المؤلفون: Andrew J. McNair, Greg R. Markby, Qiyu Tang, Vicky E. MacRae, Brendan M. Corcoran

المصدر: Frontiers in Veterinary Science, Vol 10 (2023)

مصطلحات موضوعية: myxomatous mitral valve disease, transforming growth factor-beta, canine, SMAD2, PI3K/AKT/mTOR, Veterinary medicine, SF600-1100

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fvets.2023.1202001/full; https://doaj.org/toc/2297-1769

URL الوصول: https://doaj.org/article/2f3478e8fd424d18a0516a1ff155b0bd

المؤلفون: Hiu-Gwen Tsang, Emily L. Clark, Greg R. Markby, Stephen J. Bush, David A. Hume, Brendan M. Corcoran, Vicky E. MacRae, Kim M. Summers

المصدر: Frontiers in Genetics, Vol 11 (2020)

مصطلحات موضوعية: sheep, cardiovascular system, extra cellular matrix, gene expression, RNA-seq, network analysis, Genetics, QH426-470

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fgene.2020.00919/full; https://doaj.org/toc/1664-8021

URL الوصول: https://doaj.org/article/1a066b9a08b44aa18c5857147e0a535c

المؤلفون: Greg R. Markby, Vicky E. Macrae, Kim M. Summers, Brendan M. Corcoran

المصدر: Frontiers in Genetics, Vol 11 (2020)

مصطلحات موضوعية: myxomatous mitral valve disease, gene expression, canine, transforming growth factor β, ontogeny gene expression, Genetics, QH426-470

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fgene.2020.00372/full; https://doaj.org/toc/1664-8021

URL الوصول: https://doaj.org/article/8e7081bbb14b40abacef8fc99722089c

المؤلفون: Greg R. Markby, Kim M. Summers, Vicky E. MacRae, Brendan M. Corcoran

المصدر: Veterinary Sciences, Vol 4, Iss 3, p 34 (2017)

مصطلحات موضوعية: canine, human, myxomatous mitral valve disease, Barlow’s disease, transcriptomic profiling, Veterinary medicine, SF600-1100

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2306-7381/4/3/34; https://doaj.org/toc/2306-7381

URL الوصول: https://doaj.org/article/49ff6677894446f7b44b24465ee114fd

المؤلفون: Qiyu Tang, Greg R. Markby, Andrew J. MacNair, Keyi Tang, Michal Tkacz, Maciej Parys, Kanchan Phadwal, Vicky E. MacRae, Brendan M. Corcoran

المصدر: Cell Proliferation.

مصطلحات موضوعية: Cell Biology, General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d311cad44dcfaa06cbd246b5eb9ffc31
https://doi.org/10.1111/cpr.13435

المؤلفون: Andrew J. McNair, Greg R. Markby, Qiyu Tang, Vicky E. MacRae, Brendan M. Corcoran

مصطلحات موضوعية: Animal Systematics and Taxonomy, Animal Physiology - Biophysics, Animal Physiology - Cell, Animal Physiology - Systems, Animal Behaviour, Animal Cell and Molecular Biology, Animal Developmental and Reproductive Biology, Animal Immunology, Animal Neurobiology, Animal Physiological Ecology, Animal Structure and Function, Veterinary Anaesthesiology and Intensive Care, Veterinary Anatomy and Physiology, Veterinary Diagnosis and Diagnostics, Veterinary Epidemiology, Veterinary Immunology, Veterinary Medicine, Veterinary Microbiology (excl. Virology), Veterinary Parasitology, Veterinary Pathology, Veterinary Pharmacology, Veterinary Surgery, Veterinary Virology, Veterinary Sciences not elsewhere classified, myxomatous mitral valve disease, transforming growth factor-beta, canine, SMAD2, PI3K/AKT/mTOR

Relation: https://figshare.com/articles/dataset/Data_Sheet_1_TGF-_phospho_antibody_array_identifies_altered_SMAD2_PI3K_AKT_SMAD_and_RAC_signaling_contribute_to_the_pathogenesis_of_myxomatous_mitral_valve_disease_docx/24313078

الاتاحة: https://doi.org/10.3389/fvets.2023.1202001.s001
https://figshare.com/articles/dataset/Data_Sheet_1_TGF-_phospho_antibody_array_identifies_altered_SMAD2_PI3K_AKT_SMAD_and_RAC_signaling_contribute_to_the_pathogenesis_of_myxomatous_mitral_valve_disease_docx/24313078

المؤلفون: Andrew J. McNair, Greg R. Markby, Qiyu Tang, Vicky E. MacRae, Brendan M. Corcoran

مصطلحات موضوعية: Animal Systematics and Taxonomy, Animal Physiology - Biophysics, Animal Physiology - Cell, Animal Physiology - Systems, Animal Behaviour, Animal Cell and Molecular Biology, Animal Developmental and Reproductive Biology, Animal Immunology, Animal Neurobiology, Animal Physiological Ecology, Animal Structure and Function, Veterinary Anaesthesiology and Intensive Care, Veterinary Anatomy and Physiology, Veterinary Diagnosis and Diagnostics, Veterinary Epidemiology, Veterinary Immunology, Veterinary Medicine, Veterinary Microbiology (excl. Virology), Veterinary Parasitology, Veterinary Pathology, Veterinary Pharmacology, Veterinary Surgery, Veterinary Virology, Veterinary Sciences not elsewhere classified, myxomatous mitral valve disease, transforming growth factor-beta, canine, SMAD2, PI3K/AKT/mTOR

Relation: https://figshare.com/articles/figure/Image_1_TGF-_phospho_antibody_array_identifies_altered_SMAD2_PI3K_AKT_SMAD_and_RAC_signaling_contribute_to_the_pathogenesis_of_myxomatous_mitral_valve_disease_TIF/24313084

الاتاحة: https://doi.org/10.3389/fvets.2023.1202001.s003
https://figshare.com/articles/figure/Image_1_TGF-_phospho_antibody_array_identifies_altered_SMAD2_PI3K_AKT_SMAD_and_RAC_signaling_contribute_to_the_pathogenesis_of_myxomatous_mitral_valve_disease_TIF/24313084

المؤلفون: Colin Farquharson, Vicky E MacRae, Fiona Roberts, Scott Dillon, Greg R. Markby

المصدر: Journal of Endocrinology. 245:R11-R22

مصطلحات موضوعية: Biomineralization, 0301 basic medicine, medicine.medical_specialty, Phosphoric Diester Hydrolases, Endocrinology, Diabetes and Metabolism, Druggability, 030209 endocrinology & metabolism, Disease, Area of interest, Biology, Matrix (biology), Bioinformatics, Phosphoric Monoester Hydrolases, Skeletal tissue, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Endocrinology, Metabolic Diseases, Internal medicine, medicine, Animals, Humans

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6011e55459267d089f36609ed8b692
https://doi.org/10.1530/joe-19-0460

المؤلفون: Mahmoud Abdellatif, Nuzhat Ahsan, Amelina Albornoz, Yahyah Aman, Allen Andres, Catherine Arden, Daniel Asa, Belén Bellido, Sihem Boudina, Alfredo Briones-Herrera, Mauricio Budini, Elizabeth Bueno, Olivier Camuzard, Georges F. Carle, Santosh Chauhan, Ramon Corbalan, Alfredo Criollo, Srinivasulu Dasanna, Guido R.Y. De Meyer, Abhinav Diwan, Maria Jose Donate-Lagartos, Robyn Duttenhefner, Tobias Eisenberg, Evandro F. Fang, Johannes Frank, Valeria Garrido-Moreno, Luis Garrido-Olivares, Merilin Georgiou, Saurav Ghimire, Tania Gómez-Sierra, Ruben Gudmundsrud, Andreas Guenther, Pieter-Jan Guns, Congcong He, G. Vignir Helgason, Nina Hermans, Sergio Hernandez-Diaz, Angela Ianniciello, Moydul Islam, Kautilya Kumar Jena, Hiroshi Katsuki, Martina Korfei, Viktor I. Korolchuk, Nicholas T. Ktistakis, Sergio Lavandero, Mark Li, Senka Ljubojević-Holzer, Poornima Mahavadi, Patrick Main, Maria Manifava, Greg R. Markby, Wim Martinet, Elena Martínez-Klimova, Subhash Mehto, Jason C. Mills, Cédric HG. Neutel, Ngoc Uyen Nhi Nguyen, José Pedraza-Chaverri, Daniel Peña-Oyarzún, Valérie Pierrefite-Carle, Felipe X. Pimentel-Muiños, Thomas Pulinilkunnil, Yoana Rabanal-Ruiz, Megan D. Radyk, Christian Rodríguez, Lynn Roth, Beverly A. Rothermel, Kei Sakamoto, Irene Sanchez-Mirasierra, Simon Sedej, Takahiro Seki, Alvaro Sequeida, Liu Shi, Sangita C. Sinha, Logan Slade, Sandra-Fausia Soukup, Lillian B. Spatz, Bieke Steenput, Takayuki Tatsumi, Kateřina Čechová, Marie-Charlotte Trojani, Satoshi Tsukamoto, Silvia Vega-Rubín-de-Celis, Vishaka Vinod, Martin Vyhnalek, Amelia Williams, Samuel Wyatt, Chenglong Xie, Ling Yang

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a9b7da36fa6e070b2f6b58871b491c5f
https://doi.org/10.1016/b978-0-12-822003-0.01002-0

المؤلفون: Vicky E MacRae, David A. Hume, Greg R. Markby, Kim M. Summers, Brendan Corcoran, Stephen J. Bush, Emily L. Clark, Hiu-Gwen Tsang

المصدر: Frontiers in Genetics, Vol 11 (2020)
Tsang, G, Clark, E, Markby, G, Bush, S, Hume, D, Corcoran, B, MacRae, V & Summers, K 2020, ' Expression of calcification and extracellular matrix genes in the cardiovascular system of the healthy domestic sheep (Ovis aries). ', Frontiers in genetics, vol. 11 . https://doi.org/10.3389/fgene.2020.00919
Frontiers in Genetics

مصطلحات موضوعية: 0301 basic medicine, sheep, extra cellular matrix, lcsh:QH426-470, RNA-Seq, Disease, Biology, Bioinformatics, Transcriptome, Extracellular matrix, 03 medical and health sciences, Ectopic calcification, 0302 clinical medicine, Gene expression, medicine, Genetics, Gene, network analysis, Genetics (clinical), Original Research, ectopic calcification, medicine.disease, lcsh:Genetics, 030104 developmental biology, 030220 oncology & carcinogenesis, cardiovascular system, gene expression, Molecular Medicine, RNA-seq, Calcification

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75155b50c1442b59ecd5e201513fd8e5
https://www.frontiersin.org/article/10.3389/fgene.2020.00919/full

المؤلفون: Kim M. Summers, Hiu-Gwen Tsang, Brendan Corcoran, Greg R. Markby, Simon G. Lillico, Violeta Trejo-Reveles, Mary E. B. McCulloch, C. Bruce A. Whitelaw, Vicky E MacRae, Christopher Proudfoot

مصطلحات موضوعية: Genetics, Marfan syndrome, Whole genome sequencing, Exon, Genome editing, Hydrops fetalis, medicine, CRISPR, Biology, medicine.disease, Genome, Gene

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::15525d670117e564190d8238622b0c34
https://doi.org/10.1101/2020.07.20.213108

المؤلفون: Karen Sooy, Geoff Culshaw, Brendan Corcoran, Alisdair Boag, Greg R. Markby, Natalie Z.M. Homer, Pauline Jamieson, Elizabeth Bode, Colin Farquharson, Yolanda Martinez-Pereira

المصدر: Bode, L, Markby, G, Boag, A, Martinez-Pereira, Y, Corcoran, B, Farquharson, C, Sooy, K, Homer, N, Jamieson, P & Culshaw, G 2020, ' Glucocorticoid metabolism and the action of 11 beta-hydroxysteroid dehydrogenase 2 in canine congestive heart failure ', The Veterinary Journal . https://doi.org/10.1016/j.tvjl.2020.105456

مصطلحات موضوعية: Male, medicine.medical_specialty, Hydrocortisone, 040301 veterinary sciences, medicine.medical_treatment, Mineralocorticoid receptor, 030204 cardiovascular system & hematology, Heart disease, Kidney, Gas Chromatography-Mass Spectrometry, Cortisol, 0403 veterinary science, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dogs, Internal medicine, 11-beta-Hydroxysteroid Dehydrogenase Type 2, Renal medulla, Medicine, Animals, Dog Diseases, Prospective Studies, Glucocorticoids, Aldosterone, Heart Failure, Creatinine, General Veterinary, business.industry, 04 agricultural and veterinary sciences, medicine.disease, Cortisone, Steroid hormone, Endocrinology, medicine.anatomical_structure, chemistry, Heart failure, Animal Science and Zoology, Female, business, Glucocorticoid, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25916ce82666cd73afdb68c2b8e4ca2b
https://www.pure.ed.ac.uk/ws/files/145358365/11_BHSD2_canine_CHF_REVISED_no_field_codes_edited_JM_LB_accepted.pdf

المؤلفون: David A. Hume, Greg R. Markby, Emily L. Clark, Hiu-Gwen Tsang, Brendan Corcoran, Vicky E MacRae, Kim M. Summers, Stephen J. Bush

مصطلحات موضوعية: 2. Zero hunger, 0303 health sciences, Genomics, Disease, 030204 cardiovascular system & hematology, Biology, Bioinformatics, medicine.disease, Extracellular matrix, Transcriptome, 03 medical and health sciences, Ectopic calcification, Haematopoiesis, 0302 clinical medicine, Gene expression, medicine, Gene, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0be5163d8fb8bbc1565919daca886e2

المؤلفون: Greg R. Markby, Kim M. Summers, Brendan Corcoran, Vicky E MacRae

المصدر: BMC Veterinary Research
BMC Veterinary Research, Vol 16, Iss 1, Pp 1-14 (2020)
Markby, G, MacRae, V, Corcoran, B & Summers, K 2020, ' Comparative transcriptomic profiling of myxomatous mitral valve disease in the Cavalier King Charles Spaniel ', BMC Veterinary Research . https://doi.org/10.1186/s12917-020-02542-w

مصطلحات موضوعية: Male, Pathology, medicine.medical_specialty, Myxomatous mitral valve disease, 040301 veterinary sciences, biology.animal_breed, Heart Valve Diseases, Disease, Myxomatous degeneration, Myxomatous mitral valve didease, 0403 veterinary science, TNNI3, Transcriptome, 03 medical and health sciences, Dogs, Species Specificity, Genetic variation, medicine, Animals, Genes expression, Dog Diseases, Myxomatous mitral valve, Gene clustering, 030304 developmental biology, Cavalier King Charles spaniel, 0303 health sciences, lcsh:Veterinary medicine, General Veterinary, biology, Gene Expression Profiling, Gene networks, 04 agricultural and veterinary sciences, General Medicine, medicine.disease, Breed, Cavalier King Charles Spaniel, lcsh:SF600-1100, Mitral Valve, Female, Research Article, cavalier King Charles spaniel

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf38b994cce06c9547ed0937f07a2ed
https://pubmed.ncbi.nlm.nih.gov/32967675

المؤلفون: Greg R. Markby, Vicky E MacRae, Brendan Corcoran, Kim M. Summers

المصدر: Heart Journal - SCF.

مصطلحات موضوعية: Pathology, medicine.medical_specialty, biology, business.industry, Disease, Pathogenesis, Transcriptome, CDKN2A, Gene expression, biology.protein, medicine, Gene family, ACTA2, business, Gene

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::07079241e8908ee8ec1bf6b926b815e6
https://doi.org/10.1136/heartjnl-2020-scf.1

المؤلفون: Yolanda Martinez-Pereira, Brendan Corcoran, Rachel Blake, Greg R. Markby, C. C. Lu, Geoff Culshaw

المصدر: Blake, R, Markby, G, Culshaw, G, Martinez-Pereira, Y, Lu, C & Corcoran, B 2019, ' Survival of Activated Myofibroblasts in Canine Myxomatous Mitral Valve Disease and the Role of Apoptosis ', Research in Veterinary Science, vol. 128, pp. 99-106 . https://doi.org/10.1016/j.rvsc.2019.11.004

مصطلحات موضوعية: Pathology, medicine.medical_specialty, Myxomatous mitral valve disease, 040301 veterinary sciences, Heart Valve Diseases, Apoptosis, Matrix (biology), 0403 veterinary science, 03 medical and health sciences, Basal (phylogenetics), Dogs, Gene expression, Medicine, Animals, Doxorubicin, activated myofibroblasts, Dog Diseases, Myofibroblasts, 030304 developmental biology, 0303 health sciences, cell culture, General Veterinary, business.industry, apoptosis, 04 agricultural and veterinary sciences, XIAP, Gene Expression Regulation, Cell culture, Mitral Valve, business, valve interstitial cells, Myofibroblast, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf3f1ac766ef4a4f50d8c800d0502f3
https://pubmed.ncbi.nlm.nih.gov/31765842

المؤلفون: Hiu-Gwen Tsang, Emily L. Clark, Greg R. Markby, Stephen J. Bush, David A. Hume, Brendan M. Corcoran, Vicky E. MacRae, Kim M. Summers

مصطلحات موضوعية: Genetics, Genetic Engineering, Biomarkers, Developmental Genetics (incl. Sex Determination), Epigenetics (incl. Genome Methylation and Epigenomics), Gene Expression (incl. Microarray and other genome-wide approaches), Genome Structure and Regulation, Genomics, Genetically Modified Animals, Livestock Cloning, Gene and Molecular Therapy, sheep, cardiovascular system, extra cellular matrix, gene expression, RNA-seq, network analysis, ectopic calcification

Relation: https://figshare.com/articles/dataset/Table_2_Expression_of_Calcification_and_Extracellular_Matrix_Genes_in_the_Cardiovascular_System_of_the_Healthy_Domestic_Sheep_Ovis_aries_XLSX/12927062

الاتاحة: https://doi.org/10.3389/fgene.2020.00919.s003
https://figshare.com/articles/dataset/Table_2_Expression_of_Calcification_and_Extracellular_Matrix_Genes_in_the_Cardiovascular_System_of_the_Healthy_Domestic_Sheep_Ovis_aries_XLSX/12927062

المؤلفون: Hiu-Gwen Tsang, Emily L. Clark, Greg R. Markby, Stephen J. Bush, David A. Hume, Brendan M. Corcoran, Vicky E. MacRae, Kim M. Summers

مصطلحات موضوعية: Genetics, Genetic Engineering, Biomarkers, Developmental Genetics (incl. Sex Determination), Epigenetics (incl. Genome Methylation and Epigenomics), Gene Expression (incl. Microarray and other genome-wide approaches), Genome Structure and Regulation, Genomics, Genetically Modified Animals, Livestock Cloning, Gene and Molecular Therapy, sheep, cardiovascular system, extra cellular matrix, gene expression, RNA-seq, network analysis, ectopic calcification

Relation: https://figshare.com/articles/dataset/Data_Sheet_1_Expression_of_Calcification_and_Extracellular_Matrix_Genes_in_the_Cardiovascular_System_of_the_Healthy_Domestic_Sheep_Ovis_aries_PDF/12927056

الاتاحة: https://doi.org/10.3389/fgene.2020.00919.s001
https://figshare.com/articles/dataset/Data_Sheet_1_Expression_of_Calcification_and_Extracellular_Matrix_Genes_in_the_Cardiovascular_System_of_the_Healthy_Domestic_Sheep_Ovis_aries_PDF/12927056

المؤلفون: Brendan Corcoran, Vicky E MacRae, Greg R. Markby, Colin Farquharson, Dongxing Zhu, Cui Lin

المصدر: Cui lin, L, Zhu, D, Markby, G, Corcoran, B, Farquharson, C & MacRae, V 2017, ' Isolation and characterization of primary rat valve interstitial cells: a new model to study aortic valve calcification ', Journal of Visualized Experiments (JoVE), vol. 2017, no. 129 . https://doi.org/10.3791/56126
Journal of Visualized Experiments : JoVE

مصطلحات موضوعية: Male, 0301 basic medicine, Aortic valve, Pathology, medicine.medical_specialty, General Chemical Engineering, Population, General Biochemistry, Genetics and Molecular Biology, Rats, Sprague-Dawley, 03 medical and health sciences, Ectopic calcification, Hyperphosphatemia, Calcinosis, Calcific aortic valve disease, Internal medicine, medicine.artery, Animals, Medicine, mineralization, education, Cells, Cultured, phosphate, education.field_of_study, Aorta, calcium, General Immunology and Microbiology, business.industry, General Neuroscience, Endothelial Cells, Cell Differentiation, Aortic Valve Stenosis, medicine.disease, Rats, 3. Good health, aortic valve interstitial cells, aorta, 030104 developmental biology, medicine.anatomical_structure, Aortic Valve, Aortic valve stenosis, Cardiology, Issue 129, Aortic valve calcification, business, Developmental Biology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfe48bd2fa0d804cd1199cccc9e4c4e
https://doi.org/10.3791/56126-v

المؤلفون: Rachel Blake, Greg J. Fici, Kim M. Summers, Karen Tan, Lisa M. Bergeron, Brendan Corcoran, Victoria MacRae, Greg R. Markby, Rhona Muirhead

المصدر: PLoS ONE, Vol 14, Iss 8, p e0221126 (2019)
Tan, K, Markby, G, Muirhead, R, Blake, R, Bergeron, L, Fici, G J, Summers, K, MacRae, V & Corcoran, B 2019, ' Evaluation of Canine 2D cell cultures as models of myxomatous mitral valve degeneration ', PLoS ONE . https://doi.org/10.1371/journal.pone.0221126
PLoS ONE

مصطلحات موضوعية: CD31, Cell signaling, Cell Culture Techniques, Glycobiology, Gene Expression, Signal transduction, Biochemistry, Myxomatous mitral valve degeneration, Animal Cells, Gene expression, Medicine and Health Sciences, Dog Diseases, Enzyme-Linked Immunoassays, Myofibroblasts, Connective Tissue Cells, Mitral Valve Prolapse, Multidisciplinary, biology, Models, Cardiovascular, Signaling cascades, Genomics, medicine.anatomical_structure, Connective Tissue, Mitral Valve, Medicine, Versican, Proteoglycans, Biological Cultures, Cellular Types, Anatomy, ACTA2, Transcriptome Analysis, Myofibroblast, Research Article, Endothelium, Science, Research and Analysis Methods, Andrology, Dogs, Gene Types, Genetics, medicine, Animals, Immunoassays, Endothelial Cells, Biology and Life Sciences, Computational Biology, Cell Biology, Fibroblasts, Cell Cultures, Genome Analysis, Antigens, Differentiation, Biological Tissue, TGF-beta signaling cascade, Cell culture, Immunologic Techniques, biology.protein, Regulator Genes

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87f49a7f8769eb9b9e8c5f7aad58bf2
https://doi.org/10.1371/journal.pone.0221126