المؤلفون: Richards, Ethan M., Casarrubios, Luis, D’Oyley, Jarryl M., Rzepa, Henry S., White, Andrew, Goldberg, Kristin, Goldberg, Frederick W., Bull, James, Díez-González, Silvia

المصدر: Advanced Synthesis & Catalysis ; ISSN 1615-4150 1615-4169

الاتاحة: http://dx.doi.org/10.1002/adsc.202400909
https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.202400909

المؤلفون: Pike, Kurt G., Hunt, Thomas A., Barlaam, Bernard, Benstead, David, Cadogan, Elaine, Chen, Kan, Cook, Calum R., Colclough, Nicola, Deng, Chao, Durant, Stephen T., Eatherton, Andrew, Goldberg, Kristin, Johnström, Peter, Liu, Libin, Liu, Zhaoqun, Nissink, J. Willem M., Pang, Chengling, Pass, Martin, Robb, Graeme R., Roberts, Caroline, Schou, Magnus, Steward, Oliver, Sykes, Andy, Yan, Yumei, Zhai, Baochang, Zheng, Li

المصدر: Journal of Medicinal Chemistry ; volume 67, issue 4, page 3090-3111 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.3c02277
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02277

المؤلفون: Newton, Rebecca, Bowler, Katherine A., Burns, Emily M., Chapman, Philip J., Fairweather, Emma E., Fritzl, Samantha J.R., Goldberg, Kristin M., Hamilton, Niall M., Holt, Sarah V., Hopkins, Gemma V., Jones, Stuart D., Jordan, Allan M., Lyons, Amanda J., Nikki March, H., McDonald, Neil Q., Maguire, Laura A., Mould, Daniel P., Purkiss, Andrew G., Small, Helen F., Stowell, Alexandra I.J., Thomson, Graeme J., Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.

المساهمون: Cancer Research UK

المصدر: European Journal of Medicinal Chemistry ; volume 112, page 20-32 ; ISSN 0223-5234

الاتاحة: http://dx.doi.org/10.1016/j.ejmech.2016.01.039
https://api.elsevier.com/content/article/PII:S0223523416300393?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0223523416300393?httpAccept=text/plain

المؤلفون: Jordan, Allan M., Begum, Habiba, Fairweather, Emma, Fritzl, Samantha, Goldberg, Kristin, Hopkins, Gemma V., Hamilton, Niall M., Lyons, Amanda J., March, H. Nikki, Newton, Rebecca, Small, Helen F., Vishwanath, Swamy, Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.

المساهمون: Cancer Research UK

المصدر: Bioorganic & Medicinal Chemistry Letters ; volume 26, issue 11, page 2724-2729 ; ISSN 0960-894X

الاتاحة: http://dx.doi.org/10.1016/j.bmcl.2016.03.100
https://api.elsevier.com/content/article/PII:S0960894X16303304?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0960894X16303304?httpAccept=text/xml

المؤلفون: Pappalardi, M. B., Keenan, K., Cockerill, Mark, Kellner, W. A., Stowell, Alexandra, Sherk, C., Wong, K., Pathuri, S., Briand, J., Steidel, M., Chapman, Philip, Groy, A., Wiseman, A. K., McHugh, C. F., Campobasso, N., Graves, A. P., Fairweather, E., Werner, T., Raoof, Ali, Butlin, Roger J, Rueda, L., Horton, J. R., Fosbenner, D. T., Zhang, C., Handler, J. L., Muliaditan, M., Mebrahtu, M., Jaworski, J. P., McNulty, D. E., Burt, Charlotte, Eberl, H. C., Taylor, A. N., Ho, T., Merrihew, S., Foley, S. W., Rutkowska, A., Li, M., Romeril, S. P., Goldberg, Kristin, Zhang, X., Kershaw, Christopher S, Bantscheff, M., Jurewicz, A. J., Minthorn, E., Grandi, P., Patel, M., Benowitz, A. B., Mohammad, H. P., Gilmartin, A. G., Prinjha, R. K., Ogilvie, Donald, Carpenter, C., Heerding, D., Baylin, S. B., Jones, P. A., Cheng, X., King, B. W., Luengo, J. I., Jordan, Allan M, Waddell, Ian D, Kruger, R. G., McCabe, M. T.

المساهمون: Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA

Relation: Pappalardi MB, Keenan K, Cockerill M, Kellner WA, Stowell A, Sherk C, et al. Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer. 2021;2(10):1002-17.; http://hdl.handle.net/10541/624970; Nature Cancer

الاتاحة: http://hdl.handle.net/10541/624970

المؤلفون: Pappalardi, Melissa B., Keenan, Kathryn, Cockerill, Mark, Kellner, Wendy A., Stowell, Alexandra, Sherk, Christian, Wong, Kristen, Pathuri, Sarath, Briand, Jacques, Steidel, Michael, Chapman, Philip, Groy, Arthur, Wiseman, Ashley K., McHugh, Charles F., Campobasso, Nino, Graves, Alan P., Fairweather, Emma, Werner, Thilo, Raoof, Ali, Butlin, Roger J., Rueda, Lourdes, Horton, John R., Fosbenner, David T., Zhang, Cunyu, Handler, Jessica L., Muliaditan, Morris, Mebrahtu, Makda, Jaworski, Jon-Paul, McNulty, Dean E., Burt, Charlotte, Eberl, H. Christian, Taylor, Amy N., Ho, Thau, Merrihew, Susan, Foley, Shawn W., Rutkowska, Anna, Li, Mei, Romeril, Stuart P., Goldberg, Kristin, Zhang, Xing, Kershaw, Christopher S., Bantscheff, Marcus, Jurewicz, Anthony J., Minthorn, Elisabeth, Grandi, Paola, Patel, Mehul, Benowitz, Andrew B., Mohammad, Helai P., Gilmartin, Aidan G., Prinjha, Rab K.

المساهمون: Cancer Research UK, U.S. Department of Health & Human Services | National Institutes of Health, Cancer Prevention and Research Institute of Texas, U.S. Department of Health & Human Services | NIH | National Cancer Institute, Van Andel Research Institute -Stand up to Cancer Epigenetics Dream Team. Stand Up to Cancer is a division of the Entertainment Industry Foundation, administered by AACR

المصدر: Nature Cancer ; volume 2, issue 10, page 1002-1017 ; ISSN 2662-1347

الاتاحة: http://dx.doi.org/10.1038/s43018-021-00249-x
https://www.nature.com/articles/s43018-021-00249-x.pdf
https://www.nature.com/articles/s43018-021-00249-x

المؤلفون: Nissink, J. Willem M., Bazzaz, Sana, Blackett, Carolyn, Clark, Matthew A., Collingwood, Olga, Disch, Jeremy S., Gikunju, Diana, Goldberg, Kristin, Guilinger, John P., Hardaker, Elizabeth, Hennessy, Edward J., Jetson, Rachael, Keefe, Anthony D., McCoull, William, McMurray, Lindsay, Olszewski, Allison, Overman, Ross, Pflug, Alexander, Preston, Marian, Rawlins, Philip B., Rivers, Emma, Schimpl, Marianne, Smith, Paul, Truman, Caroline, Underwood, Elizabeth, Warwicker, Juli, Winter-Holt, Jon, Woodcock, Simon, Zhang, Ying

المصدر: Journal of Medicinal Chemistry ; volume 64, issue 6, page 3165-3184 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.0c01904
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01904

المؤلفون: McCoull, William, Boyd, Scott, Brown, Martin R., Coen, Muireann, Collingwood, Olga, Davies, Nichola L., Doherty, Ann, Fairley, Gary, Goldberg, Kristin, Hardaker, Elizabeth, He, Guang, Hennessy, Edward J., Hopcroft, Philip, Hodgson, George, Jackson, Anne, Jiang, Xiefeng, Karmokar, Ankur, Lainé, Anne-Laure, Lindsay, Nicola, Mao, Yumeng, Markandu, Roshini, McMurray, Lindsay, McLean, Neville, Mooney, Lorraine, Musgrove, Helen, Nissink, J. Willem M., Pflug, Alexander, Reddy, Venkatesh Pilla, Rawlins, Philip B., Rivers, Emma, Schimpl, Marianne, Smith, Graham F., Tentarelli, Sharon, Travers, Jon, Troup, Robert I., Walton, Josephine, Wang, Cheng, Wilkinson, Stephen, Williamson, Beth, Winter-Holt, Jon, Yang, Dejian, Zheng, Yuting, Zhu, Qianxiu, Smith, Paul D.

المصدر: Journal of Medicinal Chemistry ; volume 64, issue 18, page 13524-13539 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.1c00920
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00920

المؤلفون: Boddy, Alexander J., Cordier, Christopher J., Goldberg, Kristin, Madin, Andrew, Spivey, Alan C., Bull, James A.

المساهمون: AstraZeneca, Royal Society, Imperial College London, Engineering and Physical Sciences Research Council

المصدر: Organic Letters ; volume 21, issue 6, page 1818-1822 ; ISSN 1523-7060 1523-7052

الاتاحة: http://dx.doi.org/10.1021/acs.orglett.9b00407
https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.9b00407

المؤلفون: Pearson, Stuart, Fillery, Shaun, Goldberg, Kristin, Demeritt, Julie, Eden, Jonathan, Finlayson, Jonathan, Patel, Anil

المصدر: Synthesis ; volume 50, issue 24, page 4963-4981 ; ISSN 0039-7881 1437-210X

الاتاحة: http://dx.doi.org/10.1055/s-0037-1610223
http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1610223.pdf

المؤلفون: Kettle, Jason G., Anjum, Rana, Barry, Evan, Bhavsar, Deepa, Brown, Crystal, Boyd, Scott, Campbell, Andrew, Goldberg, Kristin, Grondine, Michael, Guichard, Sylvie, Hardy, Christopher J., Hunt, Tom, Jones, Rhys D. O., Li, Xiuwei, Moleva, Olga, Ogg, Derek, Overman, Ross C., Packer, Martin J., Pearson, Stuart, Schimpl, Marianne, Shao, Wenlin, Smith, Aaron, Smith, James M., Stead, Darren, Stokes, Steve, Tucker, Michael, Ye, Yang

المصدر: Journal of Medicinal Chemistry ; volume 61, issue 19, page 8797-8810 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.8b00938
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00938

المؤلفون: Barlaam, Bernard, Cadogan, Elaine, Campbell, Andrew, Colclough, Nicola, Dishington, Allan, Durant, Stephen, Goldberg, Kristin, Hassall, Lorraine A., Hughes, Gareth D., MacFaul, Philip A., McGuire, Thomas M., Pass, Martin, Patel, Anil, Pearson, Stuart, Petersen, Jens, Pike, Kurt G., Robb, Graeme, Stratton, Natalie, Xin, Guohong, Zhai, Baochang

المصدر: ACS Medicinal Chemistry Letters ; volume 9, issue 8, page 809-814 ; ISSN 1948-5875 1948-5875

الاتاحة: http://dx.doi.org/10.1021/acsmedchemlett.8b00200
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00200

المؤلفون: Nissink, J. Willem M., Bazzaz, Sana, Blackett, Carolyn, Clark, Matthew A., Collingwood, Olga, Disch, Jeremy S., Gikunju, Diana, Goldberg, Kristin, Guilinger, John P., Hardaker, Elizabeth, Hennessy, Edward J., Jetson, Rachael, Keefe, Anthony D., McCoull, William, McMurray, Lindsay, Olszewski, Allison, Overman, Ross, Pflug, Alexander, Preston, Marian, Rawlins, Philip B.

المصدر: Journal of Medicinal Chemistry; 3/25/2021, Vol. 64 Issue 6, p3165-3184, 20p

المؤلفون: Scott, James S., Bowker, Suzanne S., Brocklehurst, Katy J., Brown, Hayley S., Clarke, David S., Easter, Alison, Ertan, Anne, Goldberg, Kristin, Hudson, Julian A., Kavanagh, Stefan L., Laber, David, Leach, Andrew G., Macfaul, Philip A., Martin, Elizabeth A., McKerrecher, Darren, Schofield, Paul, Svensson, Per H., Teague, Joanne L.

المصدر: Journal of Medicinal Chemistry. 57(21):8984-8998

مصطلحات موضوعية: 5 ({2 fluoro 4 [(methylsulfonyl)methyl]benzyl}oxy) 2 {(2r) 2methyl 4 [3 (trifluoromethyl) 1, 4 oxadiazol 5 yl]piperazin 1 yl} pyrimidine, alkyl group, anticonvulsive agent, G protein coupled receptor, g protein coupled receptor 119, potassium channel HERG, sitagliptin, sulfone, unclassified drug, 5-((2-fluoro-4-((methylsulfonyl)methyl)benzyl)oxy)-2-(2-methyl-4-(3-(trifluoromethyl)-1, 4-oxadiazol-5-yl)piperazin-1-yl)pyrimidine, antidiabetic agent, Gpr119 protein, mouse, oxadiazole derivative, pyrimidine derivative, animal cell, animal experiment, animal model, area under the curve, Article, brain slice, clinical study, controlled study, crystal structure, dose response, drug blood level, drug efficacy, drug structure, female, hippocampus, in vitro study, in vivo study, male, maximum plasma concentration, nonhuman, tonic clonic seizure, volume of distribution, wild type, agonists, animal, C57BL mouse, chemistry, Diabetes Mellitus, Type 2, dog, drug effects, Epilepsy, Tonic-Clonic, knockout mouse, structure activity relation, Animals, Dogs, Ether-A-Go-Go Potassium Channels, Hypoglycemic Agents, Mice, Inbred C57BL, Knockout, Oxadiazoles, Pyrimidines, Receptors, G-Protein-Coupled, Structure-Activity Relationship

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-45529

المؤلفون: Reilly, John, Aliagas, Ignacio, Berger, Raphaelle, Goldberg, Kristin, Nishimura, Rachel, Richardson, Paul, Richter, Daniel, Sherer, Edward, Sparling, Brian, Marian, Bryan

Relation: Reilly, John, Aliagas, Ignacio, Berger, Raphaelle, Goldberg, Kristin, Nishimura, Rachel, Richardson, Paul, Richter, Daniel, Sherer, Edward, Sparling, Brian and Marian, Bryan (2017) Sustainable Practices in Medicinal Chemistry Part 2: Green by Design. Journal of Medicinal Chemistry, 60 (14). pp. 5955-5968. ISSN 15204804

الاتاحة: https://oak.novartis.com/31431/
https://doi.org/10.1021/acs.jmedchem.6b01837

المؤلفون: Scott, James S., Birch, Alan M., Brocklehurst, Katy J., Brown, Hayley S., Goldberg, Kristin, Groombridge, Sam D., Hudson, Julian A., Leach, Andrew G., MacFaul, Philip A., McKerrecher, Darren, Poultney, Ruth, Schofield, Paul, Svensson, Per H.

المصدر: MedChemComm. 4(1):95-100

مصطلحات موضوعية: Stimulated Insulin-Secretion, Medicinal Chemistry, Glycemic Control, Discovery, Potent, G-Protein-Coupled-Receptor-119, As1535907, Release, Agent

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-116417

المؤلفون: Goldberg, Kristin, Groombridge, Sam, Hudson, Julian, Leach, Andrew G., MacFaul, Philip A., Pickup, Adrian, Poultney, Ruth, Scott, James S., Svensson, Per H., Sweeney, Joseph

المصدر: MedChemComm. 3(5):600-604

مصطلحات موضوعية: article, drug half life, drug protein binding, drug solubility, drug stability, drug structure, drug synthesis, human, hydrogen bond, isomer, lipophilicity, mouse, nonhuman, plasma protein binding, priority journal, rat, structure analysis, substitution reaction

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-98021

المؤلفون: Newton, Rebecca, Bowler, Katherine A., Burns, Emily M., Chapman, Philip J., Fairweather, Emma E., Fritzl, Samantha J.R., Goldberg, Kristin M., Hamilton, Niall M., Holt, Sarah V., Hopkins, Gemma V., Jones, Stuart D., Jordan, Allan M., Lyons, Amanda J., Nikki March, H., McDonald, Neil Q., Maguire, Laura A., Mould, Daniel P., Purkiss, Andrew G., Small, Helen F., Stowell, Alexandra I.J., Thomson, Graeme J., Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.

المصدر: European Journal of Medicinal Chemistry

مصطلحات موضوعية: Pharmacology, endocrine system, Kinase, endocrine system diseases, Organic Chemistry, Proto-Oncogene Proteins c-ret, Quinazoline, Cell Line, Molecular Docking Simulation, Mice, Piperidines, Drug Design, Drug Discovery, Quinazolines, Animals, Humans, RET, neoplasms, Protein Kinase Inhibitors, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2f24501b5885633937c91ec64f862432
https://pubmed.ncbi.nlm.nih.gov/26874741

المؤلفون: Goldberg, Kristin, Clarke, David S., Scott, James S.

المصدر: ChemInform ; volume 46, issue 2 ; ISSN 0931-7597 1522-2667

الاتاحة: http://dx.doi.org/10.1002/chin.201502163
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchin.201502163
https://onlinelibrary.wiley.com/doi/pdf/10.1002/chin.201502163

المؤلفون: Goldberg, Kristin, Clarke, David S., Scott, James S.

المصدر: Tetrahedron Letters ; volume 55, issue 32, page 4433-4436 ; ISSN 0040-4039

الاتاحة: http://dx.doi.org/10.1016/j.tetlet.2014.06.019
https://api.elsevier.com/content/article/PII:S0040403914009988?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0040403914009988?httpAccept=text/plain