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1
المؤلفون: Jonna B. Westover, Shibani Naik, Kevin W. Bailey, Luci Wandersee, Vidyasagar R. Gantla, Brady T. Hickerson, Ken McCormack, Greg Henkel, Brian B. Gowen
المصدر: Antiviral Res
مصطلحات موضوعية: Pharmacology, Mice, Junin virus, Hemorrhagic Fevers, Viral, Anti-Retroviral Agents, Virology, Pyrazines, Guinea Pigs, Animals, Arenaviridae, Amides, Hemorrhagic Fever, American, Article
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2
المؤلفون: Ashley Dagley, Shibani Naik, Eric Brown, Brian B. Gowen, Alexandra Fetsko, Jonna B. Westover, Greg Henkel, Nicole Anderson, Dallan J. Blotter, Ken McCormack, Vidyasagar Reddy Gantla
المصدر: Antiviral Res
مصطلحات موضوعية: 0301 basic medicine, Male, New World Arenavirus, viruses, 030106 microbiology, Administration, Oral, Disease, Antiviral Agents, Membrane Fusion, Virus, Article, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, Mice, Viral Envelope Proteins, Glycoprotein complex, Virology, Chlorocebus aethiops, Ribavirin, Medicine, Animals, Arenaviridae Infections, Dosing, Vero Cells, Arenaviruses, New World, Pharmacology, Arenavirus, biology, business.industry, Virus Internalization, biology.organism_classification, Hemorrhagic Fevers, 030104 developmental biology, chemistry, business
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3
المؤلفون: Eric Brown, E. Adam Kallel, Donald D. Lorimer, Arshil Master, Ken McCormack, Alexandra Fetsko, David M. Dranow, Nadezda V. Sokolova, Rana Sidhu, Alexander N. Freiberg, Vidyasagar Reddy Gantla, Plewe Michael Bruno, Jameson Bullen, Greg Henkel, Junru Wang, Shibani Naik, Birte Kalveram, Hayden Smutney, Lihong Zhang
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Cell entry, chemistry.chemical_classification, Ebola virus, 010405 organic chemistry, medicine.drug_class, viruses, Adamantane, Organic Chemistry, Carboxamide, medicine.disease_cause, 01 natural sciences, Biochemistry, Virology, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, Glycoprotein
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4
المؤلفون: Eric Brown, Vidyasagar Reddy Gantla, Landon R. Whitby, Ken McCormack, Joanne York, Dale L. Boger, Plewe Michael Bruno, Birte Kalveram, Jack H. Nunberg, Greg Henkel, Alexander N. Freiberg, Nadezda V. Sokolova, Shibani Naik, Lihong Zhang
المصدر: Bioorg Med Chem Lett
مصطلحات موضوعية: Old World, viruses, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, 01 natural sciences, Biochemistry, Antiviral Agents, Virus, Piperazines, Article, Structure-Activity Relationship, Viral Envelope Proteins, Drug Discovery, medicine, Molecular Biology, Arenavirus, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, virus diseases, biology.organism_classification, Small molecule, Virology, In vitro, 0104 chemical sciences, Entry inhibitor, 010404 medicinal & biomolecular chemistry, Hemorrhagic Fevers, Microsome, Molecular Medicine, medicine.drug
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5
المؤلفون: Birte Kalveram, Alexander N. Freiberg, Eric Brown, Nadezda V. Sokolova, Greg Henkel, Shibani Naik, Ken McCormack, Alexandra Fetsko, Young-Jun Shin, Vidyasagar Reddy Gantla, Lihong Zhang, Plewe Michael Bruno
المصدر: Bioorg Med Chem Lett
مصطلحات موضوعية: New World Arenavirus, Clinical Biochemistry, hERG, Pharmaceutical Science, Microbial Sensitivity Tests, Antiviral Agents, 01 natural sciences, Biochemistry, Article, Structure-Activity Relationship, Broad spectrum, Viral Envelope Proteins, Heterocyclic Compounds, Drug Discovery, medicine, Humans, Molecular Biology, Liver microsomes, Cell entry, Arenavirus, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Metabolic stability, biology.organism_classification, 0104 chemical sciences, Entry inhibitor, 010404 medicinal & biomolecular chemistry, biology.protein, Molecular Medicine, medicine.drug
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6
المؤلفون: Diane M. Boucher, George Huang, Edward D. Ball, Guanjing Chen, David K. Heidary, Mark N. Namchuk, Jianguo Ma, Yung-Mae Yao, Jinwang Xu, Ron Grey, Forster Cornelia J, Greg Henkel, Jie-Hua Zhou, Michael J. Arnost, Robert J. Davies, Deborah Choquette
المصدر: Journal of Medicinal Chemistry. 55:725-734
مصطلحات موضوعية: Male, Serum, Cell Survival, Morpholines, Antineoplastic Agents, Apoptosis, Pharmacology, Receptor tyrosine kinase, Mice, Myelogenous, fluids and secretions, hemic and lymphatic diseases, Precursor cell, Drug Discovery, Tumor Cells, Cultured, medicine, Animals, Humans, CD135, Receptor, IC50, chemistry.chemical_classification, Mice, Inbred BALB C, biology, hemic and immune systems, Triazoles, medicine.disease, Leukemia, Myeloid, Acute, Proto-Oncogene Proteins c-kit, Leukemia, Enzyme, fms-Like Tyrosine Kinase 3, chemistry, embryonic structures, biology.protein, Molecular Medicine, Neoplasm Transplantation
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7
المؤلفون: Jennifer L. Kirkwood, Thomas E. Edwards, Amy C. Raymond, Bart L. Staker, Jan Abendroth, James W. Fairman, Spencer O. Moen, Greg Henkel, Robin Stacy, Ken McCormack, Darren W. Begley, Ruth Baydo, Vincent C. Tam, Jameson Bullen, Steve R. Barnes, Isabelle Phan, Don Lorimer, Peter J. Myler
المصدر: Scientific Reports
مصطلحات موضوعية: Models, Molecular, animal structures, Viral protein, viruses, Molecular Sequence Data, Gene Expression, Peptide, RNA polymerase complex, Crystallography, X-Ray, Influenza A Virus, H7N9 Subtype, Virus Replication, medicine.disease_cause, Protein Structure, Secondary, Article, Viral Proteins, Influenza A Virus, H1N1 Subtype, Immune system, Transcription (biology), Enzyme Stability, Escherichia coli, Influenza A virus, medicine, Amino Acid Sequence, Polymerase, chemistry.chemical_classification, Binding Sites, Multidisciplinary, biology, virus diseases, biochemical phenomena, metabolism, and nutrition, RNA-Dependent RNA Polymerase, Virology, Recombinant Proteins, Protein Structure, Tertiary, chemistry, biology.protein, Viral genome replication, Protein Binding
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8
المؤلفون: Cameron Stuver-Moody, David K. Heidary, Deborah Choquette, Greg Henkel, Jinwang Xu, Guanjing Chen, Shi-Kai Tian, Forster Cornelia J, Ron Grey, Joanne Ma, Albert C. Pierce, Michael J. Arnost, Mark N. Namchuk, Robert J. Davies, Vincent Galullo
المصدر: Journal of medicinal chemistry. 54(20)
مصطلحات موضوعية: Models, Molecular, Morpholines, Administration, Oral, Stem cell factor, Antineoplastic Agents, Pharmacology, Rats, Sprague-Dawley, Myelogenous, Mice, Structure-Activity Relationship, fluids and secretions, hemic and lymphatic diseases, Cell Line, Tumor, Drug Discovery, medicine, Potency, Structure–activity relationship, Animals, Humans, Receptor, Mice, Inbred BALB C, Chemistry, hemic and immune systems, Hydrogen Bonding, Triazoles, medicine.disease, Rats, Leukemia, Leukemia, Myeloid, Acute, Macaca fascicularis, Proto-Oncogene Proteins c-kit, fms-Like Tyrosine Kinase 3, Drug Design, embryonic structures, Fms-Like Tyrosine Kinase 3, Injections, Intravenous, Molecular Medicine, Drug Screening Assays, Antitumor, Protein Binding
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9
المؤلفون: Jeffrey H. Stack, Hal M. Hoffman, Kevin Beaumont, John C. R. Randle, Paul D. Larsen, Greg Henkel, Kimberly Straley
المصدر: Journal of immunology (Baltimore, Md. : 1950). 175(4)
مصطلحات موضوعية: Adult, Lipopolysaccharides, Male, medicine.medical_specialty, Immunology, Drug Evaluation, Preclinical, NALP3, Stimulation, Cysteine Proteinase Inhibitors, Monocytes, Proinflammatory cytokine, Autoimmune Diseases, Familial Cold Autoinflammatory Syndrome, Internal medicine, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Hypersensitivity, Immunology and Allergy, Humans, Secretion, Prodrugs, Protein Precursors, Caspase, Aged, Aged, 80 and over, Inflammation, biology, Anti-Inflammatory Agents, Non-Steroidal, Caspase 1, Syndrome, Middle Aged, medicine.disease, Caspase Inhibitors, Cold Temperature, Neonatal onset multisystem inflammatory disease, Endocrinology, biology.protein, Cytokines, Cytokine secretion, Female, Carrier Proteins, Interleukin-1
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10
المؤلفون: Melissa A. Brown, Greg Henkel
مصطلحات موضوعية: medicine.medical_treatment, DNA Mutational Analysis, Molecular Sequence Data, Retroviridae Proteins, Oncogenic, Enhancer RNAs, Biology, DNA-binding protein, Mice, Structure-Activity Relationship, Genes, Reporter, Proto-Oncogene Proteins, medicine, Animals, GATA1 Transcription Factor, Tissue Distribution, Mast Cells, Enhancer, Transcription factor, Interleukin 4, Regulation of gene expression, Multidisciplinary, Base Sequence, Proto-Oncogene Proteins c-ets, Mast cell, Molecular biology, Introns, DNA-Binding Proteins, GATA2 Transcription Factor, Cytokine, medicine.anatomical_structure, Enhancer Elements, Genetic, Erythroid-Specific DNA-Binding Factors, Interleukin-4, Research Article, Protein Binding, Transcription Factors
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11
المؤلفون: Edward D. Ball, Jennifer Taylor, Cécile Demur, Shaolan Li, Brinley Furey, Christian Recher, Brant Firestone, Yung-Mae Yao, Jianguo Ma, Karen A. Olson, Maura Murphy, Jugnu Jain, Russell R. Hoover, Susan J. Almquist, Jianbo Zhang, Greg Henkel, Srinivasu Poondru
المصدر: Blood. 104:2530-2530
مصطلحات موضوعية: Daunorubicin, Immunology, Myeloid leukemia, Cell Biology, Hematology, Biology, Pharmacology, medicine.disease, Biochemistry, Leukemia, IMP dehydrogenase, In vivo, medicine, Potency, Doxorubicin, Clonogenic assay, medicine.drug
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12Academic Journal
المؤلفون: Robert J. Davies, Albert C. Pierce, Cornelia Forster, Ron Grey, Jinwang Xu, Michael Arnost, Deborah Choquette, Vincent Galullo, Shi-Kai Tian, Greg Henkel, Guanjing Chen, David K. Heidary, Joanne Ma, Cameron Stuver-Moody, Mark Namchuk
المصدر: Journal of Medicinal Chemistry; Oct2011, Vol. 54 Issue 20, p7184-7192, 9p