المؤلفون: Lorenzo Ferrando (6648539), Andrea Vingiani (8204229), Anna Garuti (212195), Claudio Vernieri (9744243), Antonino Belfiore (155199), Luca Agnelli (207773), Gianpaolo Dagrada (5754221), Diana Ivanoiu (14322304), Giuseppina Bonizzi (9528557), Elisabetta Munzone (5958338), Luana Lippolis (14322307), Martina Dameri (10979993), Francesco Ravera (12545903), Marco Colleoni (6393845), Giuseppe Viale (173594), Luca Magnani (167833), Alberto Ballestrero (212236), Gabriele Zoppoli (201733), Giancarlo Pruneri (384238)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Biotechnology, Cancer, Infectious Diseases, relapsing hormone receptor, negative breast cancer, copy number variation, clinically relevant patient, 52 – 7, 10 – 12, adjuvant endocrine therapies, adjuvant aromatase inhibitors, metastatic hormone receptor, surgically resected hr, worse overall survival, matched primary tumors, hr )- positive, bc patients relapsing, p value 0, adjuvant et, worse prognosis, tumors bearing, free survival, metastatic specimens, metastatic lesions, hr 5, tp53 <, tamoxifen alone

Relation: https://figshare.com/articles/journal_contribution/_Supplementary_methods_/21809071

الاتاحة: https://doi.org/10.1371/journal.pgen.1010563.s008

المؤلفون: Tamar Zahavi (6332270), Mali Salmon-Divon (240522), Roberto Salgado (8458), Michael Elkin (3873541), Esther Hermano (3873538), Ariel M. Rubinstein (8104427), Prudence A. Francis (9255218), Angelo Di Leo (9695712), Giuseppe Viale (173594), Evandro de Azambuja (9165020), Lieveke Ameye (801800), Christos Sotiriou (643), Asher Salmon (5894453), Nataly Kravchenko-Balasha (32252), Amir Sonnenblick (9929775)

مصطلحات موضوعية: Cancer, Oncology and Carcinogenesis not elsewhere classified, Medical and Health Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Heparanase, prognostic marker, breast cancer, adjuvant chemotherapy, luminal cancer, estrogen receptor

Relation: https://figshare.com/articles/online_resource/Metadata_record_for_the_article_Heparanase_A_potential_marker_of_worse_prognosis_in_estrogen_receptor-positive_breast_cancer/14485065

الاتاحة: https://doi.org/10.6084/m9.figshare.14485065.v1

المؤلفون: Lorenzo Ferrando (6648539), Andrea Vingiani (8204229), Anna Garuti (212195), Claudio Vernieri (9744243), Antonino Belfiore (155199), Luca Agnelli (207773), Gianpaolo Dagrada (5754221), Diana Ivanoiu (14322304), Giuseppina Bonizzi (9528557), Elisabetta Munzone (5958338), Luana Lippolis (14322307), Martina Dameri (10979993), Francesco Ravera (12545903), Marco Colleoni (6393845), Giuseppe Viale (173594), Luca Magnani (167833), Alberto Ballestrero (212236), Gabriele Zoppoli (201733), Giancarlo Pruneri (384238)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Biotechnology, Cancer, Infectious Diseases, relapsing hormone receptor, negative breast cancer, copy number variation, clinically relevant patient, 52 – 7, 10 – 12, adjuvant endocrine therapies, adjuvant aromatase inhibitors, metastatic hormone receptor, surgically resected hr, worse overall survival, matched primary tumors, hr )- positive, bc patients relapsing, p value 0, adjuvant et, worse prognosis, tumors bearing, free survival, metastatic specimens, metastatic lesions, hr 5, tp53 <, tamoxifen alone

Relation: https://figshare.com/articles/figure/_CONSORT-like_flow_chart_/21809050

الاتاحة: https://doi.org/10.1371/journal.pgen.1010563.s001

المؤلفون: Lorenzo Ferrando (6648539), Andrea Vingiani (8204229), Anna Garuti (212195), Claudio Vernieri (9744243), Antonino Belfiore (155199), Luca Agnelli (207773), Gianpaolo Dagrada (5754221), Diana Ivanoiu (14322304), Giuseppina Bonizzi (9528557), Elisabetta Munzone (5958338), Luana Lippolis (14322307), Martina Dameri (10979993), Francesco Ravera (12545903), Marco Colleoni (6393845), Giuseppe Viale (173594), Luca Magnani (167833), Alberto Ballestrero (212236), Gabriele Zoppoli (201733), Giancarlo Pruneri (384238)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Biotechnology, Cancer, Infectious Diseases, relapsing hormone receptor, negative breast cancer, copy number variation, clinically relevant patient, 52 – 7, 10 – 12, adjuvant endocrine therapies, adjuvant aromatase inhibitors, metastatic hormone receptor, surgically resected hr, worse overall survival, matched primary tumors, hr )- positive, bc patients relapsing, p value 0, adjuvant et, worse prognosis, tumors bearing, free survival, metastatic specimens, metastatic lesions, hr 5, tp53 <, tamoxifen alone

Relation: https://figshare.com/articles/figure/_Associations_between_gene_alteration_and_ET_broad_classes_/21809053

الاتاحة: https://doi.org/10.1371/journal.pgen.1010563.s002

المؤلفون: Lorenzo Ferrando (6648539), Andrea Vingiani (8204229), Anna Garuti (212195), Claudio Vernieri (9744243), Antonino Belfiore (155199), Luca Agnelli (207773), Gianpaolo Dagrada (5754221), Diana Ivanoiu (14322304), Giuseppina Bonizzi (9528557), Elisabetta Munzone (5958338), Luana Lippolis (14322307), Martina Dameri (10979993), Francesco Ravera (12545903), Marco Colleoni (6393845), Giuseppe Viale (173594), Luca Magnani (167833), Alberto Ballestrero (212236), Gabriele Zoppoli (201733), Giancarlo Pruneri (384238)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Biotechnology, Cancer, Infectious Diseases, relapsing hormone receptor, negative breast cancer, copy number variation, clinically relevant patient, 52 – 7, 10 – 12, adjuvant endocrine therapies, adjuvant aromatase inhibitors, metastatic hormone receptor, surgically resected hr, worse overall survival, matched primary tumors, hr )- positive, bc patients relapsing, p value 0, adjuvant et, worse prognosis, tumors bearing, free survival, metastatic specimens, metastatic lesions, hr 5, tp53 <, tamoxifen alone

Relation: https://figshare.com/articles/dataset/_Detailed_Patient-Level_Clinical_and_Treatment_Data_for_the_Study_Cohort_/21809056

الاتاحة: https://doi.org/10.1371/journal.pgen.1010563.s003

المؤلفون: Lorenzo Ferrando (6648539), Andrea Vingiani (8204229), Anna Garuti (212195), Claudio Vernieri (9744243), Antonino Belfiore (155199), Luca Agnelli (207773), Gianpaolo Dagrada (5754221), Diana Ivanoiu (14322304), Giuseppina Bonizzi (9528557), Elisabetta Munzone (5958338), Luana Lippolis (14322307), Martina Dameri (10979993), Francesco Ravera (12545903), Marco Colleoni (6393845), Giuseppe Viale (173594), Luca Magnani (167833), Alberto Ballestrero (212236), Gabriele Zoppoli (201733), Giancarlo Pruneri (384238)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Biotechnology, Cancer, Infectious Diseases, relapsing hormone receptor, negative breast cancer, copy number variation, clinically relevant patient, 52 – 7, 10 – 12, adjuvant endocrine therapies, adjuvant aromatase inhibitors, metastatic hormone receptor, surgically resected hr, worse overall survival, matched primary tumors, hr )- positive, bc patients relapsing, p value 0, adjuvant et, worse prognosis, tumors bearing, free survival, metastatic specimens, metastatic lesions, hr 5, tp53 <, tamoxifen alone

Relation: https://figshare.com/articles/dataset/_Cohort_overview_/21809062

الاتاحة: https://doi.org/10.1371/journal.pgen.1010563.s005

المؤلفون: Lorenzo Ferrando (6648539), Andrea Vingiani (8204229), Anna Garuti (212195), Claudio Vernieri (9744243), Antonino Belfiore (155199), Luca Agnelli (207773), Gianpaolo Dagrada (5754221), Diana Ivanoiu (14322304), Giuseppina Bonizzi (9528557), Elisabetta Munzone (5958338), Luana Lippolis (14322307), Martina Dameri (10979993), Francesco Ravera (12545903), Marco Colleoni (6393845), Giuseppe Viale (173594), Luca Magnani (167833), Alberto Ballestrero (212236), Gabriele Zoppoli (201733), Giancarlo Pruneri (384238)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Biotechnology, Cancer, Infectious Diseases, relapsing hormone receptor, negative breast cancer, copy number variation, clinically relevant patient, 52 – 7, 10 – 12, adjuvant endocrine therapies, adjuvant aromatase inhibitors, metastatic hormone receptor, surgically resected hr, worse overall survival, matched primary tumors, hr )- positive, bc patients relapsing, p value 0, adjuvant et, worse prognosis, tumors bearing, free survival, metastatic specimens, metastatic lesions, hr 5, tp53 <, tamoxifen alone

Relation: https://figshare.com/articles/dataset/_Sequencing_Gene_Content_Gene_Targets_and_BED_file_of_the_design_/21809059

الاتاحة: https://doi.org/10.1371/journal.pgen.1010563.s004

المؤلفون: Lorenzo Ferrando (6648539), Andrea Vingiani (8204229), Anna Garuti (212195), Claudio Vernieri (9744243), Antonino Belfiore (155199), Luca Agnelli (207773), Gianpaolo Dagrada (5754221), Diana Ivanoiu (14322304), Giuseppina Bonizzi (9528557), Elisabetta Munzone (5958338), Luana Lippolis (14322307), Martina Dameri (10979993), Francesco Ravera (12545903), Marco Colleoni (6393845), Giuseppe Viale (173594), Luca Magnani (167833), Alberto Ballestrero (212236), Gabriele Zoppoli (201733), Giancarlo Pruneri (384238)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Biotechnology, Cancer, Infectious Diseases, relapsing hormone receptor, negative breast cancer, copy number variation, clinically relevant patient, 52 – 7, 10 – 12, adjuvant endocrine therapies, adjuvant aromatase inhibitors, metastatic hormone receptor, surgically resected hr, worse overall survival, matched primary tumors, hr )- positive, bc patients relapsing, p value 0, adjuvant et, worse prognosis, tumors bearing, free survival, metastatic specimens, metastatic lesions, hr 5, tp53 <, tamoxifen alone

Relation: https://figshare.com/articles/dataset/_Purity_and_ploidy_estimate_/21809065

الاتاحة: https://doi.org/10.1371/journal.pgen.1010563.s006

المؤلفون: Lorenzo Ferrando (6648539), Andrea Vingiani (8204229), Anna Garuti (212195), Claudio Vernieri (9744243), Antonino Belfiore (155199), Luca Agnelli (207773), Gianpaolo Dagrada (5754221), Diana Ivanoiu (14322304), Giuseppina Bonizzi (9528557), Elisabetta Munzone (5958338), Luana Lippolis (14322307), Martina Dameri (10979993), Francesco Ravera (12545903), Marco Colleoni (6393845), Giuseppe Viale (173594), Luca Magnani (167833), Alberto Ballestrero (212236), Gabriele Zoppoli (201733), Giancarlo Pruneri (384238)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Biotechnology, Cancer, Infectious Diseases, relapsing hormone receptor, negative breast cancer, copy number variation, clinically relevant patient, 52 – 7, 10 – 12, adjuvant endocrine therapies, adjuvant aromatase inhibitors, metastatic hormone receptor, surgically resected hr, worse overall survival, matched primary tumors, hr )- positive, bc patients relapsing, p value 0, adjuvant et, worse prognosis, tumors bearing, free survival, metastatic specimens, metastatic lesions, hr 5, tp53 <, tamoxifen alone

Relation: https://figshare.com/articles/dataset/_GO_terms_/21809068

الاتاحة: https://doi.org/10.1371/journal.pgen.1010563.s007

المؤلفون: Lorenzo Ferrando (6648539), Andrea Vingiani (8204229), Anna Garuti (212195), Claudio Vernieri (9744243), Antonino Belfiore (155199), Luca Agnelli (207773), Gianpaolo Dagrada (5754221), Diana Ivanoiu (14322304), Giuseppina Bonizzi (9528557), Elisabetta Munzone (5958338), Luana Lippolis (14322307), Martina Dameri (10979993), Francesco Ravera (12545903), Marco Colleoni (6393845), Giuseppe Viale (173594), Luca Magnani (167833), Alberto Ballestrero (212236), Gabriele Zoppoli (201733), Giancarlo Pruneri (384238)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Biotechnology, Cancer, Infectious Diseases, relapsing hormone receptor, negative breast cancer, copy number variation, clinically relevant patient, 52 – 7, 10 – 12, adjuvant endocrine therapies, adjuvant aromatase inhibitors, metastatic hormone receptor, surgically resected hr, worse overall survival, matched primary tumors, hr )- positive, bc patients relapsing, p value 0, adjuvant et, worse prognosis, tumors bearing, free survival, metastatic specimens, metastatic lesions, hr 5, tp53 <, tamoxifen alone

Relation: https://figshare.com/articles/figure/Repertoire_of_genomic_alterations_in_primary_and_metastatic_HR_HER2-_breast_cancer_BC_/21809074

الاتاحة: https://doi.org/10.1371/journal.pgen.1010563.g001

المؤلفون: Lorenzo Ferrando (6648539), Andrea Vingiani (8204229), Anna Garuti (212195), Claudio Vernieri (9744243), Antonino Belfiore (155199), Luca Agnelli (207773), Gianpaolo Dagrada (5754221), Diana Ivanoiu (14322304), Giuseppina Bonizzi (9528557), Elisabetta Munzone (5958338), Luana Lippolis (14322307), Martina Dameri (10979993), Francesco Ravera (12545903), Marco Colleoni (6393845), Giuseppe Viale (173594), Luca Magnani (167833), Alberto Ballestrero (212236), Gabriele Zoppoli (201733), Giancarlo Pruneri (384238)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Biotechnology, Cancer, Infectious Diseases, relapsing hormone receptor, negative breast cancer, copy number variation, clinically relevant patient, 52 – 7, 10 – 12, adjuvant endocrine therapies, adjuvant aromatase inhibitors, metastatic hormone receptor, surgically resected hr, worse overall survival, matched primary tumors, hr )- positive, bc patients relapsing, p value 0, adjuvant et, worse prognosis, tumors bearing, free survival, metastatic specimens, metastatic lesions, hr 5, tp53 <, tamoxifen alone

Relation: https://figshare.com/articles/figure/_i_ESR1_i_enrichment_in_metastatic_HR_HER2-_BC_samples_/21809077

الاتاحة: https://doi.org/10.1371/journal.pgen.1010563.g002

المؤلفون: Lorenzo Ferrando (6648539), Andrea Vingiani (8204229), Anna Garuti (212195), Claudio Vernieri (9744243), Antonino Belfiore (155199), Luca Agnelli (207773), Gianpaolo Dagrada (5754221), Diana Ivanoiu (14322304), Giuseppina Bonizzi (9528557), Elisabetta Munzone (5958338), Luana Lippolis (14322307), Martina Dameri (10979993), Francesco Ravera (12545903), Marco Colleoni (6393845), Giuseppe Viale (173594), Luca Magnani (167833), Alberto Ballestrero (212236), Gabriele Zoppoli (201733), Giancarlo Pruneri (384238)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Biotechnology, Cancer, Infectious Diseases, relapsing hormone receptor, negative breast cancer, copy number variation, clinically relevant patient, 52 – 7, 10 – 12, adjuvant endocrine therapies, adjuvant aromatase inhibitors, metastatic hormone receptor, surgically resected hr, worse overall survival, matched primary tumors, hr )- positive, bc patients relapsing, p value 0, adjuvant et, worse prognosis, tumors bearing, free survival, metastatic specimens, metastatic lesions, hr 5, tp53 <, tamoxifen alone

Relation: https://figshare.com/articles/figure/Association_between_i_MAP3K_i_alterations_and_clinical_outcome_/21809080

الاتاحة: https://doi.org/10.1371/journal.pgen.1010563.g003

المؤلفون: Lorenzo Ferrando (6648539), Andrea Vingiani (8204229), Anna Garuti (212195), Claudio Vernieri (9744243), Antonino Belfiore (155199), Luca Agnelli (207773), Gianpaolo Dagrada (5754221), Diana Ivanoiu (14322304), Giuseppina Bonizzi (9528557), Elisabetta Munzone (5958338), Luana Lippolis (14322307), Martina Dameri (10979993), Francesco Ravera (12545903), Marco Colleoni (6393845), Giuseppe Viale (173594), Luca Magnani (167833), Alberto Ballestrero (212236), Gabriele Zoppoli (201733), Giancarlo Pruneri (384238)

مصطلحات موضوعية: Cell Biology, Genetics, Molecular Biology, Biotechnology, Cancer, Infectious Diseases, relapsing hormone receptor, negative breast cancer, copy number variation, clinically relevant patient, 52 – 7, 10 – 12, adjuvant endocrine therapies, adjuvant aromatase inhibitors, metastatic hormone receptor, surgically resected hr, worse overall survival, matched primary tumors, hr )- positive, bc patients relapsing, p value 0, adjuvant et, worse prognosis, tumors bearing, free survival, metastatic specimens, metastatic lesions, hr 5, tp53 <, tamoxifen alone

Relation: https://figshare.com/articles/figure/Genomic_spectrum_of_acquired_driver_alterations_/21809083

الاتاحة: https://doi.org/10.1371/journal.pgen.1010563.g004

المؤلفون: Nicola Fusco (838180), Umberto Malapelle (501208), Matteo Fassan (221852), Caterina Marchiò (464585), Simonetta Buglioni (85363), Simonetta Zupo (10432238), Carmen Criscitiello (233327), Paolo Vigneri (230304), Angelo Paolo Dei Tos (3931694), Eugenio Maiorano (806105), Giuseppe Viale (173594)

مصطلحات موضوعية: Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, breast cancer, biomarkers, PIK3CA, targeted therapy, HR+/HER2-, RT-PCR, next-generation sequencing, liquid biopsy

Relation: https://figshare.com/articles/dataset/Table_1_PIK3CA_Mutations_as_a_Molecular_Target_for_Hormone_Receptor-Positive_HER2-Negative_Metastatic_Breast_Cancer_XLSX/14300738

الاتاحة: https://doi.org/10.3389/fonc.2021.644737.s001