يعرض 1 - 20 نتائج من 10,177 نتيجة بحث عن '"Glucokinase"', وقت الاستعلام: 0.71s تنقيح النتائج
  1. 1
    Academic Journal
    Effects of glucokinase haploinsufficiency on the pancreatic β‐cell mass and function of long‐term high‐fat, high‐sucrose diet‐fed mice.

    المؤلفون: Shigesawa, Ikumi1 (AUTHOR), Nakamura, Akinobu1 (AUTHOR) akinbo@tim.hi-ho.ne.jp, Yamauchi, Yuki1 (AUTHOR), Kawata, Shinichiro1 (AUTHOR), Miyazaki, Asuka1 (AUTHOR), Nomoto, Hiroshi1 (AUTHOR), Kameda, Hiraku1 (AUTHOR), Terauchi, Yasuo2 (AUTHOR), Atsumi, Tatsuya1 (AUTHOR)

    المصدر: Journal of Diabetes Investigation. Dec2024, Vol. 15 Issue 12, p1732-1742. 11p.

    مصطلحات موضوعية: *GLUCOKINASE, *ISLANDS of Langerhans, *GLUCOSE, *ISLANDS, *INSULIN

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  2. 2
    Academic Journal
    Mild Congenital Hyperinsulinism Caused by Mutation in Human Glucokinase Gene.

    المؤلفون: Sozaeva, Leila Salikhovna1 (AUTHOR), Ismailova, Sabina Kalandarovna1 (AUTHOR), Chernyak, Irina Yurievna2 (AUTHOR), Popov, Sergey Vladimirovich1 (AUTHOR), Zakharova, Victoriya Vitalievna1 (AUTHOR), Chugunov, Igor Sergeevich1 (AUTHOR)

    المصدر: JCEM Case Reports. Dec2024, Vol. 2 Issue 12, p1-4. 4p.

    مصطلحات موضوعية: *GENETIC disorders, *GLUCOKINASE, *HYPERINSULINISM, *HUMAN genes, *HYPOGLYCEMIA, *DAUGHTERS

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  3. 3
    Academic Journal
    Conserved glucokinase regulation in zebrafish confirms therapeutic utility for pharmacologic modulation in diabetes.

    المؤلفون: Schmitner, Nicole1 (AUTHOR) nicole.schmitner@uibk.ac.at, Thumer, Sophie1 (AUTHOR), Regele, Dominik1 (AUTHOR), Mayer, Elena1 (AUTHOR), Bergerweiss, Ines1 (AUTHOR), Helker, Christian2,3 (AUTHOR), Stainier, Didier Y. R.2 (AUTHOR), Meyer, Dirk1 (AUTHOR), Kimmel, Robin A.1 (AUTHOR)

    المصدر: Communications Biology. 11/23/2024, Vol. 7 Issue 1, p1-11. 11p.

    مصطلحات موضوعية: *GLUCOKINASE, *ISLANDS of Langerhans, *METABOLIC disorders, *BLOOD sugar, *NUTRITIONAL status

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  4. 4
    Academic Journal
    Time and dose selective glucose metabolism for glucose homeostasis and energy conversion in the liver.

    المؤلفون: Pan, Yifei1 (AUTHOR), Hatano, Atsushi2,3,4 (AUTHOR), Ohno, Satoshi4,5,6 (AUTHOR), Morita, Keigo4,6 (AUTHOR), Kokaji, Toshiya4,7 (AUTHOR), Bai, Yunfan4 (AUTHOR), Sugimoto, Hikaru8 (AUTHOR), Egami, Riku1 (AUTHOR), Terakawa, Akira4 (AUTHOR), Li, Dongzi4 (AUTHOR), Uematsu, Saori1 (AUTHOR), Maehara, Hideki4 (AUTHOR), Fujita, Suguru4 (AUTHOR), Inoue, Hiroshi9 (AUTHOR), Inaba, Yuka9 (AUTHOR), Nagano, Atsushi J.10,11 (AUTHOR), Hirayama, Akiyoshi11 (AUTHOR), Soga, Tomoyoshi12 (AUTHOR), Kuroda, Shinya1,4 (AUTHOR) skuroda@bs.s.u-tokyo.ac.jp

    المصدر: NPJ Systems Biology & Applications. 9/30/2024, Vol. 10 Issue 1, p1-22. 22p.

    مصطلحات موضوعية: *GLUCOSE metabolism, *GLUCOKINASE, *GENE expression, *ENERGY conversion, *GLUCOSE, *INSULIN, *HOMEOSTASIS

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  5. 5
    Academic Journal
    Inhibition of Yeast Hexokinase by Acyl Glucosides of Phloretin and its Implication in the Warburg Effect.

    المؤلفون: Cervantes, Fadia V.1, Fernandez‐Arrojo, Lucía1, Coscolin, Cristina1, Berrojo, Alicia1, Gonzalez‐Alfonso, José L.1, Perez de la Lastra, José M.2, Ferrer, Manuel1, Curieses‐Andres, Celia M.3, Andres‐Juan, Celia4, Ballesteros, Antonio O.1, Perez‐Lebeña, Eduardo5, Plou, Francisco J.1 fplou@icp.csic.es

    المصدر: ChemistrySelect. 8/27/2024, Vol. 9 Issue 32, p1-8. 8p.

    مصطلحات موضوعية: *WARBURG Effect (Oncology), *GLUCOKINASE, *PHLORETIN, *EPIGALLOCATECHIN gallate, *YEAST, *SACCHAROMYCES cerevisiae, *PLANT polyphenols


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  6. 6
    Academic Journal
    NGF effects promote the maturation of rat pancreatic beta cells by regulating GLUT2 levels and distribution, and glucokinase activity.

    المؤلفون: Samario-Román, Jazmín1 (AUTHOR), Velasco, Myrian1 (AUTHOR), Larqué, Carlos2 (AUTHOR), Cárdenas-Vázquez, René3 (AUTHOR), Ortiz-Huidobro, Rosa Isela4 (AUTHOR), Hiriart, Marcia1 (AUTHOR) mhiriart@ifc.unam.mx

    المصدر: PLoS ONE. 6/14/2024, Vol. 19 Issue 6, p1-18. 18p.

    مصطلحات موضوعية: *PANCREATIC beta cells, *GLUCOKINASE, *INSULIN, *BIPHASIC insulin, *NERVE growth factor, *ISLANDS of Langerhans, *INSULIN aspart

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  7. 7
    Academic Journal
    Recent drug development of dorzagliatin, a new glucokinase activator, with the potential to treat Type 2 diabetes: A review study.

    المؤلفون: Jiang, Yu1,2 (AUTHOR), Wang, Luyao1,2 (AUTHOR), Dong, Zhenhua1,2 (AUTHOR), Xia, Baotian1,2 (AUTHOR), Pang, Shuguang1,2 (AUTHOR) shuguangpang@163.com

    المصدر: Journal of Diabetes. Jun2024, Vol. 16 Issue 6, p1-13. 13p.

    مصطلحات موضوعية: *TYPE 2 diabetes, *GLUCOKINASE, *DRUG development, *CLINICAL trials, *GLYCEMIC control

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  8. 8
    Academic Journal
    A computational discovery of hexokinase 2 inhibitors from Newbouldia laevis for Hepatocellular carcinoma (HCC) treatment.

    المؤلفون: Adekilekun, Habeebulahi Ajibola1 (AUTHOR), Oyewusi, Habeebat Adekilekun1,2,3 (AUTHOR) haoyewusi@utm.my, Wahab, Roswanira Abdul4,5 (AUTHOR), Huyop, Fahrul2,5 (AUTHOR), Albadrani, Ghadeer M.6 (AUTHOR), Al-Ghadi, Muath Q.7 (AUTHOR), Abdel-Daim, Mohamed M.8,9 (AUTHOR), Ajiboye, Basiru Olaitan10 (AUTHOR), Igbinoba, Sharon Iyobor1,11 (AUTHOR), Odoma, Saidi1 (AUTHOR), Onohuean, Hope1 (AUTHOR)

    المصدر: South African Journal of Botany. Jun2024, Vol. 169, p12-26. 15p.

    مصطلحات موضوعية: *GLUCOKINASE, *HEPATOCELLULAR carcinoma, *PHYTOCHEMICALS, *MOLECULAR dynamics, *URSOLIC acid

    مصطلحات جغرافية: WEST Africa


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  9. 9
    Academic Journal
    Clinical investigation of glucokinase activators for the restoration of glucose homeostasis in diabetes.

    المؤلفون: Li, Ping1 (AUTHOR) li78321@yeah.net, Zhu, Dalong1 (AUTHOR) zhudalong@nju.edu.cn

    المصدر: Journal of Diabetes. May2024, Vol. 16 Issue 5, p1-9. 9p.

    مصطلحات موضوعية: *GLUCOKINASE, *GLUCOSE, *HOMEOSTASIS, *TYPE 2 diabetes, *MOLECULAR structure

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  10. 10
    Academic Journal
    Biallelic hexokinase 1 (HK1) variants causative of non‐spherocytic haemolytic anaemia: A case series with emphasis on the HK1 promoter variant and literature review.

    المؤلفون: Ukonmaanaho, Elli‐Maija1,2 (AUTHOR) elli‐maija.ukonmaanaho@pohde.fi, Dell'Anna, Silvia3 (AUTHOR), Hakonen, Anna4 (AUTHOR), Wartiovaara‐Kautto, Ulla5 (AUTHOR), Kakko, Sakari6 (AUTHOR), Rab, Minke A. E.7 (AUTHOR), van Oirschot, Brigitte7 (AUTHOR), Kraatari‐Tiri, Minna8,9 (AUTHOR), van Wijk, Richard7 (AUTHOR), Rahikkala, Elisa8,9 (AUTHOR)

    المصدر: British Journal of Haematology. May2024, Vol. 204 Issue 5, p2040-2048. 9p.

    مصطلحات موضوعية: *HEMOLYTIC anemia, *GLUCOKINASE, *ERYTHROCYTES


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  11. 11
    Academic Journal
    The Hexokinase 1 5′-UTR Mutation in Charcot–Marie–Tooth 4G Disease Alters Hexokinase 1 Binding to Voltage-Dependent Anion Channel-1 and Leads to Dysfunctional Mitochondrial Calcium Buffering.

    المؤلفون: Ceprian, Maria1 (AUTHOR) maria.ceprian@achucarro.org, Juntas-Morales, Raul2,3 (AUTHOR) raul.juntas@vallhebron.cat, Campbell, Graham1 (AUTHOR), Walther-Louvier, Ulrike4 (AUTHOR) u-louvier@chu-montpellier.fr, Rivier, François4 (AUTHOR) f-rivier@chu-montpellier.fr, Camu, William2 (AUTHOR) w-camu@chu-montpellier.fr, Esselin, Florence2 (AUTHOR) f-esselin@chu-montpellier.fr, Echaniz-Laguna, Andoni5 (AUTHOR) andoni.echaniz-laguna@aphp.fr, Stojkovic, Tanya6 (AUTHOR) tanya.stojkovic@aphp.fr, Bouhour, Françoise7 (AUTHOR) francoise.bouhour@chu-lyon.fr, Latour, Philippe8 (AUTHOR) philippe.latour@chu-lyon.fr, Tricaud, Nicolas1,9 (AUTHOR) nicolas.tricaud@inserm.fr

    المصدر: International Journal of Molecular Sciences. Apr2024, Vol. 25 Issue 8, p4364. 12p.

    مصطلحات موضوعية: *GLUCOKINASE, *CHARCOT-Marie-Tooth disease, *MITOCHONDRIA, *CALCIUM, *MYELIN sheath, *CALCIUM ions, *NEURAL stimulation

    مصطلحات جغرافية: HONG Kong (China)

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  12. 12
    Academic Journal
    Discovery of Strong 3-Nitro-2-Phenyl- 2H -Chromene Analogues as Antitrypanosomal Agents and Inhibitors of Trypanosoma cruzi Glucokinase.

    المؤلفون: Carey, Shane M.1 (AUTHOR), O'Neill, Destiny M.1 (AUTHOR), Conner, Garrett B.1 (AUTHOR), Sherman, Julian2 (AUTHOR) ana.rodriguezfernandez@nyulangone.org, Rodriguez, Ana2 (AUTHOR), D'Antonio, Edward L.1 (AUTHOR) edantonio@uscb.edu

    المصدر: International Journal of Molecular Sciences. Apr2024, Vol. 25 Issue 8, p4319. 17p.

    مصطلحات موضوعية: *TRYPANOSOMA cruzi, *GLUCOKINASE, *AFRICAN trypanosomiasis, *NEGLECTED diseases, *DRUG discovery, *CHAGAS' disease

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  13. 13
    Academic Journal
    Abatement of the binding of human hexokinase II enzyme monomers by in-silico method with the design of inhibitory peptides.

    المؤلفون: Karamifard, Faranak1 (AUTHOR), Mazaheri, Mahta2 (AUTHOR), Dadbinpour, Ali3 (AUTHOR) Dadbin11@gmail.com

    المصدر: In Silico Pharmacology. 4/11/2024, Vol. 12 Issue 1, p1-13. 13p.

    مصطلحات موضوعية: *GLUCOKINASE, *MONOMERS, *PEPTIDES, *ENZYMES, *MOLECULAR dynamics

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  14. 14
    Academic Journal
    Tetrahydropalmatine from medicinal plants activates human glucokinase to regulate glucose homeostasis.

    المؤلفون: Singh, Sweta1,2 (AUTHOR), Ghosh, Payel3 (AUTHOR), Sharma, Shilpy4 (AUTHOR), Bhargava, Shobha1 (AUTHOR), Kumar, Ameeta Ravi2 (AUTHOR) ameeta@unipune.ac.in

    المصدر: Biotechnology & Applied Biochemistry. Apr2024, Vol. 71 Issue 2, p295-313. 19p.

    مصطلحات موضوعية: *GLUCOKINASE, *GLUCOSE, *MEDICAL botany, *GLUCAGON receptors, *MEDICINAL plants, *HOMEOSTASIS


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  15. 15
    Academic Journal
    Should Glucokinase be Given a Chance in Diabetes Therapeutics? A Clinical-Pharmacological Review of Dorzagliatin and Lessons Learned So Far.

    المؤلفون: Kaur, Upinder1 (AUTHOR) drupinder.bhu@gmail.com, Pathak, Bhairav Kumar2 (AUTHOR), Meerashahib, Tharik Jalal3 (AUTHOR), Krishna, Dondapati Venkata Vamshi4 (AUTHOR), Chakrabarti, Sankha Shubhra5 (AUTHOR) sankha.chakrabarti1@bhu.ac.in

    المصدر: Clinical Drug Investigation. Apr2024, Vol. 44 Issue 4, p223-250. 28p.

    مصطلحات موضوعية: *GLUCOKINASE, *GLYCOSYLATED hemoglobin, *CLINICAL trials, *TYPE 2 diabetes, *OLDER patients, *LIVER enzymes, *INSULIN derivatives, *SODIUM-glucose cotransporters

    مصطلحات جغرافية: CHINA


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  16. 16
    Academic Journal
    Unveiling the Influence of a High-Fat Meal on the Pharmacokinetics of Oral Globalagliatin, A Glucokinase Activator, in Healthy Chinese Volunteers.

    المؤلفون: Xu, Maodi1 (AUTHOR), Wang, Yaqin1 (AUTHOR), Wang, Xiaohu2 (AUTHOR), Pu, Zhichen1 (AUTHOR), Liu, Ya1 (AUTHOR), Jiang, Cuilian3 (AUTHOR), Shen, Xiaokun3 (AUTHOR), Sun, Hua1 (AUTHOR) 549173019@qq.com, Xie, Haitang1 (AUTHOR) xiehaitang2023@163.com

    المصدر: Drugs in R&D. Mar2024, Vol. 24 Issue 1, p41-50. 10p.

    مصطلحات موضوعية: *GLUCOKINASE, *LIQUID chromatography-mass spectrometry, *VOLUNTEERS, *DRUG side effects, *ORAL drug administration, *FAT

    الشركة/الكيان: MICROSOFT Corp. 081466849 MSFT

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  17. 17
    Academic Journal
    At the outer part of the active site in Trypanosoma cruzi glucokinase: The role of phenylalanine 337.

    المؤلفون: Carey, Shane M.1 (AUTHOR), Kearns, Sean P.1 (AUTHOR), Millington, Matthew E.1 (AUTHOR), Buechner, Gregory S.1 (AUTHOR), Alvarez, Beda E.1 (AUTHOR), Daneshian, Leily2 (AUTHOR), Abiskaroon, Brendan3 (AUTHOR), Chruszcz, Maksymilian2,3 (AUTHOR), D'Antonio, Edward L.1 (AUTHOR) edantonio@uscb.edu

    المصدر: Biochimie. Mar2024, Vol. 218, p8-19. 12p.

    مصطلحات موضوعية: *GLUCOKINASE, *TRYPANOSOMA cruzi, *PHENYLALANINE, *PHENYL group, *CYTOSKELETAL proteins


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  18. 18
    Dissertation/ Thesis
    Terapia génica para la diabetes tipo I basada en la administración intramuscular de AAV1 insulina-glucoquinasa

    المؤلفون: Jaén Sitges, Maria Luisa

    المساهمون: University/Department: Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular

    Thesis Advisors: Bosch i Tubert, Fàtima, García Martínez, Miquel

    المصدر: TDX (Tesis Doctorals en Xarxa)

    مصطلحات موضوعية: Insulina-glucoquinasa, Insulin-glucokinase, Teràpia gènica, Terapia génica, Gene therapy, Diabetis, Diabetes, Ciències Experimentals

    وصف الملف: application/pdf

    URL الوصول: http://hdl.handle.net/10803/458687

    View record in TDX

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  19. 19
    Academic Journal
    G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic α cells.

    المؤلفون: Bahl, Varun, Rifkind, Reut, Waite, Eric, Hamdan, Zenab, May, Catherine Lee, Manduchi, Elisabetta, Voight, Benjamin F., Lee, Michelle Y. Y., Tigue, Mark, Manuto, Nicholas, Glaser, Benjamin, Avrahami, Dana, Kaestner, Klaus H.

    المصدر: Science Translational Medicine; 1/1/2025, Vol. 17 Issue 779, p1-12, 12p

    مصطلحات موضوعية: GLYCEMIC control, BLOOD sugar, TYPE 2 diabetes, GENETIC variation, GLUCOKINASE, GASTRIC inhibitory polypeptide, ENTEROENDOCRINE cells


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  20. 20
    Academic Journal
    In silico design of dehydrophenylalanine containing peptide activators of glucokinase using pharmacophore modelling, molecular dynamics and machine learning: implications in type 2 diabetes.

    المؤلفون: Yadav, Siddharth, Rana, Swati, Manish, Manish, Singh, Sohini, Lynn, Andrew, Mathur, Puniti

    المصدر: Journal of Computer-Aided Molecular Design; 12/31/2024, Vol. 39 Issue 1, p1-16, 16p

    مصطلحات موضوعية: AMINO acid residues, MACHINE learning, TYPE 2 diabetes, GLUCOKINASE, PEPTIDES


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