portal/da/persons/nane-griemkrey(32786a9b-e0ae-4c1c-9c8c-a505940e3232).html

المؤلفون: Leurs, Ulrike, Klein, Anders B., McSpadden, Ethan D., Griem-Krey, Nane, Solbak, Sara Ø., Houlton, Josh, Villumsen, Inge S., Vogensen, Stine B., Hamborg, Louise, Gauger, Stine J., Palmelund, Line B., Larsen, Anne G., Shehata, Mohamed A., Kelstrup, Christian D., Olsen, Jesper V., Bach, Anders, Burnie, Robert O., Kerr, D. Steven, Gowing, Emma K., Teurlings, Selina W., Chi, Chris C., Gee, Christine L., Frølund, Bente, Kornum, Birgitte R., van Woerden, Geeske M., Clausen, Rasmus P., Kuriyan, John, Clarkson, Andrew N., Wellendorph, Petrine

مصطلحات موضوعية: 59 BASIC BIOLOGICAL SCIENCES

وصف الملف: application/pdf

Relation: http://www.osti.gov/servlets/purl/1819868; https://www.osti.gov/biblio/1819868; https://doi.org/10.1073/pnas.2108079118

الاتاحة: http://www.osti.gov/servlets/purl/1819868
https://www.osti.gov/biblio/1819868
https://doi.org/10.1073/pnas.2108079118

المؤلفون: L'Estrade, Elina T., Hansen, Hanne D., Falk-Petersen, Christina, Haugaard, Anne, Griem-Krey, Nane, Jung, Sascha, Lüddens, Hartmut, Schirmeister, Tanja, Erlandsson, Maria, Ohlsson, Tomas, Knudsen, Gitte M., Herth, Matthias M., Wellendorph, Petrine, Frølund, Bente

المصدر: ACS Omega; 5/31/2019, Vol. 4 Issue 5, p8846-8851, 6p